DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and MYO1H

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	XP_011536525.1	Gene:	MYO1H / 283446	HGNCID:	13879	Length:	1044	Species:	Homo sapiens

Alignment Length:	1058	Identity:	334/1058 - (31%)
Similarity:	511/1058 - (48%)	Gaps:	189/1058 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 NLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTN 169
            |||:|:...|||||.|...|::|||:...:||....::|:|....|:|||::||:|.||..|...
Human    31 NLRKRFSENLIYTYIGTLLVSVNPYQELGIYTVSQMELYQGVNFFELPPHVYAIADNAYRMMCAE 95

  Fly   170 HVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKT 234
            ..|..:||:|||||||||.:||::.|||......::.:.|:      |:::.:||||||||||:|
Human    96 LNNHFILISGESGAGKTEASKKILEYFAVTCPMTQSLQIAR------DRLLFSNPVLEAFGNART 154

  Fly   235 VRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSG------SV 293
            :||||||||||::.|.|...|...|..|.:||:||:||:.|...||::|||||:::|      |.
Human   155 LRNDNSSRFGKYMDIQFDFQGIPVGGHIISYLIEKSRVVYQNEGERNFHIFYQLLAGGEEERLSY 219

  Fly   294 PGVKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMH 357
            .|::    ....:|.|  :|||. ...:||.|..::.....||.::.||:.:.|:::.|.|:|:|
Human   220 LGLE----RDPQLYKY--LSQGHCAKESSISDKNDWKTVSNAFSVIDFTEADLENLFGIIASVLH 278

  Fly   358 MGGMKFKQRGREEQ--AEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVT 420
            :|.:.|::   ::|  |......|...::||.|...:.|.:.|...:|:...|.|.....::...
Human   279 LGNIGFEE---DDQGCATIPDTHEIKWIAKLLGVHPSVLLEALTHRKIEAKTEEVICPLTLELSV 340

  Fly   421 NSIGALCKGVFDRLFKWLVKKCNETLDTQQ-KRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKL 484
            .:..|:.|.|:.|.|.|||.|.|.:|..:. .|:..||:|||.|||:|:.|||||.|||:.||||
Human   341 YARDAMAKAVYGRTFTWLVNKINSSLVNKDFTRKTVIGLLDIYGFEVFDKNGFEQFCINYCNEKL 405

  Fly   485 QQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLI-EKPMGILSILEEESMFP-KATDQTF 547
            ||.........||.||:.|||:|..|.:..:.:.| ||: |:..||:|||:||.:.| .|||.:|
Human   406 QQLLIERTLKAEQAEYEMEGIEWEPIKYFNNKIIC-DLVEERHKGIISILDEECIRPGPATDLSF 469

  Fly   548 SEKLTNTHLGKSAPFQKPKPPKP-GQQA---AHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQ 608
            .||| ...:||.|.|:..|...| |::.   ..|.:.||||.|:|...|:||||.|.|...:.:.
Human   470 LEKL-EEKVGKHAHFETRKLAGPKGRKRIGWMEFRLLHYAGEVTYCTKGFLEKNNDLLYRHLKEV 533

  Fly   609 FKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRC 673
            ..||:|.:|.|.|.          .|:....::.   .||.:.:|..|:||:.||.|.:|.::||
Human   534 LCKSKNIILRECFL----------LAELENRRRP---PTVGTQFKNSLSSLLETLISKEPSYIRC 585

  Fly   674 IIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDF------------------- 719
            |.||:.|:|...|..|:.||:...|::|.:|:.|.||..|..|..|
Human   586 IKPNDRKEPSKFDDFLIRHQIKYLGLMEHLRVRRAGFAYRRKYEHFLQRYLGVELSHWVERLMMS 650

  Fly   720 ---KMRYKIMCPKL--------LQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFR-AGVLGQM 772
               |.|||.:||..        .:|||:       :||:|....::|:||.||:|.| ...|...
Human   651 LFYKDRYKSLCPDTWPHWHGPPAEGVER-------LIKYIGYKPEEYKLGKTKIFIRFPRTLFAT 708

  Fly   773 EEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRN--LRKYLQLRTWPWYKLWQKV 835
            |:..:....::::.:||..:..|.|:.:.|.::..:.|:...|.  .||.:|.|.|
Human   709 EDAFEFSKHQLVARIQATYKRCLGRREYVKKRQAAIKLEAHWRGALARKAIQRRKW--------- 764

  Fly   836 KPLLNVSR--IEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQ 898
              .:.:.|  |:..|:|.:......||.   .|.|||.. .||.:....||.|..|.....|.|:
Human   765 --AVRIIRKFIKGFISRNKPLCPDNEEF---IVFVRKNY-ILNLRYHLPKTVLDKSWLRPPGILE 823

  Fly   899 DYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKA 963
                 ||....:|..:.|.::.....:|.|   |..:.|||                    |..:
Human   824 -----NASDLLRKMCVRNLVQKYCRGITAE---RKAMMQQK--------------------VVTS 860

  Fly   964 EQDKATKDHQIRNLNDEIAHQ--DELINKLNKEKKMQGETNQK-----TGEELQAAEDKINHLNK 1021
            |..:..||....:||....:.  ||            |:.|.|     :.|::|.....|.:..|
Human   861 EIFRGRKDGYTESLNQPFVNSRIDE------------GDINPKVLQLISHEKIQYGVPVIKYDRK 913

  Fly  1022 -VKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEA--VADLERNKKELEQTIQRKD 1083
             .||:..|                             |.|||:|  |.:|.:.|:::|.:
Human   914 GFKARQRQ-----------------------------LILTQKAAYVVELAKIKQKIEYS----- 944

  Fly  1084 KELSSI-TAKLEDEQVVV 1100
             .|..: |:.|.|..:|:
Human   945 -ALKGVSTSNLSDGILVI 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832
		MYSc	81..777	CDD:214580	262/718 (36%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	259/705 (37%)
		Myosin_tail_1	842..1897	CDD:279860	60/272 (22%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
MYO1H	XP_011536525.1	MYSc	8..711	CDD:214580	262/716 (37%)
		MYSc_Myo1	26..700	CDD:276829	259/705 (37%)
		Myosin_TH1	856..1019	CDD:283635	33/173 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910