DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and MYH2

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_001093582.1 Gene:MYH2 / 4620 HGNCID:7572 Length:1941 Species:Homo sapiens


Alignment Length:1925 Identity:1074/1925 - (55%)
Similarity:1438/1925 - (74%) Gaps:17/1925 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 DPTPYLFVSLEQRRID-QSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSE 75
            :..|:|..| |:.||: |::|:|:|.|.::.:.||.::.|.|::.:|..|:|..:||....:|.:
Human    12 EAAPFLRKS-ERERIEAQNRPFDAKTSVFVAEPKESFVKGTIQSREGGKVTVKTEGGATLTVKDD 75

  Fly    76 KVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCA 140
            :|..:||||::||||||.||.|:.|.||:||::||.|.:||||||||||.:||||..|||.....
Human    76 QVFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVV 140

  Fly   141 KMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGAS--K 203
            ..||||:|.|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.||||:..:  |
Human   141 TAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEK 205

  Fly   204 KTDE--AAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYL 266
            |.:|  :.|.:|:||||::..||:|||||||||||||||||||||||||||.|||||.|||||||
Human   206 KKEEITSGKIQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYL 270

  Fly   267 LEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLT 331
            |||:||:.|...||||||||||.|...|.:.::.|:|.|.|||..||||:::||||||.||...|
Human   271 LEKSRVVFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVASIDDQEELMAT 335

  Fly   332 DQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYK 396
            |.|.||||||.:||..:|::|.||||.|.:||||:.||||||.||.|...:.:.|...::|:|.|
Human   336 DSAIDILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLK 400

  Fly   397 NLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDI 461
            .|..||:|||||:||:|:.|:||:|::|||.|.|::::|.|:|.:.|:.|||:|.||:|||||||
Human   401 ALCYPRVKVGNEYVTKGQTVEQVSNAVGALAKAVYEKMFLWMVARINQQLDTKQPRQYFIGVLDI 465

  Fly   462 AGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKP 526
            ||||||::|..|||||||||||||||||||||||||||||:|||:|.||||||||.|||:|||||
Human   466 AGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKP 530

  Fly   527 MGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNIT 591
            |||.||||||.|||||||.:|..||.:.||||||.|||||..| |:..||||:.||||.|.||||
Human   531 MGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVK-GKAEAHFALIHYAGVVDYNIT 594

  Fly   592 GWLEKNKDPLNDTVVDQFKKSQNKLLIEIFA---DHAGQSGGGEQAKGGRGKKGGGFATVSSAYK 653
            |||||||||||:|||..::||..|.|.::|:   ...|:..||...|||: |||..|.|||:.::
Human   595 GWLEKNKDPLNETVVGLYQKSAMKTLAQLFSGAQTAEGEGAGGGAKKGGK-KKGSSFQTVSALFR 658

  Fly   654 EQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPD 718
            |.||.|||.||||.|||||||||||.|.||.::..||:|||.||||||||||||||||:|::|.|
Human   659 ENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYAD 723

  Fly   719 FKMRYKIMCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERL 780
            ||.|||::....:   |.:: .|||:|.::..||:...||:.|:|||||:||:||.:||.||::|
Human   724 FKQRYKVLNASAIPEGQFID-SKKASEKLLASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKL 787

  Fly   781 GKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIE 845
            .::::..||..||:|:|..::::.|:|.|:..:|.|:|.::.::.|||.||:.|:||||..:..|
Human   788 AQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETE 852

  Fly   846 DEIARLEEKAKK-AEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTA 909
            .|:|.::|:.:| .:||..:|.| |||||.....||.||..|...:..|...|.|.:||..:|..
Human   853 KEMATMKEEFQKIKDELAKSEAK-RKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIK 916

  Fly   910 QKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQI 974
            .|..||.:::::.||...||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...::::
Human   917 TKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 981

  Fly   975 RNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLER 1039
            :||.:|:|..||.|.||.||||...|.:|:|.::|||.|||:|.|.|.|.||||.:|:||.|||:
Human   982 KNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ 1046

  Fly  1040 EKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQ 1104
            |||:|.|:|::|||:||||||.||::.|:|..|::|::.:::|:.|:|::.:|:||||.:.::.|
Human  1047 EKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQ 1111

  Fly  1105 RQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAE 1169
            ::||||||||||||||:||||.:||||||||:||:|||||:.|||||||||||||||:|||||||
Human  1112 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1176

  Fly  1170 LSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGV 1234
            ..|:|||||||.:|||:|.|.|||||.|:|||:.||:|.|.::|.|.||||:|...:::||.:.|
Human  1177 FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNV 1241

  Fly  1235 DHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQ 1299
            :.::..|...||:.:.|:..|:|::||.:|..|.:||..|.:.:|..|:.:..|||:|.|:.|||
Human  1242 ETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ 1306

  Fly  1300 LSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKAN 1364
            ||:.|.:.|.|:|:.||..:||.:.:..|....::..||.|.||||.|||.|.||:|||.|||||
Human  1307 LSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKAN 1371

  Fly  1365 AEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQL 1429
            .|...||:|||:|.:.|:|||||||:||..||..|||.:|::|.||..||||||||..|||||.|
Human  1372 TEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1436

  Fly  1430 EVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQL 1494
            :|:|.||...|.:|||:.||||:.|||.|.::..|||:|||||.|:..||||::|.||||..:||
Human  1437 DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQL 1501

  Fly  1495 EAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLR 1559
            |.::||||||..|:.||.:||.|||:.|||:||.:|::|.||.|||||||||||:||.||.|:||
Human  1502 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILR 1566

  Fly  1560 AQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINEL 1624
            .||||:||:.|:||:|.||:||.:..::||.|.::|||::|:||.:.:.:|:|:|||:|.|:||:
Human  1567 IQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM 1631

  Fly  1625 EIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRT 1689
            ||.|:|||:..|||.:|.:..|..|||.|..|::..|:::|.:|||.:.|||||.||.|:||.|.
Human  1632 EIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRA 1696

  Fly  1690 LLEQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKA 1754
            .|||.:|.|:.|||||.||.|::..:..||.|:...|:|||:::..:..:::::|.||:|:||||
Human  1697 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKA 1761

  Fly  1755 KKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVR 1819
            |||:.|||.:|:||:.|||.:...|:::|.:||.:|:||:||||||..|||||||.|||||.|||
Human  1762 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVR 1826

  Fly  1820 ELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEA 1884
            |||.|::.||:|:|:|.|.|||.|||||||::|:||||||..|:||||||||.|:|:||||.|||
Human  1827 ELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEA 1891

  Fly  1885 EEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            ||.:..|||||||.|.||||||||||:||..::|.|.|.|
Human  1892 EEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSR 1931

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 10/36 (28%)
MYSc 81..777 CDD:214580 445/705 (63%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 425/674 (63%)
Myosin_tail_1 842..1897 CDD:279860 563/1055 (53%)
V_Alix_like 1557..1877 CDD:187408 172/319 (54%)
ATP-synt_B <1671..1771 CDD:304375 48/99 (48%)
TMPIT 1739..>1825 CDD:285135 51/85 (60%)
MYH2NP_001093582.1 Myosin_N 36..73 CDD:280832 10/36 (28%)
Myosin_head 88..772 CDD:278492 433/686 (63%)
MYSc_Myh2_mammals 100..772 CDD:276877 425/674 (63%)
Actin-binding. /evidence=ECO:0000250 661..683 18/21 (86%)
Actin-binding. /evidence=ECO:0000250 763..777 8/13 (62%)
Myosin_tail_1 852..1929 CDD:279860 580/1077 (54%)
RILP-like 967..1100 CDD:304877 63/132 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1128..1149 15/20 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1155..1174 17/18 (94%)
DUF342 <1672..1769 CDD:302792 47/96 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 1116 1.000 Domainoid score I20
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 2097 1.000 Inparanoid score I44
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D41153at33208
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - otm41736
orthoMCL 1 0.900 - - OOG6_100110
Panther 1 1.100 - - O PTHR45615
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1110.870

Return to query results.
Submit another query.