DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and MYH7

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_000248.2	Gene:	MYH7 / 4625	HGNCID:	7577	Length:	1935	Species:	Homo sapiens

Alignment Length:	1918	Identity:	1087/1918 - (56%)
Similarity:	1442/1918 - (75%)	Gaps:	14/1918 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEK 79
            |||..|.::|...|::|:|.||..::||:|:.::..:|.:.:|..|:...:.|:...:|.::|.:
Human    14 PYLRKSEKERLEAQTRPFDLKKDVFVPDDKQEFVKAKIVSREGGKVTAETEYGKTVTVKEDQVMQ 78

  Fly    80 VNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYR 144
            .|||||:||||||.:|.|:.|.||:||:.||.:.:||||||||||.:||||..||||......||
Human    79 QNPPKFDKIEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYR 143

  Fly   145 GKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGA----SKKT 205
            ||:|:|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.|||.:.|    |||
Human   144 GKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKK- 207

  Fly   206 DEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKA 270
             :.:..||:||||::|.||.|||||||||||||||||||||||||||.|||||.||||||||||:
Human   208 -DQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKS 271

  Fly   271 RVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAF 335
            |||.|...||.|||||||:|...|.:.|:.|:|:|.|||..:|||:.||||||||||...||.||
Human   272 RVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAF 336

  Fly   336 DILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLK 400
            |:||||.:||..:|::|.|:||.|.||||.:.||||||.||.||..:.:.|.|.::|:|.|.|..
Human   337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCH 401

  Fly   401 PRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFE 465
            ||:|||||:||:|:|||||..:.|||.|.|::|:|.|:|.:.|.||:|:|.||:|||||||||||
Human   402 PRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFE 466

  Fly   466 IFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGIL 530
            ||::|.||||||||||||||||||||||||||||||:|||:|.||||||||.||||||||||||:
Human   467 IFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIM 531

  Fly   531 SILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLE 595
            ||||||.|||||||.||..||.:.||||||.||||:..| |:..|||::.||||.|.|||.|||:
Human   532 SILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIK-GKPEAHFSLIHYAGIVDYNIIGWLQ 595

  Fly   596 KNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLM 660
            |||||||:|||..::||..|||..:||::||.....|:.| |:.|||..|.|||:.::|.||.||
Human   596 KNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGK-GKAKKGSSFQTVSALHRENLNKLM 659

  Fly   661 TTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKI 725
            |.||||.|||||||||||.|.|||:|..||||||.||||||||||||||||||::|.||:.||:|
Human   660 TNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRI 724

  Fly   726 MCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWM 787
            :.|..:   |.:: .:|..|.::..:|:..:||:.|:|||||:||:||.:||.|||||.:|::.:
Human   725 LNPAAIPEGQFID-SRKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRI 788

  Fly   788 QAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLE 852
            ||.:||.|:|..:|||.|:|.:|.|:|.|:|.::.::.|||.||:.|:||||..:..|.|:|.::
Human   789 QAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAEREKEMASMK 853

  Fly   853 EKAKKAEE-LHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLEN 916
            |:..:.:| |..:|.: |||||.....||.||..|...:..|:..|.|.:||..:|...|..||.
Human   854 EEFTRLKEALEKSEAR-RKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEA 917

  Fly   917 QLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEI 981
            :::::.|||..||:...:|..:|:|.:.|.|.||:||:||||.:.|.|::|...:::::||.:|:
Human   918 KVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEM 982

  Fly   982 AHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGD 1046
            |..||:|.||.||||...|.:|:..::|||.|||:|.|.|.|.||||.:|:||.|||:|||||.|
Human   983 AGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMD 1047

  Fly  1047 VEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQ 1111
            :|::|||:|||||||||::.|||.:|::|::.:::||.||:::.|::||||.:..:.|:::||||
Human  1048 LERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQ 1112

  Fly  1112 ARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRD 1176
            |||||||||:||||.||||.||.|:||:|||||:.|||||||||||.|||:|||||||..|:|||
Human  1113 ARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRD 1177

  Fly  1177 LEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEK 1241
            ||||.:|||:|.|.|||||.|:|||:.||:|.|.::|.|.||||:|:..:|:|:.:.::.|...|
Human  1178 LEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAK 1242

  Fly  1242 AAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKIS 1306
            |..||:.:.|:..:||.:||.:||.|::||..:.:.||..||.:|.|||:|.|:.:|||::.|::
Human  1243 ANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLT 1307

  Fly  1307 LTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWR 1371
            .|.||||.||..:||.:.:..|....::..||.|.||||.|||.|.||:|||.|||||:|...||
Human  1308 YTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWR 1372

  Fly  1372 SKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANA 1436
            :|||:|.:.|:|||||||:||..||.||||.:|::|.||..|||||.||..|:|||.::|:|:||
Human  1373 TKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNA 1437

  Fly  1437 IANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRREN 1501
            .|.|.:|||:.||||:.|||.|.::..:||::||||.|:.|||||:||.||||..|.||..:|||
Human  1438 AAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN 1502

  Fly  1502 KNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQ 1566
            |||.:|:.||.:|:|..|:.|||:||.||:|||||.|||:|||||||:||.||.|:||||||.:|
Human  1503 KNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQ 1567

  Fly  1567 VRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHA 1631
            ::.||:|::.||:||.|..::||.|.:||:|.||:||.:.:.||||:|||:|.|:||:||.|.||
Human  1568 IKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHA 1632

  Fly  1632 NKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADR 1696
            |:..|||||.:|..|..|||.|..|::..||.||.:|.:.|.|||.|.||.||||.|.::||.:|
Human  1633 NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTER 1697

  Fly  1697 GRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDA 1761
            .|:.|||||.:..|::..:.:||.|:...|:|::::|..|.::::|.:.|.:|:|||||||:.||
Human  1698 SRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDA 1762

  Fly  1762 ARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELD 1826
            |.:|:||:.|||.:...|:::|.:||.||:||.||||||..|||||||.:||||.|||||||||:
Human  1763 AMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELE 1827

  Fly  1827 GEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALN 1891
            .||:|:|::.|.:||||||:|||::|:||||||..|:||||||||.|:|.||||.|||||.|..|
Human  1828 AEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTN 1892

  Fly  1892 LAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            |:||||.|.||:|||||||:||..::|.|||.|
Human  1893 LSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	8/36 (22%)
		MYSc	81..777	CDD:214580	452/702 (64%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	432/671 (64%)
		Myosin_tail_1	842..1897	CDD:279860	565/1055 (54%)
		V_Alix_like	1557..1877	CDD:187408	173/319 (54%)
		ATP-synt_B	<1671..1771	CDD:304375	45/99 (45%)
		TMPIT	1739..>1825	CDD:285135	51/85 (60%)
MYH7	NP_000248.2	COG5022	37..1432	CDD:227355	794/1400 (57%)
		MYSc_Myh7	99..766	CDD:276881	432/671 (64%)
		Actin-binding	655..677		18/21 (86%)
		Actin-binding	757..771		8/13 (62%)
		SMC_prok_B	1173..1930	CDD:274008	416/753 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1907..1935		12/19 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1116	1.000	Domainoid score	I20
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68044
Inparanoid	1	1.050	2097	1.000	Inparanoid score	I44
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm41736
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2660
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.860