DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and myp2

DIOPT Version :10

Sequence 1:NP_523587.4 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_593816.1 Gene:myp2 / 2543576 PomBaseID:SPAC4A8.05C Length:2104 Species:Schizosaccharomyces pombe


Alignment Length:2160 Identity:632/2160 - (29%)
Similarity:1034/2160 - (47%) Gaps:361/2160 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 YDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQ-GGETRDLKKDLLQQVNPPKYEKAEDMSNLT 95
            :|.:...||||.||.::...|....|:...|.|: .|..|.:.....::|||||::..:||:.||
pombe    34 FDERTWIWIPDSKESFVKAWIVEDLGEKYRVKLERDGSERIVDGFDAEKVNPPKFDMVDDMAALT 98

  Fly    96 YLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISD 160
            .||:.||::||.|||...|||||||||.||:|||...|:|.:...:.|:.|:..|..||||..:|
pombe    99 CLNEPSVVNNLTQRYEKDLIYTYSGLFLVAVNPYCHLPIYGDDVVRKYQSKQFKETKPHIFGTAD 163

  Fly   161 GAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPV 225
            .||..:|...:|||:|:||||||||||.|||||.|..:|     ||.:......||.::::||||
pombe   164 AAYRSLLERRINQSILVTGESGAGKTETTKKVIQYLTSV-----TDASTSDSQQLEKKILETNPV 223

  Fly   226 LEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMS 290
            |||||||:||||:|||||||||||.|...|.:.||:::.|||||:|||...|.||:||:|||::.
pombe   224 LEAFGNAQTVRNNNSSRFGKFIRIEFSNNGSIVGANLDWYLLEKSRVIHPSSNERNYHVFYQLLR 288

  Fly   291 GSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAV 355
            |:...:.:...|...:..|..:..|...:..:||.:||.........|||...|...::.|.|::
pombe   289 GADGSLLESLFLDRYVDHYSYLKNGLKHINGVDDGKEFQKLCFGLRTLGFDNNEIHSLFLIIASI 353

  Fly   356 MHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFG-CDTAEL----YKN-LLKPRIKVGNEFVTQGR 414
            :|:|.:       |..:::.|:.....::::.. |...|:    :.| .|.|:.|.|.|::...|
pombe   354 LHIGNI-------EVASDRSGQARFPSLTQIDQLCHLLEIPVDGFVNAALHPKSKAGREWIVTAR 411

  Fly   415 NVQQVTNSIGALCKGVFDRLFKWLVKKCNETL-DTQQKRQHFIGVLDIAGFEIFEYNGFEQLCIN 478
            ..:||.:::.:|.||:::|.|..|||:.|:|: .:|.:...|||||||||||||.:|.|||||||
pombe   412 TREQVVHTLQSLAKGLYERNFAHLVKRLNQTMYYSQSEHDGFIGVLDIAGFEIFTFNSFEQLCIN 476

  Fly   479 FTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEK--PMGILSILEEESMFPK 541
            ||||||||||||:|||||||||.:|.|||.|||:|.|||..||.|||  |:||.|.|:|:.:.|.
pombe   477 FTNEKLQQFFNHYMFVLEQEEYTQERIEWDFIDYGNDLQPTIDAIEKSEPIGIFSCLDEDCVMPM 541

  Fly   542 ATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVV 606
            |||.||:|||.....|||..::..|....|     |.:.||||.|.|:...||||||||||..:.
pombe   542 ATDATFTEKLHLLFKGKSDIYRPKKFSSEG-----FVLKHYAGDVEYDTKDWLEKNKDPLNACLA 601

  Fly   607 DQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFV 671
            ....||.|..:..:|.|::..:.|.:..     :|.|.|.|||..::.||:|||..|.:||||||
pombe   602 ALMFKSTNSHVSSLFDDYSSNASGRDNI-----EKKGIFRTVSQRHRRQLSSLMHQLEATQPHFV 661

  Fly   672 RCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEK 736
            ||||||.:|||..:|..||:|||.||||||||||.:.||||::.|.:|:.||.|:...|.:|..:
pombe   662 RCIIPNNLKQPHNLDKSLVLHQLRCNGVLEGIRIAQTGFPNKLFYTEFRARYGILSQSLKRGYVE 726

  Fly   737 DKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFK 801
            .||||..||..:.||...||||.|||||:|.|||.:|:.|:..|..|.:...|..||:|:|:...
pombe   727 AKKATITIINELKLPSTVYRLGETKVFFKASVLGSLEDRRNALLRVIFNSFSARIRGFLTRRRLY 791

  Fly   802 KLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIAR-------LEEKAKKAE 859
            :...::.|..::|.|||:...|:..||:.|:..:||||..::.::.:.|       |:.:.:..:
pombe   792 RFNHRQDAAILLQHNLRQLKLLKPHPWWNLFLHLKPLLGTTQTDEYLRRKDALINNLQNQLESTK 856

  Fly   860 ELHAAEVKVRKE--LEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQK-NDLENQL--- 918
            |: |.|:.:.||  |:..|.  |.|:.|    |:.||..|.:......::..:: :.||||:   
pombe   857 EV-ANELTITKERVLQLTND--LQEEQA----LAHEKDILVERANSRVEVVHERLSSLENQVTIA 914

  Fly   919 -----------RDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDH 972
                       :.|:|.|..::...:.|.......::::|.:|||.:.:....::.|:|......
pombe   915 DEKYEFLYAEKQSIEEDLANKQTEISYLSDLSSTLEKKLSSIKKDEQTISSKYKELEKDYLNIMA 979

  Fly   973 QIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEEL----QAAEDKINHLNKVKAKLEQTLDEL 1033
            ..::.:..:::.::.||:.|...:...|...:..:||    ::.:.|:..|.:..|.|:......
pombe   980 DYQHSSQHLSNLEKAINEKNLNIRELNEKLMRLDDELLLKQRSYDTKVQELREENASLKDQCRTY 1044

  Fly  1034 EDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDK-------------- 1084
            |..|........:.|....|.|.:|.:.|:.:.:.   :.:|.:..|..:|              
pombe  1045 ESQLASLVSKYSETESELNKKEAELVIFQKEITEY---RDQLHKAFQNPEKTHNINDVKSGPLNS 1106

  Fly  1085 -----ELSSITAK-LEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELE 1143
                 ..||.|.. |:|.|.:...|.::..:|..||:|:.|.:|.......|..::.::|...:|
pombe  1107 DENIYSTSSTTLSILKDVQELKSLHTKEANQLSERIKEISEMLEQSIATEEKLRRKNSELCDIIE 1171

  Fly  1144 ELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAV--------- 1199
            .|..::::              :|.|:..|..|    |:..:.|...|.|..:|.:         
pombe  1172 ALKYQIQD--------------QETEIISLNAD----NLDLKDTNGVLEKNASDFIDFQGIKSRY 1218

  Fly  1200 -AEMAEQVDQLNK-------LKAKAEK--------EKNEYYGQLNDLRAG-----VDHITNEKAA 1243
             .::::.::||.|       ||.|.|.        :.|..:....:..:|     :|...:::..
pombe  1219 EHKISDLLNQLQKERCKVGLLKQKTENRSVTQHTLDGNSPHPSFEEKHSGDPLKRIDGNNDDRKI 1283

  Fly  1244 QEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLS-------IENSDLLRQLEEAESQVSQL- 1300
            ..|:.|.:..:|:.:|..::|   .|::..:..|.||       |.||  :|:||:..|.:|:| 
pombe  1284 DNKLLKTISKSLDALQLTVEE---ELSNLYSLSKDLSFTDISGHIPNS--IRKLEKGLSTLSELK 1343

  Fly  1301 ---------------------------------SKIKISLTTQLEDTKRLADEESRERATLL--- 1329
                                             |..:..|.:.|:  |:|.:.||....|.|   
pombe  1344 ERLNASNSDRPSPDIFKDTQAIMNSRKLLSNPNSDAQSGLISSLQ--KKLYNPESNMEFTGLKPL 1406

  Fly  1330 --------------------GKFRNLEHDLD-----------NLREQVEEEAEGKADLQRQLSKA 1363
                                ||...|..:.|           |.|..|         ||.:..|.
pombe  1407 SPSKISNLPSSQPGSPSKRSGKMEALIRNFDQNSSIPDPFIVNQRNSV---------LQTEFEKI 1462

  Fly  1364 NAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDL- 1427
            |.:.:    :....|:..:::|.:....:|:.|.|.|| :::|....:|.:......:..:||: 
pombe  1463 NLKLK----EATKSGILDNKDLSKFSELIQSLLKENEE-LKNLTTSNLGSDDKMLDFAPLLEDVP 1522

  Fly  1428 -----QLE--VDRA----NAIA---NAAEKKQKAFDKIIGEWKLKVDDLAAELD----------- 1467
                 |::  |::|    .|||   :|:|:|..:.:|.:.|...:.|.|...|.           
pombe  1523 NNTRNQIKGFVEKAISSKRAIAKLYSASEEKLFSTEKALREITKERDRLLHGLQGPSVPTSPLKA 1587

  Fly  1468 --ASQ-------KECRNYSTE--------------LFRLKGAYEEGQEQLEAVRRENKNL----- 1504
              |||       ....|||.|              :..|.....:.:|||..|:..|::.     
pombe  1588 PTASQLIIPNFDGSITNYSGEEETEWLQEEVNIMKIKELTSTVNKYREQLAMVQSLNEHAESSLS 1652

  Fly  1505 -ADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQ------- 1561
             |:..|:.|.     || :.|:|:..:..:....:||..|  |:|.::|:|.:||..:       
pombe  1653 KAERSKNYLT-----GR-LQEVEELARGFQTTNADLQNEL--ADAVVKQKEYEVLYVEKSNDYNT 1709

  Fly  1562 --LELSQVRQEIDR----RIQEKEEEFENTR---KNHQRALDSMQASLEAEAKGKAEALRMKKKL 1617
              |:..::.::||.    |:|:.||..:..:   :.:|:.|:..:..||.|.:......:..:.:
pombe  1710 LLLQKEKLMKQIDEFHVIRVQDLEEREKKDQLLFQRYQKELNGFKVQLEEEREKNLRIRQDNRHM 1774

  Fly  1618 EADINELEIALDH--ANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQ-LGISERRANA 1679
            .|:|.::....|.  ..|.|...:.:|  .|..|:.:.........|:.:|:.| |.::.:    
pombe  1775 HAEIGDIRTKFDELVLEKTNLLKENSI--LQADLQSLSRVNNSSSTAQQNAQSQLLSLTAQ---- 1833

  Fly  1680 LQNELEESRTLLEQAD---RGRRQAEQELADAHEQLNEVSAQNASISAAKR-----KLESELQTL 1736
            ||...|.::||.:..|   |..|..|::|.:..||||:      ...::.|     ::|.|:.||
pombe  1834 LQEVREANQTLRKDQDTLLRENRNLERKLHEVSEQLNK------KFDSSARPFDEIEMEKEVLTL 1892

  Fly  1737 HSDL---DELLN----EAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRK---ALEQQIKE 1791
            .|:|   |:||:    ..|..|..|.|...|:          .:|.:...:|.:   .|:::.|:
pombe  1893 KSNLAQKDDLLSSLVERIKQIEMFALKTQKDS----------NNHREENLQLHRQLGVLQKEKKD 1947

  Fly  1792 LQVRLDEAEANALK-GGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEE 1855
            |:::|.:.:..... ...|.::.|::::.:||.................|..:|.:::|..|..:
pombe  1948 LELKLFDLDLKTYPISTSKDVRMLQKQISDLEASFAASDIERIKGIDECRNRDRTIRQLEAQISK 2012

  Fly  1856 DRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKF--RKAQQELEEAEERADLAEQAISK 1918
            ...:.:|:|..|.:|:::....:.|:|:.:  |:....||  |:.:..|:|..||....|....|
pombe  2013 FDDDKKRIQSSVSRLEERNAQLRNQLEDVQ--ASETQWKFALRRTEHALQEERERVKSLETDFDK 2075

  Fly  1919 FRAKGRAGSVGRGAS 1933
            :|:......|.|..|
pombe  2076 YRSLLEGQRVKRSES 2090

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_523587.4 Myosin_N 33..75 CDD:460670 13/42 (31%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 316/673 (47%)
Myosin_tail_1 842..1922 CDD:460256 262/1327 (20%)
myp2NP_593816.1 COG5022 17..1607 CDD:227355 521/1643 (32%)
CCDC158 <1622..>2070 CDD:464943 103/479 (22%)

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