DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and Myo18b

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_006249639.1 Gene:Myo18b / 304551 RGDID:1594542 Length:2551 Species:Rattus norvegicus


Alignment Length:2146 Identity:478/2146 - (22%)
Similarity:911/2146 - (42%) Gaps:487/2146 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 PKPVANQEDEDPT----PYLFVSLEQRRI-------------DQS---KPYDSKKSCWIPDEKEG 46
            |:....:|....|    |.:...:|:::|             ||:   :.|:::| .|:. :|:.
  Rat   453 PQAEGRRESVPETGMERPSMQKPMEEKQILQDPDRGGQSGDSDQAFEDRWYEAQK-VWLV-QKDR 515

  Fly    47 YLLGEIKATKGDIVSVGLQGGEVR----------DIKSEKVEKVNPPKFEKIEDMADMTVLNTPC 101
            :.|..:  .|.|..:..|..|.||          ::..|:|.:.||.:.::.||:|.:..:|...
  Rat   516 FTLATV--LKPDEGTADLPAGRVRLCIDADRTVTEVDEEQVHRANPSELDQAEDLAFLVSVNESS 578

  Fly   102 VLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDM 166
            ||:.|.:||.|:|.:|.||...:|:.|   .........|:.|| |::.:|.|:.:::..||..:
  Rat   579 VLNTLLKRYQAQLPHTCSGPDLIALQP---QTTTVPSSGKVPRG-RQDGLPAHVTSLAQRAYWAL 639

  Fly   167 LTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGN 231
            |:...:||::..|.||||||...::|:.:.  ||.:...|    .:.|:| ::..|..||:|||.
  Rat   640 LSQRRDQSIVALGRSGAGKTTCCEQVLEHL--VGMAGSVD----GRVSVE-KLRATFTVLQAFGC 697

  Fly   232 AKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGV 296
            ..|..:..::||...:.:.|..||::..|.:::.|||.:||..|...|.::.:|.|:::|     
  Rat   698 VSTSHSRRATRFAMVMSLDFNATGRVTAAQLQSMLLENSRVARQPQGEGNFEVFSQLLAG----- 757

  Fly   297 KDICLLTDNIYDYHIVSQ----GKVTVASIDD----AEEFSLTDQAFDILGFTKQEKEDVYRITA 353
            .|:.|.|:  .:.|.:::    |....:..:|    |..||....|.::||..:.|:..::|:.|
  Rat   758 LDVDLRTE--LNLHQMAESSAFGMGLWSKPEDKQKAATAFSQLRGAMELLGILEGEQRAIWRVLA 820

  Fly   354 AVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQ 418
            |:.|:|.....:.||::...   .|.....::..|||..||.....|..::...|.:|.|...|.
  Rat   821 AIYHLGAAGACKVGRKQFMR---FEWANHAAEALGCDYEELNTATFKHHLRQIIEQMTSGPQRQG 882

  Fly   419 VTNS-------------IGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYN 470
            :.::             :..:..|::..||..:|...|.:..:|......|.|:|..||:...:.
  Rat   883 LQDNEACSGLKMTGVECVEGMASGLYQELFVAVVSLINRSFSSQHLSMASIMVVDTPGFQNPRHQ 947

  Fly   471 G------FEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDL--------LACID 521
            |      ||:||.|:..|:||..|.|..||...|.|:.|||...|     ||        :|.:|
  Rat   948 GKDRAATFEELCYNYAQERLQLLFYHRTFVSTLERYREEGIPVPF-----DLPESSPGTTVAVVD 1007

  Fly   522 L------------IEKPMGILSILEEESMFPKATDQTFSEKLTNTHLG---KSAPFQKPKPPKPG 571
            .            ||...|:..:|:||.....::|....|:|   |.|   |::..::|...:..
  Rat  1008 QNPSQVHLTAGRGIEDAAGLFWVLDEEVRVEGSSDSVVLERL---HAGFEKKASGAEEPPSMRTC 1069

  Fly   572 QQAAHFAIAHYAG--CVSYNITGWLEKNKDPLN----DTVVDQFKKSQNKLLIEIFAD------- 623
            :|..:..:.|..|  .|.|::||||.:.|..|:    ..::.|.|:.:.:.|.:..|.       
  Rat  1070 EQPLNCELFHQLGRDPVRYDLTGWLRRAKPNLSALEAPQILQQSKREELQSLFQARAKLPPVCLM 1134

  Fly   624 HAGQSGGGEQAKGGRGK-KGGGFATVSSAYKE---------QLNSLMTTLRSTQPHFVRCIIPNE 678
            .||..|..:||. .||: ....||:..:|.|.         |:::|::.||.:|.||:.|::|..
  Rat  1135 VAGLEGTSQQAL-HRGRVVRRAFASSLAAVKRKAPCAQIKLQMDALISLLRRSQLHFIHCLVPTT 1198

  Fly   679 MK-----------QPG----------VVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMR 722
            ::           |||          ..|...:..||..:.:||.:|:.|.|:...|....|:.|
  Rat  1199 VETKAGQGTPTPSQPGGDQGGANEPPAPDIPALRVQLAGSHILEALRLHRAGYAEHMGLAQFRRR 1263

  Fly   723 YKIMCPKLLQGVE------KDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLG 781
            ::.:.|.||:.::      .::||.|.:::.:||.:....:|:::||.:|||:.::|..|::.:.
  Rat  1264 FQALDPALLKRLDLTSEGLDERKAVEELLQTLDLEKKAVAVGHSQVFLKAGVVSRLERQREKLVS 1328

  Fly   782 KIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLN------ 840
            :.:...||..||:|||:.:|||:.:|:|...:|:||..:|:::.|||:.|...::|||:      
  Rat  1329 RNIVLFQAACRGFLSRQEYKKLKIRRLAALCIQKNLTVFLKVKDWPWWGLLASLRPLLSSTLSTE 1393

  Fly   841 -VSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDS-LSGEKGALQDYQER 903
             :...|:|:..|.:|.:.:|.   :..::|:..:.|.:|:....:.|.|. ..|:........||
  Rat  1394 QLRAKEEELTLLRQKLQNSEN---SRSELRQSADLLESKIADLTSELADERFKGDVACQALESER 1455

  Fly   904 NAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAE-QDK 967
            ..:|.|        ||::||...:        :||.:.|   :.|::|.:|:.:..:|.|. ::|
  Rat  1456 AERLQA--------LREVQELKAK--------YQQVQDA---LGGVQKQLEEAQQRIQTANLEEK 1501

  Fly   968 AT---KDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQT 1029
            .|   .:.|:|  .|....:::.:.|                 .||..|::::...|.:.:|||.
  Rat  1502 PTGGADEWQMR--LDCAQLENDFLRK-----------------RLQQCEERLDSEMKARTELEQK 1547

  Fly  1030 LDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLE 1094
            |.||:.:.|..||....:.:....:..||:.|:..:.:.:....:||:..::.|.:|:       
  Rat  1548 LGELQSAYEEAKKTAHQLRRKCHHLTWDLEDTRVLLENQQSRNHDLEKRQKKFDLQLA------- 1605

  Fly  1095 DEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQ 1159
                            ||..|.:     .|:..|.|..::.:.:..||.:|.::||:        
  Rat  1606 ----------------QALGESM-----FEKSLREKVSRENSGVRWELGQLQQQLEQ-------- 1641

  Fly  1160 IELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYY 1224
                  :|.|.|||:.::|....| :..|.|.....|..||.:.|:|.:|         |.|   
  Rat  1642 ------KEQEASKLKEEVERLQGQ-KRELLNCASVGNQGVASLKERVWEL---------ESN--- 1687

  Fly  1225 GQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQ 1289
                            ...|||:..|.::|:.:::..            ..:.:|.||....:.|
  Rat  1688 ----------------ALEQEKVRSQQENTIKQLEQL------------RQRFELEIERMKQMHQ 1724

  Fly  1290 LEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQV-EEEAEGK 1353
             ::.|.|..:|..::.|...:|...:...::|..|:...|.:..:||..:..|.:|: ..:.:.:
  Rat  1725 -KDREDQEEELEDVRQSCQKRLRQLEMQLEQEYEEKQAALHEKHDLEGLIGTLCDQIGHRDFDVE 1788

  Fly  1354 ADLQRQLSKANA---EAQVWRSKYESDGVARS-EELEEAKRKLQARLAEAEETIESLNQKCIGLE 1414
            ..|:|.|.:.:|   :.|:..:..|....:.| ||||:...:|:...|:.|:.:           
  Rat  1789 KRLRRDLRRTHALLSDVQLLLATIEDSKTSISKEELEKVHSQLEQSEAKCEDAL----------- 1842

  Fly  1415 KTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVD--DLAAELDASQKECRNYS 1477
            ||::.|:.::|.:..|::      |....|....:::   ::|:.:  ||...:|          
  Rat  1843 KTQKVLTADLESMHSELE------NVTRSKSLVDEQL---YRLQFERADLLKRID---------- 1888

  Fly  1478 TELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAA 1542
                       |.|:.|..:.:::|:|          |.:...:|.:|:           |||..
  Rat  1889 -----------EDQDDLNGLMQKHKDL----------IAQSAADIGQIQ-----------ELQLQ 1921

  Fly  1543 LEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASL--EAEAK 1605
            ||||     ::|.:.|..||:::|:      |||..|:      ...:||:.|.|.::  :.|:|
  Rat  1922 LEEA-----KKEKQKLWEQLQVAQL------RIQYLEQ------STVERAIVSRQEAIICDLESK 1969

  Fly  1606 GKAEALRMKK------KLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARD 1664
            .:.:.::||:      :|...:.::...|..|.||.|:.::|.:.|||:|::::..::|..:..:
  Rat  1970 TEFQKVQMKRFEVLVIRLRDSMIKMGEELSRAVKAEAQQRENSQYYQQRLEELKAEMQELVQREE 2034

  Fly  1665 DAREQLGISERRANALQNELEESRTLLEQADRGRRQAEQELADAHEQLNEVSAQNA--------- 1720
            :|       .||...::..:||...:.:........:.:.:||....|.||::.::         
  Rat  2035 EA-------SRRCMEMEKYVEELAAVRQTLQTDLETSIRRIADLQAALEEVASSDSDTESVQTAV 2092

  Fly  1721 -----------SISAAKRKLESELQTLHSDLDELLNEAKN--SEEKAKKAMVDAARLADELRAEQ 1772
                       ::|....:.||.||:..|....|..::..  |.:.|..:.:.:.|:::|     
  Rat  2093 DCSSRSGKEGDNVSVISSQPESSLQSWMSCSLSLATDSVRIPSRQSAISSSLHSPRVSEE----- 2152

  Fly  1773 DHAQTQEKLRKALEQQIKELQVRLDEAEANALK------------GGKKAIQKLEQRVRELENEL 1825
              |...|:.|.|......:.....|.|.|.::.            |..:......:...|....|
  Rat  2153 --AGDSERPRPASTVLHGDWDAPRDTAGAGSVSLHPVLPQKPYHLGDGEGFAVHRKSTPERPGSL 2215

  Fly  1826 DGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAAL 1890
            .......::....|......:.|  |..|..||..:|.|.                      :.|
  Rat  2216 SSSPTSRSEVVSPLPSPSAALSE--FVEELRRKRAQRGQG----------------------STL 2256

  Fly  1891 NLA--------------KFRKAQQELEEAEERADLAEQAISKFRAKGRAGSVGRGASPAPRATSV 1941
            :|.              ..|:.:...:|.:  ..|..:..|...|:|.||:.| |.|   |:||:
  Rat  2257 HLGDGPVFPIFQTTGAFSLRRGRASSDEGD--LSLRTRVKSPLGAEGNAGATG-GLS---RSTSL 2315

  Fly  1942 R 1942
            :
  Rat  2316 K 2316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 10/46 (22%)
MYSc 81..777 CDD:214580 207/795 (26%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 197/764 (26%)
Myosin_tail_1 842..1897 CDD:279860 212/1122 (19%)
V_Alix_like 1557..1877 CDD:187408 67/361 (19%)
ATP-synt_B <1671..1771 CDD:304375 20/121 (17%)
TMPIT 1739..>1825 CDD:285135 14/99 (14%)
Myo18bXP_006249639.1 MYSc 558..1324 CDD:214580 207/795 (26%)
MYSc_Myo18 577..1312 CDD:276837 197/764 (26%)
KASH_CCD 1390..1579 CDD:291334 48/229 (21%)
GBP_C <1683..1766 CDD:303769 20/123 (16%)
coiled coil 1737..1751 CDD:293879 2/13 (15%)
Rab5-bind 1788..2082 CDD:286404 79/379 (21%)
DUF3585 <1889..2033 CDD:304905 44/181 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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