DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhc and lama5

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	XP_009294934.1	Gene:	lama5 / 321243	ZFINID:	ZDB-GENE-030131-9823	Length:	3665	Species:	Danio rerio

Alignment Length:	707	Identity:	152/707 - (21%)
Similarity:	293/707 - (41%)	Gaps:	185/707 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   979 DEIAHQDELINKLNKEKKMQGETNQKTGEELQA---AEDKINHLNKVKAKLEQTLDELEDSLERE 1040
            |.|:|..|.:            .||.|  .|.|   |..::|.||...|.:...:.....:|::.
Zfish  2158 DRISHFYESV------------ANQLT--SLNASTFAWTQLNRLNASIADIANAITNYNSTLDKS 2208

  Fly  1041 KKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLED--EQVVVLKH 1103
            :. |..|      :||:|::....:.|||:.               :|:|.|.:|  |..:...|
Zfish  2209 RN-RASV------LEGELEIIDSDIKDLEKK---------------ASVTQKKKDALEDNINSTH 2251

  Fly  1104 QRQ------IKELQARIEELEEEVE--AERQARAKAEKQRADLARELEELGERLEEAGGATSAQI 1160
            .|.      ||.:...::::.::|.  |:.:.:...||   ||||::.|:...|.:.
Zfish  2252 TRAQELFGFIKGIMRDVKDIIQQVNRTAQNETQVMDEK---DLARKIAEVESMLRDM-------- 2305

  Fly  1161 ELNKKR--EAELSKLRRDLEEAN-----IQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEK 1218
               :.|  :.:.:|.:.:|::||     :.:|  :|| |..:|:||||...     ||||
Zfish  2306 ---RFRGFDYQKNKAKNELDQANNLVDRVINE--IAN-RTWNNEAVAENIR-----NKLK----- 2354

  Fly  1219 EKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIEN 1283
               ::..||.|||..::...|..|       |.....|..|..|::..:.:|......|
Zfish  2355 ---QFNEQLMDLRDAMNEAVNNTA-------QTVEANNINQKHLEDLQKKVNSLHEKYK------ 2403

  Fly  1284 SDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEE 1348
             :::.||:.||..|:|::    .|.:.|:|:|.              .:.:|...||..|:.:.|
Zfish  2404 -EVVSQLQMAEDDVTQVN----DLLSMLQDSKE--------------DYEHLAAQLDGARQPLAE 2449

  Fly  1349 EAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGL 1413
            :.:..|....::....|..:            .:|.||:....|.:.::.:.:  ::..|:.:..
Zfish  2450 KVQKYAPAANKIPLVEAAEK------------HAEMLEQLANNLSSLISGSNQ--DNFIQRALNA 2500

  Fly  1414 EKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYST 1478
            .:....:...|.:.:....:||..|:.|.:..:  ||          ||.|:..|    .:|.||
Zfish  2501 SRAYTNIINSVLEAETTALKANETASMALENIR--DK----------DLPAQAAA----LKNQST 2549

  Fly  1479 ELFRLKGAYEEGQEQLEAVRRENKNLADEVK-DLLDQIGEGGRNIHEIEKARKRLEAEKDELQAA 1542
            ||  ||.|     |:|....:..|...|.:| .|||...:..:.:.:::..:.:|...:|::..:
Zfish  2550 EL--LKSA-----EELNNSSQSLKPRVDTIKMSLLDAEKKKEKMLQDLKDIQNKLNVSRDDIVNS 2607

  Fly  1543 LEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFEN---TRKNHQRALDSMQASLEAEA 1604
            :..|::|:||..|.|    ..:|.|...|.::::|.::::.:   |.::..:||:....|:.|
Zfish  2608 ISAAKSAVEQANNTV----ANVSGVLAPIQKQLEEWQKQYGDSNATSEDINKALNDANTSVAA-- 2666

  Fly  1605 KGKAEAL-RMKKKLE---------ADINE--------LEIALDHANKANAEAQKNIK 1643
              .::.| ::.|||:         ::|::        :|.|.:.|||.:...|.|.|
Zfish  2667 --LSDTLPKLIKKLDRLHNTTFQPSNISDSIQRIRQLIEQARNAANKVSVSMQFNGK 2721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832
		MYSc	81..777	CDD:214580
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874
		Myosin_tail_1	842..1897	CDD:279860	152/707 (21%)
		V_Alix_like	1557..1877	CDD:187408	23/108 (21%)
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
lama5	XP_009294934.1	Laminin_N	51..290	CDD:278484
		EGF_Lam	291..339	CDD:238012
		EGF_Lam	350..413	CDD:238012
		EGF_Lam	421..463	CDD:214543
		EGF_Lam	482..529	CDD:214543
		Laminin_EGF	529..577	CDD:278482
		Laminin_EGF	575..622	CDD:278482
		Laminin_EGF	620..667	CDD:278482
		EGF_Lam	664..711	CDD:238012
		Laminin_EGF	713..759	CDD:278482
		Laminin_EGF	762..812	CDD:278482
		EGF_Lam	815..858	CDD:238012
		Laminin_EGF	1421..1469	CDD:278482
		Laminin_EGF	1511..1561	CDD:278482
		Laminin_EGF	1559..1607	CDD:278482
		Laminin_B	1672..1796	CDD:278481
		EGF_Lam	1842..1881	CDD:238012
		Laminin_EGF	1894..1947	CDD:278482
		EGF_Lam	1949..2002	CDD:238012
		Laminin_EGF	2004..2048	CDD:278482
		Laminin_EGF	2051..2099	CDD:278482
		Laminin_EGF	2099..>2128	CDD:278482
		mycoplas_twoTM	2158..>2351	CDD:275320	56/250 (22%)
		Laminin_I	2171..2429	CDD:283627	75/329 (23%)
		COG1340	2319..2558	CDD:224259	71/323 (22%)
		BAR	2383..2637	CDD:299863	64/319 (20%)
		Laminin_II	2611..2741	CDD:283628	28/119 (24%)
		LamG	2757..2896	CDD:214598
		LamG	2932..3075	CDD:238058
		LamG	3110..3249	CDD:238058
		LamG	3320..3466	CDD:238058
		LamG	3490..3642	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910