DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and MYO16

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_001185879.1 Gene:MYO16 / 23026 HGNCID:29822 Length:1880 Species:Homo sapiens


Alignment Length:1084 Identity:279/1084 - (25%)
Similarity:487/1084 - (44%) Gaps:210/1084 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 LEQRRIDQSKPYD----------SKKS-CWIPDEKEGYLLGE----IKATKG--------DIVSV 62
            |....:.|.:||:          ||.| ..:|..|:..||.:    ..||||        .|...
Human   341 LSASTLAQEEPYEEIIHDLPVLSSKLSPLVLPIAKQDSLLEKDIMFKDATKGLCKQQSQDSIPEN 405

  Fly    63 GLQGGEVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAIN 127
            .:..|..   |.|:| |:.||  ...:|:|.::.||...:|:.:::|:....|||:.|...:.:|
Human   406 PMMSGST---KPEQV-KLMPP--APNDDLATLSELNDGSLLYEIQKRFGNNQIYTFIGDILLLVN 464

  Fly   128 PYKRYPVYTNRCAKMY---RGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENT 189
            |||..|:|::..:::|   .||..:.:|||:|:..:.|:..:......|..:::||.|:||:|.:
Human   465 PYKELPIYSSMVSQLYFSSSGKLCSSLPPHLFSCVERAFHQLFREQRPQCFILSGERGSGKSEAS 529

  Fly   190 KKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHF-GP 253
            |::|.:.        |..|..|:.:|:.:......:|||||:|||..||.||.|.|:..:.| ..
Human   530 KQIIRHL--------TCRAGASRATLDSRFKHVVCILEAFGHAKTTLNDLSSCFIKYFELQFCER 586

  Fly   254 TGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVT 318
            ..:|.||.|.||||||:|::||...:.::.|||.:|.| :...:...|..:|:..:..::|   |
Human   587 KQQLTGARIYTYLLEKSRLVSQPLGQSNFLIFYLLMDG-LSAEEKYGLHLNNLCAHRYLNQ---T 647

  Fly   319 VASIDDA---------EEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQ 374
            :.  |||         |:.::..:|.:::||:..|.|:::.|.||::|:|.::|........|..
Human   648 IQ--DDASTGERSLNREKLAVLKRALNVVGFSSLEVENLFVILAAILHLGDIRFTALNEGNSAFV 710

  Fly   375 DGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLV 439
            ...:...:|:.:....|.||...|.........:.:.:...:|........|.|.::.|||.:||
Human   711 SDLQLLEQVAGMLQVSTDELASALTTDIQYFKGDMIIRRHTIQIAEFFRDLLAKSLYSRLFSFLV 775

  Fly   440 KKCNETLDTQQKRQHF----IGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEY 500
            ...|..|.:|.:::..    ||:|||.|||.|:.|.|||||:|.||||:..:.|..:|:.||.|.
Human   776 NTMNSCLHSQDEQKSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHEQVEC 840

  Fly   501 KREGI--DWAF--------IDFGMDLLACIDLIEKPMGILSILEEESMFPKATDQTFSEKL---- 551
            .:||:  :.|:        :||         ..:||.|.|::|:|||....:.:..|.:||    
Human   841 VQEGVTMETAYSPGNQNGVLDF---------FFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLL 896

  Fly   552 --TNTHLGKSAPFQKPKPPKPG-------QQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVD 607
              :||:...|       |.|.|       .....|.|.||||.|.|::.|.:|||||.|:..::.
Human   897 ESSNTNAVYS-------PMKDGNGNVALKDHGTAFTIMHYAGRVMYDVVGAIEKNKDSLSQNLLF 954

  Fly   608 QFKKSQNKLLIEIFADHAGQSGGGEQA------KGGRG--------------------------- 639
            ..|.|:|.::..:|.....|:|....|      :|.:.                           
Human   955 VMKTSENVVINHLFQSKLSQTGSLVSAYPSFKFRGHKSALLSKKMTASSIIGENKNYLELSKLLK 1019

  Fly   640 KKG----------GGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQL 694
            |||          |...|::|..::.|..::..|:...|||:.||.||..|.|...|...|..||
Human  1020 KKGTSTFLQRLERGDPVTIASQLRKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQL 1084

  Fly   695 TCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATE---IIIKFIDLPEDQYR 756
            ...||||.::|.|.|:|.|:.:.||..|||.:....|: .:|::.|.|   ::::...|  ..::
Human  1085 QYIGVLEMVKIFRYGYPVRLSFSDFLSRYKPLADTFLR-EKKEQSAAERCRLVLQQCKL--QGWQ 1146

  Fly   757 LGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQ-RNLRKY 820
            :|..|||.:.....|:.:...:...||:: .|...||:|:|:...    ||::::..: .::..:
Human  1147 MGVRKVFLKYWHADQLNDLCLQLQRKIIT-CQKVIRGFLARQHLL----QRISIRQQEVTSINSF 1206

  Fly   821 LQ------LRTW------------------------PWYKLWQKVKPLLNVSRIEDEIARLEEKA 855
            ||      |:|:                        |::|  :|    |.|..:::|.::..:..
Human  1207 LQNTEDMGLKTYDALVIQNASDIARENDRLRSEMNAPYHK--EK----LEVRNMQEEGSKRTDDK 1265

  Fly   856 KKAEELHAAEVKVRKELEALNAKLLAEKT---------ALLDSLS----GEKGALQDYQERNAKL 907
            ......|.:.:.|...::.|...|:....         ::.||.|    .::...:..::.|.:|
Human  1266 SGPRHFHPSSMSVCAAVDGLGQCLVGPSIWSPSLHSVFSMDDSSSLPSPRKQPPPKPKRDPNTRL 1330

  Fly   908 TAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKK 951
            :|       ....:...|:...:|.|:...:.:....:.|.:||
Human  1331 SA-------SYEAVSACLSAAREAANEALARPRPHSDDYSTMKK 1367

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 11/49 (22%)
MYSc 81..777 CDD:214580 223/781 (29%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 216/750 (29%)
Myosin_tail_1 842..1897 CDD:279860 17/123 (14%)
V_Alix_like 1557..1877 CDD:187408
ATP-synt_B <1671..1771 CDD:304375
TMPIT 1739..>1825 CDD:285135
MYO16NP_001185879.1 ANKYR 81..332 CDD:223738
ANK repeat 86..112 CDD:293786
ANK 89..190 CDD:238125
ANK repeat 114..145 CDD:293786
ANK 142..297 CDD:238125
ANK repeat 147..178 CDD:293786
ANK repeat 180..210 CDD:293786
ANK repeat 243..274 CDD:293786
ANK repeat 276..307 CDD:293786
ANK repeat 309..335 CDD:293786
MYSc 426..1165 CDD:214580 221/771 (29%)
MYSc_Myo16 437..1155 CDD:276844 216/750 (29%)
NYAP_N 1253..1590 CDD:292079 17/122 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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