Protein Alignment Mhc and MYH4

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_060003.2
• Gene: MYH4 / 4622
• HGNCID: 7574
• Length: 1939
• Species: Homo sapiens
• Alignment Length: 1923
• Identity: 1060/1923 - (55%)
• Similarity: 1430/1923 - (74%)
• Gaps: 15/1923 - (0%)

  Fly    12 DPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGETRDLKKDL 76
            :..|:|..|.::|...|:||:|:|.|.::.|.||.|:...:::.:|..|:...:.|.|..:|:|.
Human    12 EAAPFLRKSEKERIEAQNKPFDAKTSVFVVDPKESYVKAIVQSREGGKVTAKTEAGATVTVKEDQ 76

  Fly    77 LQQVNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAK 141
            :..:|||||:|.|||:.:|:|::.:||:||::||...:||||||||||.:||||..|||......
Human    77 VFSMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVT 141

  Fly   142 MYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV---GASK 203
            .||||:|.|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.||||:   |..|
Human   142 AYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKK 206

  Fly   204 KTDEAA-KSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLL 267
            |.:.|: |.:|:||||::..||:|||||||||||||||||||||||||||.|||||.||||||||
Human   207 KEEPASGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLL 271

  Fly   268 EKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTD 332
            ||:||..|...||||||||||:|...|.:.::.|:|.|.||:..||||::||.||||.||...||
Human   272 EKSRVTFQLKAERSYHIFYQILSNKKPELIEMLLITTNPYDFAFVSQGEITVPSIDDQEELMATD 336

  Fly   333 QAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKN 397
            .|.||||||..||..:|::|.||||.|.|||||:.||||||.||.|...:.:.|...::|:|.|:
Human   337 SAVDILGFTADEKVAIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLTSLNSADLLKS 401

  Fly   398 LLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIA 462
            |..||:||||||||:|:.||||.|::|||.|.:::::|.|:|.:.|:.|||:|.||:||||||||
Human   402 LCYPRVKVGNEFVTKGQTVQQVYNAVGALAKAIYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIA 466

  Fly   463 GFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPM 527
            |||||::|..||||||||||||||||||||||||||||::|||||.||||||||..||:||||||
Human   467 GFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPM 531

  Fly   528 GILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITG 592
            ||.||||||.|||||||.:|..||...|||||..||||||.| |:..|||::.||||.|.|||.|
Human   532 GIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAK-GKPEAHFSLVHYAGTVDYNIAG 595

  Fly   593 WLEKNKDPLNDTVVDQFKKSQNKLLIEIF--ADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQ 655
            ||:|||||||:|||..::||..|.|..:|  |..|...|||.: |||: |||..|.|||:.::|.
Human   596 WLDKNKDPLNETVVGLYQKSAMKTLAFLFSGAQTAEAEGGGGK-KGGK-KKGSSFQTVSALFREN 658

  Fly   656 LNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFK 720
            ||.|||.||||.|||||||||||.|.||.::..||:|||.||||||||||||||||:|::|.|||
Human   659 LNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFK 723

  Fly   721 MRYKIMCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGK 782
            .|||::....:   |.:: .|||:|.::..|::...||:.|:|||||:||:||.:||.|||:|.:
Human   724 QRYKVLNASAIPEGQFID-SKKASEKLLGSIEIDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQ 787

  Fly   783 IMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDE 847
            :::..||..||:|.|..|:|:.|:|.::..:|.|:|.::.::.|||.||:.|:||||..:..|.|
Human   788 LITRTQAICRGFLMRVEFRKMMERRESIFCIQYNIRAFMNVKHWPWMKLYFKIKPLLKSAETEKE 852

  Fly   848 IARLEEKAKKA-EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQK 911
            :|.::|:.:|. |||...|.| |||||.....|:.||..|...:..|..||.|.:||..:|...|
Human   853 MANMKEEFEKTKEELAKTEAK-RKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTK 916

  Fly   912 NDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRN 976
            ..||.:::::.||...||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::|
Human   917 IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN 981

  Fly   977 LNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREK 1041
            |.:|:|..||.|.||.||||...|.:|:|.::||..|||:|.|.|.|.||||.:|:||.|||:||
Human   982 LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEK 1046

  Fly  1042 KVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQ 1106
            |:..|:|::|||:||||||.||:..|.|.:|::|.:.:::|:.|:|::..|:||||.:.::.|::
Human  1047 KLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKK 1111

  Fly  1107 IKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELS 1171
            ||||||||||||||:||||.:||||||||:||:|||||:.|||||||||||||||:|||||||..
Human  1112 IKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ 1176

  Fly  1172 KLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDH 1236
            |:||||||:.:|||:|.|.|||||.|:|||:.||:|.|.::|.|.||||:|...::|||.:.::.
Human  1177 KMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMET 1241

  Fly  1237 ITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLS 1301
            ::..||..||:.:.|:..|:|:::|.:|..|.:|:..|.|.:|..|:.:..|||:|.::.|||||
Human  1242 VSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLS 1306

  Fly  1302 KIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAE 1366
            :.|.:.|.|:|:.||..:||::.::||....::..||.|.||||.|||.|.||:|||.:||||:|
Human  1307 RGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSE 1371

  Fly  1367 AQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEV 1431
            ...||:|||:|.:.|:|||||||:||..||.:|||.:|::|.||..||||||||..|||||.::|
Human  1372 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDV 1436

  Fly  1432 DRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEA 1496
            :|:||...|.:|||:.|||::.|||.|.::..|||:|||||.|:.|||||::|.||||..:.||.
Human  1437 ERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLET 1501

  Fly  1497 VRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQ 1561
            ::||||||..|:.||.:||.|||::|||:||.:|:|:.||.|||.:||||||:||.||.|:||.|
Human  1502 LKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQ 1566

  Fly  1562 LELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEI 1626
            |||:||:.||||:|.||:||.:..::||.|.::|||::|:||.:.:.:|||:|||:|.|:||:||
Human  1567 LELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEI 1631

  Fly  1627 ALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLL 1691
            .|:|||:..|||.:|::..|..|||.|..|::..|.:||.:|||.:.|||||.:|.|:||.|..|
Human  1632 QLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASL 1696

  Fly  1692 EQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKK 1756
            |:.:|||:.|||||.||.|::..:..||.|:...|:|||:::..:..::::::.||:|:||||||
Human  1697 ERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKK 1761

  Fly  1757 AMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVREL 1821
            |:.|||.:|:||:.|||.:...|:::|.:||.:|:||:||||||..|||||||.|||||.|||||
Human  1762 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVREL 1826

  Fly  1822 ENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEE 1886
            |:|::.||:.:.:|.|.|||.|||||||::|:||||||..|:||||||||.|:|.||||.|||||
Human  1827 ESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEE 1891

  Fly  1887 IAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            .:.:|||||||.|.|||||:||||:||..::|.|.|.|
Human  1892 QSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSR 1929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	12/41 (29%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	422/673 (63%)
		Myosin_tail_1	842..1922	CDD:460256	571/1080 (53%)
MYH4	NP_060003.2	Myosin_N	33..77	CDD:460670	13/43 (30%)
		MYSc_Myh4	100..770	CDD:276879	422/673 (63%)
		Actin-binding. /evidence=ECO:0000250	659..681		18/21 (86%)
		Actin-binding. /evidence=ECO:0000250	761..775		8/13 (62%)
		Myosin_tail_1	850..1927	CDD:460256	571/1077 (53%)