DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and Myh14

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_038967907.1 Gene:Myh14 / 308572 RGDID:1306821 Length:2041 Species:Rattus norvegicus


Alignment Length:2069 Identity:759/2069 - (36%)
Similarity:1175/2069 - (56%) Gaps:155/2069 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 PKPVANQEDEDPTPYLFVSLEQRRIDQSKP------YDSKKSCWIPDEKEGYLLGEIKATKGDIV 60
            |.||    .|...|:||.   .|..:...|      :.:::..|:|.|..|:....::....:..
  Rat    17 PGPV----PEAAQPFLFA---PRTPNVGGPGGPQVEWTARRMVWVPSELHGFEAAALRDEGEEEA 74

  Fly    61 SVGL-QGGEVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCV 124
            .|.| :.|....:..::::::|||||.|.||||::|.||...||||||:|||:.|||||||||||
  Rat    75 EVELAESGRRLRLPRDQIQRMNPPKFSKAEDMAELTCLNEASVLHNLRERYYSGLIYTYSGLFCV 139

  Fly   125 AINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENT 189
            .|||||:.|:||....:|||||:|:||||||:|:::|||..||.:..:||:|.||||||||||||
  Rat   140 VINPYKQLPIYTEAIVEMYRGKKRHEVPPHIYAVTEGAYRSMLQDREDQSILCTGESGAGKTENT 204

  Fly   190 KKVIAYFATVGASKK--------TDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKF 246
            ||||.|.|.|.:|.|        ...:..|.|.||.|::|.||:||||||||||:||||||||||
  Rat   205 KKVIQYLAHVASSPKGRKEPGVPASVSTMSYGELERQLLQANPILEAFGNAKTVKNDNSSRFGKF 269

  Fly   247 IRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHI 311
            |||:|...|.:.||:||||||||:|.|.|...|.|:|||||::.|:...:| ..||.:....|..
  Rat   270 IRINFDIAGYIVGANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLK-ADLLLEPYSHYRF 333

  Fly   312 VSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDG 376
            ::.|..:... .:.|.|..|.::..:||...:|...:.|..:||:..|.:..|:....:||....
  Rat   334 LTNGPSSSPG-QERELFQETLESLRVLGLLPEEITAMLRTVSAVLQFGNIVLKKERNTDQATMPD 397

  Fly   377 EEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKK 441
            .....::.:|.|....:..:.||.||||||.::|.:.:..:|...::.||.|..::|||:|||.:
  Rat   398 NTAAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKAQTKEQADFALEALAKATYERLFRWLVLR 462

  Fly   442 CNETLDTQQKR-QHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGI 505
            .|..||...:: ..|:|:|||||||||:.|.|||||||:|||||||.|||.|||||||||:||||
  Rat   463 LNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFVLEQEEYQREGI 527

  Fly   506 DWAFIDFGMDLLACIDLIEKPM---GILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKP 567
            .|.|:|||:||..||||||:|.   |:|::|:||..||||||::|.||:.... |....||:|:.
  Rat   528 PWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWFPKATDKSFVEKVAQEQ-GSHPKFQRPRN 591

  Fly   568 PKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADH-------- 624
            .:   ..|.|::.||||.|.|....||.||.|||||.|.....:|.::|..||:.|.        
  Rat   592 LR---DQADFSVLHYAGKVDYKANEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDEQGGLQQFT 653

  Fly   625 ---------AGQSGG------------------------------GEQAKGGRGKKGGGFATVSS 650
                     .|.:||                              |:...|||.:: |.|.||..
  Rat   654 FLGSFPSPSPGPAGGLSSGASPPGLGSLCAPTVEGIVGLEQVSSLGDGPPGGRPRR-GMFRTVGQ 717

  Fly   651 AYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMM 715
            .|||.|:.||.||.:|.|.|||||:||..|:.|.::..||:.||.||||||||||||:|||||::
  Rat   718 LYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLRCNGVLEGIRICRQGFPNRIL 782

  Fly   716 YPDFKMRYKIMCPKLL-QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDER 779
            :.:|:.||:|:.|..: :|....|:|.|.:|:.::|..:.||:|.:|:|||||||.|:||.||.:
  Rat   783 FQEFRQRYEILTPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLK 847

  Fly   780 LGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRI 844
            :..|:...||.|||||:|:.|::.|:|:.||:|:|||...||:||.|.|::|:.||||||.|:| 
  Rat   848 VTDIIVSFQAAARGYLARRAFQRRQQQQSALRVMQRNCAAYLKLRNWQWWRLFIKVKPLLQVTR- 911

  Fly   845 EDEI--ARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKL 907
            :||:  ||.:| .:|.:||.....:...||:...|:|..|:..|.:.|..|.....:.:|..|:|
  Rat   912 QDEVLQARAQE-LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCSEAEETRARL 975

  Fly   908 TAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDH 972
            .|:|.:||..:.:::.|:.:||:...||..:||:..|.|..|:..:|..|...||.:.:|.|.:.
  Rat   976 AARKQELELVVTELEARVGEEEECSRQLQSEKKRLQQHIQELETHLEAEEGARQKLQLEKVTTEA 1040

  Fly   973 QIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSL 1037
            :::...:::...::..:||:||:::..|...:...:....|:|:..|||::.|.|.|:.::||.|
  Rat  1041 KMKKFEEDLLLLEDQNSKLSKERRLLEERLAEFSSQAAEEEEKVKSLNKLRVKYEATIADMEDRL 1105

  Fly  1038 EREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLK 1102
            ::|:|.|.::||.||:::|:....||.:.:.::..:||...:.||::||.|...:.|:|.....:
  Rat  1106 KKEEKGRQELEKLKRRLDGESSELQEQMMEQKQRAEELLIQLGRKEEELQSALVRAEEEGGARAQ 1170

  Fly  1103 HQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKRE 1167
            ..:.::|.||.:.|.:|::||||.|||||||||.||..|||.|...||:...:|:||.||..|||
  Rat  1171 LLKSLREAQAGLAEAQEDLEAERVARAKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKRE 1235

  Fly  1168 AELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRA 1232
            .|:::|::.|||....||..:..||::|:.|:.|:.||::|..:.|:..||.:.....::::|:.
  Rat  1236 QEVTELKKTLEEEARTHEVAMQELRQRHSQALVELTEQLEQARRGKSVWEKTRLSLEAEVSELKT 1300

  Fly  1233 GVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQV 1297
            .:..:...:...|:..::|:..|.|||.:..::.|...:.....::..:|...:...|.||||:.
  Rat  1301 ELSSLQTSRQEGEQKRRRLESQLQEVQGRSSDSERARAEAAEKLQRAQVELESVSTALSEAESKA 1365

  Fly  1298 SQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSK 1362
            .:|||...|..:||.||:.|..||:|.:..|..:.|.||.:...||||:|||...:....|:|..
  Rat  1366 IRLSKELSSAESQLHDTQELLQEETRAKLALGSRVRALEAEAAGLREQMEEEVVARERAGRELQT 1430

  Fly  1363 ANAEAQVWRSKYESDGVARSEELEEAKRK-------LQARLAEAEETIESLNQKCIGLEKTKQRL 1420
            ..|:...||.:.|.: .|..|..|||:|:       |..||||..|.:|.       ||:.::||
  Rat  1431 TQAQLSEWRRRQEEE-AAVLEAGEEARRRAAREAETLAQRLAEKTEAVER-------LERARRRL 1487

  Fly  1421 STEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKV-----DDLAAELDASQKECRNYSTEL 1480
            ..|::|..:::.:...:.:..||||:.||:::.|.|..|     |....|.:..::|.|..|   
  Rat  1488 QQELDDATVDLGQQKQLLSTLEKKQRKFDQLLAEEKAAVLRAVEDRERVEAEGREREARALS--- 1549

  Fly  1481 FRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEE 1545
              |..|.||.||..|.:.|:|:.|..|::.||....:.|:|:||:|:||:..|....:|:..:.|
  Rat  1550 --LTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKNVHELERARRVAEQAASDLRTQVTE 1612

  Fly  1546 AEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEA 1610
            .|..|...|:..||.::.:..::.:.:|.:|.:::..|..|:...:.|...:...:.|.|.:|.|
  Rat  1613 LEDELTAAEDAKLRLEVTVQALKAQHERDLQGRDDAGEERRRQLAKQLRDAEVERDEERKQRALA 1677

  Fly  1611 LRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDD----AREQLG 1671
            :..:||||.::.||:.....|.:...||.|.:|:.|.|:|::...:||.:.:|::    :||   
  Rat  1678 MAARKKLELELEELKAQTSAAGQGKEEAVKQLKKMQAQMKELWREVEETRSSREEMFTLSRE--- 1739

  Fly  1672 ISERRANALQNELEESRTLLEQADRGRRQAEQELADAHEQLNEVSAQNASISAA---KRKLESEL 1733
             ||:|...|:.|:...:..|..:||.||||:|   |..|...||::.|.|.:|.   ||:||..|
  Rat  1740 -SEKRLKGLEAEVLRLQEELAASDRARRQAQQ---DRDEMAEEVASGNLSKAATLEEKRQLEGRL 1800

  Fly  1734 QTLHSDLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDE 1798
            ..|..:|:|..|.::..::..:|.::....|..||.||:..:...|..|:.||:||:||:.||.|
  Rat  1801 GQLEEELEEEQNNSELLKDHYRKLVLQVETLTTELSAERSFSAKAESGRQQLERQIQELRARLGE 1865

  Fly  1799 AEANALKGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERM 1863
            .:|.|....|..|..||.::.:.|.:|:.|.|....:.|.:|::|:|:||:..|.:|:|:..:::
  Rat  1866 EDAGARARQKMLIAALESKLAQAEEQLEQESRERILSGKLVRRAEKRLKEVVLQVDEERRVADQL 1930

  Fly  1864 QDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAGSV 1928
            :|.::|...::|..|||:|||||.|:...|..|:.|:|||:..|.|:...:.::..|.:.|.|.:
  Rat  1931 RDQLEKSNLRLKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPL 1995

  Fly  1929 -----------------------GRGASPAPRATSVRPQFDGLAFPPRFDLAPE 1959
                                   ..||.|....|. .|:    |.||   .||:
  Rat  1996 TFTTRTVRQVFRLEEGVASDEEEAEGAEPGSAPTQ-EPE----APPP---AAPQ 2041

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 7/37 (19%)
MYSc 81..777 CDD:214580 352/755 (47%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 330/724 (46%)
Myosin_tail_1 842..1897 CDD:279860 337/1075 (31%)
V_Alix_like 1557..1877 CDD:187408 98/326 (30%)
ATP-synt_B <1671..1771 CDD:304375 33/102 (32%)
TMPIT 1739..>1825 CDD:285135 27/85 (32%)
Myh14XP_038967907.1 Motor_domain 115..833 CDD:419868 330/724 (46%)
Myosin_tail_1 910..1990 CDD:396244 345/1101 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.720

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