Protein Alignment Mhc and myo51

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_596233.1
• Gene: myo51 / 2540560
• PomBaseID: SPBC2D10.14C
• Length: 1471
• Species: Schizosaccharomyces pombe
• Alignment Length: 1495
• Identity: 413/1495 - (27%)
• Similarity: 668/1495 - (44%)
• Gaps: 258/1495 - (17%)

  Fly    38 CWIPDEK---EGYLLGEIKATKGD--IVSVGLQGGETRDLKKDLLQQVNPPKYEKAEDMSNLTYL 97
            ||:.:..   :...|.|||...|.  :.:|....|....:....||..|..:.|...|::||.||
pombe    12 CWVSNNNGHWDAARLIEIKDNGGGKVVATVAKSSGVLETVNYQQLQNRNIGQSESPSDLTNLPYL 76

  Fly    98 NDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYP-VYTNRCAKMYRGKRRNEVPPHIFAISDG 161
            |:.||||.|..||.||.||||||:..|:||||:..| .|.:...|.:.........||:::|:..
pombe    77 NEPSVLHALHNRYNNKQIYTYSGIVLVSINPYQNLPEFYNDNLIKHFHKDPEAAKVPHLYSIASS 141

  Fly   162 AYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVL 226
            .|..:.|:..||:::::||||||||...|.::.|..:|   :..|.....|.|:|:||:.|||::
pombe   142 CYHALTTDSKNQTIIVSGESGAGKTVAAKYIMRYLTSV---QGVDHNGVVKRSVENQVLATNPIM 203

  Fly   227 EAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSG 291
            ||||||||:||||||||||::.|.|.....:.||::.|||||::||:|....||:||||||:::|
pombe   204 EAFGNAKTIRNDNSSRFGKYVTISFDENLLITGANVNTYLLERSRVVSLLKGERNYHIFYQLITG 268

  Fly   292 SVPGVKDICLLTDNIYDYHIVSQGKV-TVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAV 355
            .....:|...| ::...::.:|||.. .::.:||:.:|::|.:|...:|.::..:|||:.:.||:
pombe   269 CTEEQRDKWFL-ESASSFNYLSQGNCDEISGVDDSNDFTITCRALSTIGISESRQEDVFCLLAAL 332

  Fly   356 MHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVT 420
            :|:|.::......|.|. |.|:....:.:.|.|.|::.|.|.::|.::|..:|.:.....::...
pombe   333 LHLGNIEVCATRNEAQI-QPGDGYLQKAALLLGVDSSTLAKWIVKRQLKTRSETIITSSTLEHAI 396

  Fly   421 NSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQ---HFIGVLDIAGFEIFEYNGFEQLCINFTNE 482
            :...::.|.::..||.|:|...|.:||..:.::   .:|||:||.|||.||.|..||.|||:.||
pombe   397 SIRDSVAKYLYSALFLWIVHMINASLDHNKVKRAAYKYIGVVDIYGFEHFEKNSMEQFCINYANE 461

  Fly   483 KLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPMGILSILEEESMFPKATDQTF 547
            ||||.||.|:|.||||||.:||::|..|::. |.|.||.|||..:||||:|:||...|....|:|
pombe   462 KLQQEFNKHVFKLEQEEYVKEGLDWRLIEYS-DNQGCISLIEDKLGILSLLDEECRLPSGNHQSF 525

  Fly   548 SEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKS 612
            .:||.|....|.:.|.|......|.    |.:.|||..|||.:..:|.||.|.:.|..:...:.|
pombe   526 LQKLNNQLPTKHSQFYKKSRFNDGS----FMVKHYALDVSYQVHDFLAKNSDAIPDEFISLLQNS 586

  Fly   613 QNKL---LIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCI 674
            :|:.   |::.:....     ..|.|..|........|:||.:|..|:.||||:.||..|::|||
pombe   587 KNEFITYLLDFYMQLV-----SSQNKNPRKTAISRKPTLSSMFKSSLSQLMTTVSSTNVHYIRCI 646

  Fly   675 IPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKK 739
            .|||.|.|......:|:.||...||.|.|||...|||.|..|.:|..|::|:... .:..|.:||
pombe   647 KPNEEKLPWTFSPPMVLSQLRACGVFETIRISSLGFPARFSYEEFAHRFRILLSS-KEWEEDNKK 710

  Fly   740 ATEIIIKFIDLPED--QYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKK 802
            .|..|:..: :|.|  .:::|.:|:|||:.|:|..||.......|....:|:..||:.:||.:
pombe   711 LTLNIVNSV-IPHDNLNFQVGRSKIFFRSNVIGNFEEAHRATCSKSTVLLQSAIRGFFTRKEY-- 772

  Fly   803 LQEQRVALKVVQRNLRKYLQLRT----WPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHA 863
                       ||.::..::|::    |            |...|.|.|  ::|..|...:....
pombe   773 -----------QRTVKFIIKLQSVIMGW------------LTRQRFERE--KIERAAILIQAHWR 812

  Fly   864 AEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQE 928
            :.::.::.|..:...::                :|....:|...:...|:|......:..:..:.
pombe   813 SYIQRKRYLSLIKCAIV----------------IQSIVRKNIAYSRYINELRESSATLLAKFWRA 861

  Fly   929 EDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNK 993
            .:||           :...||||.:    :.:|...:...|:.: :|.|.|.......|   ..|
pombe   862 YNAR-----------KTFRGLKKSV----IALQCVSRSVLTRRY-LRRLQDSAGRTSIL---YEK 907

  Fly   994 EKKMQGETNQKTGEELQAAEDKINHL-NKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGD 1057
            :|.:|....: ..::|::...|:..| ||        |:.|.:||.:.|.:..........|..|
pombe   908 QKNLQASITE-VSKQLKSNSKKVTVLRNK--------LNILNNSLSKWKCLIKKPSDFSEPVSMD 963

  Fly  1058 LKLTQEAVADLERNKKELEQTIQR-----KDKELSSITAKLEDEQVVVLKHQRQIKELQARIEEL 1117
            .....|.:..|.:.:.:|.|..|:     |..||..:.::...|.:     ....:.||..:.|.
pombe   964 FTSNDEQLVQLLQAESKLRQASQQLYMAAKKSELGFVQSQTARENL-----SNYYQALQMTVSEK 1023

  Fly  1118 EEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANI 1182
            .|                    .:.|:|..|:  ...|......::|       ||::.||...:
pombe  1024 FE--------------------YDTEQLPSRV--LFYAMDRYFSIHK-------KLKQLLELVGV 1059

  Fly  1183 QHESTLAN--LRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQE 1245
            ::.|.|.|  :.|:..|.:.|  ::|..|.::|.
pombe  1060 ENASLLPNEVVNKQTKDLLYE--KRVVFLKQIKQ------------------------------- 1091

  Fly  1246 KIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIEN--------SDLLRQLEEAESQV-SQLS 1301
              |..:....|.|..| |...|.|.....|.....:.|        .||..|:.|..||: |..:
pombe  1092 --ALTVSSLFNAVGYK-DGVMRLLETDQNSLLFAGVVNFLIFAGISLDLKTQISEFLSQLCSYFT 1153

  Fly  1302 KIKISLTTQLEDTKRLADEESRERATL-----LGKFRNLEHDLDNLREQVEEEAEGKADLQRQLS 1361
            ||...  |.:|:.|.|...|...:|.|     |.|.|:.      |...:...:.||..:...|
pombe  1154 KIVDG--TVIENDKTLDFYEKPLQAVLYWFATLHKIRSF------LVHLLSINSHGKQSVVEDL- 1209

  Fly  1362 KANAEAQVWR------SKYESDGVARSEELEEAKRKLQARLAE--AEETIES-LNQKCIG--LEK 1415
                    |.      ||:.|:       ||.:...|..:|..  .|.:|.: ||.||:.  ::.
pombe  1210 --------WNPLILKFSKHFSN-------LENSFHSLVQKLLSCCTEGSINALLNSKCLPEFIDA 1259

  Fly  1416 TKQRLSTEVEDLQLEVDRAN-----AIANAAEKK--------------QKAFDKIIG-----EWK 1456
            ..:..:....::...:||.|     .|::|.:..              |:||..:|.     .||
pombe  1260 ADENTTPTGMNIYELIDRMNLIHKLLISSALQPNLLELTISHMLQHIGQRAFQTLIHGRSPYTWK 1324

  Fly  1457  1456
            pombe  1325  1324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	9/41 (22%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	252/674 (37%)
		Myosin_tail_1	842..1922	CDD:460256	125/672 (19%)
myo51	NP_596233.1	COG5022	1..1471	CDD:227355	413/1495 (28%)