DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and myh9a

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_001091647.2 Gene:myh9a / 333938 ZFINID:ZDB-GENE-030131-5870 Length:1961 Species:Danio rerio


Alignment Length:1945 Identity:775/1945 - (39%)
Similarity:1195/1945 - (61%) Gaps:52/1945 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 SKKSCWIPDEKEGYLLGEIKATKGD--IVSVGLQGGEVRDIKSEKVEKVNPPKFEKIEDMADMTV 96
            :||..|:|.||.|:..|.||...||  :|.:...|.::: :..:.::|:|||||.|:||||::|.
Zfish    26 TKKLVWVPSEKLGFEAGSIKEETGDECLVELADSGKKIK-VNKDDIQKMNPPKFSKVEDMAELTC 89

  Fly    97 LNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDG 161
            ||...||||||:|||:.|||||||||||.|||||..|:||....:||:||:|:|:||||:||:|.
Zfish    90 LNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKYLPIYTEEIVEMYKGKKRHEMPPHIYAITDT 154

  Fly   162 AYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKT--DEA--AKSKGSLEDQVVQT 222
            ||..|:.:..:||:|.||||||||||||||||.|.|.|.:|.||  |::  |.|.|.||.|::|.
Zfish   155 AYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSFKTKKDQSSIALSHGELEKQLLQA 219

  Fly   223 NPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQ 287
            ||:||||||||||:|||||||||||||:|...|.:.||:||||||||:|.|.|...||::||||.
Zfish   220 NPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKDERAFHIFYY 284

  Fly   288 IMSGSVPGVK-DICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRI 351
            :::|:...:: ::||  ::...|..:|.|.||:....|.|.|:.|..||.|:|..:.|:..:.::
Zfish   285 LLTGAGDKLRSELCL--EDYNKYRFLSNGNVTIPGQQDRELFAETIDAFRIMGIPEDEQTGLLKV 347

  Fly   352 TAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNV 416
            .:||:.:|.|.||:....:||....:....:||.|.|.:..:..:.:|.||||||.:||.:.:..
Zfish   348 VSAVLQLGNMSFKKERNSDQASMPDDTAAQKVSHLLGMNVTDFTRAILSPRIKVGRDFVQKAQTQ 412

  Fly   417 QQVTNSIGALCKGVFDRLFKWLVKKCNETLD-TQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFT 480
            :|...::.||.|..::|||:|||.:.|:.|| |:::...|||:||||||||||.|.|||||||:|
Zfish   413 EQAEFAVEALAKATYERLFRWLVMRINKALDKTKRQGASFIGILDIAGFEIFELNSFEQLCINYT 477

  Fly   481 NEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEK---PMGILSILEEESMFPKA 542
            ||||||.|||.||:||||||:||||:|:|||||:||..||:||||   |.|||::|:||..||||
Zfish   478 NEKLQQLFNHTMFILEQEEYQREGIEWSFIDFGLDLQPCIELIEKPNGPPGILALLDEECWFPKA 542

  Fly   543 TDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVD 607
            ||::|.||:.. .||.:..|||||..|   ..|.|.|.||||.|.|....||.||.|||||.|..
Zfish   543 TDKSFVEKVVQ-ELGNNPKFQKPKKLK---DDADFCIIHYAGKVDYKANEWLMKNMDPLNDNVAT 603

  Fly   608 QFKKSQNKLLIEIFAD---HAG---QSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRST 666
            ...:|.:|.:.|::.|   ..|   .:|.||...|....:.|.|.||...|||||.:||||||:|
Zfish   604 LLNQSVDKFVSELWKDVDRIVGLDKVAGMGESLHGAVKTRKGMFRTVGQLYKEQLMNLMTTLRNT 668

  Fly   667 QPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLL 731
            .|:||||||||..|:.|.:..|||:.||.||||||||||||:|||||:::.:|:.||:|:.|..:
Zfish   669 NPNFVRCIIPNHEKKAGKLAHHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAI 733

  Fly   732 -QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYL 795
             :|....|:|..:::|.::|..:.||:|.:|||||||||..:||.||.::..::...|||.|||:
Zfish   734 PKGFMDGKQACVLMVKALELDSNLYRIGQSKVFFRAGVLAHLEEERDMKITDVIINFQAWCRGYV 798

  Fly   796 SRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDE-IARLEEKAKKAE 859
            :|:.|.|.|:|..|::|:|||...||:||.|.|::|:.||||||.|:|.|:| :|:.||..|..|
Zfish   799 ARRAFAKRQQQLTAMRVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMVAKEEELVKMKE 863

  Fly   860 ELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQER 924
            ....||.:: ||.||...:|.|||.||.:.|..|....|:.:|..::|||:..::|..|.:::.|
Zfish   864 RQQQAEDQL-KESEAKQKQLNAEKLALQEQLQAETELCQEAEEMRSRLTARMQEMEEVLHELESR 927

  Fly   925 LTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELIN 989
            |.:||:...|...:|||..|.|..|::.:::.|...||.:.:|.|.|.:::.:.:::...::...
Zfish   928 LEEEEERVAQFQSEKKKMQQNIGDLEQQLDEEEAARQKLQLEKVTMDAKLKKIEEDLMVIEDQNA 992

  Fly   990 KLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKV 1054
            ||:||||...|...:....|...|:|...|.|:|.|.|..:.:|||.|.:|:|:|.::||::||:
Zfish   993 KLSKEKKQMEERISEFTTNLAEEEEKSKSLQKLKTKHETMITDLEDRLRKEEKMRQELEKNRRKL 1057

  Fly  1055 EGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEE 1119
            |||.....:.:|:|:....||...:.:|::||.:..|::|:|..:....|:.|:|::|:|.||:|
Zfish  1058 EGDSTELHDQIAELQAQIAELRAQLAKKEEELQAALARIEEEAALKNAAQKSIREMEAQISELQE 1122

  Fly  1120 EVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQH 1184
            ::|.|:.||.||||||.||..|||.|...||:...:|:||.||..|||.|:::|::.||:....|
Zfish  1123 DLELEKAARNKAEKQRRDLGEELEALKTELEDTLDSTAAQQELRAKRETEVTQLKKTLEDEARAH 1187

  Fly  1185 ESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAK 1249
            |..|:.:|:|||.|..|:.||::|..:.||..:|.|.....:.|:|:..:..::..|...|...|
Zfish  1188 EQMLSEVRQKHNQAFEELNEQLEQSKRSKASVDKAKQALESERNELQIELKSLSQSKNDSENRRK 1252

  Fly  1250 QLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDT 1314
            :.:..|.|:|.|..|:.|..::......|:..|...|...:.:.||:..:.:|...::.:||:|.
Zfish  1253 KAESQLQELQVKHTESERQKHELLDKVSKMQAELESLQGTVTKVESKSIKAAKDCSAVESQLKDA 1317

  Fly  1315 KRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGV 1379
            :.|.:||:|::..:..:.|.||.:.:||:|.:|||.|.|.::::||..|.|:....:.|.|.:  
Zfish  1318 QALLEEETRQKLAISTRLRQLEDEQNNLKEMLEEEEESKKNVEKQLHTAQAQLAEMKKKIEQE-- 1380

  Fly  1380 ARS-EELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEK 1443
            |:| |.:|:.|:|||..:....:.:|..|.....|:|||.||..|::|:.::...........|:
Zfish  1381 AQSLESMEDGKKKLQREVESVLQQLEERNASYDKLDKTKTRLQRELDDVLVDQGHLRQTVQELER 1445

  Fly  1444 KQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEV 1508
            |||.||:::.|.|......|.|.|.::.|.|...|:...|....|...:....:.|.||.|..|:
Zfish  1446 KQKKFDQMLAEEKSISTKYAEERDRAEAEAREKETKSLTLARELEAMTDLKNELERVNKQLKTEM 1510

  Fly  1509 KDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDR 1573
            :||:....:.|:::||:|:|::.:|.:.:|::..|||.|..|:..|:..||.::.:..::.:.:|
Zfish  1511 EDLVSSKDDAGKSVHELERAKRGMEQQLEEMKTQLEELEDELQLTEDAKLRLEVNMQALKAQFER 1575

  Fly  1574 RIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEA 1638
            .:|.::|:.|..||...:.:..|:..||.|.|.:|:|:.::||||.|::||...:|.||||..||
Zfish  1576 DLQSRDEQGEEKRKQLVKQVREMEMELEDERKQRAQAVSVRKKLELDLSELAAQIDLANKARDEA 1640

  Fly  1639 QKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQAEQ 1703
            .|.:|:.|.|:|:.....|:.:.:||::..|...:||:..:::.|:.:....|..|||.:||.:|
Zfish  1641 LKQLKKLQAQMKEQMREFEDLRLSRDESLNQAKENERKIKSMEAEIMQLHEDLAAADRAKRQIQQ 1705

  Fly  1704 ELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLADEL 1768
            |..:..:::|..:|:|:..|..:|:||:.:..|..:|:|.....:...::.|||.:.|.::..||
Zfish  1706 ERDELQDEINSQNAKNSLSSDERRRLEARIAQLEEELEEEHLSVELVNDRLKKASLQAEQVTVEL 1770

  Fly  1769 RAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRRHA 1833
            .||:.::|..|.||..|::|.|:::.:|.|.|.......|..|..||.::::||.:||.|.:...
Zfish  1771 TAERSNSQRLEGLRSQLDRQNKDMKQKLQELEGAVKSKYKSTITALETKIQQLEEQLDSEMKERQ 1835

  Fly  1834 DAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKA 1898
            .:.|.:|:.|:::||:..|.|::|:|.::.:...:|...::|..|||:||.||.||...|..||.
Zfish  1836 QSTKQVRRVEKKLKEVLLQVEDERRNADQSKTETEKANIRLKQMKRQLEETEEEAARANASCRKL 1900

  Fly  1899 QQELEEAEERADLAEQAISKFRAKGRAG--------SVGR--------------GASPAP 1936
            ::|||:|.|.|....:.:|..:.|.|.|        ::||              |:.|.|
Zfish  1901 RRELEDATESASAMNREVSTLKNKLRRGDFTGNVRRAIGRTGVESDDENDLKSEGSEPTP 1960

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 13/38 (34%)
MYSc 81..777 CDD:214580 370/711 (52%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 349/680 (51%)
Myosin_tail_1 842..1897 CDD:279860 341/1056 (32%)
V_Alix_like 1557..1877 CDD:187408 97/319 (30%)
ATP-synt_B <1671..1771 CDD:304375 27/99 (27%)
TMPIT 1739..>1825 CDD:285135 26/85 (31%)
myh9aNP_001091647.2 Myosin_N 28..66 CDD:280832 13/38 (34%)
Myosin_head 81..768 CDD:278492 356/692 (51%)
MYSc_Myh18 93..768 CDD:276895 349/680 (51%)
Myosin_tail_1 845..1925 CDD:279860 350/1082 (32%)
crotonase-like 1067..>1101 CDD:304874 10/33 (30%)
DUF2570 1777..1878 CDD:305162 29/100 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
76.720

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