DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and myo51

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_596233.1	Gene:	myo51 / 2540560	PomBaseID:	SPBC2D10.14c	Length:	1471	Species:	Schizosaccharomyces pombe

Alignment Length:	1495	Identity:	407/1495 - (27%)
Similarity:	666/1495 - (44%)	Gaps:	258/1495 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 CWIPDEK---EGYLLGEIKATKGD--IVSVGLQGGEVRDIKSEKVEKVNPPKFEKIEDMADMTVL 97
            ||:.:..   :...|.|||...|.  :.:|....|.:..:..::::..|..:.|...|:.::..|
pombe    12 CWVSNNNGHWDAARLIEIKDNGGGKVVATVAKSSGVLETVNYQQLQNRNIGQSESPSDLTNLPYL 76

  Fly    98 NTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYP-VYTNRCAKMYRGKRRNEVPPHIFAISDG 161
            |.|.|||.|..||..|.||||||:..|:||||:..| .|.:...|.:.........||:::|:..
pombe    77 NEPSVLHALHNRYNNKQIYTYSGIVLVSINPYQNLPEFYNDNLIKHFHKDPEAAKVPHLYSIASS 141

  Fly   162 AYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVL 226
            .|..:.|:..||:::::||||||||...|.::.|..:|   :..|.....|.|:|:||:.|||::
pombe   142 CYHALTTDSKNQTIIVSGESGAGKTVAAKYIMRYLTSV---QGVDHNGVVKRSVENQVLATNPIM 203

  Fly   227 EAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSG 291
            ||||||||:||||||||||::.|.|.....:.||::.|||||::||:|....||:||||||:::|
pombe   204 EAFGNAKTIRNDNSSRFGKYVTISFDENLLITGANVNTYLLERSRVVSLLKGERNYHIFYQLITG 268

  Fly   292 SVPGVKDICLLTDNIYDYHIVSQGKV-TVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAV 355
            .....:|...| ::...::.:|||.. .::.:||:.:|::|.:|...:|.::..:|||:.:.||:
pombe   269 CTEEQRDKWFL-ESASSFNYLSQGNCDEISGVDDSNDFTITCRALSTIGISESRQEDVFCLLAAL 332

  Fly   356 MHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVT 420
            :|:|.::......|.|. |.|:....:.:.|.|.|::.|.|.::|.::|..:|.:.....::...
pombe   333 LHLGNIEVCATRNEAQI-QPGDGYLQKAALLLGVDSSTLAKWIVKRQLKTRSETIITSSTLEHAI 396

  Fly   421 NSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQ---HFIGVLDIAGFEIFEYNGFEQLCINFTNE 482
            :...::.|.::..||.|:|...|.:||..:.::   .:|||:||.|||.||.|..||.|||:.||
pombe   397 SIRDSVAKYLYSALFLWIVHMINASLDHNKVKRAAYKYIGVVDIYGFEHFEKNSMEQFCINYANE 461

  Fly   483 KLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESMFPKATDQTF 547
            ||||.||.|:|.||||||.:||:||..|::. |...||.|||..:||||:|:||...|....|:|
pombe   462 KLQQEFNKHVFKLEQEEYVKEGLDWRLIEYS-DNQGCISLIEDKLGILSLLDEECRLPSGNHQSF 525

  Fly   548 SEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKS 612
            .:||.|....|.:.|.|......|.    |.:.|||..|||.:..:|.||.|.:.|..:...:.|
pombe   526 LQKLNNQLPTKHSQFYKKSRFNDGS----FMVKHYALDVSYQVHDFLAKNSDAIPDEFISLLQNS 586

  Fly   613 QNKL---LIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCI 674
            :|:.   |::.:....     ..|.|..|........|:||.:|..|:.||||:.||..|::|||
pombe   587 KNEFITYLLDFYMQLV-----SSQNKNPRKTAISRKPTLSSMFKSSLSQLMTTVSSTNVHYIRCI 646

  Fly   675 IPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKK 739
            .|||.|.|......:|:.||...||.|.|||...|||.|..|.:|..|::|:... .:..|.:||
pombe   647 KPNEEKLPWTFSPPMVLSQLRACGVFETIRISSLGFPARFSYEEFAHRFRILLSS-KEWEEDNKK 710

  Fly   740 ATEIIIKFIDLPED--QYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKK 802
            .|..|:..: :|.|  .:::|.:|:|||:.|:|..||.......|....:|:..||:.:||.:
pombe   711 LTLNIVNSV-IPHDNLNFQVGRSKIFFRSNVIGNFEEAHRATCSKSTVLLQSAIRGFFTRKEY-- 772

  Fly   803 LQEQRVALKVVQRNLRKYLQLRT----WPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHA 863
                       ||.::..::|::    |            |...|.|.|  ::|..|...:....
pombe   773 -----------QRTVKFIIKLQSVIMGW------------LTRQRFERE--KIERAAILIQAHWR 812

  Fly   864 AEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQE 928
            :.::.::.|..:...::                :|....:|...:...|:|......:..:..:.
pombe   813 SYIQRKRYLSLIKCAIV----------------IQSIVRKNIAYSRYINELRESSATLLAKFWRA 861

  Fly   929 EDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNK 993
            .:||           :...||||.:    :.:|...:...|:.: :|.|.|.......|   ..|
pombe   862 YNAR-----------KTFRGLKKSV----IALQCVSRSVLTRRY-LRRLQDSAGRTSIL---YEK 907

  Fly   994 EKKMQGETNQKTGEELQAAEDKINHL-NKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGD 1057
            :|.:|....: ..::|::...|:..| ||        |:.|.:||.:.|.:..........|..|
pombe   908 QKNLQASITE-VSKQLKSNSKKVTVLRNK--------LNILNNSLSKWKCLIKKPSDFSEPVSMD 963

  Fly  1058 LKLTQEAVADLERNKKELEQTIQR-----KDKELSSITAKLEDEQVVVLKHQRQIKELQARIEEL 1117
            .....|.:..|.:.:.:|.|..|:     |..||..:.::...|.:     ....:.||..:.|.
pombe   964 FTSNDEQLVQLLQAESKLRQASQQLYMAAKKSELGFVQSQTARENL-----SNYYQALQMTVSEK 1023

  Fly  1118 EEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANI 1182
            .|                    .:.|:|..|:  ...|......::|       ||::.||...:
pombe  1024 FE--------------------YDTEQLPSRV--LFYAMDRYFSIHK-------KLKQLLELVGV 1059

  Fly  1183 QHESTLAN--LRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQE 1245
            ::.|.|.|  :.|:..|.:.|  ::|..|.::|.
pombe  1060 ENASLLPNEVVNKQTKDLLYE--KRVVFLKQIKQ------------------------------- 1091

  Fly  1246 KIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIEN--------SDLLRQLEEAESQV-SQLS 1301
              |..:....|.|..| |...|.|.....|.....:.|        .||..|:.|..||: |..:
pombe  1092 --ALTVSSLFNAVGYK-DGVMRLLETDQNSLLFAGVVNFLIFAGISLDLKTQISEFLSQLCSYFT 1153

  Fly  1302 KIKISLTTQLEDTKRLADEESRERATL-----LGKFRNLEHDLDNLREQVEEEAEGKADLQRQLS 1361
            ||...  |.:|:.|.|...|...:|.|     |.|.|:.      |...:...:.||..:...|
pombe  1154 KIVDG--TVIENDKTLDFYEKPLQAVLYWFATLHKIRSF------LVHLLSINSHGKQSVVEDL- 1209

  Fly  1362 KANAEAQVWR------SKYESDGVARSEELEEAKRKLQARLAE--AEETIES-LNQKCIG--LEK 1415
                    |.      ||:.|:       ||.:...|..:|..  .|.:|.: ||.||:.  ::.
pombe  1210 --------WNPLILKFSKHFSN-------LENSFHSLVQKLLSCCTEGSINALLNSKCLPEFIDA 1259

  Fly  1416 TKQRLSTEVEDLQLEVDRAN-----AIANAAEKK--------------QKAFDKIIG-----EWK 1456
            ..:..:....::...:||.|     .|::|.:..              |:||..:|.     .||
pombe  1260 ADENTTPTGMNIYELIDRMNLIHKLLISSALQPNLLELTISHMLQHIGQRAFQTLIHGRSPYTWK 1324

Fly 1457 1456
pombe 1325 1324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	9/39 (23%)
		MYSc	81..777	CDD:214580	262/705 (37%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	251/674 (37%)
		Myosin_tail_1	842..1897	CDD:279860	125/672 (19%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
myo51	NP_596233.1	COG5022	1..1471	CDD:227355	407/1495 (27%)
		MYSc_Myo5	79..737	CDD:276831	251/674 (37%)
		IQ	799..820	CDD:197470	2/20 (10%)
		Myo5p-like_CBD_fungal	1068..1447	CDD:271258	63/317 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910