Protein Alignment Mhc and MYH10

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_001242941.1
• Gene: MYH10 / 4628
• HGNCID: 7568
• Length: 2007
• Species: Homo sapiens
• Alignment Length: 1981
• Identity: 796/1981 - (40%)
• Similarity: 1201/1981 - (60%)
• Gaps: 91/1981 - (4%)

  Fly    11 EDPTPYLFVSLEQRRIDQSKPYD--------SKKSCWIPDEKEGYLLGEIKATKGDIVSVGL-QG 66
            |||..||||       |::..|:        :||..|||.|:.|:....||..:||.|.|.| :.
Human     8 EDPERYLFV-------DRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAEN 65

  Fly    67 GETRDLKKDLLQQVNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKR 131
            |:...:.||.:|::||||:.|.|||:.||.||:|||||||:.|||:.|||||||||||.|||||.
Human    66 GKKAMVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKN 130

  Fly   132 YPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYF 196
            .|:|:....:|||||:|:|:||||:|||:.||..||.:..:||:|.||||||||||||||||.|.
Human   131 LPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYL 195

  Fly   197 ATVGASKK----------TDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHF 251
            |.|.:|.|          :.:..|.:|.||.|::|.||:||:|||||||:|||||||||||||:|
Human   196 AHVASSHKGRKDHNIPQESPKPVKHQGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINF 260

  Fly   252 GPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGK 316
            ..||.:.||:||||||||:|.:.|...||::|||||::||:...:|. .||.:...:|..:|.|.
Human   261 DVTGYIVGANIETYLLEKSRAVRQAKDERTFHIFYQLLSGAGEHLKS-DLLLEGFNNYRFLSNGY 324

  Fly   317 VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGG 381
            :.:....|.:.|..|.:|..|:||:.:|...:.::.::|:..|.:.||:....:||.........
Human   325 IPIPGQQDKDNFQETMEAMHIMGFSHEEILSMLKVVSSVLQFGNISFKKERNTDQASMPENTVAQ 389

  Fly   382 RVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETL 446
            ::..|.|.:..|..:.:|.||||||.::|.:.:..:|...::.||.|..::|||:|||.:.|:.|
Human   390 KLCHLLGMNVMEFTRAILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKAL 454

  Fly   447 D-TQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFI 510
            | |:::...|||:||||||||||.|.|||||||:|||||||.|||.||:|||||||||||||.||
Human   455 DRTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFI 519

  Fly   511 DFGMDLQLCIDLIEKPM---GILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQ 572
            |||:|||.||||||:|.   |:|::|:||..||||||:||.|||.... |..:.||||:..|
Human   520 DFGLDLQPCIDLIERPANPPGVLALLDEECWFPKATDKTFVEKLVQEQ-GSHSKFQKPRQLK--- 580

  Fly   573 QAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQ---------- 627
            ..|.|.|.||||.|.|....||.||.|||||.|.....:|.::.:.|::.|....
Human   581 DKADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDEIQNIQRASFYDSV 645

  Fly   628 -----------------SGGGEQAKGGRGK-KGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCI 674
                             :|..|.|.|...| |.|.|.||...|||.|..||.|||:|.|:|||||
Human   646 SGLHEPPVDRIVGLDQVTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCI 710

  Fly   675 IPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLL-QGVEKDK 738
            |||..|:.|.:|.|||:.||.||||||||||||:|||||:::.:|:.||:|:.|..: :|....|
Human   711 IPNHEKRAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGK 775

  Fly   739 KATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKL 803
            :|.|.:|:.::|..:.||:|.:|:|||||||..:||.||.::..|:.:.||..||||:||.|.|.
Human   776 QACERMIRALELDPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKK 840

  Fly   804 QEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKV 868
            |:|..||||:|||...||:||.|.|::::.||||||.|:|.|:|:...:|:..|.:|   .:.||
Human   841 QQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKE---KQTKV 902

  Fly   869 RKELEALNAK---LLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEED 930
            ..|||.:..|   ||.||..|.:.|..|.....:.:|..|:|.|:|.:||..|.|::.|: :||:
Human   903 EGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRV-EEEE 966

  Fly   931 ARNQLFQ-QKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKE 994
            .|||:.| :|||....|..|::.:::.|...||.:.:|.|.:.:|:.:.:||...::..:|..||
Human   967 ERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKE 1031

  Fly   995 KKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLK 1059
            ||:..:...:...:|...|:|..:|.|::.|.|..:.:||:.|::|:|.|.::||:|||::|:..
Human  1032 KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETT 1096

  Fly  1060 LTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAE 1124
            ..|:.:|:|:....||:..:.:|::||....|:.:||.:......:.::||||:|.||:|:.|:|
Human  1097 DLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE 1161

  Fly  1125 RQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLA 1189
            :.:|.|||||:.||:.|||.|...||:....|:||.||..|||.|:::|::.|||....||:.:.
Human  1162 KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQ 1226

  Fly  1190 NLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHT 1254
            ::|::|..|:.|::||::|..:.||..||.|........:|...|..:...||..|...|:|...
Human  1227 DMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQ 1291

  Fly  1255 LNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLAD 1319
            :.|:.:|:.|.:|...:......||..|..::...|||||.:..:.:|...||.:||:||:.|..
Human  1292 VQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQ 1356

  Fly  1320 EESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEE 1384
            ||:|::..|..:.|.||.:.::|:||.|||.|.:.:|::|:....::....:.|.:.| :...|.
Human  1357 EETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDD-LGTIES 1420

  Fly  1385 LEEAKRKLQARLAEAEETIESLNQKCIG---LEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQK 1446
            |||||:||   |.:||...:.|.:|.:.   |||||.||..|::||.:::|....:|:..|||||
Human  1421 LEEAKKKL---LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQK 1482

  Fly  1447 AFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDL 1511
            .||:::.|.|......|.|.|.::.|.|...|:...|..|.||..|..|...|:||.|..:::||
Human  1483 KFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDL 1547

  Fly  1512 LDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQ 1576
            :....:.|:|:||:||:::.||.:.:|::..|||.|..|:..|:..||.::.:..::.:.:|.:|
Human  1548 MSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1612

  Fly  1577 EKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKN 1641
            .::|:.|..::...:.:..::|.||.|.|.:|.|:..|||:|.|:.:||..::.||||..|..|.
Human  1613 TRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ 1677

  Fly  1642 IKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQAEQ--- 1703
            :::.|.|:||.|..|||.:.:||:...|...||::..:|:.|:.:.:..|..::|.||.|||
Human  1678 LRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERD 1742

  Fly  1704 ELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSE---EKAKKAMVDAARLA 1765
            ||||  |..|..|.::|.:. .||:||:.:..|..:|:|   |..|.|   ::.:|..:....|.
Human  1743 ELAD--EITNSASGKSALLD-EKRRLEARIAQLEEELEE---EQSNMELLNDRFRKTTLQVDTLN 1801

  Fly  1766 DELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQR 1830
            .||.||:..||..:..|:.||:|.|||:.:|.|.|.......|..|..||.::.:||.:|:.|.:
Human  1802 AELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAK 1866

  Fly  1831 RHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKF 1895
            ..|.|.|.:|::|:::||:..|.|::|::.::.::.::|...::|..|||:|||||.|....|..
Human  1867 ERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASR 1931

  Fly  1896 RKAQQELEEAEERADLAEQAISKFRAKGRAG 1926
            ||.|:||::|.|..:...:.:|..:.:.|.|
Human  1932 RKLQRELDDATEANEGLSREVSTLKNRLRRG 1962

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	15/50 (30%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	344/707 (49%)
		Myosin_tail_1	842..1922	CDD:460256	368/1092 (34%)
MYH10	NP_001242941.1	Myosin_N	31..76	CDD:460670	17/44 (39%)
		MYSc_Myh10	99..802	CDD:276952	344/707 (49%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	692..714		15/21 (71%)
		Myosin_tail_1	879..1959	CDD:460256	368/1093 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1158..1178		10/19 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1728..1759		14/32 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1903..2007		22/60 (37%)