DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and CG31638

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_723186.2	Gene:	CG31638 / 33910	FlyBaseID:	FBgn0051638	Length:	704	Species:	Drosophila melanogaster

Alignment Length:	684	Identity:	148/684 - (21%)
Similarity:	283/684 - (41%)	Gaps:	144/684 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1345 QVEEEAEGKADLQRQLSKANAEAQV--------------WRSKYESDGVARSEELEEAKRKLQAR 1395
            :.|.||. ::..||:|.:|.|.|..              ||.|:......|::..||:|:
  Fly    40 ETEWEAR-ESQRQRELHEARARAAQMEKTMKWWSDCTANWREKWSKVRNERNKAREESKQ----- 98

  Fly  1396 LAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVD 1460
                      |:.|..|:.|....|..|..||:|::.:   :....||......|..|::...
  Fly    99 ----------LSLKLDGVMKEAHSLKREKNDLELQITQ---LKKEMEKVHTLMMKHAGQFHRA-- 148

  Fly  1461 DLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRREN---KNLADEVKDL-LDQIGEGG-- 1519
            |.:.:.:|:.::. |.|.::         ..:.|:.:..|:   ..|.::|||| :::....|
  Fly   149 DTSEDAEANGRDA-NCSPDI---------SSDGLKNINSEDGLVTKLPNDVKDLDIEEFAMKGAM 203

  Fly  1520 -RNIHEIEKA----RKRL--EAEKDE------------LQAALEEAEAALEQEENKVLRAQLELS 1565
             :::.|:::|    .|||  :..||:            ||..|:||:..|:.|.::.|.....:.
  Fly   204 PKHLTELDEAAAAEEKRLIQQLSKDDFDEDYLLQKISMLQLRLDEAQKTLQAERDEKLELHKSIE 268

  Fly  1566 QVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAK----GKAEALRMKKKLEADINELEI 1626
            ::..|| :.::.::||..:.::...|.|.::|....||.:    ...|.:..::.||..:.||..
  Fly   269 KLTLEI-QDVRGRQEEMRSAKQEAVRELLTLQEQHRAEMRIVNNSLQEEIAARENLERRLTELRT 332

  Fly  1627 ALDHANKANAEAQKNIKRYQQQLKDIQTALE-EEQRARDDAREQLGISERRANALQ-NELEESRT 1689
            .|:|....||.....    :::|:..:.|:| :.::.|.:.|:....|:|:...:| |::|
  Fly   333 ELEHLQAENASEWGK----RERLESEKLAMERDNKKLRAELRDYQERSDRKCRPMQANDVE---- 389

  Fly  1690 LLEQADRGRRQAEQELADAHEQLNEVSAQNASIS------------AAKR--KLESELQTLHSDL 1740
                    .|..:|||::.:::::||...:|.:.            |.:|  :.|:|::.|...:
  Fly   390 --------LRALQQELSERNKEISEVKMSHAKLKKLLAETNTELGHAVRRAEQYEAEVKRLRQRV 446

  Fly  1741 DELLNEAKNSEEKAKKAMVDAARLA---DELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEAN 1802
            :||..|...:|::...|:....||.   |||..:.:          .|:.||:.||.|  .|.:.
  Fly   447 EELKRELAGAEDELDSAVNQVRRLQRSNDELVGQTE----------GLQVQIQHLQNR--RAPSP 499

  Fly  1803 ALKGGKKAIQKLEQRVRELENE----LDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERM 1863
            .|: |...:|...:...||.|:    ::..::...|:|..||.|..........:...:::....
  Fly   500 QLR-GMGGVQLRNKIAVELPNDCLPNINDLRQIFDDSQAGLRSSHNGSDAAMHHAASVKRSSHTE 563

  Fly  1864 QDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQAISKF--------- 1919
            :.|:.  ||:..........|...||...||....::.:.|::.|....|:|..||
  Fly   564 RTLLQ--QQQSSAAASAAAAAAAAAAFFDAKPTHLEENIFESKSRNLEFERAKQKFDNPHGQHHH 626

  Fly  1920 ------RAKGRAGSVGRGASPAPRATSVRPQFDG 1947
                  ...||.||.|..||.|..|..::...:|
  Fly   627 HHQRQRSGNGRYGSAGSSASRANLALPLKGTTNG 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832
		MYSc	81..777	CDD:214580
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874
		Myosin_tail_1	842..1897	CDD:279860	132/617 (21%)
		V_Alix_like	1557..1877	CDD:187408	72/346 (21%)
		ATP-synt_B	<1671..1771	CDD:304375	27/117 (23%)
		TMPIT	1739..>1825	CDD:285135	23/92 (25%)
CG31638	NP_723186.2	DUF4201	284..457	CDD:290581	39/188 (21%)
		Ax_dynein_light	<300..369	CDD:287215	15/72 (21%)
		RILP-like	<312..448	CDD:304877	31/151 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466284
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930