Protein Alignment Mhc and myo6a

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_001004111.3
• Gene: myo6a / 445473
• ZFINID: ZDB-GENE-040819-2
• Length: 1288
• Species: Danio rerio
• Alignment Length: 1410
• Identity: 400/1410 - (28%)
• Similarity: 644/1410 - (45%)
• Gaps: 307/1410 - (21%)

  Fly    33 DSKKSCWIPDEKEGYLLGEIKATKGDIVSVG--LQGGETRDLKKDLLQQVNPPKYEKAEDMSNLT 95
            |..|..|.|...:|:.||.|.....|.:::.  .|.|:......|.:........:..||..:|.
Zfish     2 DDGKPVWAPHPTDGFQLGRIIDISADSLTIEPLNQRGKNFQAPVDQVFPAEDDVNKHVEDNCSLM 66

  Fly    96 YLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYP-VYTNRCAKMYRGKRRNEVPPHIFAIS 159
            |||:|::|:|:|.||....|||:.....:|:|||...| :|:....|.|:|:....:|||::||:
Zfish    67 YLNEATLLNNVRVRYSKDKIYTFVANILIAVNPYCEIPKLYSPETIKQYQGRSLGTLPPHVYAIA 131

  Fly   160 DGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFAT-VGASKKTDEAAKSKGSLEDQVVQTN 223
            |.||.||....::||::::||||||||||||.|:.|..| .|..:..||          ::|:.|
Zfish   132 DKAYRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTTSYGTGQDIDE----------RIVEAN 186

  Fly   224 PVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQI 288
            |:||||||||||||:||||||||:.|||.....:.|..:..|||||:|:.:|...||:|||||::
Zfish   187 PLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKNAVVGGFVSHYLLEKSRICTQGQEERNYHIFYRL 251

  Fly   289 MSGSVPGVKD------------IC--------------LLTDNIYDYHIVSQGKVTVASIDDAEE 327
            .:|:...:::            :|              |:..|.....::..|.:....:||..:
Zfish   252 CAGAPEDIREKFHLSSPDCFRYLCRGCTRYFSTKDSDKLIPQNRKSPELLKAGPLKDPLLDDHAD 316

  Fly   328 FSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSK------- 385
            |:....|...:|....||.:::|:.|.|:|:|.:.|         |:.|...||.|.|
Zfish   317 FNRMSVAMKKIGLDDTEKLNLFRVVAGVLHLGNIDF---------EEAGSTSGGCVLKKTCGQSL 372

  Fly   386 -----LFGCDTAELYKNLLKPRIKVGNEFVTQGR------NVQQVTNSIGALCKGVFDRLFKWLV 439
                 |.|.|..:|..:|.. |:.:.....|:|.      .|:|.:::..||.|.::.|||..:|
Zfish   373 QFCAELLGLDEEDLRVSLTS-RVMLTTAGGTKGTVIKVPLKVEQASSARDALAKAIYSRLFDHVV 436

  Fly   440 KKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREG 504
            .:.|:....... .||||||||||||.||:|.|||.|||:.|||||||||..:...|||.|||||
Zfish   437 TRINQCFPFDSS-AHFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQREG 500

  Fly   505 IEWTFIDFGMDLQLCIDLIE-KPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPP 568
            :....:.: :|.|.||||:| |.:|||.||:||:..|:.:||.|:|.:.:.|   ...|:...|.
Zfish   501 LGVNEVHY-VDNQDCIDLVESKVVGILDILDEENRLPQPSDQHFTETVHSKH---KDHFRLTVPR 561

  Fly   569 KPGQQAAH-------FAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAG 626
            |...|...       |.|.|:||.|.|..|.::|||.|.|:.::.....:|::|.:.|:|.:
Zfish   562 KSKLQVHRNVRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLACLVSESKDKFIGELFEN--- 623

  Fly   627 QSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPG-VVDAHLV 690
             |...:..|...||.  .|.:|.:.:|.|||.|:..|.||...||||:.|| :|..| ..:...:
Zfish   624 -SNHSKDTKQKAGKL--SFISVGNKFKTQLNILLEKLHSTGSSFVRCVKPN-LKMVGHHFEGAQI 684

  Fly   691 MHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATEIIIKFIDLPEDQY 755
            :.||.|:|::..:.:.:.|||:|..:.:....||...|..|..:: .:...:.:.|.:.|.|:.|
Zfish   685 LSQLQCSGMVSVLDLMQGGFPSRAPFHELYNMYKQYMPAKLTRLD-PRLFCKALFKALGLNENDY 748

  Fly   756 RLGNTKVFFRAGVLGQMEEFR---DERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQ-RN 816
            :.|.||||||.|...:.::..   .:.|.:::..:..|    |....:||:  |..||.|:: :|
Zfish   749 KFGLTKVFFRPGKFAEFDQIMKSDPDHLAELVKRVNKW----LICSRWKKV--QWCALSVIKLKN 807

  Fly   817 LRKY-----LQLRTWPWYKLW---QKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELE 873
            ...|     :|::  ...::|   :|.||     ||:..:        ||:.|       :|.:|
Zfish   808 KMLYRAQACVQMQ--KTVRMWLCRRKHKP-----RIDGLV--------KAQNL-------KKRME 850

  Fly   874 ALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQ 938
            .||           :.:||              |...|.::...::|:...:
Zfish   851 KLN-----------EVVSG--------------LKEGKQEMSKHMQDLDSSI------------- 877

  Fly   939 KKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQ 1003
                |..|..:|..:           ..:...||:.:.|   :....||::.:.|:|:
Zfish   878 ----DAHIRKIKSIV-----------MSRMDIDHEHQAL---VTRSQELLSAMQKKKQ------- 917

  Fly  1004 KTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADL 1068
                    .|:::..|.:::.::|:.....|   |.|:|.:.:.|:.::|.|.:||..||   :.
Zfish   918 --------EEEEMERLKRIQEEMEKERKRRE---EEEQKRKREEEERRQKAEMELKRKQE---EE 968

  Fly  1069 ERNKKELEQTIQRKDKELSSITAKLEDE--QVVVLKHQRQIKELQARIEELE-----EEVEAERQ 1126
            ||.|:|.|:...:::.|| .:.|:.|.|  :..||:.:|:.:||..||.:.|     ||...:..
Zfish   969 ERKKREEEERKLQEEMEL-QLEAEREQETSRQAVLEQERRDRELALRIAQSEAELIPEETPPDAG 1032

  Fly  1127 ARAKAEKQR------ADLARELEELGERLEEAGGATSAQ-----IELNKKREAEL---------- 1170
            .|:.|..|:      .::|:|:.:|..|..:. .|.:||     .||:|.:.|||
Zfish  1033 LRSVAPPQKLKSLTMEEMAKEMSDLLARGPQV-SANNAQADVKKYELSKWKYAELRDAINTSCDI 1096

  Fly  1171 -------SKLRRDL----------EEANIQHESTLANLRKKHNDAVAEMAEQ--VDQLNKLKAKA 1216
                   .:..|.|          ::.|:|.|.   ...|...|.|..:..|  :.|.|.:...|
Zfish  1097 ELLAACREEFHRRLKVYHAWKSKNKKRNVQEEQ---RAPKAITDYVGIIGSQAFIAQQNPVVPAA 1158

  Fly  1217 EKEKNEY-------YGQLNDLRAGVDHITNEKAAQEK-------------IAKQLQ-----HTLN 1256
            ...::|.       :.::..:|.|..:    |..|.|             ||:|::     |.:.
Zfish  1159 VPRQHEIVMNRQQRFFRIPFIRPGDQY----KDPQSKKKGWWYAHFDGPWIARQMELHPDKHPIL 1219

  Fly  1257 EVQSK---------LDETNRTLNDFDASKKKLSIENSDLLRQLEE 1292
            .|..|         |:||..|      .|:...|    |.||.||
Zfish  1220 LVAGKDDMEMCELSLEETGLT------RKRGAEI----LPRQFEE 1254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	11/43 (26%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	254/719 (35%)
		Myosin_tail_1	842..1922	CDD:460256	109/532 (20%)
myo6a	NP_001004111.3	None