DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and d

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	1059	Identity:	264/1059 - (24%)
Similarity:	415/1059 - (39%)	Gaps:	246/1059 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 SEKVEKV--------NPPKFEKIEDMADMTVLNTP----CVLHNLRQRYYAKLIYTYSGLFCVAI 126
            ||..:|:        :.||     ||.|:..|:.|    .|:..|:.|:..:..:|..|...::|
  Fly   455 SESQQKMQQQQQQGNSSPK-----DMQDLIHLSGPLTEHAVMRTLQARFNERRYFTNVGPILLSI 514

  Fly   127 NPYKRY--PVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENT 189
            |||...  |:       .....|...:.|.:..|...|..........|:::::|.||||||.|.
  Fly   515 NPYLDVGNPL-------TLTSTRAMPLAPQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANA 572

  Fly   190 KKVI-AYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGP 253
            ..:: ..||..|...:|| |.|       .:.....||.:.|:|||..|..|||.|:||.:.. .
  Fly   573 MLMLRQLFAIAGGGPETD-AFK-------HLAAAFTVLRSLGSAKTTTNSESSRIGQFIEVQV-T 628

  Fly   254 TGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHI------- 311
            .|.|....|..|.|::.|||.....|::||||||:::|         |..:.....|:
  Fly   629 DGALYRTKIHCYFLDQTRVIRPLPKEKNYHIFYQLLAG---------LSREERQKLHLDGYSPAN 684

  Fly   312 --VSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQ 374
              ..:|.:.....:||..|........|||....   ||.|:.|||:.:|.::|...|..| .:.
  Fly   685 LRYLRGDIGQNEQEDAARFQAWKTCLGILGIPFL---DVVRVLAAVLLLGNVQFIDGGGLE-VDV 745

  Fly   375 DGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQ-QVTNSI----------GALCK 428
            .||.|...|:.|.|...|.|::.|           .|:..||: |:..|:          ..|.|
  Fly   746 KGETELNSVASLLGVPPAALFRGL-----------TTRTHNVRGQLVKSVCGDGDANMTRDCLAK 799

  Fly   429 GVFDRLFKWLVKKCN------ETLDTQQK-------------RQH-------------------- 454
            .::.|....:|::.|      .||.|...             .||
  Fly   800 ALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHNQADVASQHASTIGGGNAGSKSMAALNNA 864

  Fly   455 --------FIGVLDIAGF-EIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGI--DWA 508
                    |||:||:.|| |...:...|.||||...|.:|.|:|.|:|....|..:.|||  | .
  Fly   865 VRHATSDGFIGILDMFGFEEPSPHAHLEHLCINLCAETMQHFYNTHIFKSSVESCRDEGIVCD-T 928

  Fly   509 FIDFGMDLLACIDLIEK-PMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQ 572
            .:|: :|.:.|||||.. ..|:||:|:.|... :.|.:::..||...|  :|:...:.||.....
  Fly   929 EVDY-VDNVPCIDLISSLRTGLLSMLDAECSV-RGTAESYVTKLKVQH--RSSTRLETKPTAEPH 989

  Fly   573 QAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKK-------------SQNKLLIEIFA-- 622
            ....|.|.|:||.|.|:.|.:|:.|:|.:.|.:|..|.|             |:.|.|   :|
  Fly   990 DPRMFLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGVFYKHTCNFGFATHLFGSELKAL---YAQQ 1051

  Fly   623 -------------DHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCI 674
                         .|:....|.|..           :|::..:..:|::|:.||...:|||||||
  Fly  1052 QAPRGLSFRISPTSHSDLLNGDEPV-----------STLTQDFHTRLDNLLRTLVHARPHFVRCI 1105

  Fly   675 IPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDK- 738
            ..|..:.....|...|:.|:....|||.:.:...|||:||.:..|..||:::.|..|....:||
  Fly  1106 RSNGTEAARSFDRATVVRQIRSLQVLETVNLMASGFPHRMRFKQFNARYRMLAPFRLLRRSEDKA 1170

  Fly   739 -KATEIIIKF-IDLP---EDQYRL----GNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGY 794
             :..::|:|: ::.|   :....|    |...||...|:...:|..|.|...|..:.|||..||:
  Fly  1171 LEDCQLILKYAMEQPPVLDGSVTLAWAPGKRHVFLSEGIRQHLEHLRTEIRHKSATLMQATWRGW 1235

  Fly   795 LSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAE 859
            ..||.......:|..:..:|:                    .||.|.....:..|    :.|.|.
  Fly  1236 WWRKKMGNGGAKRSKIPGLQQ--------------------APLPNNKTTPNSAA----QNKAAS 1276

  Fly   860 ELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQER 924
            ...||...|.........:|.|:.|:|     |..|.:...:.:....|...        |.||
  Fly  1277 STMAALAAVAAAAPISVPRLSAKTTSL-----GIGGTVARPRPQPIAGTPPP--------DPQE- 1327

  Fly   925 LTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELIN 989
                            |.||:|  :::......|::::......::.:.|.. |.:|::....:.
  Fly  1328 ----------------KCDQKI--IQQTCNLFGLDLERPPPVPPSRSYTITG-NSKISYPQNRVM 1373

  Fly   990 KLNKEKKMQGETNQ-KTGE 1007
            |:|..::.|.|..| |.||
  Fly  1374 KMNFPEEGQSEAPQLKKGE 1392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832
		MYSc	81..777	CDD:214580	214/811 (26%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	206/780 (26%)
		Myosin_tail_1	842..1897	CDD:279860	32/167 (19%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
d	NP_001188730.1	MYSc	476..1217	CDD:214580	210/799 (26%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	205/776 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466233
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930