DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and MYH10

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_011522177.1 Gene:MYH10 / 4628 HGNCID:7568 Length:2037 Species:Homo sapiens


Alignment Length:1981 Identity:790/1981 - (39%)
Similarity:1198/1981 - (60%) Gaps:91/1981 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 EDPTPYLFVSLEQRRIDQSKPYD--------SKKSCWIPDEKEGYLLGEIKATKGDIVSVGL-QG 66
            |||..||||       |::..|:        :||..|||.|:.|:....||..:||.|.|.| :.
Human    38 EDPERYLFV-------DRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAEN 95

  Fly    67 GEVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKR 131
            |:...:..:.::|:|||||.|:||||::|.||...|||||:.|||:.|||||||||||.|||||.
Human    96 GKKAMVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKN 160

  Fly   132 YPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYF 196
            .|:|:....:|||||:|:|:||||:|||:.||..||.:..:||:|.||||||||||||||||.|.
Human   161 LPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYL 225

  Fly   197 ATVGASKK----------TDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHF 251
            |.|.:|.|          :.:..|.:|.||.|::|.||:||:|||||||:|||||||||||||:|
Human   226 AHVASSHKGRKDHNIPQESPKPVKHQGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINF 290

  Fly   252 GPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGK 316
            ..||.:.||:||||||||:|.:.|...||::|||||::||:...:|. .||.:...:|..:|.|.
Human   291 DVTGYIVGANIETYLLEKSRAVRQAKDERTFHIFYQLLSGAGEHLKS-DLLLEGFNNYRFLSNGY 354

  Fly   317 VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGG 381
            :.:....|.:.|..|.:|..|:||:.:|...:.::.::|:..|.:.||:....:||.........
Human   355 IPIPGQQDKDNFQETMEAMHIMGFSHEEILSMLKVVSSVLQFGNISFKKERNTDQASMPENTVAQ 419

  Fly   382 RVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETL 446
            ::..|.|.:..|..:.:|.||||||.::|.:.:..:|...::.||.|..::|||:|||.:.|:.|
Human   420 KLCHLLGMNVMEFTRAILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKAL 484

  Fly   447 D-TQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFI 510
            | |:::...|||:||||||||||.|.|||||||:|||||||.|||.||:||||||:||||:|.||
Human   485 DRTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFI 549

  Fly   511 DFGMDLLACIDLIEKPM---GILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQ 572
            |||:||..||||||:|.   |:|::|:||..||||||:||.|||.... |..:.||||:..|   
Human   550 DFGLDLQPCIDLIERPANPPGVLALLDEECWFPKATDKTFVEKLVQEQ-GSHSKFQKPRQLK--- 610

  Fly   573 QAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQ---------- 627
            ..|.|.|.||||.|.|....||.||.|||||.|.....:|.::.:.|::.|....          
Human   611 DKADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDEIQNIQRASFYDSV 675

  Fly   628 -----------------SGGGEQAKGGRGK-KGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCI 674
                             :|..|.|.|...| |.|.|.||...|||.|..||.|||:|.|:|||||
Human   676 SGLHEPPVDRIVGLDQVTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCI 740

  Fly   675 IPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLL-QGVEKDK 738
            |||..|:.|.:|.|||:.||.||||||||||||:|||||:::.:|:.||:|:.|..: :|....|
Human   741 IPNHEKRAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGK 805

  Fly   739 KATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKL 803
            :|.|.:|:.::|..:.||:|.:|:|||||||..:||.||.::..|:.:.||..||||:||.|.|.
Human   806 QACERMIRALELDPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKK 870

  Fly   804 QEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKV 868
            |:|..||||:|||...||:||.|.|::::.||||||.|:|.|:|:...:|:..|.:|   .:.||
Human   871 QQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKE---KQTKV 932

  Fly   869 RKELEALNAK---LLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEED 930
            ..|||.:..|   ||.||..|.:.|..|.....:.:|..|:|.|:|.:||..|.|::.|: :||:
Human   933 EGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRV-EEEE 996

  Fly   931 ARNQLFQ-QKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKE 994
            .|||:.| :|||....|..|::.:::.|...||.:.:|.|.:.:|:.:.:||...::..:|..||
Human   997 ERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKE 1061

  Fly   995 KKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLK 1059
            ||:..:...:...:|...|:|..:|.|::.|.|..:.:||:.|::|:|.|.::||:|||::|:..
Human  1062 KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETT 1126

  Fly  1060 LTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAE 1124
            ..|:.:|:|:....||:..:.:|::||....|:.:||.:......:.::||||:|.||:|:.|:|
Human  1127 DLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE 1191

  Fly  1125 RQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLA 1189
            :.:|.|||||:.||:.|||.|...||:....|:||.||..|||.|:::|::.|||....||:.:.
Human  1192 KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQ 1256

  Fly  1190 NLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHT 1254
            ::|::|..|:.|::||::|..:.||..||.|........:|...|..:...||..|...|:|...
Human  1257 DMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQ 1321

  Fly  1255 LNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLAD 1319
            :.|:.:|:.|.:|...:......||..|..::...|||||.:..:.:|...||.:||:||:.|..
Human  1322 VQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQ 1386

  Fly  1320 EESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEE 1384
            ||:|::..|..:.|.||.:.::|:||.|||.|.:.:|::|:....::....:.|.:.| :...|.
Human  1387 EETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDD-LGTIES 1450

  Fly  1385 LEEAKRKLQARLAEAEETIESLNQKCIG---LEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQK 1446
            |||||:||   |.:||...:.|.:|.:.   |||||.||..|::||.:::|....:|:..|||||
Human  1451 LEEAKKKL---LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQK 1512

  Fly  1447 AFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDL 1511
            .||:::.|.|......|.|.|.::.|.|...|:...|..|.||..|..|...|:||.|..:::||
Human  1513 KFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDL 1577

  Fly  1512 LDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQ 1576
            :....:.|:|:||:||:::.||.:.:|::..|||.|..|:..|:..||.::.:..::.:.:|.:|
Human  1578 MSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1642

  Fly  1577 EKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKN 1641
            .::|:.|..::...:.:..::|.||.|.|.:|.|:..|||:|.|:.:||..::.||||..|..|.
Human  1643 TRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ 1707

  Fly  1642 IKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQAEQ--- 1703
            :::.|.|:||.|..|||.:.:||:...|...||::..:|:.|:.:.:..|..::|.||.|||   
Human  1708 LRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERD 1772

  Fly  1704 ELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSE---EKAKKAMVDAARLA 1765
            ||||  |..|..|.::|.:. .||:||:.:..|..:|:|   |..|.|   ::.:|..:....|.
Human  1773 ELAD--EITNSASGKSALLD-EKRRLEARIAQLEEELEE---EQSNMELLNDRFRKTTLQVDTLN 1831

  Fly  1766 DELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQR 1830
            .||.||:..||..:..|:.||:|.|||:.:|.|.|.......|..|..||.::.:||.:|:.|.:
Human  1832 AELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAK 1896

  Fly  1831 RHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKF 1895
            ..|.|.|.:|::|:::||:..|.|::|::.::.::.::|...::|..|||:|||||.|....|..
Human  1897 ERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASR 1961

  Fly  1896 RKAQQELEEAEERADLAEQAISKFRAKGRAG 1926
            ||.|:||::|.|..:...:.:|..:.:.|.|
Human  1962 RKLQRELDDATEANEGLSREVSTLKNRLRRG 1992

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 14/37 (38%)
MYSc 81..777 CDD:214580 360/738 (49%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 339/707 (48%)
Myosin_tail_1 842..1897 CDD:279860 360/1067 (34%)
V_Alix_like 1557..1877 CDD:187408 104/325 (32%)
ATP-synt_B <1671..1771 CDD:304375 33/105 (31%)
TMPIT 1739..>1825 CDD:285135 29/88 (33%)
MYH10XP_011522177.1 Myosin_N 64..102 CDD:280832 14/37 (38%)
Myosin_head 117..832 CDD:278492 346/719 (48%)
MYSc_Myh10 129..832 CDD:276952 339/707 (48%)
Myosin_tail_1 909..1989 CDD:279860 368/1093 (34%)
DUF342 <1105..1194 CDD:302792 30/88 (34%)
DUF2317 <1172..1283 CDD:302887 48/110 (44%)
COG5134 <1399..1527 CDD:227463 48/131 (37%)
GBP_C <1565..1671 CDD:303769 31/105 (30%)
coiled coil 1661..1671 CDD:293879 4/9 (44%)
DUF106 <1706..>1757 CDD:303007 16/50 (32%)
DUF2570 1834..>1928 CDD:305162 33/93 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.720

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