Protein Alignment Mhc and MYO1F

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_001427538.1
• Gene: MYO1F / 4542
• HGNCID: 7600
• Length: 1119
• Species: Homo sapiens
• Alignment Length: 883
• Identity: 279/883 - (31%)
• Similarity: 446/883 - (50%)
• Gaps: 132/883 - (14%)

  Fly    84 KYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRR 148
            |....:||..|..:.:.::..|||:|:.:..|:||.|...:::||:|:.|.:|:|...:|:|..:
Human    15 KQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQGAAQ 79

  Fly   149 NEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV-GASKKTDEAAKSK 212
            .|.||||:|::|..|.:||.:..||.::|:||||||||...|.::.|.:.| |..:|...
Human    80 YENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGEKVQH----- 139

  Fly   213 GSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQS 277
              ::|.::|:||:||||||||||||:|||||||:..|.|...|:..|..|..:||||:||:.|..
Human   140 --VKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVMQNE 202

  Fly   278 LERSYHIFYQIMSG-SVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFT 341
            .||::||:||::.| |....:::.|:|.:.| |::.......|...||..:|..|..|..::|..
Human   203 NERNFHIYYQLLEGASQEQRQNLGLMTPDYY-YYLNQSDTYQVDGTDDRSDFGETLSAMQVIGIP 266

  Fly   342 KQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRV------SKLFGCDTAELYKNLLK 400
            ...::.|.::.|.::|:|.:.|.:.|...:.|.        |      :.|.|.|:..|.:.|..
Human   267 PSIQQLVLQLVAGILHLGNISFCEDGNYARVES--------VDLLAFPAYLLGIDSGRLQEKLTS 323

  Fly   401 PRI--KVG--NEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDI 461
            .::  :.|  :|.:....||:|...:..||.||::.|||.:||:..|..:...|: ::.||||||
Human   324 RKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQKPQE-EYSIGVLDI 387

  Fly   462 AGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIE-- 524
            .|||||:.|||||.||||.||||||.|.......|||||.:|||.||.|.:..:..:| ||||
Human   388 YGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIQYFNNKVVC-DLIENK 451

  Fly   525 -KPMGILSILEEESMFPKAT----DQTFSEKL-----TNTHLGKSAPFQKPKPPKPGQQAAHFAI 579
             .|.||:|:|::......||    |||..:||     |:.|.              ...:|.|.|
Human   452 LSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHF--------------NSWSAGFVI 502

  Fly   580 AHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGG 644
            .||||.|||:::|:.|:|:|.|...:::..:.|:...|..:|.:...            |.|.|.
Human   503 HHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFLRMLFPEKLD------------GDKKGR 555

  Fly   645 FATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQP--------------GVVDAHLVMHQLT 695
            .:|..|..|:|.|.|:.||....||::|||.|||.|:|              |  |:....||..
Human   556 PSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEENRTGDSPPRG--DSAYPPHQSQ 618

  Fly   696 CNGVLEGIRICRKGFPNRMMYP---------DFKMRYKIMCPKLLQGVEKD-KKATEIIIKFIDL 750
            ..|.:.|.....:|..:|:..|         ...:||.|:.|:.......| ::..:.:::.:::
Human   619 APGGIPGPEGEHQGAQSRLRLPPPVRQIPAEPSALRYAILTPETWPRWRGDERQGVQHLLRAVNM 683

  Fly   751 PEDQYRLGNTKVFFR-AGVLGQMEEFRDERL-GKIMSWMQAWARGYLSRKGFKKLQEQRVALKVV 813
            ..|||::|:||||.: ...|..:||.|:.:. |...:..:||.|....|| :::::|:...:.:.
Human   684 EPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVRK-YEEMREEASNILLN 747

  Fly   814 QRNLRK----------YLQLRTWPWYKLW-----------------QKVKP----LLNVSRIEDE 847
            ::..|:          ||.|...|..:.:                 ::.||    |:...:....
Human   748 KKERRRNSINRNFVGDYLGLEERPELRQFLGKRERVDFADSVTKYDRRFKPIKRDLILTPKCVYV 812

  Fly   848 IARLEEKAKKA-EELHAAEV-KVRKELEALNAKLLAEK 883
            |.|  ||.||. |:....|| |.:.:::||....|:.:
Human   813 IGR--EKVKKGPEKGQVCEVLKKKVDIQALRGVSLSTR 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	243/712 (34%)
		Myosin_tail_1	842..1922	CDD:460256	13/44 (30%)
MYO1F	NP_001427538.1	None