DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and myo6b

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_001004110.1 Gene:myo6b / 445472 ZFINID:ZDB-GENE-030318-3 Length:1267 Species:Danio rerio


Alignment Length:1507 Identity:398/1507 - (26%)
Similarity:662/1507 - (43%) Gaps:350/1507 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 DSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSE------KVEKVNPPKFE---KI 88
            |..|..|.|...:|:.||.       ||.:|.....:..:...      .:.:|.|.:.:   .:
Zfish     2 DDGKLVWAPHPTDGFQLGM-------IVDIGADALTIEPLHQRGKTFLAPISQVFPAEDDVNKHV 59

  Fly    89 EDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYP-VYTNRCAKMYRGKRRNEVP 152
            ||...:..||...:|:|:|.||...:|||:.....:|:|||...| :|:....|.|:|:....:|
Zfish    60 EDNCSLMYLNEATLLNNIRIRYSKDMIYTFVANILIAVNPYFDIPKLYSPESIKSYQGRSLGTLP 124

  Fly   153 PHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFAT-VGASKKTDEAAKSKGSLE 216
            ||::||:|.||.||....::||::::||||||||||||.|:.|..| .|..:..||         
Zfish   125 PHVYAIADKAYRDMRVLKMSQSIIVSGESGAGKTENTKFVLRYLTTSYGTGQDIDE--------- 180

  Fly   217 DQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERS 281
             ::|:.||:||||||||||||:||||||||:.|||.....:.|..:..|||||:|:..|...||:
Zfish   181 -RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKNAVVGGFVSHYLLEKSRICMQSQEERN 244

  Fly   282 YHIFYQIMSGSVPGVKDICLL-----------------TDNIYDYHIV---------SQGKVTVA 320
            |||||::.:|:...::::..|                 .:...|..|:         ..|||...
Zfish   245 YHIFYRLCAGASEDIRNMLHLNSPDSFRYLNRGCTRYFANKDSDKQIMQNXKSPEDHKHGKVGAL 309

  Fly   321 S---IDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGR 382
            .   :||..:|:....|...:|....||.:::|:.|.|:|:|.:.|         |:.|...||.
Zfish   310 KDPLLDDLGDFNRMVVAMKKIGLDDTEKLNLFRVVAGVLHLGNIDF---------EETGSTSGGC 365

  Fly   383 VSK------------LFGCDTAELYKNLLKPRIKVGNEFVTQGR------NVQQVTNSIGALCKG 429
            :.|            |.|.|..:| :..|..|:.:......:|.      .|:|..|:..||.|.
Zfish   366 ILKNQSSQTLEYCADLLGLDQDDL-RVSLTTRVMLTTAGGAKGTVIKVPLKVEQANNARDALAKA 429

  Fly   430 VFDRLFKWLVKKCNE--TLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHM 492
            |:.|||..:||:.|:  ..||.   .:||||.||||||.||:|.|||.|||:.|||||||||..:
Zfish   430 VYSRLFDHVVKRVNQCFPFDTS---SNFIGVPDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERI 491

  Fly   493 FVLEQEEYKREGIDWAFIDFGMDLLACIDLIE-KPMGILSILEEESMFPKATDQTFSEKLTNTHL 556
            ...|||.|:|||:....:.: :|...||||:| |.:|:|.||:||:..|:.:||.|:|.:.:.| 
Zfish   492 LKEEQELYQREGLGVNEVHY-VDNQDCIDLVEAKLVGVLDILDEENRLPQPSDQHFAEAVHSKH- 554

  Fly   557 GKSAPFQKPKPPKPGQQAAH--------FAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQ 613
              ...|:...|.| .:...|        |.|.|:||.|.|..|.::|||.|.|:.::.....:|:
Zfish   555 --KDHFRLTVPRK-SKLTIHRNLRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLVCESK 616

  Fly   614 NKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNE 678
            :|.:.::|.:::......::|    ||.  .|.:|.:.:|.|||.|:..||||...|:||:.||.
Zfish   617 DKFVRDLFENNSNSKDSKQKA----GKL--SFISVGNKFKTQLNLLLEKLRSTGSSFIRCVKPNL 675

  Fly   679 MKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATEI 743
            .......:...::.||.|:|::..:.:.:.|||:|..:.:....||...|..|..:: .:...:.
Zfish   676 KMVSHQFEGAQILSQLQCSGMVSVLDLMQGGFPSRAPFHELYNMYKQYMPNKLTRLD-PRLFCKA 739

  Fly   744 IIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFR---DERLGKIMSWMQAWARGYLSRKGFKKLQE 805
            :.|.:.|.|:.|:.|.|:||||.|...:.::..   .:.|.:::..:..|    |....:||:  
Zfish   740 LFKALGLNENDYKFGLTRVFFRPGKFAEFDQIMKSDPDHLAELVKRVNKW----LVCSRWKKV-- 798

  Fly   806 QRVALKVVQ-RNLRKYLQ---LRTWPWYKLW---QKVKPLLNVSRIEDEIARLEEKAKKAEELHA 863
            |...|.|:: ||...|..   :|.....::|   ::.||.:      |.:.:::...|:.|..:.
Zfish   799 QWCTLSVIKLRNKMSYRASACIRIQKTVRMWLCRRRHKPRV------DGLVKVKNLRKRMERFNE 857

  Fly   864 AEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQE 928
            | |...||.:|..:|.:.|..|..|:|..:           .|.|.                   
Zfish   858 A-VNGLKEGKAEMSKQIEELAASTDALMAK-----------IKTTV------------------- 891

  Fly   929 EDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNK 993
                    ..:|:.:||..||          |:::||                     |::.:.|
Zfish   892 --------MSRKEIEQEYEGL----------VKRSEQ---------------------LLSSMQK 917

  Fly   994 EKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDL 1058
            :|:.|.||            :::.|              :::.:|:|:|...:.|:.:::.|.|.
Zfish   918 KKQEQEET------------ERLKH--------------IQEZMEKERKRHEEEEQLRKQEEEDR 956

  Fly  1059 KLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIE---ELEEE 1120
            ::..|    :|:.:|:.|:  :||.:|        |:|:|           |||.:|   .|:.|
Zfish   957 RMKSE----MEQKRKQEEE--ERKKRE--------EEERV-----------LQAELEMQLALDRE 996

  Fly  1121 VEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHE 1185
            .|.:||...:.|::..:||..:.:                     .||||           ||.|
Zfish   997 EETQRQTILEQERRDRELAMRIAQ---------------------NEAEL-----------IQDE 1029

  Fly  1186 STLANLRKKHNDAV------AEMAEQVDQLNKLKAKAEK-EKNEY-YGQLNDLRAGVDHITNEKA 1242
            :.:..:.::  ||.      .||..|| |.||:.|..:| :.::: |.:|.|       ..|...
Zfish  1030 AQMDPILRR--DATTGVWFFTEMGAQV-QANKVAAGVKKYDLSKWKYAELRD-------AINTSC 1084

  Fly  1243 AQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISL 1307
            ..|.:|           :..:|.:|.|..:.|.|.|....|:|                      
Zfish  1085 DIELLA-----------ACREEFHRRLKVYHAWKSKNKKRNTD---------------------- 1116

  Fly  1308 TTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRS 1372
             |::...|.:.|...:..|..: ..|..|..::..:..........||..:  ...|.:...|.:
Zfish  1117 -TEMRAPKSVTDYAQQNPAPPV-PARQQEIAMNRQQRYFRIPFIRPADQYK--DPQNKKKGWWYA 1177

  Fly  1373 KYESDGVARSEELEEAKRKLQARLAEAEETIE----SLNQKCIGLEKTKQRLSTEVEDLQLEVDR 1433
            .::...:||..||...|:.:  .|...::.:|    ||.:..:..::..:.|..:.|::......
Zfish  1178 HFDGPWIARQMELHPDKQPI--LLVAGKDDMEMCELSLEETGLTRKRGAEILPRQFEEIWERCGG 1240

  Fly  1434 ANAIANAAEKKQ 1445
            ...:.||.|.||
Zfish  1241 IQYLKNAIESKQ 1252

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 9/36 (25%)
MYSc 81..777 CDD:214580 256/761 (34%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 248/724 (34%)
Myosin_tail_1 842..1897 CDD:279860 116/619 (19%)
V_Alix_like 1557..1877 CDD:187408
ATP-synt_B <1671..1771 CDD:304375
TMPIT 1739..>1825 CDD:285135
myo6bNP_001004110.1 MYSc 59..773 CDD:214580 255/748 (34%)
MYSc_Myo6 71..761 CDD:276833 248/724 (34%)
Ax_dynein_light <847..930 CDD:287215 28/164 (17%)
Myosin-VI_CBD 1150..1240 CDD:293129 15/93 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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