DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and Myo5c

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_006510998.1 Gene:Myo5c / 208943 MGIID:2442485 Length:1749 Species:Mus musculus


Alignment Length:2022 Identity:523/2022 - (25%)
Similarity:849/2022 - (41%) Gaps:480/2022 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 YDSKKSCWIPDEKEGYLLGEIKA--TKGD-IVSVGLQGGEVRDIKSEKVEKVNPPKFEKI----- 88
            |......||||.:|.:...||..  ..|| ::.:.|:.|      .|....|:|.....:     
Mouse     7 YAQYNRVWIPDPEEVWKSAEIAKDYRAGDRVLRLLLEDG------MELEYPVDPGSLPPLRNPDI 65

  Fly    89 ----EDMADMTVLNTPCVLHNLRQRY-YAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRR 148
                .|:..::.|:.|.||||||.|: .:||||||||:..||:||||:.|:|.:.....|.|:..
Mouse    66 LVGENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNM 130

  Fly   149 NEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKG 213
            .::.|||||:::.||..|..|:.|||::::||||||||.:.:..:.|||||..|       .|..
Mouse   131 GDMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKS-------SSNA 188

  Fly   214 SLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSL 278
            .:||:|:.:||:.||.|||||.||||||||||:..|.|....::.||::.||||||:||:.|...
Mouse   189 HVEDKVLASNPITEAVGNAKTTRNDNSSRFGKYTEISFDERNQIIGANMRTYLLEKSRVVFQSEN 253

  Fly   279 ERSYHIFYQI-MSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTK 342
            ||:||||||: .|......|.:.|.:...::|..:. |...:..::|..:...|.:.|.:|||.|
Mouse   254 ERNYHIFYQLCASAQQSEFKHLKLGSAEEFNYTRMG-GNTVIEGVNDRADMVETQKTFTLLGFKK 317

  Fly   343 QEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGN 407
            ..:.||::|.||::|:|.::....|.|..:..:.:.......:|.|.:|:::.:.|...:|...:
Mouse   318 DFQMDVFKILAAILHLGNVQVTTVGNERSSVSEDDSHLKVFCELLGLETSKVAQWLCNRKIVTSS 382

  Fly   408 EFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGF 472
            |.|.:.....|..|:..||.|.::..||.::|::.|:.|....|:..|||||||.|||.|:.|.|
Mouse   383 ETVVKPMTRPQAINARDALAKKIYAHLFDFIVEQINQALHFSGKQHTFIGVLDIYGFETFDVNSF 447

  Fly   473 EQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEES 537
            ||.|||:.||||||.||.|:|.||||||.:|.|.|..||| .|....|||||..||||.:|:||.
Mouse   448 EQFCINYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDF-YDNQPVIDLIEAKMGILELLDEEC 511

  Fly   538 MFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLN 602
            :.|..||:.:.:||.|..:.|::.|:||:     ...:.|.|.|:|..|.|...|:||||:|.:.
Mouse   512 LLPHGTDENWLQKLYNNFVNKNSLFEKPR-----MSNSSFIIQHFADKVEYQCEGFLEKNRDTVY 571

  Fly   603 DTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSA---------------- 651
            |.:|:..:.|:..|....|.:....|           ...|...||.||                
Mouse   572 DMLVEILRASKFHLCAAFFQESPVPS-----------SPFGAMITVKSAKQVIKPNTKHFRTTVG 625

  Fly   652 --YKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRM 714
              ::..|..||.||.:|.||:||||.||:.|.|...|:..::.||...||||.|||..:.:|:|.
Mouse   626 NKFRSSLYLLMETLNATTPHYVRCIKPNDEKMPFEFDSKRIVQQLRACGVLETIRISAQSYPSRW 690

  Fly   715 MYPDFKMRYKIMCPKLLQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDER 779
            .|.:|..||.|:..:....:...|:..::::..:....:||:.|.||:|||||.:..:|:.|.::
Mouse   691 TYLEFYSRYGILMTQQELSLSDKKEVCKVVLHRLIQDSNQYQFGRTKIFFRAGQVAYLEKLRLDK 755

  Fly   780 LGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRI 844
            |.:....:|...||:|.|:.|  |:|::.|| .:||..|                          
Mouse   756 LRQDCIMIQKHVRGWLQRRKF--LRERQAAL-TIQRYFR-------------------------- 791

  Fly   845 EDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQE------- 902
                               .:..|||   |:.|..|.|..|.:        .||.|..       
Mouse   792 -------------------GQQTVRK---AITATALKEAWAAI--------ILQKYCRGYLVRNL 826

  Fly   903 ----RNAKLTAQKNDLENQLRDIQERLTQEEDA-RNQLFQQKKKADQEISGLKKDIEDLELNVQK 962
                |.|.:|.|.:......|....:|.||..| ..|.:.:...|.:....:::.:.:::|..: 
Mouse   827 YQLIRVATITIQAHTRGFLARRRYRKLLQEHKAVILQKYARAWLARRRFQNIRRFVLNIQLTYR- 890

  Fly   963 AEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQA-AEDKINHLNKVKAKL 1026
                                     :.:|.|:.:.|...|....|:|.: |..::..|.||:   
Mouse   891 -------------------------VQRLQKKLEDQNRENHGLVEKLTSLAALRVGDLEKVQ--- 927

  Fly  1027 EQTLDELEDSLEREKKVRGDVEKSKRK----VEGDLKLTQEAVADLERNKKELEQTIQRKDKELS 1087
                 :||..||:....|...|:..|:    ||..|...|:..|:||..::..||.:|.|.:||.
Mouse   928 -----KLEAELEKAATHRHSYEEKGRRYRDTVEERLSKLQKHNAELELQRERAEQMLQEKSEELK 987

  Fly  1088 SITAKL----------EDEQVVVLKHQRQIK--ELQARIEELEEEVEAERQARAKAEKQRADLAR 1140
            ....||          |::|.:||:...::|  ..:.:||.|.||::|       .:.:|:.|..
Mouse   988 EKMDKLTRQLFDDVQKEEQQRLVLEKGFELKTQAYEKQIESLREEIKA-------LKDERSQLHH 1045

  Fly  1141 ELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQ 1205
            :|||        |..||.::   |...|.|||..:                      .::|..::
Mouse  1046 QLEE--------GQVTSDRL---KGEVARLSKQAK----------------------TISEFEKE 1077

  Fly  1206 VDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLN 1270
            ::.|...|...||                 |:.::|       ::::..::||..:|.|:    .
Mouse  1078 IELLQAQKIDVEK-----------------HVQSQK-------REMRERMSEVTKQLLES----Y 1114

  Fly  1271 DFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNL 1335
            |.:..:.:||:|:.:.|.:..|.......|.|....|.:..:..|   |...:|...|..|..:|
Mouse  1115 DIEDVRSRLSVEDLEHLNEDGELWFAYEGLKKATRVLESHFQSQK---DCYEKEIEGLNFKVVHL 1176

  Fly  1336 EHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAE 1400
            ..::::|::...||.:....::.::::..:|     :....|...:..|||..|:.|::||.|..
Mouse  1177 SQEINHLQKLFREETDINESIRHEVTRLTSE-----NMMIPDFKQQISELERQKQDLESRLKEQA 1236

  Fly  1401 ETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAE 1465
            |.||.      .||:....|:...|:.:::....:....|.|.:                   :|
Mouse  1237 EKIEG------KLEEPFSHLNRIREEERMQGRAPHPFLRAVEAQ-------------------SE 1276

  Fly  1466 LDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARK 1530
            :....||         ||.||..|..|                               .|:..:|
Mouse  1277 MHPEGKE---------RLVGAIHEPHE-------------------------------AIKFPKK 1301

  Fly  1531 RLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEID------RRIQEKEEEFENT--RK 1587
            :.|||        ||.|:.|:||.:   |..||...:.:|:|      ||:|::.:....|  :.
Mouse  1302 QPEAE--------EEVESILQQEAS---RLSLEKRDLEEELDMKDRMIRRLQDQVKTLTKTTEKA 1355

  Fly  1588 NHQRALDSMQASL-----EAEAKGK-----------------------AEALRMKKKLEADINEL 1624
            ||.......:..|     :.|.:||                       |..|.|..:....:|:.
Mouse  1356 NHVHLPSGSREYLGMLEYKKEDEGKLIQNLILDLKPRGVVVNMIPGLPAHILFMCVRYADSLNDA 1420

  Fly  1625 EIALDHANKANAEAQKNIKRYQQQLKDIQTALEE--------EQRARDDAREQLGISERRANALQ 1681
            .:.....|.|....:..:|.:.:.|:.:...|..        :|.:.::...:....::..|.|.
Mouse  1421 NMLKSLMNSAINGIKHVVKEHFEDLEMLSFWLSNTCHFLNCLKQYSGEEEFMKYNSPQQNKNCLN 1485

  Fly  1682 N-ELEESRTLLEQADRGRRQAEQELADAHEQLNEV---------SAQNASISAAK----RKLESE 1732
            | :|.|.|.:|  :|...|...|.:......|..:         |.|  .||..|    ||..|.
Mouse  1486 NFDLTEYRQIL--SDVAIRIYHQFIIVMENNLQPIIVPGMLEYESLQ--GISGLKPTGFRKRSSS 1546

  Fly  1733 LQ-----TLHSDLDEL------LNEAKNSEEKAKKA------MVDAARLADELRAEQDHAQTQEK 1780
            :.     |:.|.|.:|      :.:.....|..::|      :|.|..|...|            
Mouse  1547 IDDTDAYTMTSILQQLSYFYSTMCQNGLDPEIVRQAVKQLFYLVGAVTLNSLL------------ 1599

  Fly  1781 LRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERR 1845
            |||.:....|.:|:|.                                         |:...|..
Mouse  1600 LRKDMCSCRKGMQIRC-----------------------------------------NISFLEEW 1623

  Fly  1846 VKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIA-------ALNLAKFRKAQQELE 1903
            :|:.:.||...::..|.:......||.|    |....:|:|||       |:.:.|...:...::
Mouse  1624 LKDKNVQSSLAKETLEPLSQAAWLLQVK----KTTDSDAKEIAQCCTSLSAVQIIKILNSYTPID 1684

  Fly  1904 EAEERAD 1910
            :.|:|.:
Mouse  1685 DFEKRVN 1691

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 11/39 (28%)
MYSc 81..777 CDD:214580 269/724 (37%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 261/684 (38%)
Myosin_tail_1 842..1897 CDD:279860 223/1165 (19%)
V_Alix_like 1557..1877 CDD:187408 69/394 (18%)
ATP-synt_B <1671..1771 CDD:304375 29/130 (22%)
TMPIT 1739..>1825 CDD:285135 14/97 (14%)
Myo5cXP_006510998.1 MYSc_Myo5 81..741 CDD:276831 261/684 (38%)
DUF3584 <767..>1043 CDD:378817 79/375 (21%)
SMC_prok_A <922..1276 CDD:274009 97/462 (21%)
ERM 1220..>1354 CDD:366293 46/209 (22%)
Myo5c_CBD 1376..1743 CDD:271260 66/377 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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