DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and Myo1d

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_037115.2	Gene:	Myo1d / 25485	RGDID:	621321	Length:	1006	Species:	Rattus norvegicus

Alignment Length:	1018	Identity:	314/1018 - (30%)
Similarity:	497/1018 - (48%)	Gaps:	121/1018 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 ADMTVLNT---PCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPP 153
            ||..:::|   |..:.|||.|:....|||:.|...|::||||...:|.....:.|:|:...|.||
  Rat    12 ADFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKVLNIYGRDTIEQYKGRELYERPP 76

  Fly   154 HIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQ 218
            |:|||:|.||..|.....:..::|:|||||||||.:|.::.|.|.:....:..|..:.|..|
  Rat    77 HLFAIADAAYKAMKRRSKDTCIMISGESGAGKTEASKYIMQYIAAITNPSQRAEIERVKNML--- 138

  Fly   219 VVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYH 283
             :::|.||||||||||.||||||||||::.|:|...|...|..|..|||||:|||.||..|||:|
  Rat   139 -LKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFH 202

  Fly   284 IFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDV 348
            .|||::.|....:.....|..::..|:.:..|....:||:||.||.:...|..::||..:|.:.|
  Rat   203 SFYQLLQGGSEQMLHSLHLQKSLSSYNYIRVGAQLKSSINDAAEFKVVADAMKVIGFKPEEIQTV 267

  Fly   349 YRITAAVMHMGGMKFKQRGREEQAEQDGEE---EGGRV----SKLFGCDTAELYKNLLKPRIKVG 406
            |:|.||::|:|.:||         ..||:.   |.|:|    ::|.......:.|.||...:..|
  Rat   268 YKILAAILHLGNLKF---------IVDGDTPLIENGKVVSVIAELLSTKADMVEKALLYRTVATG 323

  Fly   407 NEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLD------TQQKRQHFIGVLDIAGFE 465
            .:.:.:....|:.:....|..|.:::|||.|:|.:.|:.::      |...:...||||||.|||
  Rat   324 RDIIDKQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTVHGKNTVIGVLDIYGFE 388

  Fly   466 IFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKP-MGI 529
            ||:.|.|||.|||:.||||||.|...:...|||||:||||.|..||:..:.: .:||:|:. .||
  Rat   389 IFDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQI-IVDLVEQQHKGI 452

  Fly   530 LSILEEESM-FPKATDQTFSEKLTNTHLGKSAPFQKPK---PPKPGQQAAHFAIAHYAGCVSYNI 590
            ::||::..| ..|.||..|.|.| |:.|||...|...|   ..|..:....|.|.||||.|.|::
  Rat   453 IAILDDACMNVGKVTDGMFLEAL-NSKLGKHGHFSSRKTCASDKILEFDRDFRIRHYAGDVVYSV 516

  Fly   591 TGWLEKNKDPLNDTVVDQFKK----SQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSA 651
            .|:::|||    ||:...||:    |.|.:|..::.:  |:....|..|..        .|.::.
  Rat   517 IGFIDKNK----DTLFQDFKRLMYNSSNPVLKNMWPE--GKLSITEVTKRP--------LTAATL 567

  Fly   652 YKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMY 716
            :|..:.:|:..|.|.:|::||||.||:.|.|.:.|.....||:...|:||.:|:.|.||..|..|
  Rat   568 FKNSMIALVDNLASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVRRAGFAFRQTY 632

  Fly   717 PDFKMRYKIMC----PKLLQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRA-GVLGQMEEFR 776
            ..|..|||::.    |.  ..:..||:|.:.:|:.... :|....|.||:|.|. ..|..:||.|
  Rat   633 EKFLHRYKMISEFTWPN--HDLPSDKEAVKKLIERCGF-QDDVAYGKTKIFIRTPRTLFTLEELR 694

  Fly   777 DERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQ---------------------RNLRKY 820
            .:.|.:::.::|...||.|:|..:|:   .:.||.:::                     :|:|.|
  Rat   695 AQMLVRVVLFLQKVWRGTLARMRYKR---TKAALTIIRYYRRYKVKSYIHEVARRFHGVKNMRDY 756

  Fly   821 LQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTA 885
            .:...||        .|...:.|.|:.:..:..:.:.::.:        |.:.|.:...:..|.|
  Rat   757 GKHVKWP--------TPPKVLRRFEEALQSIFNRWRASQLI--------KTIPASDLPQVRAKVA 805

  Fly   886 LLDSLSGEKGALQDYQERNAKLTAQKND---LENQLRDIQERLTQEEDARNQLFQ---QKKKADQ 944
            .::.|.|::..|...:.......|.|.|   .......:...|.:::...|.||.   :|.....
  Rat   806 AMEMLKGQRADLGLQRAWEGNYLASKPDTPQTSGTFVPVANELKRKDKYMNVLFSCHVRKVNRFS 870

  Fly   945 EISGLKKDIEDLEL-NVQKAEQDKATKDHQIRNLND-EIAH-QDELI---NKLNKEKKMQGETNQ 1003
            ::......:.|..| .:...:|.|..|...:.||.. .::: :|:|:   .|.||:..:...:.|
  Rat   871 KVEDRAIFVTDRHLYKMDPTKQYKVMKTIPLYNLTGLSVSNGKDQLVVFHTKDNKDLIVCLFSKQ 935

  Fly  1004 KTGE----ELQAAEDKINHLNKVKAKLE-QTLDELEDSLEREK 1041
            .|.|    ||...  .:||....|..|: ...:.::.||..:|
  Rat   936 PTHESRIGELVGV--LVNHFKSEKRHLQVNVTNPVQCSLHGKK 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832
		MYSc	81..777	CDD:214580	257/714 (36%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	250/690 (36%)
		Myosin_tail_1	842..1897	CDD:279860	41/217 (19%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
Myo1d	NP_037115.2	MYSc_Myo1	24..682	CDD:276829	249/689 (36%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	572..594		9/21 (43%)
		Interaction with calmodulin. /evidence=ECO:0000269\|PubMed:8034741	776..896		19/127 (15%)
		Myosin_TH1	803..996	CDD:399188	37/176 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000