DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and Myo5b

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_008770307.1 Gene:Myo5b / 25132 RGDID:621347 Length:1854 Species:Rattus norvegicus


Alignment Length:2043 Identity:552/2043 - (27%)
Similarity:902/2043 - (44%) Gaps:435/2043 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 WIPDEKEGYLLGEIKATK----GD-IVSVGLQGGEVR----DIKSEKVEKV-NPPKFEKIEDMAD 93
            ||||..|.:...|:  ||    || .:.:.|:...:.    |:::.:|..: ||.......|:..
  Rat    22 WIPDPDEVWRSAEL--TKDYKDGDESLQLRLEDDTILDYPIDVQNNQVPFLRNPDILVGENDLTA 84

  Fly    94 MTVLNTPCVLHNLRQRYY-AKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFA 157
            ::.|:.|.|||||:.|:. :..||||.|:..||||||::.|:|.......|.|:...::.|||||
  Rat    85 LSHLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYAYSGQNMGDMDPHIFA 149

  Fly   158 ISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQT 222
            :::.||..|..:..|||::::||||||||.:.|..:.||||||.|       .|..::|::|:.:
  Rat   150 VAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGS-------ASDTNIEEKVLAS 207

  Fly   223 NPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQ 287
            :|::||.|||||.||||||||||:|.|.|.....:.||::.||||||:||:.|...||:||||||
  Rat   208 SPIMEAIGNAKTTRNDNSSRFGKYIEIGFDKKYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQ 272

  Fly   288 I-MSGSVPGVKDICL--LTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVY 349
            : .:.|:|..|::.|  ..|..|..|   .|..|:..:||||:|..|.||..:||..:..:..::
  Rat   273 LCAAASLPEFKELALTCAEDFFYTAH---GGNTTIEGVDDAEDFEKTRQALTLLGVRESHQISIF 334

  Fly   350 RITAAVMHMGGMKFKQRGREEQAEQDG--------EEEGGRVSKLFGCDTAELYKNLLKPRIKVG 406
            :|.|:::|:|.:       |.|||:||        :|......:|.|.:.:::...|...::...
  Rat   335 KIIASILHLGSV-------EIQAERDGDSCSISPQDEHLSNFCRLLGIEHSQMEHWLCHRKLVTT 392

  Fly   407 NEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNG 471
            :|...:..::|||.|:..||.|.::.:||.|:|:..|:.|.|..|:..|||||||.|||.||.|.
  Rat   393 SETYVKTMSLQQVVNARNALAKHIYAQLFSWIVEHINKALQTSLKQHSFIGVLDIYGFETFEINS 457

  Fly   472 FEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEE 536
            |||.|||:.||||||.||.|:|.||||||.:|.|.|..||| .|...||||||..:|||.:|:||
  Rat   458 FEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDF-YDNQPCIDLIEAKLGILDLLDEE 521

  Fly   537 SMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPL 601
            ...||.|||.:::||...| ..|..||||:     .....|.:.|:|..|.|...|:||||:|.:
  Rat   522 CKVPKGTDQNWAQKLYERH-SNSQHFQKPR-----MSNTAFIVIHFADKVEYLSDGFLEKNRDTV 580

  Fly   602 NDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRG-------------------KKGGGFAT 647
            .:..::..|.|:..|:.::|.|..........||....                   ||..|:  
  Rat   581 YEEQINILKASKFPLVADLFRDDKDSVPATNTAKSRSSSKINVRSSRPLMKAPNKEHKKSVGY-- 643

  Fly   648 VSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPN 712
               .::..||.||.||.:|.||:||||.||:.|.|...|....:.||...||||.|||...|:|:
  Rat   644 ---QFRTSLNLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPS 705

  Fly   713 RMMYPDFKMRYKIMCPKLLQGVEKDKK-----ATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQM 772
            |..|.||..||:::..|.......|||     ..|.:||    ..|:::.|.||:|||||.:..:
  Rat   706 RWTYHDFFNRYRVLMKKRELANTTDKKNICKSVLESLIK----DPDKFQFGRTKIFFRAGQVAYL 766

  Fly   773 EEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYK------L 831
            |:.|.::..:....:|...||:|.|..:::|   |.|...:||..|.||..|.....:      :
  Rat   767 EKLRADKFREATIMIQKTVRGWLQRVKYRRL---RAATLTLQRFCRGYLARRLTEHLRRTRAAIV 828

  Fly   832 WQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGA 896
            :||...:|...|....:.|    |....:.:...:.||:....:   |...|..::...:....|
  Rat   829 FQKQYRMLKARRAYCRVRR----AAVIIQSYTRAMCVRRSYRQV---LTEHKATIIQKYARGWMA 886

  Fly   897 LQDYQ-ERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNV 960
            .:.:| :|:|.:..|......:.|...:.|..|..:...|.:.....:.::..|::.|:|     
  Rat   887 RRHFQRQRDAAIVIQCAFRRLKARQALKALKIEARSAEHLKRLNVGMENKVVQLQRKIDD----- 946

  Fly   961 QKAEQDKATKDHQIRNLNDEIA-----HQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLN 1020
                |:|     :.:.|:::::     |..| :.||.|| ..:.:.||:....||          
  Rat   947 ----QNK-----EFKTLSEQLSAVTSTHAME-VEKLKKE-LARYQQNQEADPSLQ---------- 990

  Fly  1021 KVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLER-------NKKELEQT 1078
                 |::.:..|...|::....|..:|.:..:..|:|:   :.|||||.       .|:.|...
  Rat   991 -----LQEEVQSLRTELQKAHSERRVLEDTHNRENGELR---KRVADLEHENALLKDEKEHLNNQ 1047

  Fly  1079 IQRKDKELSS---------ITAKLEDEQVVVLKHQRQIKE---LQARIEELEEEVEA-------E 1124
            |.|:.|..||         |..:||:|:   .::|..:||   |:.|.|.|.:|.:.       .
  Rat  1048 ILRQSKAESSQSSVEENLLIKKELEEER---SRYQNLVKEYSQLEQRYENLRDEQQTPGHRKNPS 1109

  Fly  1125 RQARAKAEK-----------QRADLARELEELGERLEEAGGATSAQIELNKK---REAELSKLRR 1175
            .|:..:::.           ...|..:::||:|  :|:|....:..::|.|:   .|.|..||:.
  Rat  1110 NQSSLESDSNYPSISTSEIGDTEDALQQVEEIG--IEKAAMDMTVFLKLQKRVRELEQERKKLQV 1172

  Fly  1176 DLEEANIQHESTLANLRKKHN----DAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDH 1236
            .||:.  |.:|....:.:::|    |..|::|....:..:|:::.:|.||:    ||:||..|  
  Rat  1173 QLEKE--QQDSKKVQVEQQNNGLDVDQDADIAYNSLKRQELESENKKLKND----LNELRKAV-- 1229

  Fly  1237 ITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLS 1301
              .::|.|:          |...|..|..:..||....:.::|.:...::|              
  Rat  1230 --ADQAMQD----------NSTHSSPDSYSLLLNQLKLANEELEVRKEEVL-------------- 1268

  Fly  1302 KIKISLTTQL--EDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKAN 1364
                .|.||:  .|.:||:.:...........:.|.|..:|  :|...|...|       :.:.|
  Rat  1269 ----ILRTQIMNADQRRLSGKNMEPNINARTSWPNSEKHVD--QEDAIEAYHG-------VCQTN 1320

  Fly  1365 AEAQVWRSKYESDGVARSEELEEAKRKLQ--ARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDL 1427
            ::.:.| .....||     ||..|.:.|:  |||.||:...::|..     |:..:.|..:||.:
  Rat  1321 SQTEDW-GYLNEDG-----ELGLAYQGLKQVARLLEAQLQAQNLKH-----EEEVEHLKAQVEAM 1374

  Fly  1428 QLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQE 1492
            :.|:|          |:|:.|                        |:   |.|...:...|.|.:
  Rat  1375 KEEMD----------KQQQTF------------------------CQ---TLLLSPEAQVEFGVQ 1402

  Fly  1493 QLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKV 1557
            | |..|..|:||  :.|:|          :.::||..|:|   |.:|:..:::.:          
  Rat  1403 Q-EISRLTNENL--DFKEL----------VEKLEKNEKKL---KKQLKIYMKKVQ---------- 1441

  Fly  1558 LRAQLELSQVRQEIDRR---------IQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRM 1613
               .||.:|...:.|||         :|.||::|:...:.|:                :.||| :
  Rat  1442 ---DLEAAQALAQSDRRHHELTRQVTVQRKEKDFQGMLEYHK----------------EDEAL-L 1486

  Fly  1614 KKKLEADINE--------------LEIALDHANKANAE-------------AQKNIKRYQQQLKD 1651
            .:.|..|:..              |.:.:.||:..|.:             .:|.:|::.:..:.
  Rat  1487 IRNLVTDLKPQMLSGTVPCLPAYILYMCIRHADYTNDDLKVHSLLSSTINGIKKVLKKHNEDFEM 1551

  Fly  1652 IQTALEE--------EQRARDDAREQLGISERRANALQN-ELEESRTLLEQADRGRRQAEQELAD 1707
            ....|..        :|.:.|:.......:::..:.|:| :|.|.|.:|....   .|..|:|..
  Rat  1552 TSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLS---IQIYQQLIK 1613

  Fly  1708 AHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDA--ARLADELRA 1770
            ..|.|    .|...:||   .||:|      .:..|.........|...:|||.  :...:.:..
  Rat  1614 IAEGL----LQPMIVSA---MLENE------SIQGLSGVRPTGYRKRSSSMVDGENSYCLEAIIR 1665

  Fly  1771 EQDHAQT----QEKLRKALEQQIKELQVRLDEAEANALKGGKKAI-----QKLEQRVRELENELD 1826
            :.:...|    |....:.:.|..|:|...::....|.|...|.|.     .:|...:.:||..|.
  Rat  1666 QMNFFHTVLCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDACSWSTGMQLRYNISQLEEWLR 1730

  Fly  1827 GEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAAL- 1890
            |         |||::|..               .:.|:.|: :..|.::..|:..|:||.|.:| 
  Rat  1731 G---------KNLQQSGA---------------VQTMEPLI-QAAQLLQLKKKTQEDAEAICSLC 1770

  Fly  1891 ------NLAKFRKAQQELEEAEERADLA 1912
                  .:.|.......|.|.|||..::
  Rat  1771 TSLSTQQIVKILNLYTPLNEFEERVTVS 1798

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 12/42 (29%)
MYSc 81..777 CDD:214580 285/731 (39%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 276/700 (39%)
Myosin_tail_1 842..1897 CDD:279860 231/1171 (20%)
V_Alix_like 1557..1877 CDD:187408 68/375 (18%)
ATP-synt_B <1671..1771 CDD:304375 22/102 (22%)
TMPIT 1739..>1825 CDD:285135 17/96 (18%)
Myo5bXP_008770307.1 MYSc 72..770 CDD:214580 285/730 (39%)
MYSc_Myo5 91..759 CDD:276831 276/700 (39%)
IQ 871..891 CDD:197470 2/19 (11%)
DUF1690 910..1002 CDD:285231 22/122 (18%)
Rab5-bind 919..1179 CDD:286404 64/300 (21%)
RILP-like <979..1069 CDD:304877 24/107 (22%)
Uso1_p115_C 1155..1267 CDD:282695 31/131 (24%)
GBP_C <1340..1416 CDD:303769 27/120 (23%)
coiled coil 1385..1396 CDD:293879 4/37 (11%)
coiled coil 1405..1416 CDD:293879 4/12 (33%)
Myo5b_CBD 1480..1851 CDD:271261 69/377 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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