Protein Alignment Mhc and MYO16

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_001185879.1
• Gene: MYO16 / 23026
• HGNCID: 29822
• Length: 1880
• Species: Homo sapiens
• Alignment Length: 1084
• Identity: 280/1084 - (25%)
• Similarity: 488/1084 - (45%)
• Gaps: 210/1084 - (19%)

  Fly    21 LEQRRIDQSKPYD----------SKKS-CWIPDEKEGYLLGE----IKATKG--------DIVSV 62
            |....:.|.:||:          ||.| ..:|..|:..||.:    ..||||        .|...
Human   341 LSASTLAQEEPYEEIIHDLPVLSSKLSPLVLPIAKQDSLLEKDIMFKDATKGLCKQQSQDSIPEN 405

  Fly    63 GLQGGETRDLKKDLLQQVNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAIN 127
            .:..|.|:..:..|:    ||  ...:|::.|:.|||.|:|:.:::|:.|..|||:.|...:.:|
Human   406 PMMSGSTKPEQVKLM----PP--APNDDLATLSELNDGSLLYEIQKRFGNNQIYTFIGDILLLVN 464

  Fly   128 PYKRYPVYTNRCAKMY---RGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENT 189
            |||..|:|::..:::|   .||..:.:|||:|:..:.|:..:......|..:::||.|:||:|.:
Human   465 PYKELPIYSSMVSQLYFSSSGKLCSSLPPHLFSCVERAFHQLFREQRPQCFILSGERGSGKSEAS 529

  Fly   190 KKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHF-GP 253
            |::|.:.        |..|..|:.:|:.:......:|||||:|||..||.||.|.|:..:.| ..
Human   530 KQIIRHL--------TCRAGASRATLDSRFKHVVCILEAFGHAKTTLNDLSSCFIKYFELQFCER 586

  Fly   254 TGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVT 318
            ..:|.||.|.||||||:|::||...:.::.|||.:|.| :...:...|..:|:..:..::|   |
Human   587 KQQLTGARIYTYLLEKSRLVSQPLGQSNFLIFYLLMDG-LSAEEKYGLHLNNLCAHRYLNQ---T 647

  Fly   319 VASIDDA---------EEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQ 374
            :.  |||         |:.::..:|.:::||:..|.|:::.|.||::|:|.::|........|..
Human   648 IQ--DDASTGERSLNREKLAVLKRALNVVGFSSLEVENLFVILAAILHLGDIRFTALNEGNSAFV 710

  Fly   375 DGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLV 439
            ...:...:|:.:....|.||...|.........:.:.:...:|........|.|.::.|||.:||
Human   711 SDLQLLEQVAGMLQVSTDELASALTTDIQYFKGDMIIRRHTIQIAEFFRDLLAKSLYSRLFSFLV 775

  Fly   440 KKCNETLDTQQKRQHF----IGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEY 500
            ...|..|.:|.:::..    ||:|||.|||.|:.|.|||||:|.||||:..:.|..:|:.||.|.
Human   776 NTMNSCLHSQDEQKSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHEQVEC 840

  Fly   501 QREGI--EWTF--------IDFGMDLQLCIDLIEKPMGILSILEEESMFPKATDQTFSEKL---- 551
            .:||:  |..:        :||         ..:||.|.|::|:|||....:.:..|.:||
Human   841 VQEGVTMETAYSPGNQNGVLDF---------FFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLL 896

  Fly   552 --TNTHLGKSAPFQKPKPPKPG-------QQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVD 607
              :||:...|       |.|.|       .....|.|.||||.|.|::.|.:|||||.|:..::.
Human   897 ESSNTNAVYS-------PMKDGNGNVALKDHGTAFTIMHYAGRVMYDVVGAIEKNKDSLSQNLLF 954

  Fly   608 QFKKSQNKLLIEIFADHAGQSGGGEQA------KGGRG--------------------------- 639
            ..|.|:|.::..:|.....|:|....|      :|.:.
Human   955 VMKTSENVVINHLFQSKLSQTGSLVSAYPSFKFRGHKSALLSKKMTASSIIGENKNYLELSKLLK 1019

  Fly   640 KKG----------GGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQL 694
            |||          |...|::|..::.|..::..|:...|||:.||.||..|.|...|...|..||
Human  1020 KKGTSTFLQRLERGDPVTIASQLRKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQL 1084

  Fly   695 TCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATE---IIIKFIDLPEDQYR 756
            ...||||.::|.|.|:|.|:.:.||..|||.:....|: .:|::.|.|   ::::...|  ..::
Human  1085 QYIGVLEMVKIFRYGYPVRLSFSDFLSRYKPLADTFLR-EKKEQSAAERCRLVLQQCKL--QGWQ 1146

  Fly   757 LGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQ-RNLRKY 820
            :|..|||.:.....|:.:...:...||:: .|...||:|:|:...    ||::::..: .::..:
Human  1147 MGVRKVFLKYWHADQLNDLCLQLQRKIIT-CQKVIRGFLARQHLL----QRISIRQQEVTSINSF 1206

  Fly   821 LQ------LRTW------------------------PWYKLWQKVKPLLNVSRIEDEIARLEEKA 855
            ||      |:|:                        |::|  :|    |.|..:::|.::..:..
Human  1207 LQNTEDMGLKTYDALVIQNASDIARENDRLRSEMNAPYHK--EK----LEVRNMQEEGSKRTDDK 1265

  Fly   856 KKAEELHAAEVKVRKELEALNAKLLAEKT---------ALLDSLS----GEKGALQDYQERNAKL 907
            ......|.:.:.|...::.|...|:....         ::.||.|    .::...:..::.|.:|
Human  1266 SGPRHFHPSSMSVCAAVDGLGQCLVGPSIWSPSLHSVFSMDDSSSLPSPRKQPPPKPKRDPNTRL 1330

  Fly   908 TAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKK 951
            :|       ....:...|:...:|.|:...:.:....:.|.:||
Human  1331 SA-------SYEAVSACLSAAREAANEALARPRPHSDDYSTMKK 1367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	14/64 (22%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	218/750 (29%)
		Myosin_tail_1	842..1922	CDD:460256	17/123 (14%)
MYO16	NP_001185879.1	ANKYR	67..347	CDD:440430	1/5 (20%)
		ANK repeat	86..112	CDD:293786
		ANK repeat	114..145	CDD:293786
		ANK repeat	147..178	CDD:293786
		ANK repeat	180..210	CDD:293786
		ANK repeat	243..274	CDD:293786
		ANK repeat	276..307	CDD:293786
		ANK repeat	309..335	CDD:293786
		MYSc_Myo16	437..1155	CDD:276844	218/750 (29%)
		NYAP_N	1243..1590	CDD:464717	22/138 (16%)
		NYAP_C	1652..1880	CDD:464724