DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and Myo7a

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	XP_006229804.1	Gene:	Myo7a / 266714	RGDID:	628830	Length:	2276	Species:	Rattus norvegicus

Alignment Length:	2228	Identity:	552/2228 - (24%)
Similarity:	872/2228 - (39%)	Gaps:	593/2228 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 KGDIVSVGLQGGEVRDI-----------------------------KSEKVEKVNPPKFEKIEDM 91
            |||.|.:.|:.|:..|:                             .:..::.::|.....:|||
  Rat    67 KGDYVWMDLKSGQEFDVPIGAMVKLCESGQIQVVDDEGNEHWISPQNATHIKPMHPTSVHGVEDM 131

  Fly    92 ADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIF 156
            ..:..||...:|.||..||...|||||:|...||:|||:...:|::...:.|..|:..|:|||||
  Rat   132 IRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSSEHIRQYTNKKIGEMPPHIF 196

  Fly   157 AISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQ 221
            ||:|..|.:|..|:.:|..:|:|||||||||:||.::.:.|.:......         :|.||::
  Rat   197 AIADNCYFNMKRNNRDQCCIISGESGAGKTESTKLILQFLAAISGQHSW---------IEQQVLE 252

  Fly   222 TNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFY 286
            ..|:|||||||||:||||||||||:|.|||...|.:.||.||.|||||:||..|...||:||:||
  Rat   253 ATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQAPDERNYHVFY 317

  Fly   287 QIMSGSVPGVKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYR 350
            .::.|.....|. .|......||:.::.|. :|.....|::|::....|..:|.||..|..::.:
  Rat   318 CMLEGMNEEEKK-KLGLGQAADYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEILK 381

  Fly   351 ITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCD--------TAELYKNLLKPRIK--- 404
            :.||::|||.::::.|..|               .|..|:        ||..:..:..|.:.
  Rat   382 LLAAILHMGNLQYEARTFE---------------NLDACEVLFSPSLATAASHLEVNPPDLMSCL 431

  Fly   405 VGNEFVTQGRNV------QQVTNSIGALCKGVFDRLFKWLVKKCNETL-------DTQQKRQHFI 456
            .....:|:|..|      :|..:...|..||::.|||.|:|:|.|..:       .|..:|.  |
  Rat   432 TSRTLITRGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPSQEVTNSRRS--I 494

  Fly   457 GVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACID 521
            |:|||.|||.|..|.||||||||.||.|||||..|:|.||||||..|.|||..|:| .|....:|
  Rat   495 GLLDIFGFENFTVNSFEQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEF-TDNQEALD 558

  Fly   522 LI-EKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGC 585
            :| .:||.::|:::|||.|||.||.|...||.:.| ..:|.:..||    ......|.|.|:||.
  Rat   559 MIANRPMNVISLIDEESKFPKGTDATMLHKLNSQH-RLNANYVPPK----NSHETQFGINHFAGI 618

  Fly   586 VSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSS 650
            |.|...|:||||:|.|:..::.....|:||.:.:||.        .:.|.|...:|..  .|:||
  Rat   619 VYYESQGFLEKNRDTLHGDIIQLVHSSRNKFVKQIFQ--------ADVAMGAETRKRS--PTLSS 673

  Fly   651 AYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMM 715
            .:|..|..||.||.:.||.|||||.|||.|:|.:.|.||.:.||..:|::|.|||...|:|.|..
  Rat   674 QFKRSLELLMRTLGACQPFFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRHAGYPIRYS 738

  Fly   716 YPDFKMRYKIMCPKLLQGVEKD------KKATEIIIKFIDLPEDQYRLGNTKVFFR--AGVLGQM 772
            :.:|..||:::.|.:....::|      ::..|.::.    ..|.:::|.||:|.:  ..:|.::
  Rat   739 FVEFVERYRVLLPGVKPAYKQDDLQGTCQRMAEAVLG----THDDWQIGKTKIFLKDHHDMLLEV 799

  Fly   773 EE-----------------FRDE----RLGKIMSWMQAWARGYLSRK-------GFKKLQ----- 804
            |.                 |:|.    ||....:.:|...||:..||       ||.:||
  Rat   800 ERDKAITDRVILLQKVIRGFKDRSNFLRLKSAATLIQRHWRGHHCRKNYELIRLGFLRLQALHRS 864

  Fly   805 -----EQRVALKVV---QRNLRKYLQLRTWPWYKLW--------------QKVKPLLNVS---RI 844
                 :.|:|.:.:   |...|.||..|.:. ::||              :::...|.|.   |:
  Rat   865 RKLHKQYRLARQRIIKFQARCRAYLVRRAFR-HRLWAVITVQAYARGMIARRLHRRLRVEYWRRL 928

  Fly   845 EDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTA 909
            |.|..||.|           |.|:|||:.|..||..||:               .:|||.|:|..
  Rat   929 EAERMRLAE-----------EEKLRKEMSAKKAKEEAER---------------KHQERLAQLAR 967

  Fly   910 QKNDLENQLRDIQERLTQEEDAR--NQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDH 972
            :         |.:..|.::|:||  .:|.||.::|..|
  Rat   968 E---------DAERELKEKEEARRKKELLQQMERARHE--------------------------- 996

  Fly   973 QIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSL 1037
                   .|.|.|    .::|.....|.::...|:|.||...               .::||
  Rat   997 -------PINHSD----MVDKMFGFLGTSSGLPGQEGQAPSG---------------FEDLE--- 1032

  Fly  1038 EREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNK-------------------KELEQTIQRKD 1083
                  ||..|..:..|:..|.|..|...||...|                   :.|:|.:...|
  Rat  1033 ------RGRREMVEEDVDAALPLPDEDEEDLSEYKFAKFAATYFQGTTTHSYTRRPLKQPLLYHD 1091

  Fly  1084 KELSSITAKLEDEQVVVLKHQRQIKE--LQARIEELEEEVEAERQARAKAEKQRADLARELEEL- 1145
            .|...:.|..  ..:.:|:....:.|  ....:.:..|::....:......|:  ...|||:.|
  Rat  1092 DEGDQLAALA--VWITILRFMGDLPEPKYHTAMSDGSEKIPVMTKIYETLGKK--TYKRELQALQ 1152

  Fly  1146 --GE-RLEEAGGATSAQ-----IELNKKRE--AELSKLRRDLEEANIQHESTL-----ANLRKKH 1195
              || :|.|....||.:     :.|.||.:  .|::|...| .|:.:|..|.|     :||.|.|
  Rat  1153 GEGEAQLSEGQKKTSVKHKLVHLTLKKKSKLTEEVTKRLHD-GESMVQGNSMLEDRPTSNLEKLH 1216

  Fly  1196 -------------NDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQ---LNDLRAGVDHITNEKAAQ 1244
                         ::...::::|:.. |..|:.        |.:   |..|..|.      .|..
  Rat  1217 FIIGNGILRPALRDEIYCQISKQLTH-NPSKSS--------YARGWILVSLCVGC------FAPS 1266

  Fly  1245 EKIAKQLQHTLN--------EVQSKLDET--NRTLN------DFDASKKKLSIENSDLLRQLEEA 1293
            ||..|.|::.::        ..:.:|..|  |.|..      :..|:|.|..|       .|...
  Rat  1267 EKFVKYLRNFIHGGPPGYAPYCEERLRRTFVNGTRTQPPSWLELQATKSKKPI-------MLPVT 1324

  Fly  1294 ESQVSQLSKIKISLTTQLEDTKRLADEES-RER------ATLLGKFRNL----EHDLDNLREQVE 1347
            ....:..:.:..|.||..|....|||:.| ::|      ..|..|..:|    :|.:|.: .|.|
  Rat  1325 FMDGTTKTLLADSATTAKELCNALADKISLKDRFGFSLYIALFDKVSSLGSGSDHVMDAI-SQCE 1388

  Fly  1348 EEAEGKADLQRQLSKANAEAQV---------WRSKYESDGVARSEELEEAKRKL---QARLAEAE 1400
            :.|:.:...:|     ||..::         |.:..| |.||.:...::..|.:   :.|..:.:
  Rat  1389 QYAKEQGAQER-----NAPWRLFFRKEVFTPWHNPSE-DNVATNLIYQQVVRGVKFGEYRCEKED 1447

  Fly  1401 ETIESLNQKCI---GLEKTKQRL----STEVEDLQL----EVDRANAIANAAEKK---------- 1444
            :..|..:|:..   |.|...:||    .|.:.|.::    .:::...:|.||.||
  Rat  1448 DLAELASQQYFVDYGSEMILERLLSLVPTYIPDREITPLKNLEKWAQLAIAAHKKGIYAQRRTDA 1512

  Fly  1445 QKAFDKIIG----EWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLA 1505
            ||....::.    :|.|...             |.|  |.::..|......:.:.||........
  Rat  1513 QKVKQDVVNYARFKWPLLFS-------------RFY--EAYKFSGPPLPKSDVIVAVNWTGVYFV 1562

  Fly  1506 DEVKDLLDQIGEGGRNIHEI------EKARKRLEAEKDELQ-AALEEAEAALEQ----------E 1553
            ||.:.:|.::     :..||      .:.|..|.....:|. |:.....|.|..          .
  Rat  1563 DEQEQVLLEL-----SFPEIMAVSSSRECRVLLSLGCSDLGCASCHSGRAGLTPAGPCSPCWSCR 1622

  Fly  1554 ENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLE 1618
            ..|::.....|:.:          |.:|:..|..|.:...|.:...|        |.||.:.|
  Rat  1623 GAKLMAPSFTLATI----------KGDEYTFTSSNAEDIRDLVVTFL--------EGLRKRSK-- 1667

  Fly  1619 ADINELEIAL-DHANKANAEAQ-KNIKRYQQQLKDIQT-----------ALEEEQRARDD----- 1665
                 ..:|| |:.|.|..|:. .:..:....:.|..|           .:.|..:.|.|
  Rat  1668 -----YVVALQDNPNPAGEESGFLSFAKGDLIILDHDTGEQVMNSGWANGINERTKQRGDFPTDC 1727

  Fly  1666 --AREQLGISERRANALQNELEESR----TLLEQADRGRRQAEQELADAHEQLNEVS-------- 1716
              ....:.:..|...||.....:.|    .||:     .|.||.|:......|.|.|
  Rat  1728 VYVMPTVTLPPREIVALVTMTPDQRQDVVRLLQ-----LRTAEPEVRTKPYTLEEFSYDYFRSPP 1787

  Fly  1717 ---AQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQ 1778
               .....:|.|:.|......|.......||.:...|||.:::|.:....:   |:...|:...:
  Rat  1788 KHTLSRVMVSKARGKDRLWSHTREPLKQALLKKIVGSEELSQEACMSFIAV---LKYMGDYPSKR 1849

  Fly  1779 EKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSE 1843
            .:....|..||.|..|:.:..:..|.      :|.|:|.                 ...::|.||
  Rat  1850 TRSVNELTDQIFEWAVKAEPLKDEAY------VQILKQL-----------------TDNHIRYSE 1891

  Fly  1844 RRVKELSF-----------------QSEEDRKNHERMQDLVDKLQQKIKT----YKRQIEEAEEI 1887
            .:..||.:                 :..:.||:.....|.:.:||:.::.    |...:.|.|.|
  Rat  1892 EKGWELLWLCTGLFPPSNILLPHVQRFLQSRKHCPLAIDCLQRLQKALRNGSRKYPPHLVEVEAI 1956

  Fly  1888 AALNLAKFRKA--------QQELEEAEERADLAEQAISKFRAKGRAGSVGRGASPAPRATSVRPQ 1944
            .......|.|.        ..|:|.:.:..|..:...|:...|...| .......|.:..||
  Rat  1957 QHKTTQIFHKVYFPDDTDEAFEVESSTKAKDFCQNIASRLLLKSSEG-FSLFVKIADKVISV--- 2017

  Fly  1945 FDGLAFPPRFDLAPENEF 1962
                         |||:|
  Rat  2018 -------------PENDF 2022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	7/45 (16%)
		MYSc	81..777	CDD:214580	269/746 (36%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	260/696 (37%)
		Myosin_tail_1	842..1897	CDD:279860	239/1249 (19%)
		V_Alix_like	1557..1877	CDD:187408	66/375 (18%)
		ATP-synt_B	<1671..1771	CDD:304375	24/114 (21%)
		TMPIT	1739..>1825	CDD:285135	17/85 (20%)
Myo7a	XP_006229804.1	MYSc	121..802	CDD:214580	268/727 (37%)
		MYSc_Myo7	140..790	CDD:276832	260/696 (37%)
		IQ	827..848	CDD:197470	7/20 (35%)
		MAP7	<918..996	CDD:283355	32/112 (29%)
		eIF3_subunit	936..>991	CDD:285763	24/89 (27%)
		MyTH4	1078..1314	CDD:214535	50/255 (20%)
		B41	1320..1535	CDD:214604	46/234 (20%)
		FERM_N	1323..>1362	CDD:286467	9/38 (24%)
		FERM_B-lobe	1424..1524	CDD:271216	18/99 (18%)
		FERM_C1_MyoVII	1529..1665	CDD:270019	29/173 (17%)
		SH3_MYO7A	1666..1730	CDD:212814	12/70 (17%)
		MyTH4	1808..1957	CDD:214535	31/174 (18%)
		B41	1964..2176	CDD:214604	15/76 (20%)
		FERM_M	2074..2176	CDD:278785
		FERM_C2_MyoVII	2172..2267	CDD:270020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910