DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and ck

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:2109 Identity:555/2109 - (26%)
Similarity:886/2109 - (42%) Gaps:460/2109 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 KPVANQEDEDPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGG 67
            :|.:.:|.:.......||.|.|||....  |.....|:..|:      .|||.....|    || 
  Fly    13 EPASGREFDVAIGARVVSAEGRRIQVRD--DDGDEVWLAPER------RIKAMHASSV----QG- 64

  Fly    68 EVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRY 132
                                :|||..:..|:...:|.||..||...|||||:|...||:|||:..
  Fly    65 --------------------VEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQIL 109

  Fly   133 PVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFA 197
            |:||....|:|:.::..|:|||||||.|.||..|.....:|.::|:|||||||||:||.::.|.|
  Fly   110 PIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLA 174

  Fly   198 TVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADI 262
            .:......         :|.|:::.||:|||||||||:||||||||||:|.|||...|.:.||.|
  Fly   175 AISGKHSW---------IEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKI 230

  Fly   263 ETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVK---DICLLTDNIYDYHIVSQGKVTVASIDD 324
            |.|||||:|::||...||:||:||.|::|.....|   |:.:..|  |.| :.....:|....||
  Fly   231 EQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAAD--YKY-LTGGNSITCEGRDD 292

  Fly   325 AEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFK-----QRGREEQAEQDGEEEGGRVS 384
            |.|||....|..:|.|:.||..::.::.||::|.|.:|:|     .....|..|....|   ||:
  Fly   293 AAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVE---RVA 354

  Fly   385 KLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETL-DT 448
            .|.|.....|...|.:..:....|.|....:..|..:...|..||::.|:|..:|:|.|..: ..
  Fly   355 GLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKP 419

  Fly   449 QQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFG 513
            :...::.||||||.|||.|:.|.|||.|||:.||.|||||..|:|.||||||..|.|:|..|:| 
  Fly   420 RGTSRNAIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF- 483

  Fly   514 MDLLACIDLIE-KPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHF 577
            :|....:|||. |.:.|:::::||:.|||.||||...||..|| |....:.|||    ......|
  Fly   484 VDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKLHKTH-GSHKNYLKPK----SDINTSF 543

  Fly   578 AIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKG 642
            .:.|:||.|.|:..|:|:||:|..:..::....:|.||.|.:|||.....  |.|..|       
  Fly   544 GLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDIEM--GAETRK------- 599

  Fly   643 GGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICR 707
             ...|:|:.:::.|::||.||.|.||.|:|||.|||:|:|.:.|..|...||..:|::|.|||.|
  Fly   600 -RTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRR 663

  Fly   708 KGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQM 772
            .|:|.|..:.:|..||:.:.|.:......|.:|....|..:.|.:..|:||:||||.:......:
  Fly   664 AGYPIRHGFREFVERYRFLIPGVPPAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFL 728

  Fly   773 EEFRDERLGK--------IMSW---------------MQAWARGYLSRK-------GFKKLQ--- 804
            |:.||..|.:        |..|               :|.:.:||..||       |:.:||   
  Fly   729 EQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALI 793

  Fly   805 EQRVA----------LKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAE 859
            ..||.          :..:|.:.|.||..|.: .:|:|..:|...:|.|:   ||....:..:.|
  Fly   794 RSRVLSHRFRHLRGHIVGLQAHARGYLVRREY-GHKMWAVIKIQSHVRRM---IAMRRYRKLRLE 854

  Fly   860 ELHAAEV-KVRK--ELEAL-----NAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLEN 916
            ....||| ::||  |.|.|     :|:.:||               |.|::|       .::||.
  Fly   855 HKQFAEVLQLRKLEEQELLHRGNKHAREIAE---------------QHYRDR-------LHELER 897

  Fly   917 QLRDIQERLTQE---EDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRN-- 976
              |:|||:|...   |...|.:....:|.::.:.. .|.:|.:...:..:..|..| .|..|.  
  Fly   898 --REIQEQLENRRRVEVNMNIINDAARKQEEPVDD-GKLVEAMFDFLPDSSSDAPT-PHGGRETS 958

  Fly   977 -LND----EIAHQDELINKLNKEKKMQGETNQKTGEELQAA--EDKINHLNKVKAKLEQTLDELE 1034
             .||    :..:||::|..::..:. :.:.::...::..|.  :..:||....|| |:..|..|.
  Fly   959 VFNDLPHAQNVNQDDIIAPIHISED-EEDLSEFKFQKFAATYFQGNVNHQYAKKA-LKHPLLPLH 1021

  Fly  1035 DSLEREKKVRGDVEKSKRKVEGDLKLTQEAV--------ADLERNKKELEQTIQRKD--KELSSI 1089
                               .:|| :|..:|:        .|:...|   ..|:.|.|  ..:|.:
  Fly  1022 -------------------TQGD-QLAAQALWITILRFTGDMPEPK---YHTMDRMDTTSVMSKV 1063

  Fly  1090 TAKLEDEQVVVLKHQRQIKELQ-ARIEELEEEVEAERQARAKAEKQRADLARELEELGE----RL 1149
            ||.|....:       :.||.| |::..|:.:...:::.|:...|..:...:...:|||    ||
  Fly  1064 TATLGRNFI-------RSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRL 1121

  Fly  1150 -EEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLK 1213
             ::...|.|.|..|..:..:.|.||     ...|.|....|.||   ::...::.:|:.. |.||
  Fly  1122 QDDEYTADSYQSWLQSRPTSNLEKL-----HFIIGHGILRAELR---DEIYCQICKQLTN-NPLK 1177

  Fly  1214 AK---------------AEKEKNEYYGQLNDLRAGVDHITNEKA--AQEKIAKQLQH-TLNEVQS 1260
            :.               |..||     .:|.|||.:.......|  .:|::.:...: |.|:..|
  Fly  1178 SSHARGWILLSLCVGCFAPSEK-----FVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPS 1237

  Fly  1261 KLD-ETNRT-------LNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRL 1317
            .|: :..::       :...|.:.|.|..:::...|:|      .:|||. ||||..|...:..:
  Fly  1238 WLELQATKSKKPIMLPITFMDGNTKTLLADSATTAREL------CNQLSD-KISLKDQFGFSLYI 1295

  Fly  1318 ADEESRERATLLGKFRNL----EHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYES-- 1376
            |         |..|..:|    :|.:|.: .|.|:.|:.:...:|     ||.   ||..:..  
  Fly  1296 A---------LFDKVSSLGSGGDHVMDAI-SQCEQYAKEQGAQER-----NAP---WRLFFRKEI 1342

  Fly  1377 ---------DGVARSEELEEAKRKLQ------------ARLAEAEETIESLNQKCIGLEKTKQRL 1420
                     |.||.:...::..|.::            |.:|..:..||....  :.:|:....|
  Fly  1343 FAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTD--MSMERLFTLL 1405

  Fly  1421 STEVEDLQLE-----VDRANAIANAAEKKQKAFDKIIGEWKLKVDDLA-AELDASQKECRNYSTE 1479
            ...:.|..|.     ::|..|:...|.||.......|...|:|.|.:: |:........|.|   
  Fly  1406 PNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFY--- 1467

  Fly  1480 LFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALE 1544
                           ||.|....||..  .|::..:...|  ::.::      :.|:..|:.:..
  Fly  1468 ---------------EAYRNSGPNLPK--NDVIIAVNWTG--VYVVD------DQEQVLLELSFP 1507

  Fly  1545 EAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAE 1609
            |..|...|:.|||......||.||          .|||.....|.:...|.:...|:.       
  Fly  1508 EITAVSSQKTNKVFTQTFSLSTVR----------GEEFTFQSPNAEDIRDLVVYFLDG------- 1555

  Fly  1610 ALRMKKKLEADINELEIAL-DHANKANAEAQKNIKRYQQQLKDIQTALEEEQRAR---------- 1663
               :||:     ::..||| |:  :|.::....:..::..|    ..||:|....          
  Fly  1556 ---LKKR-----SKYVIALQDY--RAPSDGTSFLSFFKGDL----IILEDESCGESVLNNGWCIG 1606

  Fly  1664 --DDAREQLGISERRANALQNELEESRTLL-----EQADRGRRQA------EQELADAHEQLNEV 1715
              |.::|:..........|....:..:.:|     |:|..|||.:      ..|..|....|.|.
  Fly  1607 RCDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEY 1671

  Fly  1716 SAQNASISAAKRKLESELQTLHSDLDE-------------LLNEAKNSEEKAKKAMVDAA----- 1762
            :..:..: ..||.:...| ||.|...|             ||.:.::.||.|::|....|     
  Fly  1672 ALDHFRL-PPKRTMSKTL-TLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKY 1734

  Fly  1763 ---------RLADELR-----AEQDHAQTQEKLRKALEQQIKELQVRLDEAE-------ANALKG 1806
                     |:.:|:.     ....|...::::...|.:|:.:.:.|:.|..       |..|..
  Fly  1735 MGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIYCQLMKQLTDNRNRMSEERGWELMWLATGLFA 1799

  Fly  1807 GKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQ 1871
            ..:.:.|        |..|....|||..:|.::.:.::.::       ..::.:...|..|:.:|
  Fly  1800 CSQGLLK--------ELLLFLRTRRHPISQDSMHRLQKTIR-------HGQRKYPPHQVEVEAIQ 1849

  Fly  1872 QKI-----KTY-KRQIEEAEEIAALNLAK 1894
            .|.     |.| ....:||.|:.:...||
  Fly  1850 HKTTQIFHKVYFPDDTDEAFEVDSSTRAK 1878

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 8/36 (22%)
MYSc 81..777 CDD:214580 272/705 (39%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 267/674 (40%)
Myosin_tail_1 842..1897 CDD:279860 242/1217 (20%)
V_Alix_like 1557..1877 CDD:187408 70/387 (18%)
ATP-synt_B <1671..1771 CDD:304375 27/142 (19%)
TMPIT 1739..>1825 CDD:285135 19/124 (15%)
ckNP_001285949.1 MYSc 64..733 CDD:214580 273/720 (38%)
MYSc_Myo7 77..721 CDD:276832 267/674 (40%)
MyTH4 <1138..1245 CDD:214535 25/120 (21%)
B41 1251..1467 CDD:214604 50/242 (21%)
FERM_B-lobe 1355..1439 CDD:271216 15/85 (18%)
FERM_C1_MyoVII 1461..1559 CDD:270019 28/145 (19%)
SH3 1560..1624 CDD:302595 11/69 (16%)
MyTH4 1701..1849 CDD:214535 25/162 (15%)
B41 1856..2068 CDD:214604 7/23 (30%)
FERM_M 1966..2068 CDD:278785
FERM_C2_MyoVII 2064..2159 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466282
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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