Protein Alignment Mhc and Myh3

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_036736.1
• Gene: Myh3 / 24583
• RGDID: 3138
• Length: 1940
• Species: Rattus norvegicus
• Alignment Length: 1918
• Identity: 1074/1918 - (55%)
• Similarity: 1431/1918 - (74%)
• Gaps: 14/1918 - (0%)

  Fly    15 PYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGETRDLKKDLLQQ 79
            |:|..|.::|...|::|:|:|..|::.|.||.|..|:||:::...|:|..:...|..:|.:.:..
  Rat    15 PFLRKSEKERIEAQNQPFDAKTYCFVVDSKEEYAKGKIKSSQDGKVTVETEDNRTLVVKPEDVYA 79

  Fly    80 VNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYR 144
            :||||::|.|||:.||:||:.:||:||:.||.:.:||||||||||.:||||..||||......||
  Rat    80 MNPPKFDKIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYTPEVVDGYR 144

  Fly   145 GKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGA----SKKT 205
            ||:|.|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.||||:.|    :||.
  Rat   145 GKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKK 209

  Fly   206 DEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKA 270
            |  :|.||:||||::..||:|||||||||||||||||||||||||||.|||||.||||||||||:
  Rat   210 D--SKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKS 272

  Fly   271 RVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAF 335
            ||..|...||||||||||:|...|.:.::.|:|.|.|||..:|||::.||||||.||...||.|.
  Rat   273 RVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDREELLATDSAI 337

  Fly   336 DILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLK 400
            ||||||.:||..:|::|.||||.|.|||||:.||||||.||.|...:.:.|.|.::::|.|.|..
  Rat   338 DILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCF 402

  Fly   401 PRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFE 465
            ||:|||||:||:|:.|.||.:::.||.|.|:::||.|:|.:.|:.|||:..||||||||||||||
  Rat   403 PRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFE 467

  Fly   466 IFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPMGIL 530
            |||||..||||||||||||||||||||||||||||::||||||||||||||..||:||||||||.
  Rat   468 IFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIF 532

  Fly   531 SILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLE 595
            ||||||.|||||||.:|..||.:.|||||..|||||..| |:..|||::.||||.|.|:::||||
  Rat   533 SILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVK-GKAEAHFSLIHYAGTVDYSVSGWLE 596

  Fly   596 KNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLM 660
            |||||||:|||..::||.|:||..::|..|.....|.:.|..: |||..|.|||:.::|.||.||
  Rat   597 KNKDPLNETVVGLYQKSSNRLLAHLYATFATTDADGGKKKVAK-KKGSSFQTVSALFRENLNKLM 660

  Fly   661 TTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKI 725
            :.||:|.|||||||||||.|.||.::..||:|||.||||||||||||||||||::|.|||.||::
  Rat   661 SNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRV 725

  Fly   726 MCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWM 787
            :....:   |.:: .|||.|.::..||:...||:.|:|||||:||:||.:||.|||||.|:::..
  Rat   726 LNASAIPEGQFID-SKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDERLAKLITRT 789

  Fly   788 QAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLE 852
            ||..||:|.|..|:|:.::|.::..:|.|:|.::.::.|||.||:.|:||||..:..|.|:|.::
  Rat   790 QAVCRGFLMRVEFQKMMQRRESIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMK 854

  Fly   853 EKAKKA-EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLEN 916
            |:.:|. :||..:|.| |||||.....|:.||..|...:..|...|.|.:||..:|...|..||.
  Rat   855 EEFQKTKDELAKSEAK-RKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEA 918

  Fly   917 QLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEI 981
            :::::.||...||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:|:
  Rat   919 KIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEL 983

  Fly   982 AHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGD 1046
            |..||.|.||.:|||...|.:|:|.::|||.|||:|.|:|:|:||||.:|:||.|||:|||:|.|
  Rat   984 AGLDETIAKLTREKKALQEAHQQTLDDLQAEEDKVNSLSKLKSKLEQQVDDLESSLEQEKKLRVD 1048

  Fly  1047 VEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQ 1111
            :|::|||:||||||.||::.|||.:|::|::.:::||.|.|.:.:|:||||.:.|:.|::|||||
  Rat  1049 LERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYSQLQSKVEDEQTLSLQLQKKIKELQ 1113

  Fly  1112 ARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRD 1176
            |||||||||:||||..|||.||||:|.|||||||.||||||||.||.|||||||||||..|||||
  Rat  1114 ARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRD 1178

  Fly  1177 LEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEK 1241
            ||||.:|||:|:|.|||||.|:.||:|||:|.|.::|.|.||||:|:..:::||.:.|:.::..|
  Rat  1179 LEEATLQHEATVATLRKKHADSAAELAEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSVESVSKSK 1243

  Fly  1242 AAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKIS 1306
            |..|||.:.|:..|:|.:.|.:||.|:|::....|.:|..|..:|.|||||.||.|||||:.|.:
  Rat  1244 ANLEKICRTLEDQLSEARGKNEETQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQA 1308

  Fly  1307 LTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWR 1371
            .|.|:|:.||..:||::.:..|....::..||.|.||||.|||.||||:|||.|||||:|...||
  Rat  1309 FTQQIEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWR 1373

  Fly  1372 SKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANA 1436
            :|||:|.:.|:|||||||:||..||.::||.:|::|.||..||||||||..|||||.::|:|||:
  Rat  1374 TKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANS 1438

  Fly  1437 IANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRREN 1501
            :|.|.:|||:.|||::.|||.|.::..|||:|:.||.|:.|||||:||.||||..:|||.|:|||
  Rat  1439 LAAALDKKQRNFDKVLAEWKTKCEESQAELEAALKESRSLSTELFKLKNAYEEALDQLETVKREN 1503

  Fly  1502 KNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQ 1566
            |||..|:.||.:||.|.|::|||:||:||::|.||.::|.||||||||||.||.|:||.||||:|
  Rat  1504 KNLEQEIADLTEQIAENGKSIHELEKSRKQMELEKADIQMALEEAEAALEHEEAKILRIQLELTQ 1568

  Fly  1567 VRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHA 1631
            |:.||||:|.||:||.|..::|:||.:::||.:|:||.:.:.||:|:|||:|.|:||:||.|.||
  Rat  1569 VKSEIDRKIAEKDEEIEQLKRNYQRTVETMQGALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHA 1633

  Fly  1632 NKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADR 1696
            |:..||..|:::..|.||||.|..|::..|.::|.:|||.|.|||||.||.|:||.|..|||.:|
  Rat  1634 NRQAAETIKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTER 1698

  Fly  1697 GRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDA 1761
            .|:.|||||.|::|::..:..||.|:...|:|||::|..|.|::::...:|:|:|||||||:.||
  Rat  1699 ARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLTQLQSEVEDASRDARNAEEKAKKAITDA 1763

  Fly  1762 ARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELD 1826
            |.:|:||:.|||.:...|:::|.|||.:|:||.||||||..|||||||.|||||.|:||||.||:
  Rat  1764 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELE 1828

  Fly  1827 GEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALN 1891
            |||:|:.::.|.|||.|||||||::||||||||..|:||||||||.|:|:||||.|||:|.|.::
  Rat  1829 GEQKRNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANVH 1893

  Fly  1892 LAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            |.||||||.||||||||||:||..::|.|||.|
  Rat  1894 LTKFRKAQHELEEAEERADIAESQVNKLRAKTR 1926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	14/41 (34%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	418/671 (62%)
		Myosin_tail_1	842..1922	CDD:460256	586/1080 (54%)
Myh3	NP_036736.1	Myosin_N	33..77	CDD:460670	14/43 (33%)
		MYSc_Myh3	100..767	CDD:276878	418/671 (62%)
		Actin-binding	656..678		16/21 (76%)
		Actin-binding	758..772		8/13 (62%)
		Myosin_tail_1	847..1924	CDD:460256	586/1077 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1289		8/28 (29%)