Protein Alignment Mhc and MYH11

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_001035203.1
• Gene: MYH11 / 4629
• HGNCID: 7569
• Length: 1979
• Species: Homo sapiens
• Alignment Length: 1944
• Identity: 784/1944 - (40%)
• Similarity: 1187/1944 - (61%)
• Gaps: 41/1944 - (2%)

  Fly    12 DPTPYLFVSLEQRRIDQ---SKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGL-QGGETRDL 72
            |...:|||  ::..|:.   ...:.:|:..|:|.||:|:....||..|||.|.|.| :.|:...:
Human     9 DDEKFLFV--DKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTV 71

  Fly    73 KKDLLQQVNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTN 137
            .||.:|::||||:.|.|||:.||.||:||||||||:||::.|||||||||||.:||||..|:|:.
Human    72 GKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSE 136

  Fly   138 RCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGAS 202
            :...||:||:|:|:||||:||:|.||..||.:..:||:|.||||||||||||||||.|.|.|.:|
Human   137 KIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASS 201

  Fly   203 KK-------TDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGA 260
            .|       |...:.:.|.||.|::|.||:||||||||||:|||||||||||||:|..||.:.||
Human   202 HKGKKDTSITQGPSFAYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGA 266

  Fly   261 DIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDA 325
            :||||||||:|.|.|...||::||||.:::|:...::. .||.:...:|..:|.|.|.:.:..|.
Human   267 NIETYLLEKSRAIRQARDERTFHIFYYMIAGAKEKMRS-DLLLEGFNNYTFLSNGFVPIPAAQDD 330

  Fly   326 EEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCD 390
            |.|..|.:|..|:||:::|:..:.::.::|:.:|.:.||:....:||.........:|..|.|.:
Human   331 EMFQETVEAMAIMGFSEEEQLSILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGIN 395

  Fly   391 TAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLD-TQQKRQH 454
            ..:..:::|.||||||.:.|.:.:..:|...::.||.|..::|||:|::.:.|:.|| |.::...
Human   396 VTDFTRSILTPRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFRWILTRVNKALDKTHRQGAS 460

  Fly   455 FIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLC 519
            |:|:||||||||||.|.|||||||:|||||||.|||.||:|||||||||||||.|||||:|||.|
Human   461 FLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPC 525

  Fly   520 IDLIEK---PMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAH 581
            |:|||:   |.|:|::|:||..||||||::|.|||. |..|....|||||..|   ....|:|.|
Human   526 IELIERPNNPPGVLALLDEECWFPKATDKSFVEKLC-TEQGSHPKFQKPKQLK---DKTEFSIIH 586

  Fly   582 YAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAK--------GGR 638
            |||.|.||.:.||.||.|||||.|......|.:|.:.:::.|.....|..:.||        ..:
Human   587 YAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASK 651

  Fly   639 GKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGI 703
            .|| |.|.||...|||||..||||||:|.|:||||||||..|:.|.:||.||:.||.||||||||
Human   652 TKK-GMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGI 715

  Fly   704 RICRKGFPNRMMYPDFKMRYKIMCPKLL-QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAG 767
            ||||:|||||:::.:|:.||:|:....: :|....|:|..::||.::|..:.||:|.:|:|||.|
Human   716 RICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTG 780

  Fly   768 VLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLW 832
            ||..:||.||.::..::...||..||||:||.|.|.|:|..|:||:|||...||:||.|.|::|:
Human   781 VLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLF 845

  Fly   833 QKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGAL 897
            .||||||.|:|.|:|:...|::.:|.:|.........||||..:::|..||..|.:.|..|....
Human   846 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910

  Fly   898 QDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQK 962
            .:.:|...:|.|:|.:||..|.:::.||.:|||...||..::||..|::..|::.:|:.|...||
Human   911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975

  Fly   963 AEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLE 1027
            .:.:|.|.:.:|:.|.|||...|:..|||:||:|:..|........|...|:|..:|.|:|.|.|
Human   976 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040

  Fly  1028 QTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAK 1092
            ..:.|||..|::|:|.|.::||.|||:|||.....|.:|||:....||:..:.:|::||.:..|:
Human  1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105

  Fly  1093 LEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATS 1157
            |:||........::|:||:..|.:|:|::::||.||.|||||:.||..|||.|...||:...:|:
Human  1106 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1170

  Fly  1158 AQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNE 1222
            .|.||..|||.|::.|::.|:|....||:.:..:|:||..||.|:.||::|..:.||..:|.|..
Human  1171 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1235

  Fly  1223 YYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLL 1287
            ...:..||...:..:...|...|...|:|:..:.|:|||..:..|...:.:....||..|...:.
Human  1236 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300

  Fly  1288 RQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEG 1352
            ..|.|||.:..:|:|...||::||:||:.|..||:|::..:..|.|.||.:.::|::|::||.|.
Human  1301 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365

  Fly  1353 KADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIG---LE 1414
            |.:|:|.:|..|.:....:.|.: |..:..|.|||.|::.|   .|.|...:...:|...   ||
Human  1366 KQNLERHISTLNIQLSDSKKKLQ-DFASTVEALEEGKKRFQ---KEIENLTQQYEEKAAAYDKLE 1426

  Fly  1415 KTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTE 1479
            |||.||..|::||.:::|....:.:..||||:.||:::.|.|......|.|.|.::.|.|...|:
Human  1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491

  Fly  1480 LFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALE 1544
            ...|..|.||..|..|.:.|.||.|..|::||:....:.|:|:||:||:::.||.:.:|::..||
Human  1492 ALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1556

  Fly  1545 EAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAE 1609
            |.|..|:..|:..||.::.:..::.:.:|.:|.::|:.|..|:..||.|...:..||.|.|.:|.
Human  1557 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621

  Fly  1610 ALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISE 1674
            |...|||||.|:.:||:..|.|.|...||.|.:::.|.|:||.|..||:.:.:||:.......:|
Human  1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686

  Fly  1675 RRANALQNELEESRTLLEQADRGRRQAEQELADAHEQL-NEVSAQNASISAAKRKLESELQTLHS 1738
            ::|.:|:.:|.:.:..|..|:|.|:||:.|..:..|:| :.:|.:|| :...||:||:.:..|..
Human  1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEE 1750

  Fly  1739 DLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANA 1803
            :|:|.....:...::.:||...|.:|::||..|:..||..|..|:.||:|.|||:.:|.|.|...
Human  1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1815

  Fly  1804 LKGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVD 1868
            ....|..|..||.::.:||.:::.|.|....|.|:|::.::::||:..|.|::||..|:.::..:
Human  1816 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1880

  Fly  1869 KLQQKIKTYKRQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAGS 1927
            |...::|..|||:|||||.:....|..||.|:||:||.|..:...:.::..::|.|.|:
Human  1881 KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1939

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	15/42 (36%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	340/684 (50%)
		Myosin_tail_1	842..1922	CDD:460256	365/1083 (34%)
MYH11	NP_001035203.1	Myosin_N	31..76	CDD:460670	17/44 (39%)
		MYSc_class_II	99..778	CDD:276951	340/684 (50%)
		Actin-binding. /evidence=ECO:0000250	668..690		16/21 (76%)
		Actin-binding. /evidence=ECO:0000250	769..783		8/13 (62%)
		Myosin_tail_1	855..1935	CDD:460256	365/1084 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..889		7/23 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1751..1807		19/55 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1873..1979		23/67 (34%)
		C-terminal	1942..1979