DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and nmy-1

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_508504.2 Gene:nmy-1 / 180581 WormBaseID:WBGene00003776 Length:1963 Species:Caenorhabditis elegans


Alignment Length:1936 Identity:718/1936 - (37%)
Similarity:1149/1936 - (59%) Gaps:107/1936 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 KKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRD------IKSEKVEKVNPPKFEKIEDMAD 93
            :|.||:||:.||:|:|.||....|.|.|     |:.|      |..:.|:|.|||||:|||||::
 Worm    26 RKLCWVPDQNEGFLIGSIKRETNDEVLV-----ELVDTSRQVTISRDDVQKANPPKFDKIEDMSE 85

  Fly    94 MTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAI 158
            :|.||...|||||:.|||:.|||||||||||.|||||:.|:|:....:.::||:|:|:|||||||
 Worm    86 LTYLNEASVLHNLKDRYYSSLIYTYSGLFCVVINPYKKLPIYSEDLIEEFKGKKRHEMPPHIFAI 150

  Fly   159 SDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV-GA--SKKTDEAAKSK-------- 212
            :|.||..||....:||:|.||||||||||||||||.|.|.| ||  :|..:.||:..        
 Worm   151 ADTAYRSMLQEREDQSILCTGESGAGKTENTKKVIQYLAHVAGATRNKSLNAAAQQNIVQKPDVR 215

  Fly   213 ---GSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVIS 274
               |.||.|::|.||:||||||:|||:|||||||||||||:|..:|.::||:||.|||||:||:.
 Worm   216 NPIGELEHQLLQANPILEAFGNSKTVKNDNSSRFGKFIRINFDMSGYISGANIEFYLLEKSRVLR 280

  Fly   275 QQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILG 339
            |...|||:||||||:.|.....|...|| :.:.:|..:....:|:.::||.:||..|..:..|:|
 Worm   281 QAQDERSFHIFYQILRGCSAKEKSEYLL-EGVDNYRFLVNRGITLPNVDDVQEFHSTINSMRIMG 344

  Fly   340 FTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIK 404
            |...|...:.|:.:||:.:|.::|.|..:.:||....:....:|..|.|....||.|..|:||||
 Worm   345 FADDEISSIMRVVSAVLLLGNLEFTQEKKSDQAMLQDDRVIQKVCHLLGLPVIELQKAFLRPRIK 409

  Fly   405 VGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLD-TQQKRQHFIGVLDIAGFEIFE 468
            ||.|||.:.:|.:|...::.|:.|..::|||||||.:.|::|| |.::...|||:|||||||||:
 Worm   410 VGREFVNKAQNQEQAEFAVEAIAKASYERLFKWLVTRINKSLDRTHRQGASFIGILDIAGFEIFD 474

  Fly   469 YNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSIL 533
            .|.|||:|||:|||||||.||:.||:||||||:||||:|.|||||:||...|||||||||:|::|
 Worm   475 INSFEQICINYTNEKLQQLFNNTMFILEQEEYQREGIEWDFIDFGLDLQPTIDLIEKPMGVLALL 539

  Fly   534 EEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPK---PGQQA-AHFAIAHYAGCVSYNITGWL 594
            :||.:||||.|::|.|||..||         .|.||   |..:: :|||:.||||.|.|:...||
 Worm   540 DEECLFPKANDKSFVEKLQKTH---------NKHPKFIVPDMRSKSHFAVVHYAGRVDYSADQWL 595

  Fly   595 EKNKDPLNDTVVDQFKKSQNKLLIEIF--ADHAGQSGG--GEQAKGGRGKKGGGFATVSSAYKEQ 655
            .||.||||:.||...:.|.:..:..|:  |:.||....  .|.|.|.|.:| |.|.|||..:|||
 Worm   596 MKNMDPLNENVVGLMQNSTDPFVAGIWKDAEFAGICAAEMNETAFGMRSRK-GMFRTVSQLHKEQ 659

  Fly   656 LNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFK 720
            |..||||||:|.||||||||||..|:.|.::::||:.||.||||||||||||:|||||:.:.:|:
 Worm   660 LTKLMTTLRNTSPHFVRCIIPNHEKKSGKINSNLVLEQLRCNGVLEGIRICRQGFPNRVPFQEFR 724

  Fly   721 MRYKIMCP-----KLLQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERL 780
            .||:|:.|     ..:.|.|..:|    :|..:|:..:.||:|.:|||||.|||..:||.||.:|
 Worm   725 HRYEILTPDVIPKNFIDGKESVRK----MITALDIDTNLYRIGQSKVFFRTGVLAHLEEERDLKL 785

  Fly   781 GKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIE 845
            ..::...||..||:|||:.:.:.|:|..|::::|||...||:||.|.|::|:.||||||.|:|.:
 Worm   786 TALIMNFQAQCRGFLSRRLYTRRQQQSSAIRIIQRNGLAYLKLRNWQWWRLFTKVKPLLQVTRTD 850

  Fly   846 DEIARLEEKAKKAEELHAAEVKVRK------ELEALNAKLLAEKTALLDSLSGEKGALQDYQERN 904
            |||      ..|.:||.|.:.::.|      |.|....:::.|:..:.:.|..|.....:..:..
 Worm   851 DEI------RAKDDELRATKERLLKMEHDFRENEKKLDQVIVERAVIQEQLQQESENSAELDDIR 909

  Fly   905 AKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKAT 969
            .:|..:..:||..:.|:::||::||....:...:::|..:.:..|::.:|..|...||...||..
 Worm   910 GRLQTRNQELEYIVNDMRDRLSEEEQQNEKNNDERRKQMETVRDLEEQLEQEEQARQKLLLDKTN 974

  Fly   970 KDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELE 1034
            .|.::|||.:.:....:..:||.|||::..|..:....:|...|::..|..|.|.:||..|.|||
 Worm   975 VDQRLRNLEERLVELQDAYDKLLKEKRLLEEKVEGLTTQLLDHEERAKHGVKAKGRLENQLHELE 1039

  Fly  1035 DSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVV 1099
            ..|.||::.:.::|:.|||:..:|:.:::.:|:.....:||...:.::|:||.....:.::|...
 Worm  1040 QDLNRERQYKSELEQHKRKLLAELEDSKDHLAEKMGKVEELNNQLMKRDEELQHQLTRYDEESAN 1104

  Fly  1100 VLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEEL-GERLEEAGGATSAQIELN 1163
            |...|:|::::|..|:||.|::|.||.||.|||..|.::..:||:: |:.|::...||..| :|.
 Worm  1105 VTLMQKQMRDMQTTIDELREDMETERNARNKAEMTRREVVAQLEKVKGDVLDKVDEATMLQ-DLM 1168

  Fly  1164 KKREAELSKLRRDLEEANIQH--ESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQ 1226
            .:::.|::..:|.:|:  |||  |..:...:.|.:..|.|:.:|::|..|.:::.||::|:...:
 Worm  1169 SRKDEEVNATKRAIEQ--IQHTMEGKIEEQKAKFSRQVEELHDQIEQHKKQRSQLEKQQNQADQE 1231

  Fly  1227 LNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKL---DETNRTLND-FDASKKKLSIENSDLL 1287
            ..|:...:..:...:|..:|..|..:..|.|:|:.|   ||..|||.| .:.|:.:|    ..|.
 Worm  1232 RADMAQEIALLQASRADIDKKRKIHEAHLMEIQANLAESDEHKRTLIDQLERSRDEL----DHLN 1292

  Fly  1288 RQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEG 1352
            |..||.|...:.:.:...:...|:::......||:|.:...:.:.|.||.:.:.|.:: :|||||
 Worm  1293 RVREEEEHAFANMQRRLATAEGQIQELNEQIQEETRLKIANINRARQLEDEKNALLDE-KEEAEG 1356

  Fly  1353 -KADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRK-------LQARLAEAEETIESLNQK 1409
             :|.|::::..|...|...|.|.|.   :.:::|||.::|       ||.:|.|:|...|.:.| 
 Worm  1357 LRAHLEKEIHAARQGAGEARRKAEE---SVNQQLEELRKKNLRDVEHLQKQLEESEVAKERILQ- 1417

  Fly  1410 CIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECR 1474
                  :|:::..|:||..:|::...|....:||:||.|:..:.|.::.|.....:.||..:|.|
 Worm  1418 ------SKKKIQQELEDSSMELENVRASHRDSEKRQKKFESQMAEERVAVQKALLDRDAMSQELR 1476

  Fly  1475 NYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDEL 1539
            :..|.:..|....:..:|.||...|..::|..|::|.:....:.|:|:||:|||::.||||.:::
 Worm  1477 DRETRVLSLLNEVDIMKEHLEESDRVRRSLQQELQDSISNKDDFGKNVHELEKAKRSLEAELNDM 1541

  Fly  1540 QAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEA 1604
            :..:||.|..|:..|:..||.::....::.|.||.|..|:.|.|..|:...:.:..::..||.|.
 Worm  1542 RVQMEELEDNLQIAEDARLRLEVTNQALKSESDRAISNKDVEAEEKRRGLLKQIRDLENELENEK 1606

  Fly  1605 KGKAEALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQ 1669
            :||:.|:..:||:|..|.|||..|:.||:...|..|.:|:.||.:|:.|...||.::|::|....
 Worm  1607 RGKSGAVSHRKKIENQIGELEQQLEVANRLKEEYNKQLKKNQQIIKEYQIECEEARQAKEDIAAL 1671

  Fly  1670 LGISERRANALQNELEESRTLLEQADRGRRQAEQELADAHEQLNEVSAQNASISA-AKRKLESEL 1733
            |..::|:..|::.|.|:    |.:|:.|..||.::|...:::|.|:.|:...||: .||:||:::
 Worm  1672 LREADRKFRAVEAEREQ----LREANEGLMQARKQLELENDELEELRAKGGGISSEEKRRLEAKI 1732

  Fly  1734 QTLHSDLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDE 1798
            ..|..:|:|..:..:.:.:|.:||.|...::..:|..|:...|..|..:::||:..::.:.::.|
 Worm  1733 AQLEEELEEEQSNCELAIDKQRKAQVQLEQITTDLSMERTLNQKTEAEKQSLERSNRDYKAKITE 1797

  Fly  1799 AEANALKGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERM 1863
            .|:.|....:..:..||.:|:.||::|:.|.:....|.:..|:.|:|:.:.:.|.|::::.:|:.
 Worm  1798 LESGAQSRARAQMAALEAKVQYLEDQLNVEGQEKTAANRAARRLEKRLNDTTQQFEDEKRANEQA 1862

  Fly  1864 QDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQ 1914
            ::|::|...|.:..:||::|||:..:....|.|..|:   ||::..|..||
 Worm  1863 KELLEKSNLKNRNLRRQLDEAEDEMSRERTKHRNVQR---EADDLLDANEQ 1910

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 16/42 (38%)
MYSc 81..777 CDD:214580 365/723 (50%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 345/692 (50%)
Myosin_tail_1 842..1897 CDD:279860 297/1076 (28%)
V_Alix_like 1557..1877 CDD:187408 90/320 (28%)
ATP-synt_B <1671..1771 CDD:304375 27/100 (27%)
TMPIT 1739..>1825 CDD:285135 20/85 (24%)
nmy-1NP_508504.2 Myosin_N 27..65 CDD:280832 16/42 (38%)
Myosin_head 80..770 CDD:278492 352/704 (50%)
MYSc_class_II 92..770 CDD:276951 345/692 (50%)
Myosin_tail_1 847..1919 CDD:279860 304/1095 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.720

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