DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and Myo5c

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_006243475.1 Gene:Myo5c / 315820 RGDID:1309994 Length:1749 Species:Rattus norvegicus


Alignment Length:1505 Identity:433/1505 - (28%)
Similarity:718/1505 - (47%) Gaps:243/1505 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 YDSKKSCWIPDEKEGYLLGEIKA--TKGD-IVSVGLQGGEVRDIKSEKVEKVNPPKFEKI----- 88
            |......||||.:|.:...||..  ..|| ::.:.|:.|...|.      .|:|.....:     
  Rat     7 YAQYNRVWIPDPEEVWKSAEIAKDYRVGDQVLRLLLEDGTELDY------PVDPGSLPPLRNPDI 65

  Fly    89 ----EDMADMTVLNTPCVLHNLRQRY-YAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRR 148
                .|:..::.|:.|.||||||.|: .:||||||||:..||:||||:.|:|.:.....|.|:..
  Rat    66 LVGENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNM 130

  Fly   149 NEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKG 213
            .::.|||||:::.||..|..|:.|||::::||||||||.:.:..:.|||||..|       .|..
  Rat   131 GDMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKS-------SSNA 188

  Fly   214 SLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSL 278
            .:|::|:.:||:.||.|||||.||||||||||:..|.|....::.||::.||||||:||:.|...
  Rat   189 HVEEKVLASNPITEAVGNAKTTRNDNSSRFGKYTEISFDERNQIIGANMRTYLLEKSRVVFQSEN 253

  Fly   279 ERSYHIFYQI-MSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTK 342
            ||:||||||: .|......|.:.|.:...::|..:. |...:..:||..:.:.|.:.|.:|||.|
  Rat   254 ERNYHIFYQLCASAQQSEFKHLKLGSAEEFNYTRMG-GNTVIEGVDDRADMAETQKTFTLLGFKK 317

  Fly   343 QEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGN 407
            ..:.||::|.||::|:|.::....|.|..|..:.:.......:|.|.:|.::.:.|...:|...:
  Rat   318 DFQMDVFKILAAILHLGNVQVTTVGNERSAVSEDDSHLKVFCELLGLETIKVAQWLCNRKIVTSS 382

  Fly   408 EFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGF 472
            |.|.:.....|..|:..||.|.::..||.::|::.|:.|....|:..|||||||.|||.|:.|.|
  Rat   383 ETVVKPMTRPQAINARDALAKKIYAHLFDFIVEQINQALHFSGKQHTFIGVLDIYGFETFDVNSF 447

  Fly   473 EQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEES 537
            ||.|||:.||||||.||.|:|.||||||.:|.|.|..||| .|....|||||..||||.:|:||.
  Rat   448 EQFCINYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDF-YDNQPVIDLIEAKMGILELLDEEC 511

  Fly   538 MFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLN 602
            :.|..||:.:.:||.|..:.|::.|:||:     ...:.|.|.|:|..|.|...|:||||:|.:.
  Rat   512 LLPHGTDENWLQKLYNNFVNKNSLFEKPR-----MSNSSFIIQHFADKVEYQCEGFLEKNRDTVY 571

  Fly   603 DTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSA---------------- 651
            |.:|:..:.|:..|....|.:....|           ...|...||.||                
  Rat   572 DMLVEVLRASKFHLCAAFFQESPVPS-----------SPFGAMITVKSAKQVIKPNTKHFRTTVG 625

  Fly   652 --YKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRM 714
              ::..|..||.||.:|.||:||||.||:.|.|...|:..::.||...||||.|||..:.:|:|.
  Rat   626 NKFRSSLFLLMETLNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRW 690

  Fly   715 MYPDFKMRYKIMCPKLLQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDER 779
            .|.:|..||.::..:....:...|:..::::..:....:||:.|.||:|||||.:..:|:.|.::
  Rat   691 TYLEFYSRYGVLMTQQELSLSDKKEVCKVVLHRLIQDSNQYQFGRTKIFFRAGQVAYLEKLRLDK 755

  Fly   780 LGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRI 844
            |.:....:|...||:|.||.|  |:|:|.||.:.|             :::..|.|:..:..:.:
  Rat   756 LRQGCIVIQKHVRGWLQRKKF--LRERRAALTIQQ-------------YFRGQQTVRKAITATAL 805

  Fly   845 EDEIAR--LEEKAK------KAEELHAAEVKVRKELEALNA-----KLLAEKTALLDSLSGEKGA 896
            ::..|.  |::..:      ..:.:..|.:.::.......|     |||.|..|::         
  Rat   806 KEAWAAIILQKHCRGYLVRNLYQLIRVATITIQAHTRGFLARRRYRKLLQEHKAVI--------- 861

  Fly   897 LQDYQER---------------NAKLTAQKNDLENQLRD-------IQERLTQEEDARNQLFQQK 939
            ||.|...               |.:||.:...|:.:|.|       :.|:||             
  Rat   862 LQKYARAWLARRRFQNIRRFVLNIQLTYRVQRLQKKLEDQNRENHGLVEKLT------------- 913

  Fly   940 KKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQK 1004
            ..|...:..|:| ::.||..::||...:.:.:.:.|...|.:   :|.::||.|.........::
  Rat   914 SLAALRVGDLEK-VQRLEAELEKAATHRHSYEEKGRRYRDSM---EERLSKLQKHNAELESQRER 974

  Fly  1005 TGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKS----KRKVEGDLKLTQEAV 1065
            ..:.||...:::      |.|::|...:|.|.:::|::.|..:|||    .:..|.:::..:|.:
  Rat   975 AEQSLQERTEEL------KEKMDQLTRQLFDDVQKEEQQRLLLEKSFELKTQAYEKEIESLREEI 1033

  Fly  1066 ADLERNKKELEQTIQR---KDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAERQA 1127
            ..|:..:.:|...::.   ....|....|:|..:...:.:.:::|:.|||:..::|:.|::::: 
  Rat  1034 KALKDERTQLHHQLEEGRVTSDSLKGEVARLSKQAKTISEFEKEIELLQAQKIDVEKHVQSQKR- 1097

  Fly  1128 RAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLR-RDLEEANIQHESTLA-- 1189
                            |:.||:.|.........::...|    |:|. .|||..|...|...|  
  Rat  1098 ----------------EMRERMSEVTKQLLESYDIEDVR----SRLSVEDLEHLNEDGELWFAYE 1142

  Fly  1190 NLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQ---L 1251
            .|:|         |.:|     |::..:.:|:.|..::..|...|.|::.|....:|:.::   :
  Rat  1143 GLKK---------ATRV-----LESHFQSQKDCYEKEIEGLNFKVVHLSQEINHLQKLFREETDI 1193

  Fly  1252 QHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKR 1316
            ..::....::|...|..:.||                     :.|:|:|.:.|..|.::|::...
  Rat  1194 NESIRHEVTRLTSENMMIPDF---------------------KQQISELERQKQDLESRLKEQAE 1237

  Fly  1317 LADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDG--- 1378
            ..:.:..|      .|.:|...|:      ||..:|||  .|...:| .|||   |:...:|   
  Rat  1238 KMEGKQEE------PFSHLNRGLE------EEGRQGKA--PRPFLRA-VEAQ---SETHPEGKER 1284

  Fly  1379 -VARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAE 1442
             |.:.:|.:|| .|...:.|||||.:||:      |.:...|||.|..||:.|:|..:.:....:
  Rat  1285 LVGKIQEPQEA-IKFPKKQAEAEEEVESI------LRQEASRLSLENRDLEEELDMKDRMIRKLQ 1342

  Fly  1443 KKQKAFDKII 1452
            .:.|...:.|
  Rat  1343 DQVKTLTRTI 1352

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 12/39 (31%)
MYSc 81..777 CDD:214580 269/724 (37%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 261/684 (38%)
Myosin_tail_1 842..1897 CDD:279860 133/663 (20%)
V_Alix_like 1557..1877 CDD:187408
ATP-synt_B <1671..1771 CDD:304375
TMPIT 1739..>1825 CDD:285135
Myo5cXP_006243475.1 Myosin_N 12..48 CDD:280832 11/35 (31%)
MYSc 62..752 CDD:214580 268/714 (38%)
MYSc_Myo5 81..741 CDD:276831 261/684 (38%)
IQ 755..776 CDD:197470 7/20 (35%)
IQ 830..851 CDD:197470 2/20 (10%)
COG1340 890..1150 CDD:224259 60/312 (19%)
GBP_C <929..1030 CDD:303769 23/109 (21%)
RILP-like <977..1096 CDD:304877 25/124 (20%)
coiled coil 1001..1010 CDD:293879 2/8 (25%)
coiled coil 1019..1030 CDD:293879 1/10 (10%)
Myo5c_CBD 1376..1743 CDD:271260
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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