Protein Alignment Mhc and myh4

DIOPT Version :9

• Sequence 1: NP_001162991.1
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_001001244.1
• Gene: myh4 / 407946
• XenbaseID: XB-GENE-989283
• Length: 1935
• Species: Xenopus tropicalis
• Alignment Length: 1913
• Identity: 1067/1913 - (55%)
• Similarity: 1424/1913 - (74%)
• Gaps: 17/1913 - (0%)

  Fly    22 EQRRID-QSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEKVNPPKF 85
            |:.|:: ||||:|:|.:.::.|.||.|:.|.:.|.:...::|....|....:|..::...|||||
 Frog    20 EKERLEAQSKPFDAKNTVFVDDVKELYVKGMVTAREDGKITVKTDDGRTVTVKENQIYPQNPPKF 84

  Fly    86 EKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNE 150
            :||||||.||.||...||:||::||.|.:|||||||||..:||||..|||.......||||:|.|
 Frog    85 DKIEDMAMMTHLNEASVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYNPEVVAGYRGKKRME 149

  Fly   151 VPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGA--SKKTDEAAKSKG 213
            .|||||::||.||..|||:..|||:|||||||||||.|||:||.||||:.|  .||.:.:...:|
 Frog   150 APPHIFSLSDNAYQAMLTDRENQSVLITGESGAGKTVNTKRVIQYFATIAALGDKKKESSNSLQG 214

  Fly   214 SLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSL 278
            :||||::|.||:|||||||||||||||||||||||||||.||||:.||||||||||:||..|.|.
 Frog   215 NLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLSSADIETYLLEKSRVTFQLSA 279

  Fly   279 ERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQ 343
            ||||||||||::...|.:.::.|||.|.|||..:|||::.|.||:|.||...||.|.|:|||.::
 Frog   280 ERSYHIFYQILTNKKPEIVEMLLLTTNPYDYPSISQGELVVKSINDEEELMATDSAIDVLGFNQE 344

  Fly   344 EKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNE 408
            ||..:|::|.||||.|.:||||:.||||||.|..|...:::.|.|.::|:|.|.|..||:|||||
 Frog   345 EKMGIYKMTGAVMHHGNLKFKQKQREEQAEPDSTEVADKIAYLLGLNSADLLKGLCYPRVKVGNE 409

  Fly   409 FVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFE 473
            |||:|:.|.||.||:|||||.||::||.|:|.:.|:.|||:|.||.|||||||||||||::|..|
 Frog   410 FVTKGQTVPQVYNSVGALCKSVFEKLFLWMVTRINQQLDTKQPRQFFIGVLDIAGFEIFDFNSLE 474

  Fly   474 QLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESM 538
            ||||||||||||||||||||||||||||:|||||.||||||||.|||:|||||:||.||||||.|
 Frog   475 QLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLAACIELIEKPLGIFSILEEECM 539

  Fly   539 FPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLND 603
            ||||||.:|..||...||||...|:||||.| |:..|||::.||||.|.|||:|||||||||||:
 Frog   540 FPKATDTSFKNKLYEQHLGKCKNFEKPKPGK-GKAEAHFSLVHYAGTVDYNISGWLEKNKDPLNE 603

  Fly   604 TVVDQFKKSQNKLLIEIFADHA---GQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRS 665
            :||..::||..|||..:::.:|   |.:||    |||:.|||..|.|||..::|.||.|||.|||
 Frog   604 SVVQLYQKSSVKLLSLLYSSYAATDGDAGG----KGGKKKKGSSFQTVSGLFRENLNKLMTNLRS 664

  Fly   666 TQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKL 730
            |.||||||:||||.|.||::|.||::|||.||||||||||||||||:|::|.|||.|||::....
 Frog   665 THPHFVRCLIPNETKTPGIMDNHLLIHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASA 729

  Fly   731 L---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWAR 792
            :   |.:: .|||.|.::..||:...||:.|:|||||:||:||.:||.|||:|.::::..||..|
 Frog   730 IPEGQFID-SKKACEKLLGSIDVDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQLITRTQALCR 793

  Fly   793 GYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKK 857
            |||.|..|.|:.|:|.|:.|:|.|||.::.::.|||.||:.|:||||..:..|.|:|.::|:.:|
 Frog   794 GYLMRLEFTKMMERREAIYVIQYNLRSFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEK 858

  Fly   858 AEE-LHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDI 921
            .:| |..||.: :||||.....:|.||..|:..:..|...|.|.:||...|...|..||::::::
 Frog   859 TKEALVKAEAR-KKELEEKMVAMLQEKNDLVLQVQSESETLADSEERCEGLIKVKIQLESKIKEL 922

  Fly   922 QERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDE 986
            .|||..||::..:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:|:|..||
 Frog   923 TERLEDEEESNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAVLDE 987

  Fly   987 LINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSK 1051
            .|:||:||||...|.:|:|.::|||.|||::.|:|.|.||||.:|:||.|||:|||:|.|:|::|
 Frog   988 NISKLSKEKKALQEAHQQTLDDLQAEEDKVSSLSKAKTKLEQQVDDLEGSLEQEKKLRLDLERAK 1052

  Fly  1052 RKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEE 1116
            ||:|||||||||.|.|||.:|::.|:.:::||.|:|.:..|:||||.:..:.|::||||||||||
 Frog  1053 RKLEGDLKLTQETVMDLENDKQQTEEKLKKKDFEISQLQGKIEDEQSLGTQLQKKIKELQARIEE 1117

  Fly  1117 LEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEAN 1181
            :|||:||||.||||.|||||||:|||||:.|||||||||||||||:|||||||..|||||||||.
 Frog  1118 VEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKLRRDLEEAT 1182

  Fly  1182 IQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEK 1246
            :|||:|...|||||.|:|||:.||:|.|.::|.|.||||:|...:::||.:.:::::..||..||
 Frog  1183 LQHEATAGALRKKHADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDLASNLENVSKSKANLEK 1247

  Fly  1247 IAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQL 1311
            :.:.::..|:||::|.||..|.|||....|.:|..|..:|.|||||.||.:||||:.|...|.|:
 Frog  1248 VNRVIEDQLSEVKAKDDEHQRLLNDLSTQKARLQTETGELSRQLEERESLISQLSRGKQGFTQQV 1312

  Fly  1312 EDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYES 1376
            |:.||..:||::.:..|....::..||.|.||||.|||.|.||:|||.|||||.|...||:|||:
 Frog  1313 EELKRQLEEETKAKNALAHALQSARHDCDLLREQFEEEQEAKAELQRSLSKANGEVSQWRTKYET 1377

  Fly  1377 DGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAA 1441
            |.:.|:|||||||:||..||.:|||.:|::|.||..||||||||.:|||||.::|:|||:.|.|.
 Frog  1378 DAIQRTEELEEAKKKLAQRLQDAEEQVEAVNSKCASLEKTKQRLQSEVEDLMVDVERANSAAAAL 1442

  Fly  1442 EKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLAD 1506
            :|||:.|||::.|||.|.::..|||:|:.||.|:.|||:|::|.||||..|.:|.::||||||..
 Frog  1443 DKKQRNFDKVLVEWKQKYEEGQAELEAALKESRSLSTEIFKMKNAYEEALEHVETLKRENKNLQQ 1507

  Fly  1507 EVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEI 1571
            |:.||.:||||.|:::.|:|||:|::|.||::|||||||||.:||.||.|:||.||||:||:.|:
 Frog  1508 EISDLTEQIGESGKSVVELEKAKKQVEQEKNDLQAALEEAEGSLEHEEAKILRIQLELNQVKSEV 1572

  Fly  1572 DRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANA 1636
            ||:|.||:||.|..::|.||::|:||::|::|.:.:.:|||:|||:|.|:|||||.|.|||:..:
 Frog  1573 DRKIAEKDEEIEQLKRNSQRSIDTMQSTLDSEIRSRNDALRLKKKMEGDLNELEIQLGHANRQAS 1637

  Fly  1637 EAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQA 1701
            ||||.::..|.|.|:.|..|:|..||::|.:||:.::|||.|..|.|:||:|..|||.:|.|:.|
 Frog  1638 EAQKQLRNVQGQFKETQLQLDEAIRAQEDLKEQVAVTERRNNLFQAEIEENRAGLEQTERSRKIA 1702

  Fly  1702 EQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLAD 1766
            ||||.||.|:|..:.:||.|:..:|:||||::..|.::.:|.:.||:|:|||||||:.|||.:|:
 Frog  1703 EQELLDASERLQLLHSQNTSLINSKKKLESDICQLQNEAEEAVQEARNAEEKAKKAITDAALMAE 1767

  Fly  1767 ELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRR 1831
            ||:.|||.:...|:::|.|||.:|:||.||||||..|:|||||.:||||.||||||||||.||:.
 Frog  1768 ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAMKGGKKQLQKLESRVRELENELDNEQKH 1832

  Fly  1832 HADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFR 1896
            ..:|.|.:||.|||||||::|:|||:||..|:||||||||.|:|.||||.|||||.|..:|.:||
 Frog  1833 GVEAVKGVRKYERRVKELTYQTEEDKKNILRLQDLVDKLQSKVKAYKRQAEEAEEQANTHLGRFR 1897

  Fly  1897 KAQQELEEAEERADLAEQAISKFRAKGR 1924
            |.|.||||||||||:||..::|.|.|.|
 Frog  1898 KVQHELEEAEERADIAESQVNKLRTKSR 1925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	8/36 (22%)
		MYSc	81..777	CDD:214580	440/703 (63%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	418/672 (62%)
		Myosin_tail_1	842..1897	CDD:279860	560/1055 (53%)
		V_Alix_like	1557..1877	CDD:187408	173/319 (54%)
		ATP-synt_B	<1671..1771	CDD:304375	49/99 (49%)
		TMPIT	1739..>1825	CDD:285135	51/85 (60%)
myh4	NP_001001244.1	Myosin_N	34..72	CDD:397036	9/37 (24%)
		MYSc_class_II	99..766	CDD:276951	418/672 (62%)
		Myosin_tail_1	846..1923	CDD:396244	577/1077 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1116	1.000	Domainoid score	I21
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2089	1.000	Inparanoid score	I44
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm48957
Panther	1	1.100	-	-	O	PTHR45615
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2660
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190