DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and MYH9

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_002464.1	Gene:	MYH9 / 4627	HGNCID:	7579	Length:	1960	Species:	Homo sapiens

Alignment Length:	1939	Identity:	789/1939 - (40%)
Similarity:	1186/1939 - (61%)	Gaps:	49/1939 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SKKSCWIPDEKEGYLLGEIKATKGDIVSVGL-QGGEVRDIKSEKVEKVNPPKFEKIEDMADMTVL 97
            :||..|:|.:|.|:....:|...|:...|.| :.|:...:..:.::|:|||||.|:||||::|.|
Human    28 AKKLVWVPSDKSGFEPASLKEEVGEEAIVELVENGKKVKVNKDDIQKMNPPKFSKVEDMAELTCL 92

  Fly    98 NTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGA 162
            |...|||||::|||:.|||||||||||.|||||..|:|:....:||:||:|:|:||||:||:|.|
Human    93 NEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTA 157

  Fly   163 YVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLE 227
            |..|:.:..:||:|.||||||||||||||||.|.|.|.:|.|   :.|.:|.||.|::|.||:||
Human   158 YRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSHK---SKKDQGELERQLLQANPILE 219

  Fly   228 AFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGS 292
            ||||||||:|||||||||||||:|...|.:.||:||||||||:|.|.|...||::||||.::||:
Human   220 AFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGA 284

  Fly   293 VPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMH 357
            ...:| ..||.:....|..:|.|.||:....|.:.|..|.:|..|:|..::|:..:.|:.:.|:.
Human   285 GEHLK-TDLLLEPYNKYRFLSNGHVTIPGQQDKDMFQETMEAMRIMGIPEEEQMGLLRVISGVLQ 348

  Fly   358 MGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNS 422
            :|.:.||:....:||.........:||.|.|.:..:..:.:|.||||||.::|.:.:..:|...:
Human   349 LGNIVFKKERNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTKEQADFA 413

  Fly   423 IGALCKGVFDRLFKWLVKKCNETLD-TQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQ 486
            |.||.|..::|:|:|||.:.|:.|| |:::...|||:|||||||||:.|.|||||||:|||||||
Human   414 IEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQ 478

  Fly   487 FFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPM---GILSILEEESMFPKATDQTFS 548
            .|||.||:||||||:||||:|.|||||:||..||||||||.   |||::|:||..||||||::|.
Human   479 LFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPKATDKSFV 543

  Fly   549 EKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQ 613
            ||:.... |....|||||..|   ..|.|.|.||||.|.|....||.||.|||||.:.....:|.
Human   544 EKVMQEQ-GTHPKFQKPKQLK---DKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSS 604

  Fly   614 NKLLIEIFAD---------HAGQSGGGEQAKGGRGK-KGGGFATVSSAYKEQLNSLMTTLRSTQP 668
            :|.:.|::.|         .||.|   |.|..|..| :.|.|.||...|||||..||.|||:|.|
Human   605 DKFVSELWKDVDRIIGLDQVAGMS---ETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTNP 666

  Fly   669 HFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLL-Q 732
            :||||||||..|:.|.:|.|||:.||.||||||||||||:|||||:::.:|:.||:|:.|..: :
Human   667 NFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIPK 731

  Fly   733 GVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSR 797
            |....|:|..::||.::|..:.||:|.:|||||||||..:||.||.::..::...||..||||:|
Human   732 GFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLAR 796

  Fly   798 KGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELH 862
            |.|.|.|:|..|:||:|||...||:||.|.|::|:.||||||.|||.|:|:...||:..|..|..
Human   797 KAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQ 861

  Fly   863 AAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQ 927
            .|......|:|.|.::|:|||..|.:.|..|.....:.:|..|:|||:|.:||....|::.|:.:
Human   862 LAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEE 926

  Fly   928 EEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLN 992
            ||:....|..:|||..|.|..|::.:|:.|...||.:.:|.|.:.:::.|.:|....::...||.
Human   927 EEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLA 991

  Fly   993 KEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGD 1057
            ||||:..:...:....|...|:|...|.|:|.|.|..:.:||:.|.||:|.|.::||::||:|||
Human   992 KEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGD 1056

  Fly  1058 LKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVE 1122
            .....:.:|:|:....||:..:.:|::||.:..|::|:|........::|:||:::|.||:|::|
Human  1057 STDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLE 1121

  Fly  1123 AERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHEST 1187
            :||.:|.|||||:.||..|||.|...||:...:|:||.||..|||.|::.|::.|||....||:.
Human  1122 SERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ 1186

  Fly  1188 LANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQ 1252
            :..:|:||:.||.|:|||::|..::||..||.|.....:..:|...|..:...|...|...|:::
Human  1187 IQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVE 1251

  Fly  1253 HTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRL 1317
            ..|.|:|.|.:|..|...:......||.:|..::...|.:::|:.|:|:|...:|.:||:||:.|
Human  1252 AQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQEL 1316

  Fly  1318 ADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARS 1382
            ..||:|::.:|..|.:.:|.:.::.|||:|||.|.|.:|::|::..:|:....:.|.| |.|...
Human  1317 LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKME-DSVGCL 1380

  Fly  1383 EELEEAKRKLQARL----AEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEK 1443
            |..||.|||||..|    ...||.:.:.::    |||||.||..|::||.:::|.....|...||
Human  1381 ETAEEVKRKLQKDLEGLSQRHEEKVAAYDK----LEKTKTRLQQELDDLLVDLDHQRQSACNLEK 1441

  Fly  1444 KQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEV 1508
            |||.||:::.|.|......|.|.|.::.|.|...|:...|..|.||..||...:.|.||....|:
Human  1442 KQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEM 1506

  Fly  1509 KDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDR 1573
            :||:....:.|:::||:||:::.||.:.:|::..|||.|..|:..|:..||.::.|..::.:.:|
Human  1507 EDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER 1571

  Fly  1574 RIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEA 1638
            .:|.::|:.|..:|...|.:..|:|.||.|.|.::.|:..:||||.|:.:||..:|.|||...||
Human  1572 DLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA 1636

  Fly  1639 QKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQAEQ 1703
            .|.:::.|.|:||....|::.:.:|::...|...:|::..:::.|:.:.:..|..|:|.:|||:|
Human  1637 IKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQ 1701

  Fly  1704 ELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSE---EKAKKAMVDAARLA 1765
            |..:..:::...|.:.|.....||:||:.:..|..:|:|   |..|:|   ::.|||.:...::.
Human  1702 ERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEE---EQGNTELINDRLKKANLQIDQIN 1763

  Fly  1766 DELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQR 1830
            .:|..|:.|||..|..|:.||:|.|||:|:|.|.|.......|.:|..||.::.:||.:||.|.:
Human  1764 TDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETK 1828

  Fly  1831 RHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKF 1895
            ....|.|.:|::|:::|::..|.:::|:|.|:.:|..||...::|..|||:|||||.|....|..
Human  1829 ERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASR 1893

  Fly  1896 RKAQQELEEAEERADLAEQAISKFRAKGRAGSVGRGASP--APRATSVRPQFDG 1947
            ||.|:|||:|.|.||...:.:|..:.|.|     ||..|  .||..:.:...||
Human  1894 RKLQRELEDATETADAMNREVSSLKNKLR-----RGDLPFVVPRRMARKGAGDG 1942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	10/37 (27%)
		MYSc	81..777	CDD:214580	364/710 (51%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	343/679 (51%)
		Myosin_tail_1	842..1897	CDD:279860	359/1061 (34%)
		V_Alix_like	1557..1877	CDD:187408	101/322 (31%)
		ATP-synt_B	<1671..1771	CDD:304375	26/102 (25%)
		TMPIT	1739..>1825	CDD:285135	31/88 (35%)
MYH9	NP_002464.1	Mediates interaction with LIMCH1. /evidence=ECO:0000269\|PubMed:28228547	2..838		407/820 (50%)
		Myosin_N	29..68	CDD:367160	11/38 (29%)
		Motor_domain	95..764	CDD:354959	343/679 (51%)
		Actin-binding	654..676		15/21 (71%)
		Myosin_tail_1	841..1921	CDD:366712	370/1087 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1035..1057		11/21 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1118..1137		10/18 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1877..1960		29/71 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I8070
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47111at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.720