DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and Myo31DF

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster

Alignment Length:	1046	Identity:	310/1046 - (29%)
Similarity:	500/1046 - (47%)	Gaps:	185/1046 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 IEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVP 152
            ::|...:..::....:.|||:|:....||||.|..||::|||::..:|.....:.|:|:...|..
  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENA 73

  Fly   153 PHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLED 217
            ||:|||:|.||..:.....:..:||:|||||||||.:|.::.|.|.|..::..:|..:.|..|
  Fly    74 PHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNVL-- 136

  Fly   218 QVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSY 282
              :|:|.:||.||||||.||||||||||::.|.|.......|..|..|||||:||:.||..||::
  Fly   137 --IQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNF 199

  Fly   283 HIFYQIMSGSVPGVKDICLLTDN---IYD-------YHIVSQGKVTVASIDDAEEFSLTDQAFDI 337
            |.|||::.|:          .||   .|:       ||.::||.:.:  :.:..::..|..||..
  Fly   200 HSFYQLLRGA----------NDNELRQYELQKETGKYHYLNQGSMDI--LTEKSDYKGTCNAFKT 252

  Fly   338 LGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPR 402
            |||:..|.:.::|..|||:|:|.::|:.  .|::.....::.....:||......||...|.|..
  Fly   253 LGFSTDEVQTIWRTIAAVLHLGNVEFQT--IEDELVISNKQHLKSTAKLLQVTETELSTALTKRV 315

  Fly   403 IKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETL-----DTQQKRQHFIGVLDIA 462
            |..|...:.:..|..|......||.|.::||||.|::.:.|..:     .||.:....||||||.
  Fly   316 IAAGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIY 380

  Fly   463 GFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKP- 526
            |||||:.|.|||.|||:.||||||.|...:...|||||:||||:|..|::..:.:.| ||:|:|
  Fly   381 GFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIIC-DLVEQPH 444

  Fly   527 MGILSILEEESM-FPKATDQTF---SEKLTNTHLGKSAPFQKPKPPKP-GQQAAH---FAIAHYA 583
            .||::|::|..: ..|.||.|.   .:|..:.|     |....:..|| .::..|   |.|.|||
  Fly   445 KGIIAIMDEACLSVGKVTDDTLLGAMDKNLSKH-----PHYTSRQLKPTDKELKHREDFRITHYA 504

  Fly   584 GCVSYNITGWLEKNKDPLNDTVVDQFKK----SQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGG 644
            |.|.|||.|::||||    ||:...||:    |::..|.|::.:      |.:..|    |....
  Fly   505 GDVIYNINGFIEKNK----DTLYQDFKRLLHNSKDANLSEMWPE------GAQDIK----KTTKR 555

  Fly   645 FATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKG 709
            ..|..:.::..:..|:.||...:|.:||||.||::|...|.|...|.||:...|:||.:|:.|.|
  Fly   556 PLTAGTLFQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAG 620

  Fly   710 FPNRMMYPDFKMRYKIMC----PKLLQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRA-GVL 769
            |.:|..|..|.:|||::.    |....|.::|  ...::|:.....:| .:.|:||:|.|: ..|
  Fly   621 FVHRQRYDKFLLRYKMISQYTWPNFRAGSDRD--GVRVLIEEKKFAQD-VKYGHTKIFIRSPRTL 682

  Fly   770 GQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQ---------------RNLRK 819
            ..:|..|:|.:..|::.:|...||::.|:.|||:   :.|:.:|:               ..|||
  Fly   683 FALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKM---KAAITIVRAYKAYKLRSYVQELANRLRK 744

  Fly   820 YLQLR------TWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAK 878
            ..|:|      .||        :|.|...::|.::.|:.:..:....||...   |.|...|..:
  Fly   745 AKQMRDYGKSIQWP--------QPPLAGRKVEAKLHRMFDFWRANMILHKYP---RSEWPQLRLQ 798

  Fly   879 LLAEKTALLDSLSGEK---GALQ----DY---QERNAKLTAQKNDLENQLRDIQERLTQEEDARN 933
            ::|     ..:|:|.:   |..:    ||   .:.|:...|....::|         .:...|..
  Fly   799 IIA-----ATALAGRRPYWGQARRWVGDYLANSQENSGYEAYNGSIKN---------IRNHPADG 849

  Fly   934 QLFQQ-------------KKKADQ----------EISGLKKDIEDLELNVQKAE---------QD 966
            :.|||             .|:|::          ::.|:|...:|::..::..|         :|
  Fly   850 ETFQQVLFSSFVKKFNHFNKQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELTSISVSPGRD 914

  Fly   967 KATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGE----------ELQAAEDKINHLNK 1021
            :....|..:|        .:|:..|..|.....|  .:.||          :|...|.::|....
  Fly   915 QLIVFHSSKN--------KDLVFSLESEYTPLKE--DRIGEVVGIVCKKYHDLTGTELRVNVTTN 969

  Fly  1022 VKAKLE 1027
            :..:|:
  Fly   970 ISCRLD 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832
		MYSc	81..777	CDD:214580	250/721 (35%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	246/696 (35%)
		Myosin_tail_1	842..1897	CDD:279860	39/238 (16%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	250/721 (35%)
		MYSc_Myo1	21..677	CDD:276829	246/696 (35%)
		Myosin_TH1	801..983	CDD:283635	32/199 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466271
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840