DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and hum-4

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_001359540.1 Gene:hum-4 / 181335 WormBaseID:WBGene00002037 Length:2577 Species:Caenorhabditis elegans


Alignment Length:1329 Identity:297/1329 - (22%)
Similarity:511/1329 - (38%) Gaps:341/1329 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   102 VLHNLRQRYYAKLIYTYSGLFCVAINPYK------------RYPVYTNRCAKMYRGKRRNEVPPH 154
            :..||.:|:...:.||.:....|.:|.:.            ......|..||....|        
 Worm    15 IAQNLHERFKKGVTYTKASNVLVFVNDFNDKDSEDQLSWETSSTSGVNAVAKNALNK-------- 71

  Fly   155 IFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQV 219
            ||.:|..|          :|::..||||:||:.|..|...|..   :..|:..:.|...|:|.  
 Worm    72 IFNMSSNA----------ESIVFGGESGSGKSYNVFKAFKYLT---SQPKSKVSTKHSSSIEF-- 121

  Fly   220 VQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIE-TYLLEKARVISQQSLERSYH 283
                 |.::||.|||::||.::|||..|.:.: ....|.|.::: |..||..|||||:..||:::
 Worm   122 -----VFKSFGCAKTLKNDEATRFGCSIDLLY-KRNVLTGLNLKYTVPLEVPRVISQKPGERNFN 180

  Fly   284 IFYQIMSG------SVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTK 342
            |||::..|      :..|:|       .:..:..::||..:.....|...|...:.|..:|||:.
 Worm   181 IFYEVYHGLSDEMKAKFGIK-------GLQKFFYINQGNSSENIQHDVNRFKHLESALHVLGFSD 238

  Fly   343 QEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGR-----VSKLFGCDTAELYKNLLKPR 402
            .....:|:|.:.::|:|.:.|:.: |....|||..|.|..     ::.|...|..:|.|.|| |.
 Worm   239 DHCMSIYKIISTILHIGNIYFRTK-RNPNVEQDVVEIGNLAELKWIAFLLEVDFDQLVKFLL-PT 301

  Fly   403 IKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVK------KCNETLDTQQKRQHFIGVLDI 461
            .:.|:..     .:....::..:....:::.||||::.      ||  :|.|     ..|.:||.
 Worm   302 SEDGSTI-----ELNAALDNRDSFAMMIYEELFKWVLNRIGLQLKC--SLHT-----GVISILDH 354

  Fly   462 AGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDF----GMDLLACIDL 522
            .|||.:..||.|:..||..||:::..|..|.|..:..:|.::||.   :|:    .::....::|
 Worm   355 YGFEKYNNNGVEEFLINSVNERIENLFVKHCFHDQLIDYAKDGIS---VDYKVPNSIENGKTVEL 416

  Fly   523 I-EKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCV 586
            : :||.|:||:|.:|..|||.|.:|:.|.....|..:|| :.|.:    .::...|.:.|..|..
 Worm   417 LFKKPYGLLSLLTDECKFPKGTHETYLEHCNLNHTDRSA-YGKAR----NKERLEFGVRHCIGTT 476

  Fly   587 SYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSA 651
            .||:|.:..:||..::.:.|...:.|:|.::..:|..:.|.:..               ..||.|
 Worm   477 WYNVTDFFARNKRIISLSAVQLMRNSKNPIIGLLFESYGGNTSD---------------IIVSQA 526

  Fly   652 YKEQLNSLMTTLRSTQP----------HFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRIC 706
                    ...||..|.          ||||||..|..:|....|..||..|:....:.|.:...
 Worm   527 --------QFVLRGAQDIADKINVSHVHFVRCIKSNNERQSTKFDIPLVNRQIKNLLLAELLSFR 583

  Fly   707 RKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATEII-----IKFIDLPEDQYRLGNTKVFFRA 766
            .||:|.::....|..:|:.:.|..:...:.:|:..:.|     :|:    ||.:::|...||.|.
 Worm   584 VKGYPVKISKTTFARQYRCLLPGDIAQCQNEKEIIQDILQGQGVKY----EDDFKIGTEYVFLRE 644

  Fly   767 GVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKL 831
            .:..:.:..:::..|.....:|...:.::::|.:|::   |.|:..:|..||.:...|       
 Worm   645 RLAERYDGLQNKICGDAAIIIQKNMKSFVAQKVYKRM---RAAIIKLQSGLRGWKARR------- 699

  Fly   832 WQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTA-LLDSLSGEKG 895
                          |.|.:.||..|..    ...:|..|.|:|.:..|..|.:. |..:|.|...
 Worm   700 --------------DYIIKREEMFKAI----GRTMKRNKRLDAYHQALGTENSGQLQQTLVGYID 746

  Fly   896 ALQD---YQERNAK-----------LTA-QKNDLENQLRDIQERLTQEEDARNQLFQQK------ 939
            ..:|   :.||...           ||. .||.|.| :..|......||:.:..|.:.:      
 Worm   747 INEDAKKFLERPTSDSDATETLTHYLTVPMKNFLSN-MNSITLEQFAEENFKGHLLEPRREPIMT 810

  Fly   940 ----KKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQ--------DE-LINKL 991
                |::|.:   .:..:|..:|.::.....|.|| .|..:|...|..|        || |:..:
 Worm   811 PFLHKESDYD---FRLSVEIFKLILKYMNDIKLTK-KQREDLGRYIVQQGISNPCQRDEILVQTI 871

  Fly   992 NKEKKMQGETNQKTGEEL--------QAAED----KINHLNK----VKAKLEQTLD--------- 1031
            |:..|.|.:|....|.:|        ...|:    .|...||    :|.:|..||.         
 Worm   872 NQINKNQDKTASDNGWKLVHMAISVFPPTENIIPMLIGFFNKESVPMKEQLFATLQRRLKIYDSE 936

  Fly  1032 ---ELEDS--------------------------------------LEREKKVRG---------D 1046
               ||..|                                      .||..|.||         :
 Worm   937 IARELPPSNLELIATPNIPNTVAEINCYDGLCCDVHLSPWSTTSEIAERILKQRGVGIALGWTVE 1001

  Fly  1047 VEKSKR---------------KVEGDLKLTQEAVADLERNKKELEQTI------QRKDKELSSIT 1090
            ||...|               ::||         |:::   .|.:|.|      ::..|:...:.
 Worm  1002 VETPNRVFAPTGNHFIHDVFSQIEG---------ANMD---SENQQNIFFNFPPEKLVKKPPVVP 1054

  Fly  1091 AKLEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERL-----E 1150
            .::..||.:|.::........||.....||...:...|.::.....|..:..||..|.|     |
 Worm  1055 KEVVQEQEIVSQNTNGTIPKAARTYPTPEEWINQPPQRTESRNTPRDHQKPDEESDESLVREYNE 1119

  Fly  1151 EAGGA---------TSAQIELNKKREAELSKLRRDLEEA--NIQHESTLANLRKKHNDAVAEMAE 1204
            |||.|         ....:|.|:..|:|     .|.|:|  .:.:|:    :|.:.|..:.|..:
 Worm  1120 EAGYAYTLPRKNKPAPQAVEDNETSESE-----EDDEDAANRVGYET----VRPEENMKMMETIQ 1175

  Fly  1205 QVDQLNK-----LKAKAEKEKNEYYGQLN 1228
            ....:.|     .|..:..|::|.|..:|
 Worm  1176 DHSHILKSPVLPRKTYSRNEQHEEYTPMN 1204

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832
MYSc 81..777 CDD:214580 179/724 (25%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 178/712 (25%)
Myosin_tail_1 842..1897 CDD:279860 108/539 (20%)
V_Alix_like 1557..1877 CDD:187408
ATP-synt_B <1671..1771 CDD:304375
TMPIT 1739..>1825 CDD:285135
hum-4NP_001359540.1 MYSc_Myo12 13..643 CDD:276841 178/712 (25%)
IQ 680..701 CDD:197470 6/44 (14%)
MyTH4 803..952 CDD:214535 31/152 (20%)
PRK10263 <1162..>1357 CDD:236669 9/43 (21%)
SH3 1974..2030 CDD:388381
MyTH4 2100..2255 CDD:214535
B41 2262..2475 CDD:214604
PH-like 2489..2563 CDD:388408
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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