DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and Myh9

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_037326.2	Gene:	Myh9 / 25745	RGDID:	3140	Length:	1960	Species:	Rattus norvegicus

Alignment Length:	1915	Identity:	783/1915 - (40%)
Similarity:	1172/1915 - (61%)	Gaps:	36/1915 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SKKSCWIPDEKEGYLLGEIKATKGDIVSVGL-QGGEVRDIKSEKVEKVNPPKFEKIEDMADMTVL 97
            :||..|:|..|.|:....:|...|:...|.| :.|:...:..:.::|:|||||.|:||||::|.|
  Rat    28 AKKLVWVPSTKNGFEPASLKEEVGEEAIVELVENGKKVKVNKDDIQKMNPPKFSKVEDMAELTCL 92

  Fly    98 NTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGA 162
            |...|||||::|||:.|||||||||||.|||||..|:|:.....||:||:|:|:||||:||:|.|
  Rat    93 NEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVDMYKGKKRHEMPPHIYAITDTA 157

  Fly   163 YVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLE 227
            |..|:.:..:||:|.||||||||||||||||.|.|.|.:|.|   :.|.:|.||.|::|.||:||
  Rat   158 YRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHK---SKKDQGELERQLLQANPILE 219

  Fly   228 AFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGS 292
            ||||||||:|||||||||||||:|...|.:.||:||||||||:|.|.|...||::||||.::||:
  Rat   220 AFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGA 284

  Fly   293 VPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMH 357
            ...:| ..||.:....|..:|.|.||:....|.:.|..|.:|..|:|..:.|:..:.|:.:.|:.
  Rat   285 GEHLK-TDLLLEPYNKYRFLSNGHVTIPGQQDKDMFQETMEAMRIMGIPEDEQMGLLRVISGVLQ 348

  Fly   358 MGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNS 422
            :|.:.||:....:||.........:||.|.|.:..:..:.:|.||||||.::|.:.:..:|...:
  Rat   349 LGNIVFKKERNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTKEQADFA 413

  Fly   423 IGALCKGVFDRLFKWLVKKCNETLD-TQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQ 486
            |.||.|..::|:|:|||.:.|:.|| |:::...|||:|||||||||:.|.|||||||:|||||||
  Rat   414 IEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQ 478

  Fly   487 FFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPM---GILSILEEESMFPKATDQTFS 548
            .|||.||:||||||:||||:|.|||||:||..||||||||.   |||::|:||..||||||::|.
  Rat   479 LFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPKATDKSFV 543

  Fly   549 EKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQ 613
            ||:.... |....|||||..|   ..|.|.|.||||.|.|....||.||.|||||.:.....:|.
  Rat   544 EKVVQEQ-GTHPKFQKPKQLK---DKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSS 604

  Fly   614 NKLLIEIFAD---------HAGQSGGGEQAKGGRGK-KGGGFATVSSAYKEQLNSLMTTLRSTQP 668
            :|.:.|::.|         .||.|   |.|..|..| :.|.|.||...|||||..||.|||:|.|
  Rat   605 DKFVSELWKDVDRIIGLDQVAGMS---ETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTNP 666

  Fly   669 HFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLL-Q 732
            :||||||||..|:.|.:|.|||:.||.||||||||||||:|||||:::.:|:.||:|:.|..: :
  Rat   667 NFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIPK 731

  Fly   733 GVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSR 797
            |....|:|..::||.::|..:.||:|.:|||||||||..:||.||.::..::...||..||||:|
  Rat   732 GFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLAR 796

  Fly   798 KGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELH 862
            |.|.|.|:|..|:||:|||...||:||.|.|::|:.|||||||..|.|||:...|.:..|..|.|
  Rat   797 KAFAKRQQQLTAMKVLQRNCAAYLRLRNWQWWRLFTKVKPLLNSIRHEDELLAKEAELTKVREKH 861

  Fly   863 AAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQ 927
            .|......|:|.:.::|:|||..|.:.|..|.....:.:|..|:|||:|.:||....|::.|:.:
  Rat   862 LAAENRLTEMETMQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEE 926

  Fly   928 EEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNL-NDEIAHQDELINKL 991
            ||:....|..:|||..|.|..|::.:|:.|...||.:.:|.|.:.:::.| .|:|..:|:.. ||
  Rat   927 EEERCQYLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEDQIIMEDQNC-KL 990

  Fly   992 NKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEG 1056
            .||||:..:...:....|...|:|...|.|:|.|.|..:.:||:.|.||:|.|.::||::||:||
  Rat   991 AKEKKLLEDRVAEFTTNLMEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG 1055

  Fly  1057 DLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEV 1121
            |.....:.:|:|:....||:..:.:|::||.:..|::|:|........::|:||:.:|.||:|::
  Rat  1056 DSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELETQISELQEDL 1120

  Fly  1122 EAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHES 1186
            |:||..|.|||||:.||..|||.|...||:...:|:||.||..|||.|:|.|::.||:....||:
  Rat  1121 ESERACRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVSILKKTLEDEAKTHEA 1185

  Fly  1187 TLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQL 1251
            .:..:|:||:.||.|:|||::|..::||..||.|.....:..:|...|..:...|...|...|::
  Rat  1186 QIQEMRQKHSQAVEELAEQLEQTKRVKATLEKAKQTLENERGELANEVKALLQGKGDSEHKRKKV 1250

  Fly  1252 QHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKR 1316
            :..|.|:|.|..|..|...:......||.:|...:...|.:::|:.|:|:|...:|.:||:||:.
  Rat  1251 EAQLQELQVKFSEGERVRTELADKVSKLQVELDSVTGLLNQSDSKSSKLTKDFSALESQLQDTQE 1315

  Fly  1317 LADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVAR 1381
            |..||:|::.:|..|.:.:|.:.::.|||:|||.|.|.:|::|::..:|:....:.|.| |||..
  Rat  1316 LLQEENRQKLSLSTKLKQMEDEKNSFREQLEEEEEAKRNLEKQIATLHAQVTDMKKKME-DGVGC 1379

  Fly  1382 SEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQK 1446
            .|..|||||:||..|....:.:|........|||||.||..|::||.:::|......:..|||||
  Rat  1380 LETAEEAKRRLQKDLEGLSQRLEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSVSNLEKKQK 1444

  Fly  1447 AFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDL 1511
            .||:::.|.|......|.|.|.::.|.|...|:...|..|.||..||...:.|.||....|::||
  Rat  1445 KFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDL 1509

  Fly  1512 LDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQ 1576
            :....:.|:::||:||:::.||.:.:|::..|||.|..|:..|:..||.::.|..::.:.:|.:|
  Rat  1510 MSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQ 1574

  Fly  1577 EKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKN 1641
            .::|:.|..:|...|.:..|:|.||.|.|.::.|:..:||||.|:.:||..:|.|||...||.|.
  Rat  1575 GRDEQSEEKKKQLVRQVREMEAELEDERKQRSIAMAARKKLEMDLKDLEAHIDTANKNREEAIKQ 1639

  Fly  1642 IKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQAEQELA 1706
            :::.|.|:||....|::.:.:|::...|...:|::..:::.|:.:.:..|..|:|.:|||:||..
  Rat  1640 LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERD 1704

  Fly  1707 DAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSE---EKAKKAMVDAARLADEL 1768
            :..:::...|.:.|.....||:||:.:..|..:|:|   |..|:|   ::.|||.:...::..:|
  Rat  1705 ELADEIANSSGKGALALEEKRRLEARIAQLEEELEE---EQGNTELINDRLKKANLQIDQINTDL 1766

  Fly  1769 RAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRRHA 1833
            ..|:.|||..|..|:.||:|.|||:.:|.|.|:......|.:|..||.::.:||.:||.|.:...
  Rat  1767 NLERSHAQKNENARQQLERQNKELKAKLQEMESAVKSKYKASIAALEAKIAQLEEQLDNETKERQ 1831

  Fly  1834 DAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKA 1898
            .|.|.:|::|:::|::..|.|::|:|.|:.:|..||...::|..|||:|||||.|....|..||.
  Rat  1832 AASKQVRRAEKKLKDVLLQVEDERRNAEQFKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKL 1896

  Fly  1899 QQELEEAEERADLAEQAISKFRAKGRAGSV 1928
            |:|||:|.|.||...:.:|..:.|.|.|.:
  Rat  1897 QRELEDATETADAMNREVSSLKNKLRRGDM 1926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	10/37 (27%)
		MYSc	81..777	CDD:214580	364/710 (51%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	343/679 (51%)
		Myosin_tail_1	842..1897	CDD:279860	359/1058 (34%)
		V_Alix_like	1557..1877	CDD:187408	101/322 (31%)
		ATP-synt_B	<1671..1771	CDD:304375	26/102 (25%)
		TMPIT	1739..>1825	CDD:285135	30/88 (34%)
Myh9	NP_037326.2	Myosin_N	29..68	CDD:397036	11/38 (29%)
		Motor_domain	95..764	CDD:419868	343/679 (51%)
		Myosin_tail_1	842..1921	CDD:396244	370/1083 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47111at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720