DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and didum

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:2025 Identity:521/2025 - (25%)
Similarity:859/2025 - (42%) Gaps:495/2025 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 YDSKKSCWIPDEK---EGYLLGEIKATKGDIVSVGLQGGEVRDIK-----SEKVEKVNPPKFEKI 88
            |......|:|...   |...|.|........:.:....|:::::|     |:.....||......
  Fly     8 YAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQ 72

  Fly    89 EDMADMTVLNTPCVLHNLRQRYYAK-LIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVP 152
            .|:..::.|:.|.||||||.|:..: :||||.|:..||||||...|:|.....:.|||....::.
  Fly    73 NDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLE 137

  Fly   153 PHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLED 217
            |||||:::.||..:...:.|.|::::||||||||.:.|..:.|||.||.|       :|:..:|.
  Fly   138 PHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS-------ESETQVER 195

  Fly   218 QVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHF-GPTGK--LAGADIETYLLEKARVISQQSLE 279
            :|:.::|::||||||||.|||||||||||.::.| ...|.  |.||.:.||||||:||:.|...|
  Fly   196 KVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGE 260

  Fly   280 RSYHIFYQIMS--GSVPGVKDICLLTDNIYDYHIVSQGKV-TVASIDDAEEFSLTDQAFDILGFT 341
            |:||||||:.:  ...|.     |:.|:...:..::.|.. .:..:.|||:|:.|.||..:|||:
  Fly   261 RNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFS 320

  Fly   342 KQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCD----------TAELYK 396
            .|:..|:.:|.|.::|:|.::..::..|...|:|.:          .||          ||:|.:
  Fly   321 IQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSD----------SCDIFHNDIHLQITADLLR 375

  Fly   397 N--------LLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQ 453
            .        ||..:|:..||:|....:::....:..||.|.::.:||:::|...|::|:...|:.
  Fly   376 VSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQC 440

  Fly   454 HFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLA 518
            .|||||||.|||.||.|.|||.|||:.||||||.||.|:|.||||||.:|||.|..||| .|...
  Fly   441 SFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQP 504

  Fly   519 CIDLIEKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYA 583
            ||||||..:|:|.:|:||...||.:|::::.||    :||...|  |...||......|.|.|::
  Fly   505 CIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----IGKCNKF--PHFEKPRFGTTSFFIKHFS 563

  Fly   584 GCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIF---------ADHAGQS--GGGEQAKGG 637
            ..|.|::.|:||||:|.::..:.....:|...|..::.         .|.|..|  ||......|
  Fly   564 DTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAG 628

  Fly   638 RGKKGGGF-----------ATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVM 691
            |.::|...           .||.|.::|.|.||::||.:|.||:||||.||:.|.....:...::
  Fly   629 RKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKII 693

  Fly   692 HQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDK-----KATEIIIKFIDLP 751
            .||...||||.:||...|||:|.:||||.|||::    |:...:.||     ....|::|:|. .
  Fly   694 QQLRACGVLETVRISAAGFPSRWLYPDFYMRYQL----LVYRSKLDKNDMKLSCRNIVMKWIQ-D 753

  Fly   752 EDQYRLGNTKVFFRAGVLGQMEEFRDE-----------------------RLGKIMSWMQAWARG 793
            ||:||.|||::|||||.:..:|:.|..                       |:.|:::.:|..|||
  Fly   754 EDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARG 818

  Fly   794 YLSRKGFKKLQEQRVAL---------------------------------------------KVV 813
            ||:|:..:|::|.|..|                                             :.|
  Fly   819 YLARERTQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAV 883

  Fly   814 Q------------------RN-------LRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEE 853
            |                  ||       :|::|..|.:...|...|     .:|.:|::...||.
  Fly   884 QIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAK-----TISHMENKYMGLEN 943

  Fly   854 K----AKKAEELHAAEVKVR---KELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQK 911
            |    .::.:||:.....::   .|:..|..||..:|| |.......|.|.||   ::..:.|..
  Fly   944 KIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKKT-LEAEFKNVKAACQD---KDKLIEALN 1004

  Fly   912 NDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDL-------ELNVQKAEQDKAT 969
            ..||.:..:..:.|.:...|:.:...||:...||...|::.|:::       |:| |:.::|:..
  Fly  1005 KQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVN-QRNQEDRML 1068

  Fly   970 KDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAA-------------------EDK 1015
            .:...|.||:  |:|..:     |:|::....|....|||...                   ||.
  Fly  1069 AEIDNRELNE--AYQRAI-----KDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDD 1126

  Fly  1016 INHLNKVKAKLEQTLD------------ELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADL 1068
            :.:     |..:.|||            ...||.....|:|..:|:.|:|    .|:.||....|
  Fly  1127 VGY-----ASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQK----HKVLQEQYIKL 1182

  Fly  1069 ERNKKELEQTIQRKDKELSSITAKLEDEQV-VVLKHQRQIKELQARIEELEEEVEAERQARAKAE 1132
            ....|..|.:.:..:.|:.:...:.|.:|: ..:||..:|.||.|:...|:|||...|:...:.:
  Fly  1183 SSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRRREECIQLK 1247

  Fly  1133 K---QRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKK 1194
            .   |::...|.||.  |.|:..|.      ::|:..||..|:     :..|.|.||.|..:.::
  Fly  1248 AVLLQQSQSMRSLEP--ESLQMRGN------DVNELMEAFHSQ-----KLINRQLESELKAITEE 1299

  Fly  1195 HNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQ 1259
            ||..:.||.:::::||                            |||              :|:|
  Fly  1300 HNSKLVEMTQEIERLN----------------------------NEK--------------DELQ 1322

  Fly  1260 SKLDETNRTLNDFDASKKKLSIENSDLLRQLE-----EAESQVSQLSKIKISLTTQLEDTKRLAD 1319
            ..:.|   ::::|:.|       |.|.|||.:     |.:..|:|.               .|..
  Fly  1323 KVMFE---SIDEFEDS-------NVDTLRQNDRYLRRELQKAVAQF---------------LLVQ 1362

  Fly  1320 EESRERATLLGKFR----NLEHDLDNLREQVEEEAEG-KADLQRQLSKANAEAQVWRSKYESDGV 1379
            ||.:.....|..:|    .|||.::  .|.:..::.| .||:...::|..::......|:     
  Fly  1363 EELKLANAKLKAYRQDGGQLEHKIE--EEMIRNKSNGTSADVGANVTKQKSQNPQGLMKF----- 1420

  Fly  1380 ARSEELEEAKRKLQAR--------------------------LAEAEETIESLNQKCIGLEKTKQ 1418
             .|.:|::..::|.:.                          |..|::.:..|..|.:...|...
  Fly  1421 -HSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMH 1484

  Fly  1419 RLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRL 1483
            |....:|:..:.:..:..:.|..        |..|:    ||:..           .::||    
  Fly  1485 RTPHPIENRVIWLVNSITLLNLM--------KQYGD----VDEYV-----------KFNTE---- 1522

  Fly  1484 KGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEA 1548
                ::.|:||     :|.||.:..:.:||.|    .|::                ||.:.:.:.
  Fly  1523 ----KQNQQQL-----KNFNLFEYRRVILDLI----VNLY----------------QALIMQIQG 1558

  Fly  1549 ALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRM 1613
            .|:.   |::.|.|               ..:|.:..|:.|  .:.|...|:.|.:..:......
  Fly  1559 LLDP---KIVPAIL---------------NNDEIQRGRQAH--GMRSRATSIGASSSPEHGGGPA 1603

  Fly  1614 KKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDD---------AREQ 1669
            .|:|...:........|....|..|:   :.:.|.|..|..........|.|         .|..
  Fly  1604 WKQLIGQLEHFYKQFQHFGLDNCYAE---QIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYN 1665

  Fly  1670 LGISER--RANALQNELEESRTLLEQADR--GRRQAEQE---LADAHEQLNEVSAQNASISAAKR 1727
            :|..|.  |:..:.|::..:...|.|..:  ..|::||:   :.|....|:.........|....
  Fly  1666 IGCIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQDVQTICDLCTSLSTAQVLKVMKSYKLD 1730

  Fly  1728 KLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKEL 1792
            ..|||:..:..   |.|.|..|:.:..|..       :||...:|...|..:.:.:..:.:::::
  Fly  1731 DYESEITNVFL---EKLTEKLNARQMQKSN-------SDEFTIDQKFIQPFKVVFRYSDIKLEDI 1785

  Fly  1793 Q----VRLDE 1798
            :    :.|||
  Fly  1786 ELPSHLNLDE 1795

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 6/39 (15%)
MYSc 81..777 CDD:214580 283/747 (38%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 274/716 (38%)
Myosin_tail_1 842..1897 CDD:279860 206/1062 (19%)
V_Alix_like 1557..1877 CDD:187408 46/262 (18%)
ATP-synt_B <1671..1771 CDD:304375 22/106 (21%)
TMPIT 1739..>1825 CDD:285135 12/64 (19%)
didumNP_724569.1 MYSc 65..778 CDD:214580 283/746 (38%)
MYSc_Myo5 84..767 CDD:276831 274/716 (38%)
IQ 900..922 CDD:197470 5/21 (24%)
GBP_C <971..1086 CDD:303769 30/126 (24%)
coiled coil 1049..1068 CDD:293879 4/19 (21%)
coiled coil 1077..1086 CDD:293879 3/15 (20%)
JAKMIP_CC3 <1190..1299 CDD:292653 31/121 (26%)
Myo5_CBD 1424..1792 CDD:271254 73/456 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466254
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - otm2587
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.840

Return to query results.
Submit another query.