DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and Myo10A

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster


Alignment Length:2606 Identity:549/2606 - (21%)
Similarity:960/2606 - (36%) Gaps:809/2606 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ANQEDEDPTPYLFV---SLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIV-----SV 62
            |:.||.:..|.|..   :|...|:.:.|       |..|.     ::..:.....|::     :.
  Fly    85 ASLEDFEDLPNLSAKHPALPSSRLRRLK-------CRYPQ-----VVKRLSTLCSDVIARHPQTF 137

  Fly    63 GLQGGE-----VRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLF 122
            .||.||     .:|:.|..|           |||..:..|:...:|.|||.||...||||::|..
  Fly   138 ALQPGEGSLRARQDLGSSGV-----------EDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSI 191

  Fly   123 CVAINPYKRYP-VYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKT 186
            .:|:||||.:| .|....||.|.|:....:|||:|||...|:..:.:..|   ::|:||||:|||
  Fly   192 LIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSPQV---VVISGESGSGKT 253

  Fly   187 ENTKKVIAYFATV---GASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIR 248
            |:||.|:.|.|.|   |.|        :...:.:|:::..|:|||||||:|.||||||||||::.
  Fly   254 ESTKLVMQYLAAVVPGGGS--------ASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLE 310

  Fly   249 IHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSG-SVPGVKDICLLTDNIYDYHIV 312
            ::| .:|.:.||.|..|||||:|:::|...||:||:||:::.| |........||..:.|.|  :
  Fly   311 VYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFY--L 372

  Fly   313 SQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGE 377
            :||....||  ...::.....|..:||.::.|:|.:.|:.|||:|:|.:.|.:  |:.:..|:|.
  Fly   373 NQGATDCAS--GRVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHR--RQLRHGQEGV 433

  Fly   378 EEGGR-----VSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKW 437
            |.|..     .:.|.......|::.|.....:...|.:.....:.|..::..|..|.::..||.|
  Fly   434 EVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNW 498

  Fly   438 LVKKCNETLDTQQK----RQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQE 498
            ||.:.|..:   ||    ..|.|.:|||.|||....|.|||||||:.||.||.:||.|:|.|||.
  Fly   499 LVSRINSIV---QKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQA 560

  Fly   499 EYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQ 563
            ||.||.::|..:.:..:|.....|.:||:||..:|::||.||:|||.:|.||....| ..|..:.
  Fly   561 EYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYA 624

  Fly   564 KPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQS 628
            :|:     ..|..|.:.||||.|.|.:.|:|:||:|.|...|::....|:..|:.|:......|.
  Fly   625 RPR-----IGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQR 684

  Fly   629 GGGEQ-AKGGRGKKGGGFA-------TVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVV 685
            ..|:. .||..|:    |.       ||::.:.:.|..|:.::....|.|||||.||:.|....:
  Fly   685 DAGKTLPKGSNGR----FVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRM 745

  Fly   686 DAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATEIIIKF--- 747
            |...|:.||...|:|:.|:|.::|:|.|:.:..|..||:.:.|..|......::....:::.   
  Fly   746 DMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPR 810

  Fly   748 --IDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVAL 810
              ::.|:  |:||.|:||.|..:...:|..|.|||.:....:|...||.|.|:...:.|.....|
  Fly   811 TGVEGPD--YQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRL 873

  Fly   811 KV---VQRNLRKYLQL--------RTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAA 864
            :.   .||..::|.:|        |.|...:..::|:.|.:..|...|.....::|::|.|...|
  Fly   874 QARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQA 938

  Fly   865 EVK--------VRKELEALNAKLLA--------EKTALLDSLSGEKGALQDYQERNAKLTAQK-- 911
            .::        :..||..:.:||..        ....:|.::.|...:.....|...:.:..|  
  Fly   939 VLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFS 1003

  Fly   912 ----NDLENQLR--DIQERLTQEEDARNQLFQQ---------KKKADQEISGLK----------- 950
                |.|..|.|  .|...|.....:|:|.||.         :...|:.:.|.|           
  Fly  1004 SVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHK 1068

  Fly   951 ----KDIEDLELNVQKAEQ--------DKATKDHQI-------------------RNLNDEIAH- 983
                :.:.| |:.||...|        .:||:..|:                   |.::||... 
  Fly  1069 ALSSRGLRD-EILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPES 1132

  Fly   984 -QDELINKLNKEK-------------------------------------KMQGETNQKTGEEL- 1009
             :..|:.:|.:::                                     .:..|.:|....:. 
  Fly  1133 LRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSW 1197

  Fly  1010 ----QAAEDKINHLNKVKAKLEQTLD---ELEDS--------LEREKKV-------RGDVEKSKR 1052
                :||...::.|..........||   :|.||        |..||::       |.|:.:|..
  Fly  1198 TSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGA 1262

  Fly  1053 KVEGDLKLTQEAVADLERNKKELEQTIQRK--DKELSSITAKLEDEQVVVLKHQRQIKELQARIE 1115
            |..                :..|...::|.  .......::..||    |.:.:|..:||.:|..
  Fly  1263 KFA----------------RTTLPDAVKRPAVPPPAPPTSSGKED----VPRERRSSRELLSRSS 1307

  Fly  1116 ELEEEV----------EAERQARAKAEKQRAD--LARE-------------LEELG--------- 1146
            .|.|..          :.....:||:..:..|  ||.:             |..||         
  Fly  1308 ALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDR 1372

  Fly  1147 ----ERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRK--KHNDAVAEMAEQ 1205
                |||...|..|..:.:  |.:.|.    ||....::..|.|..|:..:  ..:.|:::.:|.
  Fly  1373 YHSAERLAPVGKDTGPRYQ--KSQHAG----RRSHAASHGSHSSKYADKAEYATRSSAMSDTSEA 1431

  Fly  1206 ---VDQLNKLKAKAEKEKNEYYGQLNDLRAGV-----DHITNEKAAQEKIAKQLQHTLNEVQSKL 1262
               ...:.:::..::....:.:  |:||.:.|     |.:::.::....|........||.:|::
  Fly  1432 PSLASHVRRVRVPSQASDVDQF--LDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEI 1494

  Fly  1263 DETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKI-----------KISLTTQLEDTKR 1316
            |:.:..:||.        .:...|::.||:..|: .||:.|           :....:::||...
  Fly  1495 DDLDDYINDI--------FQPIPLVQNLEKLTSK-DQLAAIIKGGGVASKPEERDEESEIEDLDD 1550

  Fly  1317 LADE--ESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEA---------QVW 1370
            ..:|  |....|..|.|..:.||...::|.....::.|...|..||.:...|.         ||.
  Fly  1551 YINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQ 1615

  Fly  1371 RSKYESDGVARSEELEE----AKRKLQARLAE---------------AEETIESLN------QKC 1410
            |:..:| .:|::.::::    ..:.||..|::               |...:.||:      |..
  Fly  1616 RAFLQS-AMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSP 1679

  Fly  1411 IGLEKTKQRLSTEVEDLQ-------------LEVDRANAIANAAEKKQKAFDKIIGEWK------ 1456
            :.::.|:..| ..:|.||             ||....:...:..:...:|....||:|:      
  Fly  1680 MRMKATRSSL-VVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQD 1743

  Fly  1457 -----LKVDDLAAELDASQKE----------------------CRNYST-----ELFRLKGAYE- 1488
                 .:.|..|.::...|::                      .|..|.     |.|.::.... 
  Fly  1744 EPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPP 1808

  Fly  1489 --EGQEQLEAVRRE-----------NKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKD--- 1537
              .||....::|.|           |::...|.:|    :|:..:::...:.|:|..|...|   
  Fly  1809 PMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQD----VGQPMQSVVTTKLAKKSFEIGADRPP 1869

  Fly  1538 -----------ELQAALEE------------------AEAALEQEENKVLRAQL----------- 1562
                       |::..||:                  |.|.||.....:|:.||           
  Fly  1870 PGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGN 1934

  Fly  1563 --------ELSQVRQEIDR---------------------------------------------- 1573
                    ..:.||.:|:|                                              
  Fly  1935 SGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPP 1999

  Fly  1574 --------RIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDH 1630
                    |..|.|.::..:  :.|...:.:.|.::.:.:....|:|.::.:.:....||   ||
  Fly  2000 APQSPPTARSPEPEPDYRTS--SSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLE---DH 2059

  Fly  1631 ANKAN------AEAQKNIKRYQQQLKDIQ------------------TALEEEQRARDDAREQL- 1670
            :..::      .:|::...|.:.:.:|.:                  :..|:|:..|:..||:| 
  Fly  2060 SASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLY 2124

  Fly  1671 ----------------------------------------GISERRANALQNELEESRTLLEQAD 1695
                                                    |::..|.:..| :.|..|.....|.
  Fly  2125 EIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQ-KYEHERKRKSSAS 2188

  Fly  1696 RGRRQ----------------------------------------------------------AE 1702
            .|.|:                                                          ..
  Fly  2189 SGMREELDSMHMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTACLTYNRVPWKLRVR 2253

  Fly  1703 QELADAHEQ--------------LNEVSAQNASISAAKRKLESELQTLHS---DLDELLNE---- 1746
            :|:...||.              |.:|......:....::..|.|..||.   .:|.|.|.    
  Fly  2254 KEVFQPHEPIGPPVALDLLFAQVLGDVFGVTPCLRITPQEKSSALNMLHGHGVSVDTLSNRNGSG 2318

  Fly  1747 ----AKNSEEKA--KKAMVDAAR--------------------------------LADELRAEQD 1773
                ....:.:|  |:.:||.||                                ||   |.:.|
  Fly  2319 AGGGGNGGQVRALVKRHLVDMARDWPLYFARLFAVQGAPLYPDVSIMGVSHSGLYLA---RRDAD 2380

  Fly  1774 H---------------------AQTQEKLRK------------ALEQQIKEL--QVRLDEAEANA 1803
            :                     |..|..||.            |::..:...  :.|..:::|:.
  Fly  2381 YLIVVQAISFGEIQSAVTLPRPAALQLNLRNGKHLALHAARAAAIQSMVTTFVQEFRKSQSKAST 2445

  Fly  1804 LKGGKKA--------IQKLEQR---VRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDR 1857
            |..|.:|        :::||.|   .:..|:.:||..|::    :.|::||........|.::.:
  Fly  2446 LSSGARAAAQTLNVPLERLESRQAHAQRNEHGVDGGSRQN----EQLQQSELHHHLQQQQQQQQQ 2506

  Fly  1858 KNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKAQQEL--EEAEERADLAEQAISKFR 1920
            :.|.:.|      ||     ::|:|:|.|...:.....::.||:|  ::.:::..|.:|:.....
  Fly  2507 QQHHQQQ------QQ-----QQQLEDAMEEQHMATDHQQQQQQQLGQQQGQQQRFLKQQSYLHSA 2560

  Fly  1921 AKGRAG 1926
            .|..||
  Fly  2561 RKSNAG 2566

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 8/46 (17%)
MYSc 81..777 CDD:214580 245/722 (34%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 239/691 (35%)
Myosin_tail_1 842..1897 CDD:279860 259/1686 (15%)
V_Alix_like 1557..1877 CDD:187408 82/620 (13%)
ATP-synt_B <1671..1771 CDD:304375 29/216 (13%)
TMPIT 1739..>1825 CDD:285135 27/173 (16%)
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 245/723 (34%)
MYSc_Myo15 169..828 CDD:276838 239/691 (35%)
MyTH4 1014..1171 CDD:295320 23/157 (15%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466279
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.840

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