DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and Myh6

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_058935.2	Gene:	Myh6 / 29556	RGDID:	62029	Length:	1939	Species:	Rattus norvegicus

Alignment Length:	1922	Identity:	1090/1922 - (56%)
Similarity:	1443/1922 - (75%)	Gaps:	20/1922 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEK 79
            |||..|.::|...|::|:|.:..|::||:||.|:..:|.:.:|..|:...:.|:...:|.::|.:
  Rat    14 PYLRKSEKERLEAQTRPFDIRTECFVPDDKEEYVKAKIVSREGGKVTAETENGKTVTVKEDQVMQ 78

  Fly    80 VNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYR 144
            .|||||:||||||.:|.|:.|.||:||::||.|.:||||||||||.:||||..|||.......||
  Rat    79 QNPPKFDKIEDMAMLTFLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYR 143

  Fly   145 GKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGA----SKKT 205
            ||:|:|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.|||::.|    |||
  Rat   144 GKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRSKK- 207

  Fly   206 DEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKA 270
            |....:||:||||::|.||.|||||||||||||||||||||||||||.|||||.||||||||||:
  Rat   208 DNPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKS 272

  Fly   271 RVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAF 335
            |||.|...||:|||||||:|...|.:.|:.|:|:|.|||..||||:|:||||||:||...||.||
  Rat   273 RVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAF 337

  Fly   336 DILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLK 400
            |:||||.:||..||::|.|:||.|.|||||:.||||||.||.|:..:.:.|.|.::|:|.|.|..
  Rat   338 DVLGFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCH 402

  Fly   401 PRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFE 465
            ||:|||||:||:|::||||..|||||.|.|::::|.|:|.:.|.||:|:|.||:|||||||||||
  Rat   403 PRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFE 467

  Fly   466 IFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGIL 530
            ||::|.||||||||||||||||||||||||||||||:|||:|.||||||||.||||||||||||:
  Rat   468 IFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIM 532

  Fly   531 SILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLE 595
            ||||||.|||||||.||..||.:.|||||..||||:..| |:|.|||::.||||.|.|||.||||
  Rat   533 SILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNVK-GKQEAHFSLVHYAGTVDYNILGWLE 596

  Fly   596 KNKDPLNDTVVDQFKKSQNKLLIEIFADHA----GQSGGGEQAKGGRGKKGGGFATVSSAYKEQL 656
            |||||||:|||..::||..||:..:|:.:|    |.||.|   |||: |||..|.|||:.::|.|
  Rat   597 KNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDSGKG---KGGK-KKGSSFQTVSALHRENL 657

  Fly   657 NSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKM 721
            |.|||.||:|.|||||||||||.|.|||:|..||||||.||||||||||||||||||::|.||:.
  Rat   658 NKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQ 722

  Fly   722 RYKIMCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKI 783
            ||:|:.|..:   |.:: .:|..|.::..:|:..:||:.|:|||||:||:||.:||.|||||.:|
  Rat   723 RYRILNPAAIPEGQFID-SRKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRI 786

  Fly   784 MSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEI 848
            ::.:||.|||.|.|..|||:.|:|.||.|:|.|:|.::.::.|||.||:.|:||||..:..|.|:
  Rat   787 ITRIQAQARGQLMRIEFKKMVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEM 851

  Fly   849 ARLEEKAKKAEE-LHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKN 912
            |.::|:..:.:: |..:|.: |||||.....||.||..|...:..|:..|.|.:||..:|...|.
  Rat   852 ANMKEEFGRVKDALEKSEAR-RKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKI 915

  Fly   913 DLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNL 977
            .||.:::::.|||..||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||
  Rat   916 QLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 980

  Fly   978 NDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKK 1042
            .:|:|..||:|.||.||||...|.:|:..::|||.|||:|.|.|.|.||||.:|:||.|||:|||
  Rat   981 TEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLIKSKVKLEQQVDDLEGSLEQEKK 1045

  Fly  1043 VRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQI 1107
            ||.|:|::|||:|||||||||::.|||.:|.:||:.:::|:.::|...:|:||||.:.|:.|:::
  Rat  1046 VRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKL 1110

  Fly  1108 KELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSK 1172
            ||.||||||||||:||||.||||.||.|:||.|||||:.|||||||||||.|||:|||||||..|
  Rat  1111 KENQARIEELEEELEAERTARAKVEKLRSDLTRELEEISERLEEAGGATSVQIEMNKKREAEFQK 1175

  Fly  1173 LRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHI 1237
            :|||||||.:|||:|.|.|||||.|:|||:.||:|.|.::|.|.||||:|:..:|:|:.:.::.|
  Rat  1176 MRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQI 1240

  Fly  1238 TNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSK 1302
            ...||..||:::.|:...||.:.||:|..|:||||...:.||..||.:|.|||||.|:.:|||::
  Rat  1241 IKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTR 1305

  Fly  1303 IKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEA 1367
            .|:|.|.|:||.||..:||.:.:..|....::..||.|.||||.|||.|.||:|||.|||||:|.
  Rat  1306 GKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEEMEAKAELQRVLSKANSEV 1370

  Fly  1368 QVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVD 1432
            ..||:|||:|.:.|:|||||||:||..||.:|||.:|::|.||..|||||.||..|:|||.::|:
  Rat  1371 AQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVE 1435

  Fly  1433 RANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAV 1497
            |:||.|.|.:|||:.||||:.|||.|.::..:||::||||.|:.|||||:||.||||..|.||..
  Rat  1436 RSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETF 1500

  Fly  1498 RRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQL 1562
            :||||||.:|:.||.:|:||||:|:||:||.||:||.||.|||:|||||||:||.||.|:|||||
  Rat  1501 KRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQL 1565

  Fly  1563 ELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIA 1627
            |.:|::.||:|::.||:||.|..::||.|.:||:|.||:||.:.:.||||:|||:|.|:||:||.
  Rat  1566 EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQ 1630

  Fly  1628 LDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLE 1692
            |..||:..:||||::|..|..|||.|..|::..||.||.:|.:.|.|||...||.||||.|.::|
  Rat  1631 LSQANRIASEAQKHLKNAQAHLKDTQLQLDDAVRANDDLKENIAIVERRNTLLQAELEELRAVVE 1695

  Fly  1693 QADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKA 1757
            |.:|.|:.|||||.:..|::..:.:||.|:...|:|::::|..|.::::|.:.|.:|:|||||||
  Rat  1696 QTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKA 1760

  Fly  1758 MVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELE 1822
            :.|||.:|:||:.|||.:...|:::|.:||.||:||.||||||..|||||||.:||||.||||||
  Rat  1761 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELE 1825

  Fly  1823 NELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEI 1887
            |||:.||:|:|::.|.:||||||:|||::|:|||:||..|:||||||||.|:|.||||.|||||.
  Rat  1826 NELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLVRLQDLVDKLQLKVKAYKRQAEEAEEQ 1890

  Fly  1888 AALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            |..||:||||.|.||:|||||||:||..::|.|||.|
  Rat  1891 ANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	10/36 (28%)
		MYSc	81..777	CDD:214580	455/706 (64%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	435/675 (64%)
		Myosin_tail_1	842..1897	CDD:279860	562/1055 (53%)
		V_Alix_like	1557..1877	CDD:187408	169/319 (53%)
		ATP-synt_B	<1671..1771	CDD:304375	44/99 (44%)
		TMPIT	1739..>1825	CDD:285135	51/85 (60%)
Myh6	NP_058935.2	Myosin_N	34..72	CDD:397036	10/37 (27%)
		MYSc_class_II	99..768	CDD:276951	435/675 (64%)
		Actin-binding	657..679		17/21 (81%)
		Actin-binding	759..773		8/13 (62%)
		Calmodulin-binding. /evidence=ECO:0000250	790..807		10/16 (63%)
		Calmodulin-binding. /evidence=ECO:0000250	816..833		6/16 (38%)
		Myosin_tail_1	848..1925	CDD:396244	578/1077 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1908..1939		13/20 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1109	1.000	Domainoid score	I19
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2097	1.000	Inparanoid score	I38
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm45868
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830