DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and MYH11

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_001035203.1	Gene:	MYH11 / 4629	HGNCID:	7569	Length:	1979	Species:	Homo sapiens

Alignment Length:	1944	Identity:	778/1944 - (40%)
Similarity:	1184/1944 - (60%)	Gaps:	41/1944 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DPTPYLFVSLEQRRIDQ---SKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGL-QGGEVRDI 72
            |...:|||  ::..|:.   ...:.:|:..|:|.||:|:....||..|||.|.|.| :.|:...:
Human     9 DDEKFLFV--DKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTV 71

  Fly    73 KSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTN 137
            ..:.::|:|||||.|:||||::|.||...||||||:||::.|||||||||||.:||||..|:|:.
Human    72 GKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSE 136

  Fly   138 RCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGAS 202
            :...||:||:|:|:||||:||:|.||..||.:..:||:|.||||||||||||||||.|.|.|.:|
Human   137 KIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASS 201

  Fly   203 KK-------TDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGA 260
            .|       |...:.:.|.||.|::|.||:||||||||||:|||||||||||||:|..||.:.||
Human   202 HKGKKDTSITQGPSFAYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGA 266

  Fly   261 DIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDA 325
            :||||||||:|.|.|...||::||||.:::|:...::. .||.:...:|..:|.|.|.:.:..|.
Human   267 NIETYLLEKSRAIRQARDERTFHIFYYMIAGAKEKMRS-DLLLEGFNNYTFLSNGFVPIPAAQDD 330

  Fly   326 EEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCD 390
            |.|..|.:|..|:||:::|:..:.::.::|:.:|.:.||:....:||.........:|..|.|.:
Human   331 EMFQETVEAMAIMGFSEEEQLSILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGIN 395

  Fly   391 TAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLD-TQQKRQH 454
            ..:..:::|.||||||.:.|.:.:..:|...::.||.|..::|||:|::.:.|:.|| |.::...
Human   396 VTDFTRSILTPRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFRWILTRVNKALDKTHRQGAS 460

  Fly   455 FIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLAC 519
            |:|:||||||||||.|.|||||||:|||||||.|||.||:||||||:||||:|.|||||:||..|
Human   461 FLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPC 525

  Fly   520 IDLIEK---PMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAH 581
            |:|||:   |.|:|::|:||..||||||::|.|||. |..|....|||||..|   ....|:|.|
Human   526 IELIERPNNPPGVLALLDEECWFPKATDKSFVEKLC-TEQGSHPKFQKPKQLK---DKTEFSIIH 586

  Fly   582 YAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAK--------GGR 638
            |||.|.||.:.||.||.|||||.|......|.:|.:.:::.|.....|..:.||        ..:
Human   587 YAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASK 651

  Fly   639 GKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGI 703
            .|| |.|.||...|||||..||||||:|.|:||||||||..|:.|.:||.||:.||.||||||||
Human   652 TKK-GMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGI 715

  Fly   704 RICRKGFPNRMMYPDFKMRYKIMCPKLL-QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAG 767
            ||||:|||||:::.:|:.||:|:....: :|....|:|..::||.::|..:.||:|.:|:|||.|
Human   716 RICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTG 780

  Fly   768 VLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLW 832
            ||..:||.||.::..::...||..||||:||.|.|.|:|..|:||:|||...||:||.|.|::|:
Human   781 VLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLF 845

  Fly   833 QKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGAL 897
            .||||||.|:|.|:|:...|::.:|.:|.........||||..:::|..||..|.:.|..|....
Human   846 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910

  Fly   898 QDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQK 962
            .:.:|...:|.|:|.:||..|.:::.||.:|||...||..::||..|::..|::.:|:.|...||
Human   911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975

  Fly   963 AEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLE 1027
            .:.:|.|.:.:|:.|.|||...|:..|||:||:|:..|........|...|:|..:|.|:|.|.|
Human   976 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040

  Fly  1028 QTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAK 1092
            ..:.|||..|::|:|.|.::||.|||:|||.....|.:|||:....||:..:.:|::||.:..|:
Human  1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105

  Fly  1093 LEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATS 1157
            |:||........::|:||:..|.:|:|::::||.||.|||||:.||..|||.|...||:...:|:
Human  1106 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1170

  Fly  1158 AQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNE 1222
            .|.||..|||.|::.|::.|:|....||:.:..:|:||..||.|:.||::|..:.||..:|.|..
Human  1171 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1235

  Fly  1223 YYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLL 1287
            ...:..||...:..:...|...|...|:|:..:.|:|||..:..|...:.:....||..|...:.
Human  1236 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300

  Fly  1288 RQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEG 1352
            ..|.|||.:..:|:|...||::||:||:.|..||:|::..:..|.|.||.:.::|::|::||.|.
Human  1301 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365

  Fly  1353 KADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIG---LE 1414
            |.:|:|.:|..|.:....:.|.: |..:..|.|||.|::.|   .|.|...:...:|...   ||
Human  1366 KQNLERHISTLNIQLSDSKKKLQ-DFASTVEALEEGKKRFQ---KEIENLTQQYEEKAAAYDKLE 1426

  Fly  1415 KTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTE 1479
            |||.||..|::||.:::|....:.:..||||:.||:::.|.|......|.|.|.::.|.|...|:
Human  1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491

  Fly  1480 LFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALE 1544
            ...|..|.||..|..|.:.|.||.|..|::||:....:.|:|:||:||:::.||.:.:|::..||
Human  1492 ALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1556

  Fly  1545 EAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAE 1609
            |.|..|:..|:..||.::.:..::.:.:|.:|.::|:.|..|:..||.|...:..||.|.|.:|.
Human  1557 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621

  Fly  1610 ALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISE 1674
            |...|||||.|:.:||:..|.|.|...||.|.:::.|.|:||.|..||:.:.:||:.......:|
Human  1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686

  Fly  1675 RRANALQNELEESRTLLEQADRGRRQAEQELADAHEQL-NEVSAQNASISAAKRKLESELQTLHS 1738
            ::|.:|:.:|.:.:..|..|:|.|:||:.|..:..|:| :.:|.:|| :...||:||:.:..|..
Human  1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEE 1750

  Fly  1739 DLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANA 1803
            :|:|.....:...::.:||...|.:|::||..|:..||..|..|:.||:|.|||:.:|.|.|...
Human  1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1815

  Fly  1804 LKGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVD 1868
            ....|..|..||.::.:||.:::.|.|....|.|:|::.::::||:..|.|::||..|:.::..:
Human  1816 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1880

  Fly  1869 KLQQKIKTYKRQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAGS 1927
            |...::|..|||:|||||.:....|..||.|:||:||.|..:...:.::..::|.|.|:
Human  1881 KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	14/37 (38%)
		MYSc	81..777	CDD:214580	355/715 (50%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	335/684 (49%)
		Myosin_tail_1	842..1897	CDD:279860	357/1058 (34%)
		V_Alix_like	1557..1877	CDD:187408	102/320 (32%)
		ATP-synt_B	<1671..1771	CDD:304375	29/100 (29%)
		TMPIT	1739..>1825	CDD:285135	28/85 (33%)
MYH11	NP_001035203.1	Myosin_N	34..71	CDD:280832	14/36 (39%)
		Myosin_head	87..778	CDD:278492	342/696 (49%)
		MYSc_class_II	99..778	CDD:276951	335/684 (49%)
		Actin-binding. /evidence=ECO:0000250	668..690		16/21 (76%)
		Actin-binding. /evidence=ECO:0000250	769..783		8/13 (62%)
		Myosin_tail_1	855..1935	CDD:279860	365/1084 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	865..889		7/23 (30%)
		FAM76	<997..1089	CDD:292665	36/91 (40%)
		V_Alix_like	<1027..1299	CDD:187408	97/271 (36%)
		crotonase-like	1073..>1131	CDD:304874	17/57 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1751..1807		19/55 (35%)
		DUF2570	1787..>1874	CDD:305162	30/86 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1873..1979		23/67 (34%)
		C-terminal	1942..1979
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I8070
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47111at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.720