DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and MYH6

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_002462.2	Gene:	MYH6 / 4624	HGNCID:	7576	Length:	1939	Species:	Homo sapiens

Alignment Length:	1917	Identity:	1091/1917 - (56%)
Similarity:	1442/1917 - (75%)	Gaps:	12/1917 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 YLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEKV 80
            ||..|.::|...|::|:|.:..|::||:||.::..:|.:.:|..|....:.|:...:|.::|.:.
Human    15 YLRKSEKERLEAQTRPFDIRTECFVPDDKEEFVKAKILSREGGKVIAETENGKTVTVKEDQVLQQ 79

  Fly    81 NPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRG 145
            |||||:||||||.:|.|:.|.||.||::||.|.:||||||||||.:||||..|||.......|||
Human    80 NPPKFDKIEDMAMLTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRG 144

  Fly   146 KRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFAT---VGASKKTDE 207
            |:|:|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.|||:   :|...|.|.
Human   145 KKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRGKKDN 209

  Fly   208 AAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARV 272
            |..:||:||||::|.||.|||||||||||||||||||||||||||.|||||.||||||||||:||
Human   210 ANANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRV 274

  Fly   273 ISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDI 337
            |.|...||:|||||||:|...|.:.|:.|:|:|.|||..||||:|:||||||:||...||.|||:
Human   275 IFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELMATDSAFDV 339

  Fly   338 LGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPR 402
            ||||.:||..||::|.|:||.|.|||||:.||||||.||.|:..:.:.|.|.::|:|.|.|..||
Human   340 LGFTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPR 404

  Fly   403 IKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIF 467
            :|||||:||:|::||||..|||||.|.|::::|.|:|.:.|.||:|:|.||:|||||||||||||
Human   405 VKVGNEYVTKGQSVQQVYYSIGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIF 469

  Fly   468 EYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSI 532
            ::|.||||||||||||||||||||||||||||||:|||:|.||||||||.||||||||||||:||
Human   470 DFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSI 534

  Fly   533 LEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKN 597
            ||||.|||||||.||..||.:.|||||..||||:..| |:|.|||::.||||.|.|||.||||||
Human   535 LEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIK-GKQEAHFSLIHYAGTVDYNILGWLEKN 598

  Fly   598 KDPLNDTVVDQFKKSQNKLLIEIFADHA-GQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMT 661
            |||||:|||..::||..||:..:|:.:| ..:|...::|||: |||..|.|||:.::|.||.|||
Human   599 KDPLNETVVALYQKSSLKLMATLFSSYATADTGDSGKSKGGK-KKGSSFQTVSALHRENLNKLMT 662

  Fly   662 TLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIM 726
            .||:|.|||||||||||.|.|||:|..||||||.||||||||||||||||||::|.||:.||:|:
Human   663 NLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRIL 727

  Fly   727 CPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQ 788
            .|..:   |.:: .:|.||.::..:|:..:||:.|:|||||:||:||.:||.|||||.:|::.||
Human   728 NPVAIPEGQFID-SRKGTEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRMQ 791

  Fly   789 AWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEE 853
            |.|||.|.|..|||:.|:|.||.|:|.|:|.::.::.|||.||:.|:||||..:..|.|:|.::|
Human   792 AQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMATMKE 856

  Fly   854 KAKKAEE-LHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQ 917
            :..:.:| |..:|.: |||||.....||.||..|...:..|:..|.|.:||..:|...|..||.:
Human   857 EFGRIKETLEKSEAR-RKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAK 920

  Fly   918 LRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIA 982
            ::::.|||..||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:|:|
Human   921 VKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 985

  Fly   983 HQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDV 1047
            ..||:|.||.||||...|.:|:..::||..|||:|.|:|.|.||||.:|:||.|||:|||||.|:
Human   986 GLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDL 1050

  Fly  1048 EKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQA 1112
            |::|||:|||||||||::.|||.:|.:||:.:::|:.:::...:|:|||||:.|:.|:::||.||
Human  1051 ERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQA 1115

  Fly  1113 RIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDL 1177
            ||||||||:||||.||||.||.|:||:|||||:.|||||||||||.|||:|||||||..|:||||
Human  1116 RIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL 1180

  Fly  1178 EEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKA 1242
            |||.:|||:|.|.|||||.|:|||:.||:|.|.::|.|.||||:|:..:|:|:.:.::.|...||
Human  1181 EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA 1245

  Fly  1243 AQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISL 1307
            ..||:::.|:...||.:.||:|..|:||||...:.||..||.:|.|||||.|:.:|||::.|:|.
Human  1246 NLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSY 1310

  Fly  1308 TTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRS 1372
            |.|:||.||..:||.:.:..|....::..||.|.||||.|||.|.||:|||.|||||:|...||:
Human  1311 TQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRT 1375

  Fly  1373 KYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAI 1437
            |||:|.:.|:|||||||:||..||.:|||.:|::|.||..|||||.||..|:|||.::|:|:||.
Human  1376 KYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA 1440

  Fly  1438 ANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENK 1502
            |.|.:|||:.||||:.|||.|.::..:||::||||.|:.|||||:||.||||..|.||..:||||
Human  1441 AAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENK 1505

  Fly  1503 NLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQV 1567
            ||.:|:.||.:|:||||:|:||:||.||:||.||.|||:|||||||:||.||.|:||||||.:|:
Human  1506 NLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQI 1570

  Fly  1568 RQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHAN 1632
            :.||:|::.||:||.|..::||||.:||:|.||:||.:.:.|.||:|||:|.|:||:||.|.|||
Human  1571 KAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHAN 1635

  Fly  1633 KANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRG 1697
            :..|||||.:|..|..|||.|..|::..||.||.:|.:.|.|||.|.||.||||.|.::||.:|.
Human  1636 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS 1700

  Fly  1698 RRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAA 1762
            |:.|||||.:..|::..:.:||.|:...|:|:||:|..|.|:::|.:.|.:|:|||||||:.|||
Human  1701 RKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAA 1765

  Fly  1763 RLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDG 1827
            .:|:||:.|||.:...|:::|.:||.||:||.||||||..|||||||.:||||.||||||.||:.
Human  1766 MMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEA 1830

  Fly  1828 EQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNL 1892
            ||:|:|::.|.:||||||:|||::|:|||:||..|:||||||||.|:|.||||.|||||.|..||
Human  1831 EQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNL 1895

  Fly  1893 AKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            :||||.|.||:|||||||:||..::|.|||.|
Human  1896 SKFRKVQHELDEAEERADIAESQVNKLRAKSR 1927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	9/36 (25%)
		MYSc	81..777	CDD:214580	452/702 (64%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	432/671 (64%)
		Myosin_tail_1	842..1897	CDD:279860	567/1055 (54%)
		V_Alix_like	1557..1877	CDD:187408	174/319 (55%)
		ATP-synt_B	<1671..1771	CDD:304375	48/99 (48%)
		TMPIT	1739..>1825	CDD:285135	50/85 (59%)
MYH6	NP_002462.2	Myosin_N	35..72	CDD:280832	9/36 (25%)
		Myosin_head	87..768	CDD:278492	439/683 (64%)
		MYSc_class_II	99..768	CDD:276951	432/671 (64%)
		Actin-binding	657..679		17/21 (81%)
		Actin-binding	759..773		8/13 (62%)
		Myosin_tail_1	848..1925	CDD:279860	583/1077 (54%)
		SPEC	881..1043	CDD:295325	70/161 (43%)
		MM_CoA_mutase	<1134..1295	CDD:294532	90/160 (56%)
		MIT_CorA-like	<1297..>1409	CDD:294313	59/111 (53%)
		TMPIT	1740..>1832	CDD:285135	53/91 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1826..1849		12/22 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1909..1939		12/19 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1116	1.000	Domainoid score	I20
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2097	1.000	Inparanoid score	I44
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm41736
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2660
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860