DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and smyhc1

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_001018343.1 Gene:smyhc1 / 321552 ZFINID:ZDB-GENE-030131-271 Length:1938 Species:Danio rerio


Alignment Length:1924 Identity:1076/1924 - (55%)
Similarity:1433/1924 - (74%) Gaps:10/1924 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 PYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEK 79
            |:|..|.::|...|::.:|.||.|::||.:..|:...|.:..||.|:|..:.|:....|...|..
Zfish    14 PFLRKSDKERLEAQTRIFDMKKECFVPDPEVEYVKASITSRDGDKVTVDTEYGKTLTFKECDVHP 78

  Fly    80 VNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYR 144
            .|||||:||||||..|.|:.|.||.||::||.|.:||||||||||.:||||..|||.:...|.||
Zfish    79 QNPPKFDKIEDMAMFTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYDSSVVKAYR 143

  Fly   145 GKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGA-SKKTDEA 208
            ||:|.|.|||||:|||.||..||::..|||:|||||||||||.|||:||.|||::.| |.|.|.|
Zfish   144 GKKRTEAPPHIFSISDNAYQYMLSDRENQSVLITGESGAGKTVNTKRVIQYFASIAAVSGKKDAA 208

  Fly   209 AKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVI 273
            ::.||:||||::|.||.|||||||||:|||||||||||||||||.:||||.||||||||||:||.
Zfish   209 SEKKGTLEDQIIQANPALEAFGNAKTIRNDNSSRFGKFIRIHFGVSGKLASADIETYLLEKSRVT 273

  Fly   274 SQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDIL 338
            .|...||.|||||||:|...|.:.::.|:|:|.|||..:|||:..|||||||||...||.|||:|
Zfish   274 YQLKAERDYHIFYQILSQKKPELLEMLLITNNPYDYSYISQGETQVASIDDAEELIATDDAFDVL 338

  Fly   339 GFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRI 403
            |||:.||..:|::|.|:||.|.|||||:.||||||.||.|:..:|:.|.|.::|:|.|.|..||:
Zfish   339 GFTQDEKSGIYKLTGAIMHFGNMKFKQKQREEQAEADGTEDADKVAYLMGLNSADLIKGLCHPRV 403

  Fly   404 KVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFE 468
            |||||:||:|:|||||..|||||.|.|::::|.|:|.:.|::|||:|.||:|||||||||||||:
Zfish   404 KVGNEWVTKGQNVQQVYYSIGALAKSVYEKMFLWMVVRINQSLDTKQPRQYFIGVLDIAGFEIFD 468

  Fly   469 YNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSIL 533
            :|.||||||||||||||||||||||||||||||:|||||.||||||||.|||:||||||||:|||
Zfish   469 FNTFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLQACIELIEKPMGIMSIL 533

  Fly   534 EEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNK 598
            |||.|||||:||||..||.:.||||:..||||:..| |:..||||:.||||.|.|||:.||.|||
Zfish   534 EEECMFPKASDQTFKAKLYDNHLGKNPTFQKPRIVK-GRPEAHFALVHYAGTVDYNISNWLVKNK 597

  Fly   599 DPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRG---KKGGGFATVSSAYKEQLNSLM 660
            ||||:|||..|:||..|||..:||.::| :...:.:|||:|   |||..|.|||:.::|.||.||
Zfish   598 DPLNETVVGLFQKSTVKLLSFLFAGYSG-ADSAQDSKGGKGGGKKKGSSFQTVSALHRENLNKLM 661

  Fly   661 TTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKI 725
            |.||||.||||||:||||.|.||.::..||||||.||||||||||||||||||::|.|||.||:|
Zfish   662 TNLRSTHPHFVRCLIPNETKTPGAMENPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRI 726

  Fly   726 MCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWM 787
            :.|...   |.:: :|||.|.::..:|:..:||:||:|||||:||:||.:||.||:||..|::.:
Zfish   727 LNPSANPEGQFID-NKKAAEKLLGSLDIDHNQYKLGHTKVFFKAGLLGTLEEMRDDRLALIITGI 790

  Fly   788 QAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLE 852
            ||.|||.|||..|:|:.|:|.:|.|:|.|:|.::.::.|||.||:.|:||||..:..|.|:|.::
Zfish   791 QARARGILSRLEFQKIVERRDSLLVIQWNVRAFMGVKNWPWMKLYFKIKPLLKTAETEKEMANMK 855

  Fly   853 EKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQ 917
            |:..|.:|.:|.....:||||.....||.||..|..::..|:..|.|.:||...|...|..||.:
Zfish   856 EEFTKLKEAYAKSEARKKELEEKMVSLLQEKNDLQLAVQSEQDNLVDAEERCEGLIKSKIQLEAK 920

  Fly   918 LRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIA 982
            .:::.|||..||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:|:|
Zfish   921 AKELTERLEDEEEMNAELVAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 985

  Fly   983 HQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDV 1047
            ..||:|.||.||||...|.:|:|.::||:.|||:|.|.|.||||||.:|:||.|||:|||:|.|:
Zfish   986 ALDEIIAKLTKEKKALQEAHQQTLDDLQSEEDKVNTLTKAKAKLEQQVDDLEGSLEQEKKLRMDL 1050

  Fly  1048 EKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQA 1112
            |::|||:|||||||||::.|||.:|:::|:.:::||.|:|.:.:|:||||.:..:.|:::|||||
Zfish  1051 ERAKRKLEGDLKLTQESIMDLENDKQQMEEKLKKKDFEISQLNSKIEDEQALGAQLQKKLKELQA 1115

  Fly  1113 RIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDL 1177
            ||||||||:||||.||||.|||||||:|||||:.||||||||||:||||:|||||||..||||||
Zfish  1116 RIEELEEELEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRDL 1180

  Fly  1178 EEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKA 1242
            |||.:|||:|.|.|||||.|:||::.||:|.|.::|.|.||||:|...:|:|:.:.::.|...|:
Zfish  1181 EEATLQHEATAATLRKKHADSVADLGEQIDNLQRVKQKLEKEKSELKLELDDVVSNMEQIVKSKS 1245

  Fly  1243 AQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISL 1307
            ..||:.:.|:..::|.::|.:|..||:|||...|.||..||.:|.|||||.:|.||||::.|.|.
Zfish  1246 NLEKMCRTLEDQMSEYRTKAEEGQRTINDFTMQKAKLQTENGELSRQLEEKDSLVSQLTRGKQSY 1310

  Fly  1308 TTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRS 1372
            |.|:||.||..:||.:.:..|....::..||.|.||||.|||.|.||:|||.|||.|:|...||:
Zfish  1311 TQQIEDLKRQLEEEVKAKNALAHAVQSARHDSDLLREQFEEEQEAKAELQRSLSKTNSEVAQWRT 1375

  Fly  1373 KYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAI 1437
            |||:|.:.|:||||:||:||..||.||||.:|::|.||..|||||.||..|:|||.::|:|:||.
Zfish  1376 KYETDAIQRTEELEDAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA 1440

  Fly  1438 ANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENK 1502
            |.|.:|||:.|||::.|||.|.::...||:::|||.|:.|||||:||.:|||..:|||.::||||
Zfish  1441 AAALDKKQRNFDKVLAEWKQKYEESQTELESAQKESRSLSTELFKLKNSYEEVLDQLETMKRENK 1505

  Fly  1503 NLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQV 1567
            ||.:|:.||.:|:||.|::|||:||.||:||.||.|:|.||||||.:||.||.|:||||||.:||
Zfish  1506 NLQEEISDLTEQLGETGKSIHELEKIRKQLEQEKAEIQTALEEAEGSLEHEEGKILRAQLEFNQV 1570

  Fly  1568 RQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHAN 1632
            :.:|:|::.||:||.|..::|.||.:|::|:|||:|.:.:.||||:|||:|.|:||:||.|..||
Zfish  1571 KADIERKLSEKDEEMEQAKRNQQRVVDTLQSSLESETRSRNEALRLKKKMEGDLNEMEIQLSQAN 1635

  Fly  1633 KANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRG 1697
            :..:||||.:|.....:||.|..|::..|..||.:|.:.|.|||.|.||.||:|.|:|:||.:||
Zfish  1636 RQASEAQKQLKGLHGHVKDSQMQLDDALRGNDDLKENIAIVERRNNLLQAELDELRSLVEQTERG 1700

  Fly  1698 RRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAA 1762
            |:.|||||.|..|::..:.|||.|:...|:|||.:...|.::::|.:.|.:|:|||||||:.|||
Zfish  1701 RKLAEQELMDVSERVQLLHAQNTSLLNQKKKLEGDNTQLQTEVEEAVQECRNAEEKAKKAITDAA 1765

  Fly  1763 RLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDG 1827
            .:|:||:.|||.:...|:::|.:||.||:||.||||||..|:|||||.:||||.||||||||::.
Zfish  1766 MMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAMKGGKKQVQKLEARVRELENEVEL 1830

  Fly  1828 EQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNL 1892
            |||:.:::.|.:||.|||:|||::|:||||||..|:||||||||.|:|:|||..|||||.|..||
Zfish  1831 EQRKASESVKGVRKYERRIKELTYQTEEDRKNLARLQDLVDKLQLKVKSYKRAAEEAEEQANSNL 1895

  Fly  1893 AKFRKAQQELEEAEERADLAEQAISKFRAKGRAGSVGRG 1931
            .||||.|.||:|||||||:||..::|.|||.|.....:|
Zfish  1896 GKFRKLQHELDEAEERADIAESQVNKMRAKSRDSGPKKG 1934

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 11/36 (31%)
MYSc 81..777 CDD:214580 450/702 (64%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 430/671 (64%)
Myosin_tail_1 842..1897 CDD:279860 554/1054 (53%)
V_Alix_like 1557..1877 CDD:187408 167/319 (52%)
ATP-synt_B <1671..1771 CDD:304375 49/99 (49%)
TMPIT 1739..>1825 CDD:285135 50/85 (59%)
smyhc1NP_001018343.1 Myosin_N 35..72 CDD:280832 11/36 (31%)
Myosin_head 87..768 CDD:278492 437/683 (64%)
MYSc_class_II 99..768 CDD:276951 430/671 (64%)
Myosin_tail_1 848..1925 CDD:279860 570/1076 (53%)
RILP-like 963..1096 CDD:304877 66/132 (50%)
COG6 1374..>1507 CDD:303003 74/132 (56%)
TMPIT 1457..>1562 CDD:285135 60/104 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 1098 1.000 Domainoid score I20
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H68044
Inparanoid 1 1.050 2094 1.000 Inparanoid score I40
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D41153at33208
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - otm24867
orthoMCL 1 0.900 - - OOG6_100110
Panther 1 1.100 - - O PTHR45615
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1110.970

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