DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and MYO18A

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_001333694.1 Gene:MYO18A / 399687 HGNCID:31104 Length:2058 Species:Homo sapiens


Alignment Length:1930 Identity:489/1930 - (25%)
Similarity:872/1930 - (45%) Gaps:418/1930 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 QRRIDQSKPYDSKKSCWIPDEKEGY-LLGEIKATKGDI----VSVGL-QGGEVRDIKSEKVEKVN 81
            :.:|...:.::..:..|:. .::|: |..::|:.:.::    |.|.| ..|.:.|:..:.|||.|
Human   349 EEQIAAEEAWNETEKVWLV-HRDGFSLASQLKSEELNLPEGKVRVKLDHDGAILDVDEDDVEKAN 412

  Fly    82 PPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGK 146
            .|..:::||:|.:..||...|||.|||||.|.|::||:|...:.:.|.....||:.:...|::|.
Human   413 APSCDRLEDLASLVYLNESSVLHTLRQRYGASLLHTYAGPSLLVLGPRGAPAVYSEKVMHMFKGC 477

  Fly   147 RRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKS 211
            ||.::.|||:|::..||..||.:..:||:::.|.||:|||.:.:.::.|.||:.........:..
Human   478 RREDMAPHIYAVAQTAYRAMLMSRQDQSIILLGSSGSGKTTSCQHLVQYLATIAGISGNKVFSVE 542

  Fly   212 KGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQ 276
            |.    |.:.|  :||||||:.|:.|.|::||.:.:.:.|...|::|.|.|:|.||||.||..:.
Human   543 KW----QALYT--LLEAFGNSPTIINGNATRFSQILSLDFDQAGQVASASIQTMLLEKLRVARRP 601

  Fly   277 SLERSYHIFYQIMSGSVPGVKDIC---LLTDNIYDYHIVSQ---GKVTVASIDD----AEEFSLT 331
            :.|.::::||.:::         |   .|...::..|:...   |.|.:|..::    |::||..
Human   602 ASEATFNVFYYLLA---------CGDGTLRTELHLNHLAENNVFGIVPLAKPEEKQKAAQQFSKL 657

  Fly   332 DQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAE--QDGEEEGGR------VSKLFG 388
            ..|..:||.:..|::..:.|.||:.|:|.....:...|||||  :.|.::..|      .:.|.|
Human   658 QAAMKVLGISPDEQKACWFILAAIYHLGAAGATKEAPEEQAEAAEAGRKQFARHEWAQKAAYLLG 722

  Fly   389 CDTAELYKNLLKPRIKVG----NEFVTQGRNVQQVTNSIG----------ALCKGVFDRLFKWLV 439
            |...||...:.|.:.|.|    :....||.....:.:..|          .:..|::..||..||
Human   723 CSLEELSSAIFKHQHKGGTLQRSTSFRQGPEESGLGDGTGPKLSALECLEGMAAGLYSELFTLLV 787

  Fly   440 KKCNETLDTQQKRQHFIGVLDIAGFEIFEYNG------FEQLCINFTNEKLQQFFNHHMFVLEQE 498
            ...|..|.:.|.....:.::|..||:..|..|      ||:||.|:|.::||:.|:...||.|.|
Human   788 SLVNRALKSSQHSLCSMMIVDTPGFQNPEQGGSARGASFEELCHNYTQDRLQRLFHERTFVQELE 852

  Fly   499 EYKREGIDWAFIDFGM---DLLACID------LI------EKPMGILSILEEESMFPKATDQTFS 548
            .||.|.|:.||.|...   |.:|.:|      |:      ::..|:|.:||||::.|.|::.|..
Human   853 RYKEENIELAFDDLEPPTDDSVAAVDQASHQSLVRSLARTDEARGLLWLLEEEALVPGASEDTLL 917

  Fly   549 EKLTNTH-------LGKSAPFQKPKPPKPGQQAAHFAIAHYAGC--VSYNITGWLEKNK-DPLND 603
            |:|.:.:       .|:|......||       .||.:.|..|.  |.||:||||...| :|...
Human   918 ERLFSYYGPQEGDKKGQSPLLHSSKP-------HHFLLGHSHGTNWVEYNVTGWLNYTKQNPATQ 975

  Fly   604 TVVDQFKKSQNKLLIEIFADHAGQS-----------GGGEQAKGGRGKKGGGFATVSSAYKE--- 654
            ......:.||.|::..:|...||.:           ||.:.|..........|.|..:|.|:   
Human   976 NAPRLLQDSQKKIISNLFLGRAGSATVLSGSIAGLEGGSQLALRRATSMRKTFTTGMAAVKKKSL 1040

  Fly   655 ------QLNSLMTTLRSTQPHFVRCIIP--------------------NEMKQPG---------V 684
                  |:::|:.|::.::.|||.|.:|                    :|:..|.         .
Human  1041 CIQMKLQVDALIDTIKKSKLHFVHCFLPVAEGWAGEPRSASSRRVSSSSELDLPSGDHCEAGLLQ 1105

  Fly   685 VDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQG------VEKDKKATEI 743
            :|..|:..||..:.:|:.:|:.|:|:|:.|::.:|:.|:.::.|.|.:.      |..:::|.|.
Human  1106 LDVPLLRTQLRGSRLLDAMRMYRQGYPDHMVFSEFRRRFDVLAPHLTKKHGRNYIVVDERRAVEE 1170

  Fly   744 IIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRV 808
            :::.:||.:....:|.::||||||.|.::||.|||:..:.::..||..||||:|:.|||.:.|.:
Human  1171 LLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDL 1235

  Fly   809 ALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIE-------DEIARLEEKAKKAEELHAAEV 866
            |::.||:|::|...::.|||:||:..|:||:.|...|       :||.:|..|.:|||       
Human  1236 AIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAE------- 1293

  Fly   867 KVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLE--NQLRDIQ--ERLTQ 927
            |.|.||. ||:..|..:.:                |..::||.::|..|  :||.|.:  |||..
Human  1294 KERNELR-LNSDRLESRIS----------------ELTSELTDERNTGESASQLLDAETAERLRA 1341

  Fly   928 EEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLN 992
            |        ::.|:...:...|||.:|.:|:.|.:|...:|.:      :|.|:...|       
Human  1342 E--------KEMKELQTQYDALKKQMEVMEMEVMEARLIRAAE------INGEVDDDD------- 1385

  Fly   993 KEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGD 1057
                       ..||.....|..:..::..|.:|:|   |.||.||.|       :::||::|  
Human  1386 -----------AGGEWRLKYERAVREVDFTKKRLQQ---EFEDKLEVE-------QQNKRQLE-- 1427

  Fly  1058 LKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLED-----EQVVVLKHQRQIKE--LQARIE 1115
                 ..:.||:.:.:|.::.:|:..|:...:||:|:|     |...|..|:.:.|:  ..:.:.
Human  1428 -----RRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELS 1487

  Fly  1116 ELEEEVEAERQARAKAEKQRADLARELEELGERLEE----AGGATSAQIELNKKREAELSKLRRD 1176
            :..||.:.|:..|.|.::::..|..|...|.::|||    ..|.|...:.|    ||||    :|
Human  1488 QAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSL----EAEL----QD 1544

  Fly  1177 LEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEK 1241
            :.....:.|::||.::|              ||..|:||.:.::.|                   
Human  1545 ISSQESKDEASLAKVKK--------------QLRDLEAKVKDQEEE------------------- 1576

  Fly  1242 AAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQL--EEAESQVSQLSKIK 1304
                                |||...|:...:.:|.:|.:| .:.:||.  :|.||:..::.:.:
Human  1577 --------------------LDEQAGTIQMLEQAKLRLEME-MERMRQTHSKEMESRDEEVEEAR 1620

  Fly  1305 ISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQV 1369
            .|...:|:..:...:||..::..:|.:.|.||..|..|.:||.                      
Human  1621 QSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVN---------------------- 1663

  Fly  1370 WRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRA 1434
             |..:||:     :.|.:..::.:|.||:|:..::.|        |.......|:..|:.:::.:
Human  1664 -RRDFESE-----KRLRKDLKRTKALLADAQLMLDHL--------KNSAPSKREIAQLKNQLEES 1714

  Fly  1435 NAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLE---- 1495
            .....||.|.:||.:..|.:..|::||:|....|.:::......|...::...||.||.:.    
Human  1715 EFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMK 1779

  Fly  1496 ----AVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDEL-------------QAAL 1543
                ||.:.:::|| ::.||..|:.|..:...|:::..:.|:::.:.|             :|.:
Human  1780 KHKAAVAQASRDLA-QINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKI 1843

  Fly  1544 EEAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEF--ENTRKNH----QRALDSMQASLEA 1602
            .|.|..||.|..:|.|.:...|::::.:::..:|:::..  ||..|..    ||.|...:..:..
Human  1844 RELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGE 1908

  Fly  1603 EAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAR 1667
            .|:.:|||.|.|.:||.|:..||       .||...|.::|...:::.|:|.|:|:|..:  |..
Human  1909 LARKEAEASRKKHELEMDLESLE-------AANQSLQADLKLAFKRIGDLQAAIEDEMES--DEN 1964

  Fly  1668 EQLGISERRANALQNELEES----RTLLEQ--------ADRGRRQAE------QELA-----DAH 1709
            |.| |:....:.:.:|||:.    ::.|.:        :|.|..::.      :.||     |.|
Human  1965 EDL-INSEGDSDVDSELEDRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDEH 2028

  Fly  1710 EQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKA 1754
            :.|:..|....|               ||.|.:...|||.:|..|
Human  2029 DPLDNTSRPRYS---------------HSYLSDSDTEAKLTETNA 2058

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 9/42 (21%)
MYSc 81..777 CDD:214580 228/813 (28%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 214/782 (27%)
Myosin_tail_1 842..1897 CDD:279860 220/987 (22%)
V_Alix_like 1557..1877 CDD:187408 55/227 (24%)
ATP-synt_B <1671..1771 CDD:304375 22/107 (21%)
TMPIT 1739..>1825 CDD:285135 6/16 (38%)
MYO18ANP_001333694.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..34
Interaction with actin 114..118
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 140..167
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1469..1499 6/29 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1871..1920 12/48 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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