Protein Alignment Mhc and MYH2

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_060004.3
• Gene: MYH2 / 4620
• HGNCID: 7572
• Length: 1941
• Species: Homo sapiens
• Alignment Length: 1925
• Identity: 1071/1925 - (55%)
• Similarity: 1438/1925 - (74%)
• Gaps: 17/1925 - (0%)

  Fly    12 DPTPYLFVSLEQRRID-QSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGETRDLKKD 75
            :..|:|..| |:.||: |::|:|:|.|.::.:.||.::.|.|::.:|..|:|..:||.|..:|.|
Human    12 EAAPFLRKS-ERERIEAQNRPFDAKTSVFVAEPKESFVKGTIQSREGGKVTVKTEGGATLTVKDD 75

  Fly    76 LLQQVNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCA 140
            .:..:|||||:|.|||:.:|:|::.:||:||::||...:||||||||||.:||||..|||.....
Human    76 QVFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVV 140

  Fly   141 KMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGAS--K 203
            ..||||:|.|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.||||:..:  |
Human   141 TAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEK 205

  Fly   204 KTDE--AAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYL 266
            |.:|  :.|.:|:||||::..||:|||||||||||||||||||||||||||.|||||.|||||||
Human   206 KKEEITSGKIQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYL 270

  Fly   267 LEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLT 331
            |||:||:.|...||||||||||.|...|.:.::.|:|.|.|||..||||:::||||||.||...|
Human   271 LEKSRVVFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVASIDDQEELMAT 335

  Fly   332 DQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYK 396
            |.|.||||||.:||..:|::|.||||.|.:||||:.||||||.||.|...:.:.|...::|:|.|
Human   336 DSAIDILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLK 400

  Fly   397 NLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDI 461
            .|..||:|||||:||:|:.|:||:|::|||.|.|::::|.|:|.:.|:.|||:|.||:|||||||
Human   401 ALCYPRVKVGNEYVTKGQTVEQVSNAVGALAKAVYEKMFLWMVARINQQLDTKQPRQYFIGVLDI 465

  Fly   462 AGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKP 526
            ||||||::|..||||||||||||||||||||||||||||::||||||||||||||..||:|||||
Human   466 AGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKP 530

  Fly   527 MGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNIT 591
            |||.||||||.|||||||.:|..||.:.||||||.|||||..| |:..||||:.||||.|.||||
Human   531 MGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVK-GKAEAHFALIHYAGVVDYNIT 594

  Fly   592 GWLEKNKDPLNDTVVDQFKKSQNKLLIEIFA---DHAGQSGGGEQAKGGRGKKGGGFATVSSAYK 653
            |||||||||||:|||..::||..|.|.::|:   ...|:..||...|||: |||..|.|||:.::
Human   595 GWLEKNKDPLNETVVGLYQKSAMKTLAQLFSGAQTAEGEGAGGGAKKGGK-KKGSSFQTVSALFR 658

  Fly   654 EQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPD 718
            |.||.|||.||||.|||||||||||.|.||.::..||:|||.||||||||||||||||:|::|.|
Human   659 ENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYAD 723

  Fly   719 FKMRYKIMCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERL 780
            ||.|||::....:   |.:: .|||:|.::..||:...||:.|:|||||:||:||.:||.||::|
Human   724 FKQRYKVLNASAIPEGQFID-SKKASEKLLASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKL 787

  Fly   781 GKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIE 845
            .::::..||..||:|:|..::::.|:|.|:..:|.|:|.::.::.|||.||:.|:||||..:..|
Human   788 AQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETE 852

  Fly   846 DEIARLEEKAKK-AEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTA 909
            .|:|.::|:.:| .:||..:|.| |||||.....||.||..|...:..|...|.|.:||..:|..
Human   853 KEMATMKEEFQKIKDELAKSEAK-RKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIK 916

  Fly   910 QKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQI 974
            .|..||.:::::.||...||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...::::
Human   917 TKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 981

  Fly   975 RNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLER 1039
            :||.:|:|..||.|.||.||||...|.:|:|.::|||.|||:|.|.|.|.||||.:|:||.|||:
Human   982 KNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ 1046

  Fly  1040 EKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQ 1104
            |||:|.|:|::|||:||||||.||::.|:|..|::|::.:::|:.|:|::.:|:||||.:.::.|
Human  1047 EKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQ 1111

  Fly  1105 RQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAE 1169
            ::||||||||||||||:||||.:||||||||:||:|||||:.|||||||||||||||:|||||||
Human  1112 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1176

  Fly  1170 LSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGV 1234
            ..|:|||||||.:|||:|.|.|||||.|:|||:.||:|.|.::|.|.||||:|...:::||.:.|
Human  1177 FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNV 1241

  Fly  1235 DHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQ 1299
            :.::..|...||:.:.|:..|:|::||.:|..|.:||..|.:.:|..|:.:..|||:|.|:.|||
Human  1242 ETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ 1306

  Fly  1300 LSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKAN 1364
            ||:.|.:.|.|:|:.||..:||.:.:..|....::..||.|.||||.|||.|.||:|||.|||||
Human  1307 LSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKAN 1371

  Fly  1365 AEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQL 1429
            .|...||:|||:|.:.|:|||||||:||..||..|||.:|::|.||..||||||||..|||||.|
Human  1372 TEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1436

  Fly  1430 EVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQL 1494
            :|:|.||...|.:|||:.||||:.|||.|.::..|||:|||||.|:..||||::|.||||..:||
Human  1437 DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQL 1501

  Fly  1495 EAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLR 1559
            |.::||||||..|:.||.:||.|||:.|||:||.:|::|.||.|||||||||||:||.||.|:||
Human  1502 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILR 1566

  Fly  1560 AQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINEL 1624
            .||||:||:.|:||:|.||:||.:..::||.|.::|||::|:||.:.:.:|:|:|||:|.|:||:
Human  1567 IQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM 1631

  Fly  1625 EIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRT 1689
            ||.|:|||:..|||.:|.:..|..|||.|..|::..|:::|.:|||.:.|||||.||.|:||.|.
Human  1632 EIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRA 1696

  Fly  1690 LLEQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKA 1754
            .|||.:|.|:.|||||.||.|::..:..||.|:...|:|||:::..:..:::::|.||:|:||||
Human  1697 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKA 1761

  Fly  1755 KKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVR 1819
            |||:.|||.:|:||:.|||.:...|:::|.:||.:|:||:||||||..|||||||.|||||.|||
Human  1762 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVR 1826

  Fly  1820 ELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEA 1884
            |||.|::.||:|:|:|.|.|||.|||||||::|:||||||..|:||||||||.|:|:||||.|||
Human  1827 ELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEA 1891

  Fly  1885 EEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            ||.:..|||||||.|.||||||||||:||..::|.|.|.|
Human  1892 EEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSR 1931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	14/41 (34%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	423/674 (63%)
		Myosin_tail_1	842..1922	CDD:460256	580/1080 (54%)
MYH2	NP_060004.3	Myosin_N	33..77	CDD:460670	15/43 (35%)
		MYSc_Myh2_mammals	100..772	CDD:276877	423/674 (63%)
		Actin-binding. /evidence=ECO:0000250	661..683		18/21 (86%)
		Actin-binding. /evidence=ECO:0000250	763..777		8/13 (62%)
		Myosin_tail_1	852..1929	CDD:460256	580/1077 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1128..1149		15/20 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1155..1174		17/18 (94%)