DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and myo2

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_588114.1	Gene:	myo2 / 2539513	PomBaseID:	SPCC645.05c	Length:	1526	Species:	Schizosaccharomyces pombe

Alignment Length:	1798	Identity:	585/1798 - (32%)
Similarity:	901/1798 - (50%)	Gaps:	348/1798 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 KPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIK---SEKVEKVNPPKFEKIEDM 91
            |..|.|:..||.|.:..:....||....|...| ::....||.|   .::::.|||.||:::.||
pombe    19 KDIDDKRWVWISDPETAFTKAWIKEDLPDKKYV-VRYNNSRDEKIVGEDEIDPVNPAKFDRVNDM 82

  Fly    92 ADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIF 156
            |::|.||.|.|.:||.|||.:..||||||||.||:|||...|:||....::|:.|.:....||:|
pombe    83 AELTYLNEPAVTYNLEQRYLSDQIYTYSGLFLVAVNPYCGLPIYTKDIIQLYKDKTQERKLPHVF 147

  Fly   157 AISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQ 221
            ||:|.||.::|.|..|||:|:|||||||||||||::|.|.|.:.:|     .......:|:|:::
pombe   148 AIADLAYNNLLENKENQSILVTGESGAGKTENTKRIIQYLAAIASS-----TTVGSSQVEEQIIK 207

  Fly   222 TNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFY 286
            ||||||:||||:||||:|||||||||::.|..:|:::.|.||.|||||:||:.|...||:||:||
pombe   208 TNPVLESFGNARTVRNNNSSRFGKFIKVEFSLSGEISNAAIEWYLLEKSRVVHQNEFERNYHVFY 272

  Fly   287 QIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRI 351
            |::||:...:|:..|||||..||..:......:..:||.|||.....||..|||..:|..|::.|
pombe   273 QLLSGADTALKNKLLLTDNCNDYRYLKDSVHIIDGVDDKEEFKTLLAAFKTLGFDDKENFDLFNI 337

  Fly   352 TAAVMHMGGMKFKQRGREEQAEQDG------EEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFV 410
            .:.::|||.:       :..|::.|      .:|..::..|.|.......:||::||||.|:|:|
pombe   338 LSIILHMGNI-------DVGADRSGIARLLNPDEIDKLCHLLGVSPELFSQNLVRPRIKAGHEWV 395

  Fly   411 TQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQL 475
            ...|:..||.:||.||.|.:::|.|.||||:.|.:|:....:.:|||:||||||||||.|.||||
pombe   396 ISARSQTQVISSIEALAKAIYERNFGWLVKRLNTSLNHSNAQSYFIGILDIAGFEIFEKNSFEQL 460

  Fly   476 CINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEK--PMGILSILEEESM 538
            |||:|||||||||||||||||||||.:|.|.|.|||||.||...||||||  |:||||.|:||.:
pombe   461 CINYTNEKLQQFFNHHMFVLEQEEYMKEEIVWDFIDFGHDLQPTIDLIEKANPIGILSCLDEECV 525

  Fly   539 FPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLND 603
            .|||||.||:.||......||.   |.||.|...|.  |.:.|||..|.|:..||||||.||||:
pombe   526 MPKATDATFTSKLDALWRNKSL---KYKPFKFADQG--FILTHYAADVPYSTEGWLEKNTDPLNE 585

  Fly   604 TVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGK-KGGGFATVSSAYKEQLNSLMTTLRSTQ 667
            .|.....:|.||.:..:|:|:.     ..:.|..||: |.|.|.||:..:|||||.||....|||
pombe   586 NVAKLLAQSTNKHVATLFSDYQ-----ETETKTVRGRTKKGLFRTVAQRHKEQLNQLMNQFNSTQ 645

  Fly   668 PHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQ 732
            |||:|||:|||.|:....:..||:.||.||||||||||.|.|||||:.:.||::||:||......
pombe   646 PHFIRCIVPNEEKKMHTFNRPLVLGQLRCNGVLEGIRITRAGFPNRLPFNDFRVRYEIMAHLPTG 710

  Fly   733 GVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSR 797
            ...:.::|:.:|::.:.:.|..||:|.:|:||:||||.::||.|...|.::|:.:|...||:|.|
pombe   711 TYVESRRASVMILEELKIDEASYRIGVSKIFFKAGVLAELEERRVATLQRLMTMLQTRIRGFLQR 775

  Fly   798 KGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELH 862
            |.|:|..:...|:|::|.||:.|.:.||:||.||:..::|||:.::.:
pombe   776 KIFQKRLKDIQAIKLLQANLQVYNEFRTFPWAKLFFNLRPLLSSTQND----------------- 823

  Fly   863 AAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKN----------DLENQ 917
                   |:|:..:|:::..|..|....:.:....:|..|.|..|||.:|          |.|..
pombe   824 -------KQLKKRDAEIIELKYELKKQQNSKSEVERDLVETNNSLTAVENLLTTERAIALDKEEI 881

  Fly   918 LRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIA 982
            ||..||||...||:.::..||.:...:|.:.||:                         :|:|:
pombe   882 LRRTQERLANIEDSFSETKQQNENLQRESASLKQ-------------------------INNEL- 920

  Fly   983 HQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKK----V 1043
             :.||:.|.:|.:.:..|.|                             ||::.|..|:|    .
pombe   921 -ESELLEKTSKVETLLSEQN-----------------------------ELKEKLSLEEKDLLDT 955

  Fly  1044 RGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIK 1108
            :|::|..:   |.:..:..|. |:.....|.|::||..||.||..:|..:.|       ::.:|:
pombe   956 KGELESLR---ENNATVLSEK-AEFNEQCKSLQETIVTKDAELDKLTKYISD-------YKTEIQ 1009

  Fly  1109 ELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKL 1173
            |::...:::.|          |:.:|...|:..|:.: ::||.......:.:.:.|:::.|||.|
pombe  1010 EMRLTNQKMNE----------KSIQQEGSLSESLKRV-KKLERENSTLISDVSILKQQKEELSVL 1063

  Fly  1174 RRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAE--KEKNEYYGQLNDLRAGVDH 1236
            :      .:| |.|:.||.:|.|...|:    |.||.|||.:.|  .:|::.|
pombe  1064 K------GVQ-ELTINNLEEKVNYLEAD----VKQLPKLKKELESLNDKDQLY------------ 1105

  Fly  1237 ITNEKAAQEKIAKQLQHTLN-EVQSKLDETNRTLNDFDASKKKLSIEN-SDLLRQLEEAESQVSQ 1299
                         |||.|.| |:::|:.|   .||:..:..|:|  || .:..:.|.:|..:..:
pombe  1106 -------------QLQATKNKELEAKVKE---CLNNIKSLTKEL--ENKEEKCQNLSDASLKYIE 1152

  Fly  1300 LSKIKISL---TTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQ-RQL 1360
            |.:|..:|   .:.||:.|:              |:..|:.||:.|::         .|.. ::|
pombe  1153 LQEIHENLLLKVSDLENYKK--------------KYEGLQLDLEGLKD---------VDTNFQEL 1194

  Fly  1361 SKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVE 1425
            ||.:.:.     .:..:.:.|    :.|..|.:..||.:|                .:.||.:|.
pombe  1195 SKKHRDL-----TFNHESLLR----QSASYKEKLSLASSE----------------NKDLSNKVS 1234

  Fly  1426 DLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEG 1490
            .|..:|:..:..|:                  ||.:|       :::..|...|..:|...:|:.
pombe  1235 SLTKQVNELSPKAS------------------KVPEL-------ERKITNLMHEYSQLGKTFEDE 1274

  Fly  1491 QEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEEN 1555
            :.:.....|:|    :|::.|..::           :::::||.   |.|..|||.:.      .
pombe  1275 KRKALIASRDN----EELRSLKSEL-----------ESKRKLEV---EYQKVLEEVKT------T 1315

  Fly  1556 KVLRAQLELSQVR----QEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKK 1616
            :.||:::.|.:.:    :.|..::.|.|.:..:|||....||||.                  ||
pombe  1316 RSLRSEVTLLRNKVADHESIRSKLSEVEMKLVDTRKELNSALDSC------------------KK 1362

  Fly  1617 LEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDA-REQLGISERRANAL 1680
            .||:|:.|:.......:.|..|.|..:...:.:...:|..:.:||..:.| .|.|.....|.|..
pombe  1363 REAEIHRLKEHRPSGKENNIPAVKTTEPVLKNIPQRKTIFDLQQRNANQALYENLKRDYDRLNLE 1427

  Fly  1681 QNELEESRTLLEQADRGRRQAEQELAD---AH--------EQLNEVSAQNASISAAKRKLESELQ 1734
            ::.||:....|:.|:...:...|.|..   ||        :|:|...|:..|:.....|.|.|||
pombe  1428 KHNLEKQVNELKGAEVSPQPTGQSLQHVNLAHAIELKALKDQINSEKAKMFSVQVQYEKREQELQ 1492

  Fly  1735 TLHSDLDELLNEAKNSEEKAKKAMVDA-------ARLADELRA 1770
            ...:.|          |:..|.:::|.       |.|.|||||
pombe  1493 KRIASL----------EKVNKDSLIDVRALRDRIASLEDELRA 1525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	9/36 (25%)
		MYSc	81..777	CDD:214580	340/704 (48%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	323/673 (48%)
		Myosin_tail_1	842..1897	CDD:279860	205/974 (21%)
		V_Alix_like	1557..1877	CDD:187408	58/237 (24%)
		ATP-synt_B	<1671..1771	CDD:304375	30/118 (25%)
		TMPIT	1739..>1825	CDD:285135	11/39 (28%)
myo2	NP_588114.1	COG5022	6..1516	CDD:227355	578/1787 (32%)
		Myosin_N	25..>48	CDD:280832	5/22 (23%)
		MYSc_class_II	91..743	CDD:276951	323/673 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	621	1.000	Domainoid score	I26
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68044
Inparanoid	1	1.050	794	1.000	Inparanoid score	I68
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		mtm9311
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
TreeFam	1	0.960	-	-
	12	11.820