Protein Alignment Mhc and Myo15b

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_001371162.1
• Gene: Myo15b / 217328
• MGIID: 2685534
• Length: 3069
• Species: Mus musculus
• Alignment Length: 2347
• Identity: 498/2347 - (21%)
• Similarity: 837/2347 - (35%)
• Gaps: 705/2347 - (30%)

  Fly    11 EDP-------TPYLFVSLEQRRIDQSKPYDSKKSCWIP-DEKEGYLLGEIKATKGDIVSVGLQGG 67
            |||       .|.|.:   :.|:.|:.|..|.:..|.| |:.|..|
Mouse   595 EDPELGADTLLPQLTL---ETRLRQNSPCRSPRERWEPEDDTEAAL------------------- 637

  Fly    68 ETRDLKKDLLQQVNPPKY------------EKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSG 120
             .|||:..|.:.:..|.:            |..||::.|..:.|:|||..|::|::...|||:.|
Mouse   638 -ERDLELSLQRNLEMPPFLGAKTGSLPESLEDIEDLARLRLVCDSSVLLCLKKRFHLGRIYTFGG 701

  Fly   121 LFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGK 185
            ...:|:||::..|::::.....|..::.....||||||...||....:...:..:|:.|.||:||
Mouse   702 PLLLALNPHRSLPLFSSEVLASYHPRKAPNTTPHIFAIGAAAYSLSQSTGQDSCILLGGHSGSGK 766

  Fly   186 TENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIH 250
            ||..||::.:.:::|  :|..||  :...|||.:    |||.:||:|||:.|.|:||||:.||:.
Mouse   767 TEGAKKILEFLSSLG--QKPMEA--NLAQLEDIL----PVLGSFGHAKTILNANASRFGQEIRLC 823

  Fly   251 FGPTGKLAGADIETYLLEKARVI-----------------------SQQSL-------------E 279
            . ..|.:.||.:..||||.:||:                       |.|:|             |
Mouse   824 L-QQGLIVGASVSHYLLETSRVVFQVMTSLLPTPSPALKVGKRTGHSPQALLPTKPVSLPKAQAE 887

  Fly   280 RSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQE 344
            ||:|:||::::|..|..::...|......|::...|...:...:||::|....:|...||...:|
Mouse   888 RSFHVFYELLAGLDPTEREQLSLQGPEAYYYLNQGGACRLQGKEDAQDFKELMKALRGLGLCAEE 952

  Fly   345 KEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVS-----------------KLFGCDTA 392
            ...|:.:.|.::|:|.:.|....||.|       |...||                 :|.|..|.
Mouse   953 LTAVWAVLATILHLGNICFSSSERESQ-------EVAAVSSWAEIHLAARLLQVPPERLEGAVTK 1010

  Fly   393 ELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHF-- 455
            .:......|        |::...|:...::..||.|.::.|||.||:|..|..|...::....
Mouse  1011 RVMDTPYGP--------VSRPLPVEGAIDARDALAKTLYTRLFTWLLKHINARLSPPREADSVAT 1067

  Fly   456 IGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCI 520
            |.|:|..|||....||.||||.|..:|:||.|.:..:...|:|..|:|.::|..|. ....|.|:
Mouse  1068 IAVVDAFGFEALRVNGLEQLCSNLASERLQLFSSQKLLAQEEEVCQQELLKWVPIP-QPPRQSCL 1131

  Fly   521 D-LIEKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAG 584
            | |:.:|..:|:||:.::...:|||.||.:| .:.|.|....:.||:.|.|     .|.:.||||
Mouse  1132 DLLVGQPHSLLNILDTQTWLSQATDHTFLQK-CHYHHGDHPSYAKPQLPLP-----IFTVRHYAG 1190

  Fly   585 CVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVS 649
            .|:|.:..::.:|:..|:..|::..::||.:|:..:|.: |....|.||.|          .|::
Mouse  1191 TVTYQVHKFINRNRGHLDPAVLEMLRQSQLQLMGSLFQE-AEPQAGTEQNK----------PTLA 1244

  Fly   650 SAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRM 714
            |.:::.|..|:..|.....:.:.|:.|...|.||::|...|..||...|:||.|......||.|:
Mouse  1245 SRFQQTLGDLLARLGRGHVYVIHCLNPTPGKIPGLLDVGHVAEQLRQAGILEIIGTRSTHFPVRV 1309

  Fly   715 MYPDFKMRYKIMCPKLLQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDER 779
            .:..|..|:..:.....:.....::...|:.:.:......|.||.|:|..:.....|:|:...:|
Mouse  1310 SFQVFLARFHALGSGRQKAASDQERCGAILSEVLGAESPLYHLGVTQVLLQEQGWQQLEQLWAQR 1374

  Fly   780 LGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRI 844
            ..:.:..:....|..::|:..:.|...:..::.:|.. ::|||.|:    .|.| :..:|.|:|
Mouse  1375 RSQALLTLHRGLRACITRQRLRLLPRMQARVRGLQAR-KRYLQRRS----ALGQ-LNTILLVAR- 1432

  Fly   845 EDEIARLEEKAKKAEELHAAEVKVRKELEALNAK--------LLAEKTALLDSLSGEKGALQDYQ 901
              .:.|..:|.:......||.       |||..:        :.|:...||:...|.:
Mouse  1433 --PLLRRRQKLRLLSWGWAAS-------EALETRPSDLGRLEIPAQLATLLERAEGHQ------- 1481

  Fly   902 ERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIED------LELNV 960
               |.||.          .|.|.|..|..||..|            .|..||:.      :..:.
Mouse  1482 ---ALLTG----------SITESLPPEVPARPSL------------TLPPDIDQFPFSSFVSTSF 1521

  Fly   961 QKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAK 1025
            ||....:..:.            .||.:.:|:      ||..|      ||.|     :|:|..:
Mouse  1522 QKPFLPRPGQP------------LDEPLTRLD------GENPQ------QALE-----INRVMLR 1557

  Fly  1026 LEQTLDELEDSLER-EKKVRGD--VEKSKRKVEGDLKLTQEAVADLERNKKE------------- 1074
            |..     |.||:. :::..|.  |::::|:.....:|..:.||.|.||..|
Mouse  1558 LLG-----EGSLQSWQEQTMGTFLVQQAQRRPGLRDELFSQLVAQLWRNPDEQQNQRGWALMVIL 1617

  Fly  1075 ---------LEQTIQR--KDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAERQAR 1128
                     ||:.:.:  .|:..|.:.|..:.:.:..|:        |..:..:........|..
Mouse  1618 LSSFAPTPALEKPLLKFVSDQAPSGMAALCQHKLLGALE--------QTPLAPMASRSHPPTQLE 1674

  Fly  1129 AKAEKQRADLARELEELGERLEEAGGATSAQIE-----------LNKKREAEL-----------S 1171
            .||..:|..:|.::....|.      :.||::|           :.:.|..|.           .
Mouse  1675 WKAGLRRGRMALDVFTFNEE------SYSAEVESWTTGEQFAGWILQSRGLEAPPRGWSVSLHSG 1733

  Fly  1172 KLRRDLEEAN-----IQHESTLANLRKKHNDAVAE--MAEQVDQLNKLKA--------------- 1214
            ...|||...:     |.....|.:....||..:..  :||.:.....::|
Mouse  1734 DAWRDLPGCDFVLDLIGQTEDLGDPAGPHNYPITPLGLAESIPPAPGVQAPSLPPGLPPGPAPIL 1798

  Fly  1215 -------KAEKEKNEYYGQLNDLRAGVDHITNEKAA----------------------------- 1243
                   :|.|.:|        |...|||:.....|
Mouse  1799 ASSRPPGEASKPEN--------LDGFVDHLFEPALAPGFSDLEQGWALSRRMKGGGSVGPTQQGY 1855

  Fly  1244 ---------------------------------------------------QEKIAKQLQHTLNE 1257
                                                               ..::|.|.|:.:|:
Mouse  1856 PMVYPGMVQAPSYQPAMIPAPMPVMPAMGAVPTMPAMMVPPQPQPLVPSLDSRQLALQQQNFINQ 1920

  Fly  1258 VQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEES 1322
            ....|.:...|      ....||:|..:   |..:.::|.|..:......||..:..|..|.:|.
Mouse  1921 QAMILAQQMTT------QAMSLSLEQQN---QRHQHQAQTSGATSQPPPSTTAPKAKKPPAPQEK 1976

  Fly  1323 RERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLS---------------------KANAE 1366
            .|        .|||.....|||...||||.|.  ||..|                     |..|:
Mouse  1977 PE--------SNLEPSGVGLREDTPEEAESKP--QRPKSFQQKRDYFQKMGQEPIRVKTVKPPAK 2031

  Fly  1367 AQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIE--------SLNQKCIGLEKTKQRLSTE 1423
            .|:           ..||:||.:.       |.|||.|        .:.:|.:...:.|.....|
Mouse  2032 VQI-----------PQEEMEETEE-------EEEETAELSPPPPPPPVVKKPLKASRPKAVKEDE 2078

  Fly  1424 VEDLQLEV-----DRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDA-----SQKECRNYST 1478
            .|..|.||     |.....:|:|.:..|         ..:|..:.:...|     ..:|.||
Mouse  2079 AEPAQEEVPTQGEDPPVHSSNSAPQHPK---------PSRVPPVQSSNSAPPRPQPSREIRN--- 2131

  Fly  1479 ELFRLKGAYE----------EGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIH---------- 1523
             :.|:   |:          :....::..:::|    |...:.|.::|..|  :|
Mouse  2132 -IIRM---YQSRPGPVAVPVQPTRPIKTFQKKN----DPKDEALAKLGING--VHLPLSTSPNQG 2186

  Fly  1524 --------EIEKARKRLEAEK--DELQAALE---------------------------------- 1544
                    ...|||.|||...  .|.|..|.
Mouse  2187 KSSPPAVVPRPKARPRLEPSLSIQEKQGPLRDLFGPCSPNPPTAPAPPPPPALPPPLSGEPKTPS 2251

  Fly  1545 -EAEAALEQEENKVLRAQL---------ELSQVRQEIDRRIQEKEEEFENTRKNHQRAL------ 1593
             |:.|..|..|:|.:..:|         ..:....::..|   ||..:.....:|...|
Mouse  2252 VESHALTEPMEDKNISTKLLVPSGSVCFSYANAPWKLFLR---KEVFYPRENFSHPYCLSLLCQQ 2313

  Fly  1594 ---DSMQASLEAEAKGKAEALR-MKKKLEADINELEIALDHANK-ANAEAQKNIKRYQQQL---- 1649
               |:...|....::.:...:: :...||..:..|:|..|...| ....|:.|...|..::
Mouse  2314 ILRDTFTESCTRISQDERHKMKGLLGDLEVSLETLDIVEDSIKKRIVVAARDNWANYFSRIFPVS 2378

  Fly  1650 ----KDIQTALEEEQRARDDAREQLGISERRANALQ------NELEESRTLLEQADRGRRQAEQE 1704
                .|:|.               ||:|.|....|:      ..|::.:||.
Mouse  2379 GESGSDVQL---------------LGVSHRGLRLLKVTQSPSFHLDQLKTLC------------- 2415

  Fly  1705 LADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLADELR 1769
               ::.....::.|....|..:..|::|...||:           :..:|.|||||.  ...|||
Mouse  2416 ---SYSYAEVLTVQCRGRSTLELSLKNEQLILHT-----------AWARAIKAMVDL--FLSELR 2464

  Fly  1770 AEQDHAQTQEKLRKALEQQIKELQ------VRLDEAEANALK--------GGKKAI--QKLEQ-- 1816
            .:..:...   ||..:......|.      :||  ....||:        ||:..:  ..:.|
Mouse  2465 KDSGYVIA---LRSYITDDNSLLSFHRGDLIRL--LPVTALEPGWQFGSAGGRSGLFPDDVVQPA 2524

  Fly  1817 RVRELENEL---DGEQRRHADAQKNLRKSERRVKELSFQSE-----------EDRKNHERMQDLV 1867
            ...:|...|   :..||:........|.:..|.:|.|..||           .|..|: .||:..
Mouse  2525 AAPDLSFSLGKRNSWQRKSKLGPAQERPTHPRKQEPSEDSEATSFTTYSSLSADPHNY-TMQEFA 2588

  Fly  1868 DKLQQKIKTYKRQI-EEAEEIAALNLAKFRKAQ-QELEEAEERADLAEQAISKFRAKGRAGSVGR 1930
            .:..:|..|:..|: .:.:|.||:||.::.|.. ||...:....|...:|::.|:|..:.    .
Mouse  2589 LRYFRKPHTWLTQMSRDTKEKAAINLIQYTKDPIQESLTSFCNGDTNSKAVAGFKALMQF----M 2649

  Fly  1931 GASPAPR 1937
            |..|.||
Mouse  2650 GDQPKPR 2656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	9/42 (21%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	204/720 (28%)
		Myosin_tail_1	842..1922	CDD:460256	250/1423 (18%)
Myo15b	NP_001371162.1	PTZ00449	<185..>326	CDD:185628
		MYSc_Myo35	681..1360	CDD:276861	204/720 (28%)
		MyTH4	1575..1677	CDD:459939	17/109 (16%)
		SH3	2469..2523	CDD:473055	9/58 (16%)
		MyTH4	2617..2763	CDD:470587	11/44 (25%)
		FERM_M	2853..2968	CDD:459788
		PH-like	2964..3064	CDD:473070