DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and MYH4

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_060003.2	Gene:	MYH4 / 4622	HGNCID:	7574	Length:	1939	Species:	Homo sapiens

Alignment Length:	1923	Identity:	1064/1923 - (55%)
Similarity:	1430/1923 - (74%)	Gaps:	15/1923 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEK 76
            :..|:|..|.::|...|:||:|:|.|.::.|.||.|:...:::.:|..|:...:.|....:|.::
Human    12 EAAPFLRKSEKERIEAQNKPFDAKTSVFVVDPKESYVKAIVQSREGGKVTAKTEAGATVTVKEDQ 76

  Fly    77 VEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAK 141
            |..:||||::||||||.||.|:.|.||:||::||.|.:||||||||||.:||||..|||......
Human    77 VFSMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVT 141

  Fly   142 MYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV---GASK 203
            .||||:|.|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.||||:   |..|
Human   142 AYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKK 206

  Fly   204 KTDEAA-KSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLL 267
            |.:.|: |.:|:||||::..||:|||||||||||||||||||||||||||.|||||.||||||||
Human   207 KEEPASGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLL 271

  Fly   268 EKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTD 332
            ||:||..|...||||||||||:|...|.:.::.|:|.|.||:..||||::||.||||.||...||
Human   272 EKSRVTFQLKAERSYHIFYQILSNKKPELIEMLLITTNPYDFAFVSQGEITVPSIDDQEELMATD 336

  Fly   333 QAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKN 397
            .|.||||||..||..:|::|.||||.|.|||||:.||||||.||.|...:.:.|...::|:|.|:
Human   337 SAVDILGFTADEKVAIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLTSLNSADLLKS 401

  Fly   398 LLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIA 462
            |..||:||||||||:|:.||||.|::|||.|.:::::|.|:|.:.|:.|||:|.||:||||||||
Human   402 LCYPRVKVGNEFVTKGQTVQQVYNAVGALAKAIYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIA 466

  Fly   463 GFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPM 527
            |||||::|..|||||||||||||||||||||||||||||:|||:|.||||||||.|||:||||||
Human   467 GFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPM 531

  Fly   528 GILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITG 592
            ||.||||||.|||||||.:|..||...|||||..||||||.| |:..|||::.||||.|.|||.|
Human   532 GIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAK-GKPEAHFSLVHYAGTVDYNIAG 595

  Fly   593 WLEKNKDPLNDTVVDQFKKSQNKLLIEIF--ADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQ 655
            ||:|||||||:|||..::||..|.|..:|  |..|...|||.: |||: |||..|.|||:.::|.
Human   596 WLDKNKDPLNETVVGLYQKSAMKTLAFLFSGAQTAEAEGGGGK-KGGK-KKGSSFQTVSALFREN 658

  Fly   656 LNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFK 720
            ||.|||.||||.|||||||||||.|.||.::..||:|||.||||||||||||||||:|::|.|||
Human   659 LNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFK 723

  Fly   721 MRYKIMCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGK 782
            .|||::....:   |.:: .|||:|.::..|::...||:.|:|||||:||:||.:||.|||:|.:
Human   724 QRYKVLNASAIPEGQFID-SKKASEKLLGSIEIDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQ 787

  Fly   783 IMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDE 847
            :::..||..||:|.|..|:|:.|:|.::..:|.|:|.::.::.|||.||:.|:||||..:..|.|
Human   788 LITRTQAICRGFLMRVEFRKMMERRESIFCIQYNIRAFMNVKHWPWMKLYFKIKPLLKSAETEKE 852

  Fly   848 IARLEEKAKKA-EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQK 911
            :|.::|:.:|. |||...|.| |||||.....|:.||..|...:..|..||.|.:||..:|...|
Human   853 MANMKEEFEKTKEELAKTEAK-RKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTK 916

  Fly   912 NDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRN 976
            ..||.:::::.||...||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::|
Human   917 IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN 981

  Fly   977 LNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREK 1041
            |.:|:|..||.|.||.||||...|.:|:|.::||..|||:|.|.|.|.||||.:|:||.|||:||
Human   982 LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEK 1046

  Fly  1042 KVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQ 1106
            |:..|:|::|||:||||||.||:..|.|.:|::|.:.:::|:.|:|::..|:||||.:.::.|::
Human  1047 KLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKK 1111

  Fly  1107 IKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELS 1171
            ||||||||||||||:||||.:||||||||:||:|||||:.|||||||||||||||:|||||||..
Human  1112 IKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ 1176

  Fly  1172 KLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDH 1236
            |:||||||:.:|||:|.|.|||||.|:|||:.||:|.|.::|.|.||||:|...::|||.:.::.
Human  1177 KMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMET 1241

  Fly  1237 ITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLS 1301
            ::..||..||:.:.|:..|:|:::|.:|..|.:|:..|.|.:|..|:.:..|||:|.::.|||||
Human  1242 VSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLS 1306

  Fly  1302 KIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAE 1366
            :.|.:.|.|:|:.||..:||::.::||....::..||.|.||||.|||.|.||:|||.:||||:|
Human  1307 RGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSE 1371

  Fly  1367 AQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEV 1431
            ...||:|||:|.:.|:|||||||:||..||.:|||.:|::|.||..||||||||..|||||.::|
Human  1372 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDV 1436

  Fly  1432 DRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEA 1496
            :|:||...|.:|||:.|||::.|||.|.::..|||:|||||.|:.|||||::|.||||..:.||.
Human  1437 ERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLET 1501

  Fly  1497 VRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQ 1561
            ::||||||..|:.||.:||.|||::|||:||.:|:|:.||.|||.:||||||:||.||.|:||.|
Human  1502 LKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQ 1566

  Fly  1562 LELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEI 1626
            |||:||:.||||:|.||:||.:..::||.|.::|||::|:||.:.:.:|||:|||:|.|:||:||
Human  1567 LELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEI 1631

  Fly  1627 ALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLL 1691
            .|:|||:..|||.:|::..|..|||.|..|::..|.:||.:|||.:.|||||.:|.|:||.|..|
Human  1632 QLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASL 1696

  Fly  1692 EQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKK 1756
            |:.:|||:.|||||.||.|::..:..||.|:...|:|||:::..:..::::::.||:|:||||||
Human  1697 ERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKK 1761

  Fly  1757 AMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVREL 1821
            |:.|||.:|:||:.|||.:...|:::|.:||.:|:||:||||||..|||||||.|||||.|||||
Human  1762 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVREL 1826

  Fly  1822 ENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEE 1886
            |:|::.||:.:.:|.|.|||.|||||||::|:||||||..|:||||||||.|:|.||||.|||||
Human  1827 ESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEE 1891

  Fly  1887 IAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            .:.:|||||||.|.|||||:||||:||..::|.|.|.|
Human  1892 QSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSR 1929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	8/36 (22%)
		MYSc	81..777	CDD:214580	445/704 (63%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	425/673 (63%)
		Myosin_tail_1	842..1897	CDD:279860	555/1055 (53%)
		V_Alix_like	1557..1877	CDD:187408	171/319 (54%)
		ATP-synt_B	<1671..1771	CDD:304375	46/99 (46%)
		TMPIT	1739..>1825	CDD:285135	50/85 (59%)
MYH4	NP_060003.2	Myosin_N	36..73	CDD:280832	8/36 (22%)
		Myosin_head	88..770	CDD:278492	433/685 (63%)
		MYSc_Myh4	100..770	CDD:276879	425/673 (63%)
		Actin-binding. /evidence=ECO:0000250	659..681		18/21 (86%)
		Actin-binding. /evidence=ECO:0000250	761..775		8/13 (62%)
		Myosin_tail_1	850..1927	CDD:279860	571/1077 (53%)
		RILP-like	965..1098	CDD:304877	61/132 (46%)
		MIT_CorA-like	<1299..>1411	CDD:294313	58/111 (52%)
		COG6	1376..>1511	CDD:303003	79/134 (59%)
		DUF342	<1670..1767	CDD:302792	45/96 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1116	1.000	Domainoid score	I20
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2097	1.000	Inparanoid score	I44
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm41736
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2660
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.900