DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and MYH15

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_011510861.1 Gene:MYH15 / 22989 HGNCID:31073 Length:1946 Species:Homo sapiens


Alignment Length:1904 Identity:920/1904 - (48%)
Similarity:1316/1904 - (69%) Gaps:17/1904 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 QSKPYDSKKSCWIPDEKEGYLLGEIKATKGD-IVSVGLQGGEVRDIKSEKVEKVNPPKFEKIEDM 91
            |:...|.||.|||||.:..|:..|:|.::.| .|.|....||...||.:|::::|||:||.||||
Human    44 QATALDGKKKCWIPDGENAYIEAEVKGSEDDGTVIVETADGESLSIKEDKIQQMNPPEFEMIEDM 108

  Fly    92 ADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIF 156
            |.:|.||...|||.|::||...:||||||||||.|||||..|||.......|:||||:|.|||||
Human   109 AMLTHLNEASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIF 173

  Fly   157 AISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQ 221
            |:::.|:.|||.|..|||:|.|||||||||.|:|.:|.||||:.|   ..|:.|.:|:||||::|
Human   174 AVANNAFQDMLHNRENQSILFTGESGAGKTVNSKHIIQYFATIAA---MIESRKKQGALEDQIMQ 235

  Fly   222 TNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFY 286
            .|.:|||||||||:|||||||||||||:|||..|.|:..||:.|||||:|||.||:.||:|||||
Human   236 ANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFY 300

  Fly   287 QIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRI 351
            ||:||. ..:.|:.|::.|..|:|..|.|.|||.|:|||||...|:||.|||||...||...|::
Human   301 QILSGQ-KELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMDILGFLPDEKYGCYKL 364

  Fly   352 TAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNV 416
            |.|:||.|.|||||:.||||.|.||.|...:.:.|.|.:::||.|.|:.||||||||:||:|:.:
Human   365 TGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTI 429

  Fly   417 QQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTN 481
            :|||.::|||.|.:::|:|||||.:.|..||.:..||.|||:|||.||||.|||..|||||||||
Human   430 EQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTN 494

  Fly   482 EKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESMFPKATDQT 546
            ||||||||.|||||||||||:|.|:|..|.||:||.|||||||||||||||||||.|||||||.|
Human   495 EKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGLDLQACIDLIEKPMGILSILEEECMFPKATDLT 559

  Fly   547 FSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKK 611
            |..||.:.|.|||...|||||.|. :..|||.:.||||.|.|||:||||||||.||:|||..|:|
Human   560 FKTKLFDNHFGKSVHLQKPKPDKK-KFEAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQK 623

  Fly   612 SQNKLLIEIFADHAGQSGG---GEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRC 673
            |.|:||..:|.::......   ||:.:    |||..|.||:|.:||.||.|||.|:||.||||||
Human   624 SSNRLLASLFENYMSTDSAIPFGEKKR----KKGASFQTVASLHKENLNKLMTNLKSTAPHFVRC 684

  Fly   674 IIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVE--K 736
            |.||..|.||::|.:||:.||.|||||||.||||:|||||:.|.|||.||.|:.|:.....:  .
Human   685 INPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFVS 749

  Fly   737 DKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFK 801
            .:||.|.::..:::...|||.|.|||||:||.|||:|..|||||.|:.:..||.|:|.|.|..|:
Human   750 SRKAAEELLGSLEIDHTQYRFGITKVFFKAGFLGQLEAIRDERLSKVFTLFQARAQGKLMRIKFQ 814

  Fly   802 KLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARL-EEKAKKAEELHAAE 865
            |:.|:|.||.::|.|:|.::.::.|||.:|:.|:|||:..|.:.:|:|.| ||.|:..:.|..:|
Human   815 KILEERDALILIQWNIRAFMAVKNWPWMRLFFKIKPLVKSSEVGEEVAGLKEECAQLQKALEKSE 879

  Fly   866 VKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEED 930
            .: |:||:|....|..||..|:..|..|:..|.:.:|:...|...|..||.:::::.||:.:||:
Human   880 FQ-REELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEE 943

  Fly   931 ARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEK 995
            ..::|..:.:|.:.|...|||:|:|||..:.|:|::|.|.:|:::||.:|:...:|.|:|||:..
Human   944 INSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAA 1008

  Fly   996 KMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKL 1060
            |:..|.:|:|.::|...|:|::.|:|...||||.:||||.:||:|:|.|.:.|:...|:||:|||
Human  1009 KVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKL 1073

  Fly  1061 TQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAER 1125
            .:|::.:||.:::.|.:.:::|:.|||.:.:|:|:|:.:|.:.|:.:||||.:|::|:|::||||
Human  1074 NRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAER 1138

  Fly  1126 QARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLAN 1190
            ..|||.|::||||.::|.:|.|||||.||::.||:|:.||:|.:..||.||:|||.:..|:|.|:
Human  1139 TTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSAS 1203

  Fly  1191 LRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTL 1255
            |:|:|.|::||:..||:.|.::|.|.||:|::...:::||...|:.:|..||..||:....:..|
Human  1204 LKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERL 1268

  Fly  1256 NEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADE 1320
            :|..:|||:..:..||..|.|.||..|:.:.||:|||.|:.::|||:.|.:.|.|:||.:...::
Human  1269 HEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEK 1333

  Fly  1321 ESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEEL 1385
            |::.::.|....:..:.|.|.||||.|||.|.||:|.|.|||.|||...||.|||::.:.|:|:|
Human  1334 ETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDL 1398

  Fly  1386 EEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDK 1450
            |:||::|..||.||.|.:...|.:...||:.:.:|..|:.|...::.:..:.|...::||....|
Human  1399 EDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGK 1463

  Fly  1451 IIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQI 1515
            .:.:||.|.::..|.|||||||.:..||||.:||..|||.....|.:|||||||.:|:.:|.:|:
Human  1464 ALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQV 1528

  Fly  1516 GEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEE 1580
            .||.:|:.|:||.:|.:|.||.|:|..|||.|.|||:.|:|:|..||||.:.:.|::|::.||:|
Human  1529 REGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDE 1593

  Fly  1581 EFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKNIKRY 1645
            |.||.|:..|..:||:|:||::|||.:.|..|:|||:|.|:||:|:.|..||:..:||.|::.:.
Human  1594 EIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQL 1658

  Fly  1646 QQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQAEQELADAHE 1710
            |.|:||:|..|::..:...|.:||:.::|||.:.||:|||:.|:|.||.:||||.:|:||.:|.|
Human  1659 QIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATE 1723

  Fly  1711 QLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHA 1775
            ::|....||.|:.:.|:|||:::..:..:.:|::.|.:|:|||||||.::||.|::||:.:||..
Human  1724 RINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTI 1788

  Fly  1776 QTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLR 1840
            ...|:.|:.:||.|.:||.||.|||..||.|.:|.|||||.||||||.||:||.||.|:||:..|
Human  1789 AHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGAR 1853

  Fly  1841 KSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKAQQELEEA 1905
            :.||.:|||::|:|||:||..|||..:||||.|::.||:|:|.||..|...|:|::|.|.||.|.
Human  1854 RLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEV 1918

  Fly  1906 EERADLAEQAISKFRAKGR 1924
            :|||::||..::|.:.|.|
Human  1919 KERAEVAESQVNKLKIKAR 1937

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 14/37 (38%)
MYSc 81..777 CDD:214580 412/700 (59%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 392/669 (59%)
Myosin_tail_1 842..1897 CDD:279860 446/1055 (42%)
V_Alix_like 1557..1877 CDD:187408 150/319 (47%)
ATP-synt_B <1671..1771 CDD:304375 44/99 (44%)
TMPIT 1739..>1825 CDD:285135 44/85 (52%)
MYH15XP_011510861.1 Myosin_N 52..90 CDD:280832 14/37 (38%)
Myosin_head 105..778 CDD:278492 400/681 (59%)
MYSc_Myh15_mammals 117..778 CDD:276892 392/669 (59%)
Myosin_tail_1 859..1935 CDD:279860 456/1076 (42%)
CENP-Q 1017..1164 CDD:289839 63/146 (43%)
DUF2317 <1487..1600 CDD:302887 54/112 (48%)
DUF4337 <1864..>1940 CDD:290935 36/74 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 1116 1.000 Domainoid score I20
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 2097 1.000 Inparanoid score I44
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D41153at33208
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - otm41736
orthoMCL 1 0.900 - - OOG6_100110
Panther 1 1.100 - - O PTHR45615
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.830

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