DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and myo7aa

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	XP_021323248.1	Gene:	myo7aa / 252846	ZFINID:	ZDB-GENE-020709-1	Length:	2185	Species:	Danio rerio

Alignment Length:	2080	Identity:	539/2080 - (25%)
Similarity:	843/2080 - (40%)	Gaps:	545/2080 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 WIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSE------------KVEKVNPPKFEKIEDM 91
            |: |.|.|:   |.:...|.:|.: ...|:::.:..|            .::.::|.....:|||
Zfish    11 WL-DLKTGH---EFEVPIGAVVKL-CDSGQIQVLDDEGNEHWISPQNATNIKPMHPTSIHGVEDM 70

  Fly    92 ADMTVLNTPCVLHNLRQRYYAKLIY------TYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNE 150
            ..:..||...:|.||..||...|||      ||:|...||:|||:..|:||....::|..|:..|
Zfish    71 IRLGDLNEAGILRNLLIRYREHLIYTNCGGRTYTGSILVAVNPYQLLPIYTADQIRLYTNKKIGE 135

  Fly   151 VPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSL 215
            :|||||||:|..|.:|..|:.:|..:|:|||||||||:||.::.:.|.:......         :
Zfish   136 MPPHIFAIADNCYFNMQRNNKDQCCIISGESGAGKTESTKLILQFLAAISGQHSW---------I 191

  Fly   216 EDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLER 280
            |.||::.||:|||||||||:||||||||||:|.|||...|.:.||.||.|||||:||..|...||
Zfish   192 EQQVLEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQARDER 256

  Fly   281 SYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVA-SIDDAEEFSLTDQAFDILGFTKQE 344
            :|||||.::.|..|..|....|: ...||..::.|..||. ..||.:|:|....|..:|.||.:|
Zfish   257 NYHIFYCMLKGMTPDQKKQLGLS-KATDYTYLTIGNCTVCDGRDDQKEYSNIRSAMKVLMFTDKE 320

  Fly   345 KEDVYRITAAVMHMGGMKFKQRGRE--EQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGN 407
            ..::.::.||::|||.::::.|..:  :..|..........:.|...|..:|...|....|....
Zfish   321 NWEISKLLAAILHMGNLRYEARTYDNLDACEVVRCSALTTAAVLLEVDLKDLMNCLTSRTIITRG 385

  Fly   408 EFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCN------ETLDTQQKRQHFIGVLDIAGFEI 466
            |.|:...:::|..:...|..||::.|||.|:|:|.|      .:|:.:..|:. ||:|||.|||.
Zfish   386 ETVSTPLSIEQALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPSLELKAVRRS-IGLLDIFGFEN 449

  Fly   467 FEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDF-----GMDLLACIDLIEKP 526
            |..|.||||||||.||.|||||..|:|.||||||..|.|:|..|:|     .:|::|.     ||
Zfish   450 FMVNSFEQLCINFANENLQQFFVRHVFKLEQEEYNLENINWQHIEFTDNQDALDMIAI-----KP 509

  Fly   527 MGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNIT 591
            |.|:|:::|||.|||.||.|...||.:.|...:...    ||| ......|.|.|:||.|.|...
Zfish   510 MNIISLIDEESKFPKGTDTTMLNKLNSQHKLNTNYI----PPK-NTYETQFGIQHFAGVVYYETR 569

  Fly   592 GWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQL 656
            |:||||:|.|:..::.....|:||.:.:||.        .:.|.|...:|..  .|:||.:|..|
Zfish   570 GFLEKNRDTLHGDIIQLVHSSKNKFIKQIFQ--------ADVAMGAETRKRS--PTLSSQFKRSL 624

  Fly   657 NSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKM 721
            ..||.||...||.|||||.|||.|:|.:.|..|.:.||..:|::|.|||.|.|:|.|..:.:|..
Zfish   625 ELLMRTLSVCQPFFVRCIKPNEYKKPMLFDRELCVRQLRYSGMMETIRIRRAGYPIRYTFVEFVD 689

  Fly   722 RYKIMCPKLLQGV-----EKDKKAT-EIIIKFIDLPEDQYRLGNTKVFFR--AGVLGQMEE---- 774
            ||:::.|    ||     ::|.:.| :.|.:.:...:|.:::|.||:|.:  ..:|.::|.
Zfish   690 RYRVLMP----GVKPAYKQEDLRGTCQRIAEAVLGRDDDWQMGKTKIFLKDHHDMLLEIERDKAI 750

  Fly   775 -------------FRDE----RLGKIMSWMQAWARGYLSRK-------GFKKLQ----------- 804
                         |:|.    ::.|....:|...|||..||       ||.:||
Zfish   751 TDKVILIQKVVRGFKDRSNFLKMKKSAMLIQKTWRGYYCRKNYGAMRGGFSRLQALYRSRKLYQT 815

  Fly   805 ----EQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNV-SRIEDEIARLEEKAKKAEELHAA 864
                .||:.|  .|...|.:|..|.:. ::||    .::.: :.....|||...|..|.|
Zfish   816 YHVARQRIML--FQGRCRGFLVRRAFR-HRLW----AVITIQAYTRGMIARRLYKRLKGE----- 868

  Fly   865 EVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQ-- 927
               .|:.|||...: |||:..|.:.:|.          |.||..|:|..        ||||.|
Zfish   869 ---YRRRLEAEKLR-LAEEQKLRNQMSA----------RKAKEEAEKMH--------QERLAQLA 911

  Fly   928 EEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLN 992
            .|||     :::||..||   .::.:|.|: .::||.|:.         :||     .::::|:
Zfish   912 REDA-----EREKKERQE---ARRKMEMLD-QMEKARQEP---------VND-----SDMVDKM- 952

  Fly   993 KEKKMQGETNQKTGEELQAA---EDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKV 1054
              ....|.||...|:|.||.   ||           ||:|..|||..         |:::|....
Zfish   953 --FGFLGTTNSFPGQEGQAPAGFED-----------LERTHRELEVE---------DLDESLPLP 995

  Fly  1055 EGDLK-LTQEAVADLERN-----------KKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQI 1107
            |.||: |::...|.....           ::.|:|.:...:.|...:.|..  ..:.||:....:
Zfish   996 EDDLEDLSEYKFAKFSATYFQGTSTHTYMRRPLKQPLLFHEDEGDQLAALA--VWITVLRFMGDL 1058

  Fly  1108 KE--LQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAEL 1170
            .|  ....|.:..|::....:......|:  ...|||:.|      .|...:..||.:||
Zfish  1059 PEPKYHTAISDGSEKIPVMTKIYETLGKK--TYKRELQAL------QGEGENTNIESHKK----- 1110

  Fly  1171 SKLRRDLEEANIQHESTLA-NLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGV 1234
            |.:|..|....::.:|.:. .:.|:.||  .|.....:.:.:.:..:..||..:......||.|:
Zfish  1111 SSVRHKLVSLTLKKKSKITEEVTKRLND--GEYTVHGNSMLEDRPTSNLEKLHFIIGNGILRPGL 1173

  Fly  1235 -DHI-------TNEK--------------------AAQEKIAKQLQHTLNE--------VQSKLD 1263
             |.|       .|:.                    |..||..|.|::.::|        .:.:|.
Zfish  1174 RDEIYCQICKQLNQNPSKSSHARGWILMSLCVGCFAPSEKFVKYLRNFISEGPPGYAPYCEERLR 1238

  Fly  1264 ET----NRT--------------------LNDFDASKKKLSIENSDLLRQLEEAES-QVSQLSKI 1303
            .|    .||                    :...|.:.|.|..:::...::|..|.| ::|...:.
Zfish  1239 RTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNALSDKISLQDRF 1303

  Fly  1304 KISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQ 1368
            ..||...|.|           :.:.||.  ..:|.:|.: .|.|:.|:.:...:|     ||.
Zfish  1304 GFSLYIALFD-----------KVSSLGS--GNDHVMDAV-SQCEQYAKEQGAQER-----NAP-- 1347

  Fly  1369 VWRSKYE-----------SDGVARSEELEEAKR--KLQARLAEAEETIESLNQKC-------IGL 1413
             ||..:.           .|.||.:...::..|  |......:.|:..|..:|:.       |.:
Zfish  1348 -WRLFFRKEIFTPWHDPAEDAVATNLIYQQIVRGVKFGEYRCDREDLAELASQQYYVDYGSEILV 1411

  Fly  1414 EKTKQRLSTEVEDLQLE----VDRANAIANAAEKK----------QKAFDKIIG----EWKLKVD 1460
            |:....:.:.:.|.::.    |:|......||.||          ||..::::.    :|.|...
Zfish  1412 ERLLSLIPSYIPDREISSAKTVERWAQFIMAAHKKGVYTQKRVDPQKVKEEVVDFARYKWPLLFS 1476

  Fly  1461 DLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEI 1525
                         |.|  |.|:..|......:.:.||........||.:.:|
Zfish  1477 -------------RFY--EAFKFSGPSLPKNDVIVAVNWTGVYFVDEQEQVL------------- 1513

  Fly  1526 EKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQ 1590
                         |:.:..|..|....:..|:......|:.:          |.:||..|..|.:
Zfish  1514 -------------LELSFPEITAVSSSKGGKLQAQSFTLATI----------KADEFTFTSNNAE 1555

  Fly  1591 RALDSMQASLEAEAKGKAEALRMKKK----------------------------LEADINELEIA 1627
            ...|.:...|        |.||.:.|                            |:.|..|..:.
Zfish  1556 DIRDLVVTFL--------EGLRKRSKFVVALQDNPSPAADDSTFLSFLKGDLIVLDQDTGEQVMT 1612

  Fly  1628 LDHANKANAEAQK-------------NIKRYQQQLKDIQTALEEEQRARDDAREQLGIS------ 1673
            ...|:..|...::             .:.|....:....| :..:||     :|.|.||
Zfish  1613 SGWAHGTNDRTKQRGDFPADCVYVLPTVVRPPHDVVAFVT-MTPDQR-----QESLRISHVPALT 1671

  Fly  1674 ERRANALQNELEE--------------SRTLLEQADRGR-----------RQAEQELADAHEQL- 1712
            |.........|||              ||.::.: :||:           :||..:....||:|
Zfish  1672 ETEERVKPYTLEEFSYDYFRPPPKHTLSRVMITK-NRGKDKLWCCTREPIKQALLKKCGGHEELS 1735

  Fly  1713 -------------------------NEVSAQ--NASISAAKRKLESELQTLHSDLDELLNEAKNS 1750
                                     ||::.|  ..::.|...|.|...|.| ..|.|  |..|.|
Zfish  1736 QEACMAFIAVMKYMGDYPSKRTRSVNELTDQIFEGALKAEPLKDEIYCQIL-KQLTE--NHIKYS 1797

  Fly  1751 EEKAKKAM-----------VDAARLADELRAEQDH---AQTQEKLRKALEQQIKELQVRLDEAEA 1801
            |||..:.:           |....:...|::::.|   ....::|:|||....::....|.|.||
Zfish  1798 EEKGWELLWLCVGLFPPSNVLLPHVQRFLQSKKHHPLALDCMQRLQKALRNGSRKYPPHLVEVEA 1862

Fly 1802 1801
Zfish 1863 1862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	8/33 (24%)
		MYSc	81..777	CDD:214580	279/740 (38%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	270/690 (39%)
		Myosin_tail_1	842..1897	CDD:279860	230/1193 (19%)
		V_Alix_like	1557..1877	CDD:187408	65/359 (18%)
		ATP-synt_B	<1671..1771	CDD:304375	33/169 (20%)
		TMPIT	1739..>1825	CDD:285135	19/77 (25%)
myo7aa	XP_021323248.1	MYSc_Myo7	79..735	CDD:276832	270/690 (39%)
		IQ	772..793	CDD:197470	7/20 (35%)
		MAP7	<863..941	CDD:310345	33/113 (29%)
		UFD1	893..>1160	CDD:332114	75/337 (22%)
		MyTH4	1023..1259	CDD:214535	45/252 (18%)
		B41	1265..1479	CDD:214604	45/248 (18%)
		FERM_C1_MyoVII	1473..1571	CDD:270019	26/156 (17%)
		SH3	1572..1636	CDD:327375	6/63 (10%)
		MyTH4	1716..1864	CDD:214535	32/150 (21%)
		B41	1871..2083	CDD:214604
		FERM_C2_MyoVII	2079..2174	CDD:270020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910