DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and Myh11

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_006245904.1 Gene:Myh11 / 24582 RGDID:3136 Length:1979 Species:Rattus norvegicus


Alignment Length:1941 Identity:777/1941 - (40%)
Similarity:1182/1941 - (60%) Gaps:35/1941 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 DPTPYLFVSLEQRRIDQ---SKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGL-QGGEVRDI 72
            |...:|||  ::..|:.   ...:.:||..|:|.||:|:....||..|||.|.|.| :.|:...:
  Rat     9 DDEKFLFV--DKNFINSPMAQADWVAKKLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTV 71

  Fly    73 KSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTN 137
            ..:.::|:|||||.|:||||::|.||...||||||:||::.|||||||||||.:||||..|:|:.
  Rat    72 GKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSE 136

  Fly   138 RCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGAS 202
            :...||:||:|:|:||||:||:|.||..||.:..:||:|.||||||||||||||||.|.|.|.:|
  Rat   137 KIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASS 201

  Fly   203 KK-------TDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGA 260
            .|       |...:.:.|.||.|::|.||:||||||||||:|||||||||||||:|..||.:.||
  Rat   202 HKGKKDSSITQGPSFAYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGA 266

  Fly   261 DIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDA 325
            :||||||||:|.|.|...||::||||.:::|:...::: .||.::...|..:|.|.|.:.:..|.
  Rat   267 NIETYLLEKSRAIRQARDERTFHIFYYLIAGAKEKMRN-DLLLESFNSYTFLSNGFVPIPAAQDD 330

  Fly   326 EEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCD 390
            |.|..|.:|..|:||:::|:..:.::.::|:.:|.:.||:....:||.........:|..|.|.:
  Rat   331 EMFQETLEAMSIMGFSEEEQLAILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLVGIN 395

  Fly   391 TAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLD-TQQKRQH 454
            ..:..:.:|.||||||.:.|.:.:..:|...:|.||.|..::|||:|::.:.|:.|| |.::...
  Rat   396 VTDFTRAILTPRIKVGRDVVQKAQTKEQADFAIEALAKATYERLFRWILSRVNKALDKTHRQGAS 460

  Fly   455 FIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLAC 519
            |:|:||||||||||.|.|||||||:|||||||.|||.||:||||||:||||:|.|||||:||..|
  Rat   461 FLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPC 525

  Fly   520 IDLIEK---PMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAH 581
            |:|||:   |.|:|::|:||..||||||::|.|||.:.. |....|||||..|   ....|:|.|
  Rat   526 IELIERPNNPPGVLALLDEECWFPKATDKSFVEKLCSEQ-GNHPKFQKPKQLK---DKTEFSIIH 586

  Fly   582 YAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAK--------GGR 638
            |||.|.||.:.||.||.|||||.|......|.:|.:.:::.|.....|..:.||        ..:
  Rat   587 YAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASK 651

  Fly   639 GKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGI 703
            .|| |.|.||...|||||..||||||:|.|:||||||||..|:.|.:||.||:.||.||||||||
  Rat   652 TKK-GMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGI 715

  Fly   704 RICRKGFPNRMMYPDFKMRYKIMCPKLL-QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAG 767
            ||||:|||||:::.:|:.||:|:....: :|....|:|..::||.::|..:.||:|.:|:|||.|
  Rat   716 RICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTG 780

  Fly   768 VLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLW 832
            ||..:||.||.::..::...||..||||:||.|.|.|:|..|:||:|||...||:||.|.|::|:
  Rat   781 VLAHLEEERDLKITDVIMAFQAMCRGYLARKAFTKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLF 845

  Fly   833 QKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGAL 897
            .||||||.|:|.|:|:...||:.:|.:|.........||||..:.:|..|||.|.:.|..|....
  Rat   846 TKVKPLLQVTRQEEEMQAKEEEMQKIKERQQKAESELKELEQRHTQLAEEKTLLQEQLQAETELY 910

  Fly   898 QDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQK 962
            .:.:|...:|.|:|.:||..|.:::.||.:|||...||..::||..|::..|::.:|:.|...||
  Rat   911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRSQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975

  Fly   963 AEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLE 1027
            .:.:|.|.:.:|:.|.|:|...|:..|||:||:|:..|........|...|:|..:|.|:|:|.|
  Rat   976 LQLEKVTAEAKIKKLEDDILVMDDQNNKLSKERKLLEERVSDLTTNLAEEEEKAKNLTKLKSKHE 1040

  Fly  1028 QTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAK 1092
            ..:.|||..|::|:|.|.::||.|||:|||.....|.:|||:....||:..:.:|::||.:..|:
  Rat  1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105

  Fly  1093 LEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATS 1157
            |::|........::|:||:..:.:|:|::::||.||.|||||:.||..|||.|...||:...:|:
  Rat  1106 LDEEITQKNNALKKIRELEGHVSDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1170

  Fly  1158 AQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNE 1222
            .|.||..|||.|::.|::.|:|....||:.:..:|:||..||.|:.||::|..:.||..:|.|..
  Rat  1171 TQQELRAKREQEVTMLKKALDEETRSHEAQVQEMRQKHTQAVEELTEQLEQFKRAKANLDKSKQT 1235

  Fly  1223 YYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLL 1287
            ...:..||...:..:...|...|...|:|:..|.|:|||..:..|...:......||..|...:.
  Rat  1236 LEKENADLAGELRVLGQAKQEVEHKKKKLEGQLQELQSKCSDGERARTELSDKVHKLQNEVESVT 1300

  Fly  1288 RQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEG 1352
            ..|.|||.:..:|:|...||.:||:||:.|..||:|::..:..|.|.||.:.::|::|::||.|.
  Rat  1301 GMLNEAEGKAIKLAKEVASLGSQLQDTQELLQEETRQKLNVSTKLRQLEDERNSLQDQLDEEMEA 1365

  Fly  1353 KADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTK 1417
            |.:|:|.:|..|.:....:.|.: |..:..|.:||.|::||..:....:..|........|||||
  Rat  1366 KQNLERHVSTLNIQLSDSKKKLQ-DLASTIEVMEEGKKRLQKEMEGLGQQYEEKAAAYDKLEKTK 1429

  Fly  1418 QRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFR 1482
            .||..|::||.:::|....:.:..|||||.||:::.|.|......|.|.|.::.|.|...|:...
  Rat  1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQKKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494

  Fly  1483 LKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAE 1547
            |..|.||..|..|.:.|.||.|..|::||:....:.|:|:||:||:::.||.:.:|::..|||.|
  Rat  1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMRTQLEELE 1559

  Fly  1548 AALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALR 1612
            ..|:..|:..||.::.:..::.:.:|.:|.::|:.|..|:..||.|...:..||.|.|.:|.|..
  Rat  1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA 1624

  Fly  1613 MKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRA 1677
            .|||||.|:.:||:..|.|.|...||.|.:::.|.|:||.|..|::.:.:||:.......:|::|
  Rat  1625 AKKKLEGDLKDLELQADSAVKGREEAIKQLRKLQAQMKDFQRELDDARASRDEIFATSKENEKKA 1689

  Fly  1678 NALQNELEESRTLLEQADRGRRQAEQELADAHEQL-NEVSAQNASISAAKRKLESELQTLHSDLD 1741
            .:|:.||.:.:..|..|:|.|:||:.|..:..|:| :.:|.:| ::...||:||:.:..|..:|:
  Rat  1690 KSLEAELMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN-TLQDEKRRLEARIAQLEEELE 1753

  Fly  1742 ELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKG 1806
            |.....:...::.:||.:.|.:|::||..|:..||..|..|:.||:|.|||:.:|.|.|......
  Rat  1754 EEQGNMEAMSDRVRKATLQAEQLSNELVTERSAAQKNESARQQLERQNKELRSKLQEVEGAVKAK 1818

  Fly  1807 GKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQ 1871
            .|..:..||.::.:||.:::.|.|....|.|.|::.::::||:..|.|::||..|:.::..:|..
  Rat  1819 LKSTVAALEAKIVQLEEQIEQEAREKQAATKLLKQKDKKLKEVLLQVEDERKMVEQYKEQAEKGN 1883

  Fly  1872 QKIKTYKRQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAGS 1927
            .|:|..|||:|||||.:....|..||.|:||:||.|..:...:.::..::|.|.|:
  Rat  1884 TKVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 15/37 (41%)
MYSc 81..777 CDD:214580 355/715 (50%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 335/684 (49%)
Myosin_tail_1 842..1897 CDD:279860 355/1055 (34%)
V_Alix_like 1557..1877 CDD:187408 101/320 (32%)
ATP-synt_B <1671..1771 CDD:304375 29/100 (29%)
TMPIT 1739..>1825 CDD:285135 27/85 (32%)
Myh11XP_006245904.1 Myosin_N 34..71 CDD:280832 15/36 (42%)
Myosin_head 87..778 CDD:278492 342/696 (49%)
MYSc_class_II 99..778 CDD:276951 335/684 (49%)
Myosin_tail_1 855..1935 CDD:279860 363/1081 (34%)
FAM76 <997..1089 CDD:292665 36/91 (40%)
UBAN 1049..1163 CDD:301588 44/113 (39%)
BAR <1166..>1295 CDD:299863 40/128 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.820

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