DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and hum-2

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_001317742.1 Gene:hum-2 / 179321 WormBaseID:WBGene00002036 Length:1811 Species:Caenorhabditis elegans


Alignment Length:1935 Identity:498/1935 - (25%)
Similarity:836/1935 - (43%) Gaps:418/1935 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 NPPKFEKIEDMADMTVLNTPCVLHNLRQRYY-AKLIYTYSGLFCVAINPYKRYP-VYTNRCAKMY 143
            ||......:|:..::.|:.|.|||||:.|:. ...||||.|:..||||||.... :|.....::|
 Worm    74 NPAFLVGKDDLTLLSYLHEPAVLHNLQVRFVKGSSIYTYCGIVLVAINPYADCSHIYGEEIIQVY 138

  Fly   144 R--GKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTD 206
            |  ||...|:.|||||:::.|:.||.....:||::::||||||||.:.|.|:.|.|:|.|||..:
 Worm   139 RGAGKSAREMDPHIFAVAEEAHFDMGAFGKSQSIIVSGESGAGKTVSAKFVMRYLASVAASKTRN 203

  Fly   207 EAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTG-KLAGADIETYLLEKA 270
            ....   |:|.:|:.:||::|:.|||||:||||||||||||:|:|...| ::.||:::||||||:
 Worm   204 GGTT---SIEARVLASNPIMESIGNAKTIRNDNSSRFGKFIQINFCERGRRIVGAEMKTYLLEKS 265

  Fly   271 RVISQQSLERSYHIFYQIMSGSVPGV-KDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQA 334
            |::.|...||:||||||:.:.....| ||:.|.....|.| :...|...:..:||..:|....:|
 Worm   266 RLVFQAPGERNYHIFYQLCAARNHQVLKDLHLGPCESYSY-LTQGGDSRIPGVDDKADFEALLKA 329

  Fly   335 FDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLF-GCDTAELYKNL 398
            ..:|||.:::..||:|:.|.::.:|.:.|:.............:|..|:.:.| ....::|...|
 Worm   330 LQLLGFDEKQMSDVFRLLAGLLLLGNVHFENGEGSSAVSASSCQEISRLCREFWKISESDLRIWL 394

  Fly   399 LKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLD-------TQQKRQ--H 454
            .:..|:..||.||:.....:...|..||.|.::..||.|||.|.||.|:       |.||::  .
 Worm   395 TRREIRAVNEIVTKPLTKNEAVRSRDALTKMLYSHLFGWLVDKINEALNEKDKLDGTNQKKRPDR 459

  Fly   455 FIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLAC 519
            |||||||.|||.|:.|.|||..||:.||||||.||.|:|.||||||.||.|:|..:|| .|....
 Worm   460 FIGVLDIYGFETFDVNSFEQFSINYANEKLQQQFNQHVFKLEQEEYIREEIEWVRVDF-HDNQPA 523

  Fly   520 IDLIEKPMGILSILEEESMFPKATDQTFSEKLTN-THLGKSAPFQKPKPPKPGQQAAHFAIAHYA 583
            |||||.|:|::::|:|:......:|..:..:|.| |.|.::     |:...|..::..|.:.|:|
 Worm   524 IDLIEGPVGMINLLDEQCKRLNGSDADWLSQLQNSTELKRN-----PQLAFPKVRSNDFIVRHFA 583

  Fly   584 GCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATV 648
            ..|:|:..|::|||:|.:.:.::|....|:...:..:....|..|.....:....||:... .||
 Worm   584 ADVTYSTDGFVEKNRDAIGEQLLDVVVASKFPFIRTVIGSTAPTSVSSSSSSSTPGKRTIK-KTV 647

  Fly   649 SSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNR 713
            :|.:::.|..||:.|.||:||:||||.||:.|.....:....:.||...||||.:||...|||:|
 Worm   648 ASQFRDSLKELMSVLCSTRPHYVRCIKPNDSKISFDFEPKRAIQQLRACGVLETVRISAAGFPSR 712

  Fly   714 MMYPDFKMRYKIMCPK---LLQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEF 775
            ..|.:|..||:::..|   |.:  :|.|:..|:..:.. |.|.:|.:|.||:|.|.|.:..:|..
 Worm   713 YPYEEFARRYRVIYTKEAALWR--DKPKQFAELACQQC-LEEGKYAVGKTKIFLRTGQVAVLERV 774

  Fly   776 RDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLN 840
            |.:.|....:.:|...:|:|:|   :|.:..|.:|.:||.:|:.:|..|         ::|.|  
 Worm   775 RLDTLAAAATVIQKMWKGFLAR---RKYETMRRSLLIVQASLKAFLAFR---------RIKYL-- 825

  Fly   841 VSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQ--DYQE- 902
                               ::|.|.:.::                     |..:|.|:  .|:: 
 Worm   826 -------------------QMHRAVIVMQ---------------------SAVRGYLERRKYEQI 850

  Fly   903 RNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDK 967
            |::.:..|.....|::|...|:|..|:.|                          :.:|.|.:..
 Worm   851 RDSIIGIQAMFKANRVRRYVEKLRYEKSA--------------------------ITIQAAWRGY 889

  Fly   968 ATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDE 1032
            ..:..||.|....:..|..:...|.|.:.          .||:.....:.||.|:...||..:.|
 Worm   890 LARREQIANRKKVVMVQCAVRKWLAKRRL----------RELKIEARSVGHLQKLNTGLENKIIE 944

  Fly  1033 LEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQ 1097
            |:        :|.|:..::.|.|.:...|  |..:|::.|.:|               |.:|.|:
 Worm   945 LQ--------MRLDIANARTKEEAEKFAT--ASKNLQKTKADL---------------AMMEAER 984

  Fly  1098 VVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIEL 1162
            :.:|:.:.:::.||..:|.||.|.:.:...|...|.:..:|...|::.  :::...|.|.  :||
 Worm   985 LTLLEARNRVEVLQEEVERLETECDLKEAQRGGMETKMVELQSRLDQF--QMQSESGQTI--VEL 1045

  Fly  1163 NKKREAELSKLRRD---LEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNK---------LKAK 1215
            .:    :|.|.:.|   .:|...:.|:.|...|...|...||||...:||.|         .:.:
 Worm  1046 TE----QLEKAKADRVLWDEERQRMEAALNTERSARNALDAEMAAMREQLMKNVDLFESSTFQKR 1106

  Fly  1216 AEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASK-KKL 1279
            ..::||......:...:.:..:|....|:         |:|.|.|....:...|.|..||. ::|
 Worm  1107 PSQKKNRDDDSCSRTTSNLSQLTGSFTAE---------TINGVHSTSRGSPEVLLDNMASTFEQL 1162

  Fly  1280 SIENSDLLRQLEEAESQVSQLSKIKISLTTQLE--DTK-RLADEESRERATLLGKFRNLEHDLDN 1341
            .:.| ||.::.|..:.:..::..| |..:|.:|  |.| .|...||.....|.|.:..|::|::.
 Worm  1163 RMIN-DLRQRNEHCQRETERMKAI-IEASTLIETLDKKTSLKAFESIRVGELEGAYNRLKNDMER 1225

  Fly  1342 L------------------REQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEELEEA 1388
            |                  .|::.|||   .:|:..||          |.:|...||.|.....:
 Worm  1226 LVSGENGATHSVFERIMEENERLREEA---VELRSMLS----------SHFEKQSVAGSSGYRRS 1277

  Fly  1389 KRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIG 1453
            .|.....              |.|.:........::|                            
 Worm  1278 PRPDSGH--------------CSGADSEDGSSGADLE---------------------------- 1300

  Fly  1454 EWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEG 1518
                  :||..|     ::||:.                         ||||:.:..:|.     
 Worm  1301 ------EDLCIE-----RQCRHL-------------------------KNLAENLTKMLT----- 1324

  Fly  1519 GRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFE 1583
            .:|: |||:.:::|..  .|.|.....::.:|::......:....|:|...:::.::..:.||..
 Worm  1325 NQNL-EIERLQQQLRF--SESQTVFRPSDCSLDEAVRGAHKQTQLLAQQNMDLNDKLTRQSEELA 1386

  Fly  1584 NTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQ 1648
            ..|               |:.:|.:..|.::...:.:|..||          |..:.:||     
 Worm  1387 EAR---------------AQLRGYSGPLGLENASDEEIIRLE----------AFEKGSIK----- 1421

  Fly  1649 LKDIQTALEEEQRARDDAREQLGISERR---ANALQNELEESRTLLEQADRGRRQAEQELADAHE 1710
                .:...|.....:.||  :.:.|.:   |..|...|  ...||..|.|.           |:
 Worm  1422 ----HSGFLEVYNVPEFAR--IIVCELKPTLARLLTKNL--PAYLLVAAFRN-----------HD 1467

  Fly  1711 QLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLADELR--AEQD 1773
            :..:.:|.....|:....|:..:...| |||.|           ...:|:..||.:.||  :.:|
 Worm  1468 EKRDETALTGLFSSVHLVLKDTISRSH-DLDLL-----------SLWLVNLWRLFNLLRQYSGED 1520

  Fly  1774 --------HAQTQEKLR-KALE-QQIK-ELQVRLDEAEANALKGGKKAIQ-----KLEQRVRELE 1822
                    :.:||...| ||.: ..|: :|::|::|...:.:   ||||:     |:...:.:.|
 Worm  1521 SQPEWHVANTETQNSYRFKAYDVAPIRDQLKLRIEECYTSLM---KKAIEHVLSPKIVPGILQHE 1582

  Fly  1823 NELD----GEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTY------ 1877
            :..|    |::||..:               |...|..||:.:.:...::.:..|:.||      
 Worm  1583 SSSDLMTAGQERRDRN---------------SGSVESQRKSLDDLLQFMEIVHTKLTTYGGDDIV 1632

  Fly  1878 -KRQIEEAEE---IAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKG 1923
             |:.|.:...   ..|||...||:.....|:|.:......|..:...|||
 Worm  1633 VKQVIGQMARWMCALALNYMMFRRELCNFEKAIQIKHNVTQIQNWLNAKG 1682

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832
MYSc 81..777 CDD:214580 265/715 (37%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 258/684 (38%)
Myosin_tail_1 842..1897 CDD:279860 210/1126 (19%)
V_Alix_like 1557..1877 CDD:187408 64/344 (19%)
ATP-synt_B <1671..1771 CDD:304375 22/104 (21%)
TMPIT 1739..>1825 CDD:285135 25/103 (24%)
hum-2NP_001317742.1 MYSc_Myo5 93..764 CDD:276831 258/684 (38%)
IQ 779..799 CDD:197470 5/22 (23%)
IQ 826..847 CDD:197470 5/41 (12%)
CCDC158 <864..1473 CDD:318193 156/836 (19%)
Myo5_CBD 1429..1803 CDD:271254 64/299 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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