DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and Myh7b

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_001101264.2	Gene:	Myh7b / 311570	RGDID:	1307994	Length:	1941	Species:	Rattus norvegicus

Alignment Length:	1907	Identity:	1032/1907 - (54%)
Similarity:	1374/1907 - (72%)	Gaps:	15/1907 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PYDSKKSCWIPDEKEGYLLGEIKA-TKGDIVSVGLQGGEVRDIKSEKVEKVNPPKFEKIEDMADM 94
            |:|.||..|:|||::.|:..|:|. ..|..|:|..:..:|..::..:::.:|||:|:.:||||.|
  Rat    28 PWDGKKRVWVPDEQDAYVEAEVKTEATGGRVTVETKDQKVLTVRETEMQPMNPPRFDLLEDMAMM 92

  Fly    95 TVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAIS 159
            |.||...|||||||||...:||||||||||.|||||..||||......|:||||:|.||||:|::
  Rat    93 THLNEAAVLHNLRQRYARWMIYTYSGLFCVTINPYKWLPVYTATVVAAYKGKRRSEAPPHIYAVA 157

  Fly   160 DGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV-----GASKKTD-EAAKSKGSLEDQ 218
            |.||.|||.|..|||||||||||||||.|||:||.|||.|     |..||.. .|.|:.|:||||
  Rat   158 DNAYNDMLRNRENQSMLITGESGAGKTVNTKRVIQYFAIVAALGDGPGKKAQFLATKTGGTLEDQ 222

  Fly   219 VVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYH 283
            :::.||.:||||||||:|||||||||||||||||||||||.|||::|||||:|||.|...||.||
  Rat   223 IIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPTGKLASADIDSYLLEKSRVIFQLPGERGYH 287

  Fly   284 IFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDV 348
            ::|||:||..|.::|:.||:.|.||||..|||..||.:::|.||...||.|.|||||:..||...
  Rat   288 VYYQILSGKKPELQDMLLLSMNPYDYHFCSQGVTTVDNMNDGEELIATDHAMDILGFSVDEKCAC 352

  Fly   349 YRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQG 413
            |:|..|::|.|.|||||:.||||||.||.|...:.:.|.|..:.:|.|.||.||::||||:||:|
  Rat   353 YKIVGALLHFGNMKFKQKQREEQAEADGTESADKAAYLMGVSSGDLLKGLLHPRVRVGNEYVTKG 417

  Fly   414 RNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCIN 478
            ::|:||..::|||.|..:||||:|||.:.|:||||:..||.||||||||||||||:|.|||||||
  Rat   418 QSVEQVVFAVGALAKATYDRLFRWLVSRINQTLDTKLPRQFFIGVLDIAGFEIFEFNSFEQLCIN 482

  Fly   479 FTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESMFPKAT 543
            |||||||||||.|||||||||||||||||.|||||:||..||||||||:|||||||||.|||||:
  Rat   483 FTNEKLQQFFNQHMFVLEQEEYKREGIDWVFIDFGLDLQPCIDLIEKPLGILSILEEECMFPKAS 547

  Fly   544 DQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQ 608
            |.:|..||.:.|.|||..||:|:|.|..:..|||.:.||||.|.|:|.|||||||||||:|||..
  Rat   548 DASFRAKLYDNHSGKSPNFQQPRPDKKRKYQAHFEVVHYAGVVPYSIVGWLEKNKDPLNETVVPI 612

  Fly   609 FKKSQNKLLIEIFADHAGQSGGGEQAKGG---RGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHF 670
            |:||||:||..::.::|| |...|..|.|   :.||...|.|||..:||.||.|||.||:|||||
  Rat   613 FQKSQNRLLATLYENYAG-SCSTEPPKSGVKEKRKKAASFQTVSQLHKENLNKLMTNLRATQPHF 676

  Fly   671 VRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLL--QG 733
            ||||:|||.|.|||:|:.||:|||.||||||||||||:|||||::|.||:.||:|:.|..:  ..
  Rat   677 VRCIVPNENKTPGVMDSFLVLHQLRCNGVLEGIRICRQGFPNRLLYADFRQRYRILNPSAIPDDT 741

  Fly   734 VEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRK 798
            ....:||||.::..:|:...||:.|:|||||:||:||.:||.||:||.|:::.:||.:||.|.|.
  Rat   742 FVDSRKATEKLLGSLDIDHTQYQFGHTKVFFKAGLLGILEELRDQRLAKVLTLLQARSRGRLMRL 806

  Fly   799 GFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAE-ELH 862
            .::::...|.||..:|.|:|.:..::.|.|.||:.|:||||..::.|:|:|.|..:.:... .|.
  Rat   807 EYQRMLGGRDALFTIQWNIRAFNAVKNWSWMKLFFKMKPLLRSAQAEEELAALRAELRGLRGALA 871

  Fly   863 AAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQ 927
            .||.| |:|||.....:..||..|...|..|:..|.|.:||...|...|..||.:::::.|||..
  Rat   872 TAEAK-RQELEETQVSVTQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEAKVKELNERLED 935

  Fly   928 EEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLN 992
            ||:....|..:::|.:.|.:.|||||:||||.:.|||::|...:::::||.:|:|..||.:.:|.
  Rat   936 EEEVNADLAARRRKLEDECTELKKDIDDLELTLAKAEKEKQATENKVKNLTEEMAALDESVVRLT 1000

  Fly   993 KEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGD 1057
            ||||...|.:|:...:|||.||:::.|.|.|.:|||.:::||.|||:|||:|.|.|::|||:|||
  Rat  1001 KEKKALQEAHQQALGDLQAEEDRVSALAKAKIRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGD 1065

  Fly  1058 LKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVE 1122
            ||||||.|.|..::|::||:.:::||.|||.::.::||||::..:.|::|||||||.||||||:|
  Rat  1066 LKLTQETVTDTTQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQLQKKIKELQARAEELEEELE 1130

  Fly  1123 AERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHEST 1187
            |||.|||:.|||||:.|||||||.|||||||||::.|.|..:||||||.:|||:|||..::||:|
  Rat  1131 AERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEETVLRHEAT 1195

  Fly  1188 LANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQ 1252
            :|.||:|..|:.||::||||.|.:::.|.||||:|...:::||.|.|:.:...||:.||:.:..:
  Rat  1196 VAALRRKQADSAAELSEQVDSLQRIRQKLEKEKSELRMEVDDLGASVETLARGKASAEKLCRTYE 1260

  Fly  1253 HTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRL 1317
            ..|:|.:.|::|..|.|.|....:.:|..||.:|.|.|||.||.:||||:.|.|....||:.:|.
  Rat  1261 DQLSEAKIKVEELQRQLTDASTQRGRLQTENGELGRLLEEKESMISQLSRGKTSAAQSLEELRRQ 1325

  Fly  1318 ADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARS 1382
            .:|||:.:..|....:.|.||.|.||||.|||:|.:|:|||.|||||||...||||||:|.:.|:
  Rat  1326 LEEESKAKGALAHAVQALRHDCDLLREQHEEESEAQAELQRLLSKANAEVAQWRSKYEADAIQRT 1390

  Fly  1383 EELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKA 1447
            |||||||:||..||.||||.:|:.|.||..|||.|.||.||.||:.||::||.:.|.|.:|||:.
  Rat  1391 EELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRH 1455

  Fly  1448 FDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLL 1512
            .::.:.|.:.:.:::..||:|:|:|.|...||||||:.::||..|.||.::||||||.:|:.||.
  Rat  1456 LERALEERRRQEEEMQRELEAAQREARGLGTELFRLRHSHEEALEALETLKRENKNLQEEISDLT 1520

  Fly  1513 DQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQE 1577
            ||:...|::|.|:|||:|.||.||.||||||||||.|||.||.|.||.|||||||:.|:||::.|
  Rat  1521 DQVSLSGKSIQELEKAKKALEGEKSELQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAE 1585

  Fly  1578 KEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKNI 1642
            |:||..|.|:|||||::|:||||:||.:.:.||||:|||:|.|:|:||:.|.||.:...|||...
  Rat  1586 KDEECTNLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQAMEAQAAT 1650

  Fly  1643 KRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQAEQELAD 1707
            :..|.|||:.|...:||||...:.|||....||||..|.:||||.|..|||.:|.||.|||||.:
  Rat  1651 RLLQAQLKEEQAGRDEEQRLAAELREQGQALERRAALLASELEELRAALEQGERSRRLAEQELLE 1715

  Fly  1708 AHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLADELRAEQ 1772
            |.|:||.:.:||..:...|:|||.:|..|..:::|...|.:.:|||||||:.|||.:|:||:.||
  Rat  1716 ATERLNLLHSQNTGLLNQKKKLEVDLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQ 1780

  Fly  1773 DHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRRHADAQK 1837
            |.:...|:::|.|||.::|||.||:|||..||:||||.:||||.:|||||.|||.||::||:|.|
  Rat  1781 DTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALK 1845

  Fly  1838 NLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKAQQEL 1902
            .:||.|||||||::|:||||||..||||||||||.|:|:||||.||||:.|:.||||:||||.||
  Rat  1846 GVRKHERRVKELAYQTEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQASTNLAKYRKAQHEL 1910

  Fly  1903 EEAEERADLAEQAISKFRAKGR 1924
            ::||||||:||...:|.||:.|
  Rat  1911 DDAEERADMAETQANKLRARSR 1932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	12/37 (32%)
		MYSc	81..777	CDD:214580	437/706 (62%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	418/675 (62%)
		Myosin_tail_1	842..1897	CDD:279860	536/1055 (51%)
		V_Alix_like	1557..1877	CDD:187408	176/319 (55%)
		ATP-synt_B	<1671..1771	CDD:304375	48/99 (48%)
		TMPIT	1739..>1825	CDD:285135	46/85 (54%)
Myh7b	NP_001101264.2	Myosin_N	32..71	CDD:397036	13/38 (34%)
		myosin head (motor domain)	86..773		426/687 (62%)
		MYSc_Myh7b	98..773	CDD:276953	418/675 (62%)
		Myosin_tail_1	853..1930	CDD:396244	552/1077 (51%)
		myosin tail	1075..1933		460/858 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1109	1.000	Domainoid score	I19
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2097	1.000	Inparanoid score	I38
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm45868
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830