DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and MYH8

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_002463.2	Gene:	MYH8 / 4626	HGNCID:	7578	Length:	1937	Species:	Homo sapiens

Alignment Length:	1919	Identity:	1070/1919 - (55%)
Similarity:	1429/1919 - (74%)	Gaps:	10/1919 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEK 76
            :..|||..|.::|...|:||:|:|.|.::.:.||.|:...|::.:|..|:|..:||....::.::
Human    14 EAAPYLRKSEKERIEAQNKPFDAKTSVFVAEPKESYVKSTIQSKEGGKVTVKTEGGATLTVREDQ 78

  Fly    77 VEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAK 141
            |..:||||::||||||.||.|:.|.||:||::||.|.:||||||||||.:||||..|||......
Human    79 VFPMNPPKYDKIEDMAMMTHLHEPGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVA 143

  Fly   142 MYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGAS--KK 204
            .||||:|.|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.||||:..:  ||
Human   144 AYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKK 208

  Fly   205 TDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEK 269
            .||:.|.:|:||||::..||:|||||||||||||||||||||||||||.|||||.||||||||||
Human   209 KDESGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEK 273

  Fly   270 ARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQA 334
            :||..|...||||||||||.|...|.:.::.|:|.|.|||..||||::||.||||.||...||.|
Human   274 SRVTFQLKAERSYHIFYQITSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSA 338

  Fly   335 FDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLL 399
            .||||||.:||..:|::|.||||.|.|||||:.||||||.||.|...:.:.|...::|:|.|.|.
Human   339 IDILGFTPEEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALC 403

  Fly   400 KPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGF 464
            .||:|||||:||:|:.||||.|::|||.|.|::::|.|:|.:.|:.|||:|.||:||||||||||
Human   404 YPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGF 468

  Fly   465 EIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGI 529
            |||::|..|||||||||||||||||||||||||||||:|||:|.||||||||.|||:|||||:||
Human   469 EIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPLGI 533

  Fly   530 LSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWL 594
            .||||||.|||||||.:|..||.:.||||||.|||||..| |:..|||::.||||.|.|||||||
Human   534 FSILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVK-GKAEAHFSLIHYAGTVDYNITGWL 597

  Fly   595 EKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSL 659
            :|||||||||||..::||..|.|..:|:.:|.........||.: |||..|.|||:.::|.||.|
Human   598 DKNKDPLNDTVVGLYQKSAMKTLASLFSTYASAEADSSAKKGAK-KKGSSFQTVSALFRENLNKL 661

  Fly   660 MTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYK 724
            ||.||||.|||||||||||.|.||.::..||:|||.||||||||||||||||:|::|.|||.|||
Human   662 MTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYK 726

  Fly   725 IMCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSW 786
            ::....:   |.:: .|||:|.::..||:...||:.|:|||||:||:||.:||.|||:|.:|::.
Human   727 VLNASAIPEGQFID-SKKASEKLLASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQIITR 790

  Fly   787 MQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARL 851
            .||..||:|.|..::|:.::|.||..:|.|:|.::.::.|||.||:.|:||||..:..|.|:|.:
Human   791 TQAVCRGFLMRVEYQKMLQRREALFCIQYNVRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATM 855

  Fly   852 EEKAKKA-EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLE 915
            :|:.:|. :||..:|.| |||||.....||.||..|...:..|..:|.|.:||..:|...|..||
Human   856 KEEFQKTKDELAKSEAK-RKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLE 919

  Fly   916 NQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDE 980
            .:::::.||..:||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:|
Human   920 AKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 984

  Fly   981 IAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRG 1045
            :|..||.|.||:||||...||:|:|.::|||.|||:|.|.|.|.||||.:|:||.|||:|||:|.
Human   985 MAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRM 1049

  Fly  1046 DVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKEL 1110
            |:|::|||:||||||.||:..|:|.:|::|::.:::|:.|:|::.:|:||||.|.::.|::||||
Human  1050 DLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKEL 1114

  Fly  1111 QARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRR 1175
            |||||||.||:||||.:||||||||:||:|||||:.|||||||||||||:|||||||||..||||
Human  1115 QARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRR 1179

  Fly  1176 DLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNE 1240
            |||||.:|||:.:|.|||||.|::||:.||:|.|.::|.|.||||:|...:.:||.:..:.|:..
Human  1180 DLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKA 1244

  Fly  1241 KAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKI 1305
            |...||:.:.|:..::|:::|.:|..|.:||..|.:.:|..|..:..|||:|.::.|||||:.|.
Human  1245 KGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQ 1309

  Fly  1306 SLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVW 1370
            :.|.|:|:.|...:||::.:..|....::..||.|.||||.|||.||||:|||.|||||:|...|
Human  1310 ASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQW 1374

  Fly  1371 RSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRAN 1435
            |:|||:|.:.|:|||||||:||..||.||||.:|::|.||..||||||||..|||||.|:|:|:|
Human  1375 RTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSN 1439

  Fly  1436 AIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRE 1500
            |...|.:|||:.|||::.|||.|.::..|||:|||||.|:.|||||::|..|||..:|||.:|||
Human  1440 AACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRE 1504

  Fly  1501 NKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELS 1565
            ||||..|:.||.:||.|||:.|||:||.:|::|.||.|:|||||||||:||.||.|:||.||||:
Human  1505 NKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELN 1569

  Fly  1566 QVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDH 1630
            ||:.|:||:|.||:||.:..::||.|.:::||::|:||.:.:.:|||:|||:|.|:||:||.|:|
Human  1570 QVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNH 1634

  Fly  1631 ANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQAD 1695
            ||:..||:.:|.:..|..||:.|..|::..|.::|.:|||.|.|||||.||.|:||....|||.:
Human  1635 ANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTE 1699

  Fly  1696 RGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVD 1760
            |.|:.|||||.||.|::..:..||.|:...|:|||:::..|.|:::|::.|::|:|||||||:.|
Human  1700 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITD 1764

  Fly  1761 AARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENEL 1825
            ||.:|:||:.|||.:...|:::|.|||.:|:||.||||||..|||||||.|||||.||||||.|:
Human  1765 AAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEV 1829

  Fly  1826 DGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAAL 1890
            :.||:|:|:|.|.|||.|||||||::|:||||||..|:||||||||.|:|:||||.|||||.:..
Human  1830 ENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNA 1894

  Fly  1891 NLAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            ||:||||.|.||||||||||:||..::|.|.|.|
Human  1895 NLSKFRKLQHELEEAEERADIAESQVNKLRVKSR 1928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	10/36 (28%)
		MYSc	81..777	CDD:214580	443/700 (63%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	423/669 (63%)
		Myosin_tail_1	842..1897	CDD:279860	559/1055 (53%)
		V_Alix_like	1557..1877	CDD:187408	172/319 (54%)
		ATP-synt_B	<1671..1771	CDD:304375	49/99 (49%)
		TMPIT	1739..>1825	CDD:285135	51/85 (60%)
MYH8	NP_002463.2	Myosin_N	38..75	CDD:280832	10/36 (28%)
		Myosin_head	90..769	CDD:278492	431/681 (63%)
		MYSc_Myh8	102..769	CDD:276882	423/669 (63%)
		Actin-binding	658..680		18/21 (86%)
		Actin-binding	760..774		8/13 (62%)
		Myosin_tail_1	849..1926	CDD:279860	576/1077 (53%)
		eIF-4B	<1042..1099	CDD:283846	26/56 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1126..1146		15/19 (79%)
		COG6	1375..>1510	CDD:303003	82/134 (61%)
		DUF342	<1505..1581	CDD:302792	48/75 (64%)
		TMPIT	1741..>1828	CDD:285135	52/86 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1116	1.000	Domainoid score	I20
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2097	1.000	Inparanoid score	I44
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm41736
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.870