Protein Alignment Mhc and myo-2

DIOPT Version :9

• Sequence 1: NP_001162991.1
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_510092.2
• Gene: myo-2 / 181404
• WormBaseID: WBGene00003514
• Length: 1947
• Species: Caenorhabditis elegans
• Alignment Length: 1943
• Identity: 969/1943 - (49%)
• Similarity: 1364/1943 - (70%)
• Gaps: 26/1943 - (1%)

  Fly     9 EDEDPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIK 73
            |::....||..|.|:...|||:.|||||:.||||.::||:.|.|..|.||.|:|.:..|..:.:|
 Worm     4 ENDPGWKYLRRSREEMLQDQSRAYDSKKNVWIPDSEDGYIEGVITKTAGDNVTVSIGQGAEKTVK 68

  Fly    74 SEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNR 138
            .:.|:::|||||||.|||:::|.||...||:||:.||.|.|||||||||||.||||||.|:||:.
 Worm    69 KDVVQEMNPPKFEKTEDMSNLTFLNDASVLYNLKARYAAMLIYTYSGLFCVVINPYKRLPIYTDS 133

  Fly   139 CAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASK 203
            .|:|:.||||.|:|||:||:||.||.:||.||.||||||||||||||||||||||:|||.|||::
 Worm   134 VARMFMGKRRTEMPPHLFAVSDEAYRNMLQNHENQSMLITGESGAGKTENTKKVISYFAAVGAAQ 198

  Fly   204 K----------TDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLA 258
            :          .::..|.|.:||||:||||||||||||||||||:|||||||||||||...|::|
 Worm   199 QETFGAKKAATEEDKNKKKVTLEDQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFSKQGRVA 263

  Fly   259 GADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASID 323
            ..|||.|||||:|||.|...||.||||||:.|..:|.:|...||...:.||..::|.::.:..|:
 Worm   264 SCDIEHYLLEKSRVIRQAPGERCYHIFYQVFSDYLPNLKKDLLLNKPVKDYWFIAQAELIIDGIN 328

  Fly   324 DAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFG 388
            |.||..|||:|||||.||..||.:.||:.||:||||.||||||.||||||.||.::..|.:|.||
 Worm   329 DKEEHQLTDEAFDILKFTPTEKMECYRLVAAMMHMGNMKFKQRPREEQAEPDGTDDAERAAKCFG 393

  Fly   389 CDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQK-- 451
            .|:.|..|.|.:||:|||||:|.:|:|::||..::||:.||::.|:|.|||||||:|||  ||
 Worm   394 IDSEEFLKALTRPRVKVGNEWVNKGQNIEQVNWAVGAMAKGLYSRIFNWLVKKCNQTLD--QKGI 456

  Fly   452 -RQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMD 515
             |.||||||||||||||::|.||||.|||.||||||||||||||||||||.||||.|.|||||:|
 Worm   457 SRDHFIGVLDIAGFEIFDFNSFEQLWINFVNEKLQQFFNHHMFVLEQEEYAREGIQWTFIDFGLD 521

  Fly   516 LLACIDLIEKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIA 580
            |.|||:|||||:||:::|:||.:.|||||.|.::||.:.||||...|:||||||..|..||||:.
 Worm   522 LQACIELIEKPLGIIAMLDEECIVPKATDLTLAQKLIDQHLGKHPNFEKPKPPKGKQAEAHFAMR 586

  Fly   581 HYAGCVSYNITGWLEKNKDPLNDTVVDQFKKS-QNKLLIEIFADHAGQ-SGGGEQAKG--GRGKK 641
            ||||.|.||...||||||||||||||...|.| ::.|::|::.|:..| ......|||  |..||
 Worm   587 HYAGTVRYNCLNWLEKNKDPLNDTVVTVMKASKEHALIVEVWQDYTTQEEAAAAAAKGTAGAKKK 651

  Fly   642 G--GGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIR 704
            |  |.|.|||..|:|.||.|||.|.||.|||:|||||||.|..||:||.||::||||||||||||
 Worm   652 GKSGSFMTVSMLYRESLNKLMTMLHSTHPHFIRCIIPNEKKASGVIDAGLVLNQLTCNGVLEGIR 716

  Fly   705 ICRKGFPNRMMYPDFKMRYKIM-CPKLLQGVEKDKKATEI----IIKFIDLPEDQYRLGNTKVFF 764
            |||||||||.::|||..||.:: ..:.:.|....||.:.:    ::|...|.|:.:|:|.|||||
 Worm   717 ICRKGFPNRTLHPDFVQRYALLAADESIIGKTDAKKGSALMLARLVKEKKLEEENFRVGLTKVFF 781

  Fly   765 RAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWY 829
            :||::..:|:.||:.|.::::.:||..|.|......|:..|:..|||::|||:|.:.:||||.|:
 Worm   782 KAGIVAHLEDLRDQSLAQLITGLQAQIRWYYQTIERKRRVEKITALKIIQRNIRSWAELRTWVWF 846

  Fly   830 KLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEK 894
            ||:.|||||:|..:||.:..:|:|.....::....|.:.:::|:....:|..|...||..|...|
 Worm   847 KLYGKVKPLVNSGKIEAQYEKLQETVATLKDTVVQEEEKKRQLQEGAERLNKETADLLAQLEASK 911

  Fly   895 GALQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELN 959
            |:.::.:||...:..||..||.:|.|..::|..||....::.:|||..:.|.:.|||:.:|::|:
 Worm   912 GSTREVEERMTAMNEQKVALEGKLADASKKLEVEEARAVEINKQKKLVEAECADLKKNCQDVDLS 976

  Fly   960 VQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKA 1024
            ::|.|.:|..|:||||.|.||:..|||.|:|||||:|.|.|.|:|..|:|||||::....||:||
 Worm   977 LRKVEAEKNAKEHQIRALQDEMRQQDENISKLNKERKNQEEQNKKLTEDLQAAEEQNLAANKLKA 1041

  Fly  1025 KLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSI 1089
            ||.|:|::.|.::||||:.|.|::|:|||.||:||:.||.:.:|.::|.:.|..::||:.||.::
 Worm  1042 KLMQSLEDSEQTMEREKRNRADMDKNKRKAEGELKIAQETLEELNKSKSDAENALRRKETELHTL 1106

  Fly  1090 TAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGG 1154
            ..||||||..|.|.|:.|::.:||:::|.:::..|:.||.:|::.|||...|.:||.|:||:...
 Worm  1107 GMKLEDEQAAVAKLQKGIQQDEARVKDLHDQLADEKDARQRADRSRADQQAEYDELTEQLEDQAR 1171

  Fly  1155 ATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKE 1219
            ||:|||||.||::|||:||||||||:.::....|..|:||.:||:.|:::|::||.|.|.:.|||
 Worm  1172 ATAAQIELGKKKDAELTKLRRDLEESGLKFGEQLTVLKKKGSDAIQELSDQIEQLQKQKGRIEKE 1236

  Fly  1220 KNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENS 1284
            |.....:.::..|.:|.....:|.||:|||..:..|.|::.|.||.:|.|.||.:||.:|:.|||
 Worm  1237 KGHMQREFDESSAALDQEAKLRADQERIAKGYEVRLLELRLKADEQSRQLQDFVSSKGRLNSENS 1301

  Fly  1285 DLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEE 1349
            ||.||:||.|:::...:::|:..:.:|:..||.|:||||||..|....:||..:|:.|:|.:|:|
 Worm  1302 DLARQVEELEAKIQAANRLKLQFSNELDHAKRQAEEESRERQNLSNLSKNLARELEQLKESIEDE 1366

  Fly  1350 AEGKADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLE 1414
            ..||.:..||||||:.|...||:|:|::|:..::|.:|.|::...:.:|.::.:::.|.|.:.||
 Worm  1367 VAGKNEASRQLSKASVELDQWRTKFETEGLIGADEFDEVKKRQNQKTSEIQDALDACNAKIVALE 1431

  Fly  1415 KTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTE 1479
            ..:.||:.|.:..:||.:......::.|||||||||:|.|||.|||||..|||.:|::.|..|.|
 Worm  1432 NARSRLTAEADANRLEAEHHAQAVSSLEKKQKAFDKVIDEWKKKVDDLYLELDGAQRDARQLSGE 1496

  Fly  1480 LFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALE 1544
            ..:|:|.::...:|:|.:|||||:|:||.:||.:.:.||||..|.:.|..:|||.||:|||..|:
 Worm  1497 AHKLRGQHDTLADQVEGLRRENKSLSDETRDLTESLSEGGRATHALSKNLRRLEMEKEELQRGLD 1561

  Fly  1545 EAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAE 1609
            |||||||.||:|.||.|:|:||:|.||::||.||||||||.||.||:.:||:||:|::|.|.|:|
 Worm  1562 EAEAALESEESKALRCQIEVSQIRAEIEKRIAEKEEEFENHRKVHQQTIDSIQATLDSETKAKSE 1626

  Fly  1610 ALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISE 1674
            ..|:||||||||||||||||||||||.:|||||:||..|::::|..::|||:.|::.||.|..:|
 Worm  1627 LFRVKKKLEADINELEIALDHANKANEDAQKNIRRYLDQIRELQQTVDEEQKRREEFREHLLAAE 1691

  Fly  1675 RRANALQNELEESRTLLEQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSD 1739
            |:....:.|.||....||..:|.||..|..:.:..|..||:::||.:::|||.:|::|:..|:||
 Worm  1692 RKLAVAKQEQEELIVKLEALERARRVVESSVKEHQEHNNELNSQNVALAAAKSQLDNEIALLNSD 1756

  Fly  1740 LDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANAL 1804
            :.|...|...||::.::|..|||:||::||.||:.:|..|:.:|.||..:|:||.|.|.|||..:
 Worm  1757 IAEAHTELSASEDRGRRAASDAAKLAEDLRHEQEQSQQLERFKKQLESAVKDLQERADAAEAAVM 1821

  Fly  1805 KGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDK 1869
            |||.|||||.|||::..:::|:.|.||..:|.|.|.:::|:|:|..||..||:||::::|:||:|
 Worm  1822 KGGAKAIQKAEQRLKAFQSDLETESRRAGEASKTLARADRKVREFEFQVAEDKKNYDKLQELVEK 1886

  Fly  1870 LQQKIKTYKRQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAGS 1927
            |..|:|..|:|:|||||.|..:|:|:|..|..||.||||||.|||.:.:.|::.||.:
 Worm  1887 LTAKLKLQKKQLEEAEEQANSHLSKYRTVQLSLETAEERADSAEQCLVRIRSRTRANA 1944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	15/36 (42%)
		MYSc	81..777	CDD:214580	431/719 (60%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	414/688 (60%)
		Myosin_tail_1	842..1897	CDD:279860	464/1054 (44%)
		V_Alix_like	1557..1877	CDD:187408	156/319 (49%)
		ATP-synt_B	<1671..1771	CDD:304375	36/99 (36%)
		TMPIT	1739..>1825	CDD:285135	39/85 (46%)
myo-2	NP_510092.2	Myosin_N	31..68	CDD:280832	15/36 (42%)
		Myosin_head	83..782	CDD:278492	420/700 (60%)
		MYSc_class_II	95..782	CDD:276951	414/688 (60%)
		Myosin_tail_1	876..1939	CDD:279860	474/1062 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	812	1.000	Domainoid score	I24
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2227	1.000	Inparanoid score	I15
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm14456
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830