DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and MYH3

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_002461.2	Gene:	MYH3 / 4621	HGNCID:	7573	Length:	1940	Species:	Homo sapiens

Alignment Length:	1921	Identity:	1072/1921 - (55%)
Similarity:	1424/1921 - (74%)	Gaps:	20/1921 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEK 79
            |:|..|.::|...|::|:|:|..|::.|.||.|..|:||:::...|:|..:......:|.|.|..
Human    15 PFLRKSEKERIEAQNQPFDAKTYCFVVDSKEEYAKGKIKSSQDGKVTVETEDNRTLVVKPEDVYA 79

  Fly    80 VNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYR 144
            :|||||::|||||.:|.||.|.||:||:.||.:.:||||||||||.:||||..|||.....:.||
Human    80 MNPPKFDRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYR 144

  Fly   145 GKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGA----SKKT 205
            ||:|.|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.||||:.|    :||.
Human   145 GKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKK 209

  Fly   206 DEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKA 270
            |  :|.||:||||::..||:|||||||||||||||||||||||||||.|||||.||||||||||:
Human   210 D--SKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKS 272

  Fly   271 RVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAF 335
            ||..|...||||||||||:|...|.:.::.|:|.|.|||..:|||::.|||||||||...||.|.
Human   273 RVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAI 337

  Fly   336 DILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLK 400
            ||||||.:||..:|::|.||||.|.|||||:.||||||.||.|...:.:.|.|.::::|.|.|..
Human   338 DILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCF 402

  Fly   401 PRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFE 465
            ||:|||||:||:|:.|.||.:::.||.|.|:::||.|:|.:.|:.|||:..||||||||||||||
Human   403 PRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFE 467

  Fly   466 IFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGIL 530
            |||||..|||||||||||||||||||||||||||||:|||:|.||||||||.|||:||||||||.
Human   468 IFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIF 532

  Fly   531 SILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLE 595
            ||||||.|||||||.:|..||.:.|||||..|||||..| |:..|||::.||||.|.|:::||||
Human   533 SILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVK-GRAEAHFSLIHYAGTVDYSVSGWLE 596

  Fly   596 KNKDPLNDTVVDQFKKSQNKLLIEIFADHA---GQSGGGEQAKGGRGKKGGGFATVSSAYKEQLN 657
            |||||||:|||..::||.|:||..::|..|   ..||..:.||    |||..|.|||:.::|.||
Human   597 KNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAK----KKGSSFQTVSALFRENLN 657

  Fly   658 SLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMR 722
            .||:.||:|.|||||||||||.|.||.::..||:|||.||||||||||||||||||::|.|||.|
Human   658 KLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQR 722

  Fly   723 YKIMCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIM 784
            |:::....:   |.:: .|||.|.::..||:...||:.|:|||||:||:||.:||.||:||.|::
Human   723 YRVLNASAIPEGQFID-SKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDDRLAKLI 786

  Fly   785 SWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIA 849
            :..||..||:|.|..|:|:.::|.::..:|.|:|.::.::.|||.||:.|:||||..:..|.|:|
Human   787 TRTQAVCRGFLMRVEFQKMVQRRESIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMA 851

  Fly   850 RLEEKAKKA-EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKND 913
            .::|:.:|. :||..:|.| |||||.....|:.||..|...:..|...|.|.:||..:|...|..
Human   852 TMKEEFQKTKDELAKSEAK-RKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQ 915

  Fly   914 LENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLN 978
            ||.:::::.||...||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.
Human   916 LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 980

  Fly   979 DEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKV 1043
            :|::..||.|.||.:|||...|.:|:..::|||.|||:|.|||.|:||||.:::||.|||:|||:
Human   981 EELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKL 1045

  Fly  1044 RGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIK 1108
            |.|:|::|||:||||||.||::.|||.:|::|::.:::||.|...:.:|:||||.:.|:.|::||
Human  1046 RVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIK 1110

  Fly  1109 ELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKL 1173
            ||||||||||||:||||..|||.||||:|.|||||||.||||||||.||.|||||||||||..||
Human  1111 ELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKL 1175

  Fly  1174 RRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHIT 1238
            |||||||.:|||:.:|.|||||.|:|||:.||:|.|.::|.|.||||:|:..:::||.:.::.::
Human  1176 RRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVS 1240

  Fly  1239 NEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKI 1303
            ..||..|||.:.|:..|:|.:.|.:|..|:|::....|.:|..|..:|.|||||.||.|||||:.
Human  1241 KSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRS 1305

  Fly  1304 KISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQ 1368
            |.:.|.|.|:.||..:||::.:..|....::..||.|.||||.|||.||||:|||.|||||:|..
Human  1306 KQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1370

  Fly  1369 VWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDR 1433
            .||:|||:|.:.|:|||||||:||..||.::||.:|::|.||..||||||||..|||||.::|:|
Human  1371 QWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVER 1435

  Fly  1434 ANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVR 1498
            ||::|.|.:|||:.|||::.|||.|.::..|||:||.||.|:.|||||:||.||||..:|||.|:
Human  1436 ANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVK 1500

  Fly  1499 RENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLE 1563
            ||||||..|:.||.:||.|.|:.|||:||:||::|.||.::|.||||||||||.||.|:||.|||
Human  1501 RENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLE 1565

  Fly  1564 LSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIAL 1628
            |:||:.||||:|.||:||.|..::|:||.:::||::|:||.:.:.||:|:|||:|.|:||:||.|
Human  1566 LTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQL 1630

  Fly  1629 DHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQ 1693
            .|||:..||..|:::..|.||||.|..|::..|.::|.:|||.|.|||||.||.|:||.|..|||
Human  1631 SHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQ 1695

  Fly  1694 ADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAM 1758
            .:|.|:.|||||.|::|::..:..||.|:...|:|||::|..|.|::::...:|:|:|||||||:
Human  1696 TERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAI 1760

  Fly  1759 VDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELEN 1823
            .|||.:|:||:.|||.:...|:::|.|||.:|:||.||||||..|||||||.|||||.|:||||.
Human  1761 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEF 1825

  Fly  1824 ELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIA 1888
            ||:|||:::.::.|.|||.|||||||::||||||||..|:||||||||.|:|:||||.|||:|.|
Human  1826 ELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQA 1890

  Fly  1889 ALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            ..:|.||||||.||||||||||:||..::|.|||.|
Human  1891 NAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTR 1926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	10/36 (28%)
		MYSc	81..777	CDD:214580	441/705 (63%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	421/674 (62%)
		Myosin_tail_1	842..1897	CDD:279860	562/1055 (53%)
		V_Alix_like	1557..1877	CDD:187408	175/319 (55%)
		ATP-synt_B	<1671..1771	CDD:304375	49/99 (49%)
		TMPIT	1739..>1825	CDD:285135	49/85 (58%)
MYH3	NP_002461.2	Myosin_N	36..73	CDD:280832	10/36 (28%)
		Myosin_head	88..767	CDD:278492	429/686 (63%)
		MYSc_Myh3	100..767	CDD:276878	421/674 (62%)
		Actin-binding	656..678		16/21 (76%)
		Actin-binding	758..772		8/13 (62%)
		GrpE	843..>962	CDD:295646	45/119 (38%)
		Myosin_tail_1	847..1924	CDD:279860	580/1077 (54%)
		BAR	<956..1063	CDD:299863	54/106 (51%)
		MIT_CorA-like	<1296..>1408	CDD:294313	60/111 (54%)
		COG6	1373..>1506	CDD:303003	79/132 (60%)
		TMPIT	1739..>1850	CDD:285135	63/110 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1116	1.000	Domainoid score	I20
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2097	1.000	Inparanoid score	I44
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm41736
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.870