Protein Alignment Mhc and jar

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Alignment Length: 1512
• Identity: 411/1512 - (27%)
• Similarity: 643/1512 - (42%)
• Gaps: 357/1512 - (23%)

  Fly    39 WIPDEKEGYLLGEIKATKGDIVSVGLQGGETRDLKK----------DLLQQVNPPKYEKAEDMSN 93
            |:.|..|||:       :|.|..:|.:..|.....:          |:....:.|  :..:|...
  Fly     9 WVRDAAEGYI-------QGRITEIGAKEFEVTPTDRKYPKRTCHFDDIHSSCDGP--QDHDDNCE 64

  Fly    94 LTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRY-PVYTNRCAKMYRGKRRNEVPPHIFA 157
            |..||:|:.|.||:.|||...||||.....:|:|||:.. .:|.....|.|.|:...|:|||:||
  Fly    65 LMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFA 129

  Fly   158 ISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQT 222
            |:|.|..||....::||::::|||||||||:||.::.|..         .:..|.|.:|.:::..
  Fly   130 IADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLC---------YSHDSAGPIETKILDA 185

  Fly   223 NPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQ 287
            ||||||||||||.||:|||||||||.:|:....::.|..|..|||||:|:.:|.:.||:||:||.
  Fly   186 NPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYM 250

  Fly   288 IMSGSVPGVKDICLL--TDNIYDYHIVS--------------------------QGKVTVASIDD 324
            :::|:...::|...|  .|   ||..:|                          :|.:....|||
  Fly   251 LLAGAPQQLRDKLSLGKPD---DYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDD 312

  Fly   325 AEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQ-----RGREEQAEQDGEEEGGRVS 384
            .:.|...|:|...||.:..||..:|.:.|||:|:|.:.|::     || ..|..:..|:.....|
  Fly   313 YQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRG-GCQVSEASEQSLTITS 376

  Fly   385 KLFGCDTAELYKNLLKPRI--KVGNEF----VTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCN 443
            .|.|.|..|| :..|..|:  ..|..|    :.....:.:.:|:..||.|.::.|||..:|...|
  Fly   377 GLLGVDQTEL-RTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLIN 440

  Fly   444 ETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWT 508
            :::..|.. ..:||||||||||.|..|.|||.|||:.|||||:|||.::...|||.|:|||:...
  Fly   441 QSIPFQAS-NFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVP 504

  Fly   509 FIDFGMDLQLCIDLIE-KPMGILSILEEESMFPKATDQTFSEKL-----TNTHLGKSAPFQKPKP 567
            .|.| .|.|..|:||| |..||.::|:|||..||.:...|:.::     .:..||.
  Fly   505 EITF-TDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGL--------- 559

  Fly   568 PKPGQQAAH--------FAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADH 624
            |:..:..||        |.:.|:||.|.||...::|||.|.|:.::....::..|.||..:|
  Fly   560 PRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLF--- 621

  Fly   625 AGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHL 689
              .||.....   |||.  .|.:|.|.:|.||..||..|.....:|:|||.||........:..|
  Fly   622 --PSGSSTSV---RGKL--NFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSL 679

  Fly   690 VMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATEIIIKFIDLPEDQ 754
            .:.||.|:|.:..:.:...|:|:|:::.|....||.:.|..|..:.. :...|.:.:.::|....
  Fly   680 ALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPA-RTFCEAMFQSLNLSAKD 743

  Fly   755 YRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRK 819
            ::.|.||||||.|                                                   |
  Fly   744 FKFGITKVFFRPG---------------------------------------------------K 757

  Fly   820 YLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKT 884
            :::.                      |.|.|.:     .|.:.|...||:|.|  :.::.:  |:
  Fly   758 FVEF----------------------DRIMRSD-----PENMLAIVAKVKKWL--IRSRWV--KS 791

  Fly   885 ALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGL 949
            ||        |||...:.||..:...|..|      |.:|:     ||.  |..:|:......|:
  Fly   792 AL--------GALCVIKLRNRIIYRNKCVL------IAQRI-----ARG--FLARKQHRPRYQGI 835

  Fly   950 KKDIEDLELNVQK----AEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQ 1010
            .| |..:..|..|    |...|..::..|..:||.....|:.|.|:    ||.....|:..:.:.
  Fly   836 GK-INKIRTNTLKTIEIASGLKMGREEIISGVNDIYRQIDDAIKKI----KMNPRITQREMDSMY 895

  Fly  1011 AAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKEL 1075
            ..  .:.::||:...|...|.|.:.:.|:|:                |:..|||: :.||..||.
  Fly   896 TV--VMANMNKLTVDLNTKLKEQQQAEEQER----------------LRKIQEAL-EAERAAKEA 941

  Fly  1076 EQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLAR 1140
            |:  ||:.:|:.:                   |.|:|.:|...:..||:| .|.:.|.:||.||
  Fly   942 EE--QRQREEIEN-------------------KRLKAEMETRRKAAEAQR-LRQEEEDRRAALA- 983

  Fly  1141 ELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLE-------EANIQHESTLANLRKKHNDA 1198
                |.|:||:       :.:.:.|...:|.:.|||.|       |:|.|.|.:...:|...|||
  Fly   984 ----LQEQLEK-------EAKDDAKYRQQLEQERRDHELALRLANESNGQVEDSPPVIRNGVNDA 1037

  Fly  1199 VAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLD 1263
             :.|..     |||.:.::...|.....||...       |.:|.|:.:.||
  Fly  1038 -SPMGP-----NKLISFSQVVSNIASRYLNKSE-------NVRAQQQALGKQ------------- 1076

  Fly  1264 ETNRTLNDFDASKKKLS-----IENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLA-DEES 1322
                   .:|.||.|.|     |..|..:..||....:..:  ::|:....:.::.||.. ||..
  Fly  1077 -------KYDLSKWKYSELRDAINTSCDIELLEACRQEFHR--RLKVYHAWKAKNRKRTTMDENE 1132

  Fly  1323 R-ERATLLGKFRNLEHDLDNLREQVEEEAEG-----KADLQRQLSKANAEAQVWRSKYESDGVAR 1381
            | .|:.:...|:.     ..|.:.::|....     :....|..:..|.:..:|.:.::...:||
  Fly  1133 RAPRSVMEAAFKQ-----PPLVQPIQEIVTAQHRYFRIPFMRANAPDNTKRGLWYAHFDGQWIAR 1192

  Fly  1382 SEELEEAKRKLQARLAEAEETIESLNQKC-IGLEKTKQRLSTEVEDLQLEVDR------------ 1433
            ..||...|..: ..:|..::.     |.| :.||:|........|.|:.|.:|
  Fly  1193 QMELHADKPPI-LLVAGTDDM-----QMCELSLEETGLTRKRGAEILEHEFNREWERNGGKAYKN 1251

  Fly  1434 -----ANAIANAAEKKQ 1445
                 .|..|.|.:|:|
  Fly  1252 LGAAKPNGPAAAMQKQQ 1268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	9/45 (20%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	247/718 (34%)
		Myosin_tail_1	842..1922	CDD:460256	145/645 (22%)
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	9/46 (20%)
		MYSc_Myo6	71..754	CDD:276833	247/718 (34%)
		CBD_MYO6-like	765..913	CDD:409646	42/184 (23%)
		ERM_helical	<954..1020	CDD:466641	23/78 (29%)
		MYO6_MIU_linker	1002..1093	CDD:480843	30/123 (24%)
		MyUb_Myo6	1076..1116	CDD:439319	11/61 (18%)
		Myosin-VI_CBD	1160..1246	CDD:465157	18/91 (20%)