DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and Myo1g

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	XP_006514763.1	Gene:	Myo1g / 246177	MGIID:	1927091	Length:	1039	Species:	Mus musculus

Alignment Length:	1020	Identity:	298/1020 - (29%)
Similarity:	484/1020 - (47%)	Gaps:	133/1020 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 IYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITG 179
            ||||.|...|::|||:..|:|.......|:|:...|.|||::|:::.||..|.....:..::|:|
Mouse    59 IYTYIGEVLVSVNPYQELPLYGPEAIAKYQGRELYERPPHLYAVANAAYKAMKRRSRDTCIVISG 123

  Fly   180 ESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFG 244
            ||||||||.:|.::.|.|.|....:..|..:.|..|    :::..||||||||:|.||.||||||
Mouse   124 ESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKNVL----LKSTCVLEAFGNARTNRNHNSSRFG 184

  Fly   245 KFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDY 309
            |::.|:|...|...|..|.:|||||:||:.|...||::|.|||::.||.........|..|...|
Mouse   185 KYMDINFDFKGDPVGGHIHSYLLEKSRVLKQHVGERNFHAFYQLLRGSEDQELQGLHLERNPAVY 249

  Fly   310 HIVSQG---KVTVASIDDAEEFSLTD--QAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGRE 369
            :...||   .:.|.:..|::|.|...  :|..|:||:..|.|.::||.||::|:|.::|
Mouse   250 NFTRQGAGLNMGVHNALDSDEKSHQGVMEAMRIIGFSPDEVESIHRILAAILHLGNIEF------ 308

  Fly   370 EQAEQDGEEEG----------GRVSKLFGCDTAELYKNLLKPRI-KVGNEFVTQGRNVQQVTNSI 423
            .:.|::|.::|          |.|:||.......:.:.||...: ..|.|.:.:...|.:.:.:.
Mouse   309 VETEENGPQKGGLEVADEALVGYVAKLTATPRDLVLRTLLARTVASGGREVIEKSHTVAEASYAR 373

  Fly   424 GALCKGVFDRLFKWLVKKCNETLDTQQK------RQHFIGVLDIAGFEIFEYNGFEQLCINFTNE 482
            .|..|.::.|||:|:|.|.|..::.:.:      :...||||||.|||:|..|.|||.|||:.||
Mouse   374 DACAKAMYQRLFEWVVNKINSIMEPRNRDPRCDGKDTVIGVLDIYGFEVFPVNSFEQFCINYCNE 438

  Fly   483 KLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKP-MGILSILEEE-SMFPKATDQ 545
            ||||.|...:...|||||:||||.|..|:: .:....::|:|:| .|||::|:|. |.....||:
Mouse   439 KLQQLFIQLILKQEQEEYEREGIAWQTIEY-FNNATIVELVEQPHRGILAVLDEACSTAGPITDR 502

  Fly   546 TFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFA----IAHYAGCVSYNITGWLEKNKDPLNDTVV 606
            .|.:.|...|  :..|....:...|..:...|.    |.||||.|:|::.|:::||:|.|    .
Mouse   503 IFLQTLDTHH--RHHPHYSSRQLCPTDKTMEFGRDFQIKHYAGDVTYSVEGFIDKNRDSL----F 561

  Fly   607 DQFKK----SQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQ 667
            ..||:    |.:..|..::.|  ||....|..|..        .|..:.:|..:.:|:..|.|.:
Mouse   562 QDFKRLLYNSVDPTLRAMWPD--GQQDITEVTKRP--------LTAGTLFKNSMVALVENLASKE 616

  Fly   668 PHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMC----P 728
            |.:||||.|||.|..|.:|.....||:...|:||.:|:.|.||.:|..||.|.:|||:.|    |
Mouse   617 PFYVRCIKPNEDKVAGRLDEAHCRHQVEYLGLLENVRVRRAGFASRQPYPRFLLRYKMTCEYTWP 681

  Fly   729 KLLQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRA-GVLGQMEEFRDERLGKIMSWMQ-AWA 791
            ..|.|.::|  |...:::...|..| ...|::|:|.|: ..|..:|:.|...:..|:..:| ||
Mouse   682 NHLLGSDRD--AVSALLEQHGLQGD-VAFGHSKLFIRSPRTLVTLEQSRARLIPIIVLLLQKAW- 742

  Fly   792 RGYLSRKGFKKLQEQRVALKVVQRN---------LRKYLQLRTWPWY---KLWQK----VKPLLN 840
            ||.|:|...::|:.....::..:|:         .|::...|..|.|   .:|..    ::|..:
Mouse   743 RGTLARWHCRRLRAIYTIMRWFRRHKVRAHLIELQRRFQAARQPPLYGRDLVWPTPPAVLQPFQD 807

  Fly   841 VSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNA 905
            ..|:.....|..:..|........::|         ||:.|            .||||..::
Mouse   808 TCRVLFSRWRARQLVKNIPPSDMIQIK---------AKVAA------------MGALQGLRQ--- 848

  Fly   906 KLTAQKNDLENQLRDIQERLTQEED--ARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKA 968
                   |...|....::.|:.:.|  ..:.||.::.||.:|..|....:  ...:|:|..:.:.
Mouse   849 -------DWGCQRAWARDYLSSDTDNPTASHLFAEQLKALREKDGFGSVL--FSSHVRKVNRFRK 904

  Fly   969 TKDHQIRNLND------EIAHQDELINKLNKEK----KMQGETNQKTGEELQAAEDKINHLNKVK 1023
            ::|..:. |.|      |...|..::..:..|.    .:....:|......|..:|.:..|::.:
Mouse   905 SRDRALL-LTDRYLYKLEPGRQYRVMRAVPLEAVTGLSVTSGRDQLVVLHAQGYDDLVVCLHRSQ 968

  Fly  1024 AKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADL 1068
            ..|:..:.||...|...  .:|:....:.:|...:.|:|.....|
Mouse   969 PPLDNRIGELVGMLAAH--CQGEGRTLEVRVSDCIPLSQRGARRL 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832
		MYSc	81..777	CDD:214580	239/698 (34%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	236/685 (34%)
		Myosin_tail_1	842..1897	CDD:279860	42/239 (18%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
Myo1g	XP_006514763.1	MYSc_Myo1	52..715	CDD:276829	236/685 (34%)
Myo1g	XP_006514763.1	Myosin_TH1	836..1007	CDD:368706	36/197 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000