DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and Myh4

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_062198.1	Gene:	Myh4 / 360543	RGDID:	3139	Length:	1939	Species:	Rattus norvegicus

Alignment Length:	1922	Identity:	1070/1922 - (55%)
Similarity:	1433/1922 - (74%)	Gaps:	13/1922 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEK 76
            :..|||..|.::|...|:||:|:|.|.::.|.||.|:...:::.:|..|:...:||....:|.::
  Rat    12 EAAPYLRKSEKERIEAQNKPFDAKSSVFVVDAKESYVKATVQSREGGKVTAKTEGGATVTVKEDQ 76

  Fly    77 VEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAK 141
            |..:||||::||||||.||.|:.|.||:||::||.|.:||||||||||.:||||..|||......
  Rat    77 VFSMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVA 141

  Fly   142 MYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGAS--KK 204
            .||||:|.|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.||||:..:  ||
  Rat   142 AYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDKK 206

  Fly   205 TDEA--AKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLL 267
            .:||  .|.:|:||||::..||:|||||||||||||||||||||||||||.|||||.||||||||
  Rat   207 KEEAPSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLL 271

  Fly   268 EKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTD 332
            ||:||..|...|||||||||:||...|.:.::.|:|.|.||:..||||::||.||||.||...||
  Rat   272 EKSRVTFQLKAERSYHIFYQVMSNKKPELIEMLLITTNPYDFAYVSQGEITVPSIDDQEELMATD 336

  Fly   333 QAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKN 397
            .|.||||||..||..:|::|.||||.|.|||||:.||||||.||.|...:.:.|...::|:|.|.
  Rat   337 TAVDILGFTADEKVAIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLTSLNSADLLKA 401

  Fly   398 LLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIA 462
            |..||:|||||:||:|:.||||.||:|||.|.:::::|.|:|.:.|:.|||:|.||:||||||||
  Rat   402 LCYPRVKVGNEYVTKGQTVQQVYNSVGALAKAMYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIA 466

  Fly   463 GFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPM 527
            |||||::|..|||||||||||||||||||||||||||||:|||:|.||||||||.|||:||||||
  Rat   467 GFEIFDFNTLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPM 531

  Fly   528 GILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITG 592
            ||.||||||.|||||||.:|..||...|||||..||||||.| |:..|||::.||||.|.|||.|
  Rat   532 GIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAK-GKAEAHFSLVHYAGTVDYNIIG 595

  Fly   593 WLEKNKDPLNDTVVDQFKKSQNKLLIEIFA-DHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQL 656
            ||:|||||||:|||..::||..|.|..:|: ..|.::.||...|||: |||..|.|||:.::|.|
  Rat   596 WLDKNKDPLNETVVGLYQKSGLKTLAFLFSGGQAAEAEGGGGKKGGK-KKGSSFQTVSALFRENL 659

  Fly   657 NSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKM 721
            |.|||.|:||.||||||:||||.|.||.::..||:|||.||||||||||||||||:|::|.|||.
  Rat   660 NKLMTNLKSTHPHFVRCLIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQ 724

  Fly   722 RYKIMCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKI 783
            |||::....:   |.:: .|||:|.::..||:...||:.|:|||||:||:||.:||.|||:|.::
  Rat   725 RYKVLNASAIPEGQFID-SKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQL 788

  Fly   784 MSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEI 848
            ::..||..||||.|..|:|:.|:|.::..:|.|:|.::.::.|||.||:.|:||||..:..|.|:
  Rat   789 ITRTQAVCRGYLMRVEFRKMMERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEM 853

  Fly   849 ARLEEKAKKA-EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKN 912
            |.::|..:|| |:|..:|.| |||||.....|:.||..|...:..|...|.|.:||..:|...|.
  Rat   854 ATMKEDFEKAKEDLAKSEAK-RKELEEKMVALMQEKNDLQLQVQAEADGLADAEERCDQLIKTKI 917

  Fly   913 DLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNL 977
            .||.:::::.||...||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||
  Rat   918 QLEAKIKELTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 982

  Fly   978 NDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKK 1042
            .:|:|..||.|.||.||||...|.:|:|.::|||.|||:|.|.|.|.||||.:|:||.|||:|||
  Rat   983 TEEMAGLDENIVKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKK 1047

  Fly  1043 VRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQI 1107
            :|.|:|::|||:||||||.||:..|:|.:|::|::.:::|:.|:|::.:|:||||.:.::.|::|
  Rat  1048 LRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSNLQSKIEDEQALGMQLQKKI 1112

  Fly  1108 KELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSK 1172
            |||||||||||||:||||.:||||||||:||:|||||:.|||||||||||||||:|||||||..|
  Rat  1113 KELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQK 1177

  Fly  1173 LRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHI 1237
            :|||||||.:|||:|.|.|||||.|:|||:.||:|.|.::|.|.||||:|...:::||.:.::.:
  Rat  1178 MRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDLASNMETV 1242

  Fly  1238 TNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSK 1302
            :..|...||:.:.|:..|:||::|.:|..|.:|:..|.|.:|..|:.:..|||:|.::.|||||:
  Rat  1243 SKAKGNLEKMCRTLEDQLSEVKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSR 1307

  Fly  1303 IKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEA 1367
            .|.:.|.|:|:.||..:|||:.:..|....::..||.|.||||.|||.|.||:|||.:||||:|.
  Rat  1308 GKQAFTQQIEELKRQLEEESKAKNALAHALQSARHDCDLLREQYEEEQEAKAELQRAMSKANSEV 1372

  Fly  1368 QVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVD 1432
            ..||:|||:|.:.|:|||||||:||..||.:|||.:|::|.||..||||||||..|||||.::|:
  Rat  1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVE 1437

  Fly  1433 RANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAV 1497
            |:||...|.:|||:.|||::.|||.|.::..|||:|||||.|:.|||||::|.||||..:|||.:
  Rat  1438 RSNAACAALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDQLETL 1502

  Fly  1498 RRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQL 1562
            :||||||..|:.||.:||.|||::|||:||.:|:::.||.||||:||||||:||.||.|:||.||
  Rat  1503 KRENKNLQQEISDLTEQIAEGGKHIHELEKIKKQIDQEKSELQASLEEAEASLEHEEGKILRIQL 1567

  Fly  1563 ELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIA 1627
            ||:||:.||||:|.||:||.:..::||.|.::|||::|:||.:.:.:|||:|||:|.|:||:||.
  Rat  1568 ELNQVKSEIDRKIAEKDEEIDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQ 1632

  Fly  1628 LDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLE 1692
            |:|||:..|||.:|::..|..|||.|..|::..|.:||.:|||.:.|||||.:|.|:||.|..||
  Rat  1633 LNHANRQAAEAIRNLRNTQGMLKDTQLHLDDALRGQDDLKEQLAMVERRANLMQAEIEELRASLE 1697

  Fly  1693 QADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKA 1757
            |.:|.||.|||||.||.|::..:..||.|:...|:|||:::..:..::::::.||:|:|||||||
  Rat  1698 QTERSRRVAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKA 1762

  Fly  1758 MVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELE 1822
            :.|||.:|:||:.|||.:...|:::|.:||.:|:||.||||||..|||||||.|||||.||||||
  Rat  1763 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELE 1827

  Fly  1823 NELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEI 1887
            ||::.||:|:.:|.|.|||.|||||||::|:||||||..|:||||||||.|:|.||||.|||||.
  Rat  1828 NEVENEQKRNIEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQTKVKAYKRQAEEAEEQ 1892

  Fly  1888 AALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            :.:|||||||.|.||||||||||:||..::|.|.|.|
  Rat  1893 SNVNLAKFRKIQHELEEAEERADIAESQVNKLRVKSR 1929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	9/36 (25%)
		MYSc	81..777	CDD:214580	442/703 (63%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	422/672 (63%)
		Myosin_tail_1	842..1897	CDD:279860	560/1055 (53%)
		V_Alix_like	1557..1877	CDD:187408	174/319 (55%)
		ATP-synt_B	<1671..1771	CDD:304375	47/99 (47%)
		TMPIT	1739..>1825	CDD:285135	51/85 (60%)
Myh4	NP_062198.1	Myosin_N	36..73	CDD:280832	9/36 (25%)
		Myosin_head	88..770	CDD:278492	430/684 (63%)
		MYSc_Myh4	100..770	CDD:276879	422/672 (63%)
		Actin-binding. /evidence=ECO:0000250	659..681		16/21 (76%)
		Actin-binding. /evidence=ECO:0000250	761..775		8/13 (62%)
		Myosin_tail_1	850..1927	CDD:279860	577/1077 (54%)
		RILP-like	<994..1098	CDD:304877	53/103 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1128..1147		14/18 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1153..1172		17/18 (94%)
		MIT_CorA-like	<1299..>1411	CDD:294313	58/111 (52%)
		COG6	1376..>1511	CDD:303003	80/134 (60%)
		DUF342	<1506..1582	CDD:302792	48/75 (64%)
		DUF342	<1670..1767	CDD:302792	46/96 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1109	1.000	Domainoid score	I19
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2097	1.000	Inparanoid score	I38
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm45868
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870